Relationship between subclinical hypothyroidism and serum homocysteine concentration in premenopausal women

Objective: In our study we aimed to examine serum homocysteinelevels of patients without thyroid dysfunctionswho have high serum anti thyroid peroxidase (anti-TPO)levels and patients with subclinical hypothyroidism whohave high serum thyroid stimulating hormone (TSH) andanti-TPO levels.Methods: One hundred and seven premenopause femaleoutpatients who referred to endocrine clinic of our hospitalwere included in our study. We generated 3 groups. Firstgroup (Control) consists of 53 (50%) patients between theages of 30-40 years. Second group (Euthyroid) consistsof 31 (29%) patients between the ages of 26-49. Thirdgroup (Subclinical Hypothyroidism) consists of 23 (21%)patients between the ages of 33-53 years. Serum totalcholesterol, triglycerides, high density lipoprotein (HDL)levels were measured by Olympus 2700 autoanalyzer.Serum TSH, free T4, anti-TPO and homocysteine levelswere measured by Siemens Immulite 2000 autoanalyzer.Results: In our study, total cholesterol, triglycerides, lowdensity lipoprotein (LDL) and very low density lipoprotein(VLDL) levels were not statistically significantly differentamong the groups. Although serum homocysteine levelsof the third group were higher than the other groups it wasnot statistically significantly different among the groups.Conclusion: Serum homocysteine and lipid levels of patientswith euthyroidism and subclinical hypothyroidismwho have positive anti-TPO levels may be inadequate inassessing the risk of cardiovascular diseases. J Clin ExpInvest 2013; 4 (3): 293-297Key words: Hypothyroidsm, homocysteine, premenopaus

Serum amilaz aktivitesi, hastaneye yatış ve operasyon oranlarını öngörebilir

WOS: 000432828600007Objective:The levels of serum amylase is an indicator of several diseases. Therefore, a routine amylase test is frequently requested in hospital emergency admissions. This research aims to evaluate the hospitalization and surgery rates of patients with high amylase levels. Methods: A retrospective clinical study was performed on 64,909 patients aged 53.30 +/- 19.45 years who had a serum amylase test at hospital admission in the emergency ward between 2011 and 2015. Age, gender, serum amylase levels, diagnosis, hospitalization, and surgery status of the patients were obtained from the electronic medical records. The diseases were classified into seven groups according to the International Statistical Classification of Diseases and Related Health Problems codes.The patients were divided into three groups with respect to amylase levels- group 1 (376 U/L).The results were statistically analyzed using the SPSS commercial tool package version 21.0.The x2 test and Fisher's exact probability test were adapted for categorical variables, while Student's t-test was performed for the unpaired data of continuous variables. Results:The hospitalization rate increased 2.4-fold and 4.7-fold and the surgery rate increased 1.6-fold and 1.4-fold in group 2 and group 3 compared to group 1, respectively. The hospitalization rate of the patients (N=571) in group 3 was 59.4%. Among them, only 93 patients were diagnosed with acute pancreatitis. Conclusion: Elevated serum amylase levels can predict hospitalization and surgery status.Amaç: Serum amilaz düzeyi birçok hastalığın göstergesidir. Bu yüzden, rutin amilaz testi hastaneye acil başvurularda sıklıkla istenmektedir. Bu araştırmanın amacı, yüksek amilaz düzeyine sahip hastalarda hastaneye yatış durumu ve cerrahi riskleri değerlendirmektir. Yöntemler: Acil serviste serum amilaz testi yapılmış, 53,30±19,45 yaşında 64909 hasta ile retrospektif klinik çalışma yapıldı. Yaş, cinsiyet, serum amilaz miktarı düzeyi, tanı, hastaların hastaneye yatış ve operasyonel durumlarına ait bilgiler tıbbi kayıtlar (Probel, Hastane İşletim Sistemi) kullanılarak elde edildi. Hastalıklar, ICD 10 kodlarına göre yedi grupta sınıflandırıldı. Serum amilaz düzeyleri amilaz konsantrasyonlarına göre üç gruba ayrıldı; Grup 1 ( 376 U/L). Sonuçlar istatistiksel olarak SPSS ticari paket programı (versiyon 21,0) kullanılarak analiz edildi. Kategorik değişkenler için χ2 ve Fisher kesin olasılık testi; sürekli değişkenlerin eşleştirilmemiş verileri için ise Student t testi kullanıldı. Bulgular: Hastaneye yatış ve ameliyat oranlarının Grup 2 ve Grup 3’te Grup 1’e göre sırasıyla 2,4 ve 4,7 ve 1,6 ve 1,4 arttığı saptandı. Amilaz değeri 376 U/L üzerinde olan hastaların (N=571) hastaneye yatış oranları %59,4 idi. Bu hastalardan yalnızca 93’ünde akut pankreas iltihabı vardı. Sonuç: Yüksek serum amilaz düzeyi hastaneye yatış ve ameliyatı öngörmede kullanılan parametrelerden biri olabilir