92 research outputs found
Quality management system as part of integrated management system in nuclear industry organization
ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΠ° Β«Π£ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎΠΌΒ», ΡΠ²Π»ΡΡΡΠ΅Π³ΠΎΡΡ ΡΠ°ΡΡΡΡ ΠΈΠ½ΡΠ΅Π³ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½ΡΠ° ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡ.This article describes the Β«Quality ManagementΒ» process that is part of the integrated management system
People of the British Isles: preliminary analysis of genotypes and surnames in a UK control population
There is a great deal of interest in fine scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to play a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. Here we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK control population that can be used as a resource by the research community as well as
providing fine scale genetic information on the British population. So far, some 4,000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3,865 samples that have been geocoded indicates that 75% have
a mean distance between grandparental places of birth of 37.3km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1,057
samples demonstrates the value of these samples for investigating fine scale population structure within the UK, and shows how this can be enhanced by the use of surnames
Prevalence of hiv infection in one of the risk behavior groups
The article presents the results of a sentinel behavioral study among commercial sex workers in the city of Yekaterinburg. The analysis revealed the prevalence of HIV infection in this cohort and the main behavioral risks of infection, and suggested recommendations for prevention. ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°. ΠΠΠ§-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ,ΡΠ΅ΠΊΡ-ΡΠ°Π±ΠΎΡΠ½ΠΈΠΊΠΈ, ΡΠΈΡΠΊΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅, Π΄ΠΎΠ·ΠΎΡΠ½ΡΠΉ Π½Π°Π΄Π·ΠΎΡ.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄ΠΎΠ·ΠΎΡΠ½ΠΎΠ³ΠΎ Π±ΠΈΠΎΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ΅Π΄ΠΈ ΡΠ΅ΠΊΡ-ΡΠ°Π±ΠΎΡΠ½ΠΈΠΊΠΎΠ² Π³ΠΎΡΠΎΠ΄Π° ΠΠΊΠ°ΡΠ΅ΡΠΈΠ½Π±ΡΡΠ³Π°. Π Ρ
ΠΎΠ΄Π΅ Π°Π½Π°Π»ΠΈΠ·Π° Π²ΡΡΠ²Π»Π΅Π½Π° ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ ΠΠΠ§-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π² Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠΎΠ³ΠΎΡΡΠ΅ ΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π±ΠΈΠΎΠΏΠΎΠ²Π΅Π΄Π΅Π½ΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΡΠΊΠΈ ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊ
A case of acute disseminated encephalomyelitis with reversible cognitive deficits
Acute disseminated encephalomyelitis is a monophasic autoimmune demyelinating disease of the central nervous system. The diagnosis of acute disseminated encephalomyelitis is based on clinical and radiological features. The presence of encephalopathy is obligatory for diagnosis. The differential diagnosis may be difficult in a case of dementia as a main clinical manifestation of disease. We report a case of subacute severe cognitive deficits and movement disorders. Acute disseminated encephalomyelitis was diagnosed. MRI showed a combination of abnormalities in the white matter of the cerebral hemispheres, brainstem and the deep gray nuclei, with a contrast of enhancement. We reviewed clinical features and diagnostic criteria of acute disseminated encephalomyelitis, differential diagnosis.ΠΡΡΡΡΠΉ ΡΠ°ΡΡΠ΅ΡΠ½Π½ΡΠΉ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΎΠΌΠΈΠ΅Π»ΠΈΡβ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΠΎΠ΅ Π΄Π΅ΠΌΠΈΠ΅Π»ΠΈΠ½ΠΈΠ·ΠΈΡΡΡΡΠ΅Π΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° Π΅Π³ΠΎ Π±Π°Π·ΠΈΡΡΠ΅ΡΡΡ Π½Π° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π½Π΅ΠΉΡΠΎΠ²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
, Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΠΌ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠΌ Π΄Π»Ρ ΠΏΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΡΠ½ΡΠ΅ΡΠ°Π»ΠΎΠΏΠ°ΡΠΈΠΈ. ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠ»ΡΡΠ°ΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΉ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ, ΠΊΠΎΠ³Π΄Π° ΠΊΡΠ°ΠΉΠ½Π΅ ΡΠ»ΠΎΠΆΠ½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ ΡΡΠ°Π½ΠΎΠ²ΠΈΡΡΡ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΠ· Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΠΏΡΠΈΡΠΈΠ½Π°ΠΌΠΈ Π΄Π΅ΠΌΠ΅Π½ΡΠΈΠΈ. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ΄ΠΎΡΡΡΠΎ ΡΠ°Π·Π²ΠΈΠ²ΡΠ΅Π³ΠΎΡΡ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π΄Π΅ΡΠΈΡΠΈΡΠ° Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΡΠΊΡΡΡΠ°ΠΏΠΈΡΠ°ΠΌΠΈΠ΄Π½ΡΠΌΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΡΠΌΠΈ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π°Π½Π½ΡΡ
