Out-of-Hospital Cardiac Arrest in General Population and Sudden Cardiac Death in Athletes

Sudden cardiac death (SCD) is still one of the leading causes of cardiovascular death in the developed countries. The incidence of out-of-hospital cardiac arrest in Europe varies from 67 to 170 per 100,000 population. The chain of survival will be described in detailed steps. We are going to summarize the treatment options for sudden cardiac arrest from recognition of SCD to resuscitation and post cardiac arrest care. The role of awereness and Automated External Defibrillator and Public Access Defibrillation (AED-PAD) programs will be discussed in brief. SCD is one of the most common causes of death among athletes. Sport can trigger SCD in individuals who already have unknown form of heart disease. Our aim was to detail the underlying causes of SCD in athletes and to identify the possible screening techniques. Existing disease (e.g., myocardial hypertrophy, fibrosis) can be seen as a substrate, and sport as a trigger can cause arrhythmias, increased catecholamine release, acidosis, and dehydration. We will highlight the importance of sports medicine and periodic examination in screening for these conditions. Depending on the etiology, this may include exercise ECG, Holter monitor, CT, MR, echocardiography, and coronagraphy. We are going to conclude the new recommendations for COVID-19 post-infection care for athletes

Alpha-MSH induces vasodilatation and exerts cardioprotection via the heme-oxygenase pathway in rat hearts

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Comparison of Safety of RADial comPRESSion Devices: A Multi-Center Trial of Patent Hemostasis following Percutaneous Coronary Intervention from Conventional Radial Access (RAD-PRESS Trial)

Although radial access is the current gold standard for the implementation of percutaneous coronary interventions (PCI), post-procedural radial compression devices are seldom compared with each other in terms of safety or efficacy. Our group aimed to compare a cost effective and potentially green method to dedicated radial compression devices, with respect to access site complications combined in a device oriented complex endpoint (DOCE), freedom from which served as our primary endpoint. Patients undergoing PCI were randomized to receive either the cost effective or a dedicated device, either of which were removed using patent hemostasis. Twenty-four hours after the procedure, radial artery ultrasonography was performed to evaluate the access site. The primary endpoint was assessed using a non-inferiority framework with a non-inferiority margin of five percentage points, which was considered as the least clinically meaningful difference. The cost-effective technique and the dedicated devices were associated with a comparably low rate of complications (freedom from DOCE: 83.3% vs. 70.8%, absolute risk difference: 12.5%, one-sided 95% confidence interval (CI): 1.11%). Composition of the DOCE (i.e., no complication, hematoma, pseudoaneurysm, and radial artery occlusion) and compression time were also assessed in superiority tests as secondary endpoints. Both the cost-effective technique and the dedicated devices were associated with comparably low rates of complications: p = 0.1289. All radial compression devices performed similarly when considering the time to complete removal of the respective device (120.0 (inter-quartile range: 100.0–142.5) for the vial vs. 120.0 (inter-quartile range: 110.0–180) for the dedicated device arm, with a median difference of [95% CI]: 7.0 [−23.11 to 2.00] min, p = 0.2816). In conclusion, our cost-effective method was found to be non-inferior to the dedicated devices with respect to safety, therefore it is a safe alternative to dedicated radial compression devices, as well as seeming to be similarly effective

Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype

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Radiálisartéria-hemosztázis: korábbi gyakorlat, aktualitások [Radial artery hemostatis: earlier practice, actualities]

Az intervenciós kardiológia hajnalán az arteria femoralis punkciója volt az elsőként választandó behatolási kapu, amelyet az eszközök fejlődésével felváltott a transzradiális behatolás. Ennek okai a csökkent mortalitás, kevesebb vérzéses szövődmény, korai betegmobilizáció és az alacsonyabb kórházi kezelési költség. A szúrás következtében egyik leginkább elkerülni vágyott szövődmény a radiális artéria okklúziója, amely nem intakt tenyéri ív keringés esetén iszkémiás tüneteket okozhat. Ennek elkerülése részben a rövidebb manuális kompressziós idő és a patent hemosztázis módszerének alkalmazásával lehetséges. A patent hemosztázis létrehozása során a manuális kompresszió mértéke folyamatosan monitorozott, emellett a nyomókötés lazításával a radiális artériában az anterográd áramlás fenntartható. A beavatkozás előtt végzett noninvazív tesztek a szúrás biztonságosságát segítik meghatározni. Az új típusú, facilitált nyomókötések segítségével lehetőség nyílik a kompressziós idő rövidítésére, amelynek leggyakrabban használt formái kitozán és kálium-ferrát bevonatú eszközök. A disztális radiális artéria „snuffbox” punkciója az elmúlt néhány évben terjedt el a klinikai gyakorlatban. Alkalmazásával kevesebb radiálisartéria-okklúziót figyeltek meg, de az elzáródása esetén sem kompromittálja a tenyéri ív keringését, ultrahanggal biztonságos szúrása. A punkciót követően alkalmazott radiális koktél elemeinek optimalizálása és az új típusú nyomókötések megfelelő alkalmazása érdekében további randomizált kontrollált klinikai vizsgálatok szükségesek

Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice

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