Π±ΡΠ» Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ ΠΎΡΡΡΡΠΉ ΡΠ°ΡΡΠ΅ΡΠ½Π½ΡΠΉ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΎΠΌΠΈΠ΅Π»ΠΈΡ. ΠΡΠΈ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎ-ΡΠ΅Π·ΠΎΠ½Π°Π½ΡΠ½ΠΎΠΌ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π±ΡΠ»ΠΈ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΡΠ°Π³ΠΈ Π² Π±Π΅Π»ΠΎΠΌ Π²Π΅ΡΠ΅ΡΡΠ²Π΅ ΠΈ ΠΏΠΎΠ΄ΠΊΠΎΡΠΊΠΎΠ²ΡΡ
ΡΡΡΡΠΊΡΡΡΠ°Ρ
Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΡΠ°ΡΡΠ½ΠΎΠ³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π°. Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΎΡΡΡΠΎΠ³ΠΎ ΡΠ°ΡΡΠ΅ΡΠ½Π½ΠΎΠ³ΠΎ ΡΠ½ΡΠ΅ΡΠ°Π»ΠΎΠΌΠΈΠ΅Π»ΠΈΡΠ°, Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΠ· Ρ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ, ΠΏΡΠΎΡΠ²Π»ΡΡΡΠΈΠΌΠΈΡΡ Π΄Π΅ΠΌΠ΅Π½ΡΠΈΠ΅ΠΉ
Studies of Genetic Diversity of Yersinia pestis Strains Isolated in Central-Caucasian High-Mountain Natural Plague Focus
Studied have been Yersinia pestis strains isolated in Central-Caucasian high-mountain natural plague focus within the period of 1971β2012 using MLVA typing on 25 VNTR-loci. Analysis of dendrogram cluster association with certain areas, objects, and periods of the strain isolation has been carried out by means of Arc GIS 10.1 software. Established has been the connection between 25 MLVA Y. pestis types and spatial and temporal characteristics of strains isolation in the Central-Caucasian high-mountain natural plague focus, and proline requirement too. Clusters, groups and subgroups of the strains are confined to particular territories as it follows: groups are attributed to landscape-epizootiological regions, subgroups β to mountain souslik settlements. Occasionally groups of the strains disseminate onto the other landscape-epizootiological regions of the focus. Genetic variations of plague agent strains within the limits of mountain souslik settlements evolve over time which can be viewed as indirect evidence of microevolution mechanism effect
The genetic history of admixture across inner Eurasia
This is the author accepted manuscript. The final version is available from Nature Research via the DOI in this record.Data Availability. Genome-wide sequence data of two Botai individuals (BAM format) are available at the European Nucleotide Archive under the accession number PRJEB31152 (ERP113669). Eigenstrat format array genotype data of 763 present-day individuals and 1240K pulldown genotype data of two ancient Botai individuals are available at the Edmond data repository of the Max Planck Society
(https://edmond.mpdl.mpg.de/imeji/collection/Aoh9c69DscnxSNjm?q=).The indigenous populations of inner Eurasia, a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra, harbor tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine, and Uzbekistan. We furthermore report additional damage-reduced genome-wide data of two previously published individuals from the Eneolithic Botai culture in Kazakhstan (~5,400 BP). We find that present-day inner Eurasian populations are structured into three distinct admixture clines stretching between various western and eastern Eurasian ancestries, mirroring geography. The Botai and more recent ancient genomes from Siberia show a decrease in contribution from so-called βancient North Eurasianβ ancestry over time, detectable only in the northern-most βforest-tundraβ cline. The intermediate βsteppe-forestβ cline descends from the Late Bronze Age steppe ancestries, while the βsouthern steppeβ cline further to the South shows a strong West/South Asian influence. Ancient genomes suggest a northward spread of the southern steppe cline in Central Asia during the first millennium BC. Finally, the genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North
Caucasus populations from the steppe.Max Planck SocietyEuropean Research Council (ERC)Russian Foundation for Basic Research (RFBR)Russian Scientific FundNational Science FoundationU.S. National Institutes of HealthAllen Discovery CenterUniversity of OstravaCzech Ministry of EducationXiamen UniversityFundamental Research Funds for the Central UniversitiesMES R
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