Investigating the Structure of the Windy Torus in Quasars

Thermal mid-infrared emission of quasars requires an obscuring structure that can be modeled as a magneto-hydrodynamic wind in which radiation pressure on dust shapes the outflow. We have taken the dusty wind models presented by Keating and collaborators that generated quasar mid-infrared spectral energy distributions (SEDs), and explored their properties (such as geometry, opening angle, and ionic column densities) as a function of Eddington ratio and X-ray weakness. In addition, we present new models with a range of magnetic field strengths and column densities of the dust-free shielding gas interior to the dusty wind. We find this family of models -- with input parameters tuned to accurately match the observed mid-IR power in quasar SEDs -- provides reasonable values of the Type 1 fraction of quasars and the column densities of warm absorber gas, though it does not explain a purely luminosity-dependent covering fraction for either. Furthermore, we provide predictions of the cumulative distribution of E(B-V) values of quasars from extinction by the wind and the shape of the wind as imaged in the mid-infrared. Within the framework of this model, we predict that the strength of the near-infrared bump from hot dust emission will be correlated primarily with L/L_Edd rather than luminosity alone, with scatter induced by the distribution of magnetic field strengths. The empirical successes and shortcomings of these models warrant further investigations into the composition and behaviour of dust and the nature of magnetic fields in the vicinity of actively accreting supermassive black holes.Comment: 11 pages, 6 figures, accepted for publication in MNRA

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction

Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown. One possibility, demonstrated in peripheral tissue cell lines, is that apoE stimulates nitric oxide synthase (NOS) via a receptor-dependent signalling pathway and that apoE4 generates inappropriate amounts of nitric oxide (NO) compared to apoE3. Prior to biochemical investigations, we have quantified the expression of several candidate receptor genes, including low-density lipoprotein-receptor (LDL-r) family members and scavenger receptor class B, types I and II (SR-BI/II), as well as the three NOS isoenzymes and protein kinase B (Akt), in 38 human cell lines, of which 12 derive from brain. Expression of apoE receptor 2 (apoER2), a known signalling receptor in brain, was readily detected in SH-SY-5Y and CCF-STTG1 cells, common models of neurons and astrocytes, respectively, and was highest in H4 neuroglioma, NT-2 precursor cells and IMR-32 neuroblastoma cells. Transcripts of the other lipoprotein receptors were widely, but variably, distributed across the different cell types. Of particular note was the predominant expression of SR-BII over SR-BI in many of the brain-derived cells. As the C-terminus of SR-BII, like apoER2, contains potential SH3 signalling motifs, we suggest that in brain SR-BII functions as a signal transducer receptor. (c) 2004 Elsevier Inc. All rights reserved

Students get wise about AIDS - The acceptability, feasibility and impact of an AIDS education programme in a suburban school in Cape Town

Objectives. The study assessed the acceptability and feasibility of an AIDS education programme for South African high-school students.Design, setting and sUbjects. A 'before-after' study was conducted in a suburban high school in Cape Town. All 232 standard 8 students were included, and were exposed to the programme over 9 months.Outcome measures. Students' knowledge about AIDS and sexually transmitted diseases (SIDs), attitudes towards people with AIDS and towards AIDS prevention, perceptions of self-efficacy with regard to risk reduction, self-reported behaviour and opinions on the programme were measured using questionnaires. In addition, teachers' opinions of and experiences with the programme were assessed.Results. After the programme, significantly more students knew how to protect themselves from HIV, could identity the symptoms of STOs and understood why people with STOs had a higher risk of becoming infected with HIV. After the programme, significantly more students believed that they knew how to use a condom (77% at baseline, 88.6% at follow-up; P < 0.01). Prior to the programme only 20.8% of the students reported ever having had sexual intercourse. After the programme, significantly more students (32.8%) reported having had sexual intercourse. Most students (80.5%) reported that the programme had helped them to make plans to protect themselves from HIV infection. Teachers found the programme valuable and easy to use.Conclusions. There are severaJ South African school programmes such as 'Get Wise about AIDS' which have been shown to be acceptable and feasible, and which seem to be effective. Randomised controlled trials are now needed to provide conclusive evidence of their effectiveness

Time dependent CP asymmetry in B0→ρ0γB^0 \to \rho^0 \gamma decay to probe the origin of CP violation

Since the CP violation in the $B$ system has been investigated up to now only through processes related to the $B$--$\bar{B}$ mixing, urgently required is new way of study for the CP violation and establishing its origin in the $B$ system independent of the mixing process. In this work, we explore the exclusive $B^0 \to \rho^0 \gamma$ decay to obtain the time-dependent CP asymmetry in $b \to d$ decay process in the standard model and the supersymmetric model. We find that the complex RL and RR mass insertion to the squark sector in the MSSM can lead to a large CP asymmetry in $b \to d \gamma$ decay through the gluino-squark diagrams, which is not predicted in the Standard Model induced by the $B$--$\bar{B}$ mixing.Comment: 10 pages, 4 eps figure

Longitudinal Assessment of Critical Thinking Skills Across a Dental Curriculum

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153614/1/jddjde018088.pd

Quintessential Kination and Leptogenesis

Thermal leptogenesis induced by the CP-violating decay of a right-handed neutrino (RHN) is discussed in the background of quintessential kination, i.e., in a cosmological model where the energy density of the early Universe is assumed to be dominated by the kinetic term of a quintessence field during some epoch of its evolution. This assumption may lead to very different observational consequences compared to the case of a standard cosmology where the energy density of the Universe is dominated by radiation. We show that, depending on the choice of the temperature T_r above which kination dominates over radiation, any situation between the strong and the super--weak wash--out regime are equally viable for leptogenesis, even with the RHN Yukawa coupling fixed to provide the observed atmospheric neutrino mass scale ~ 0.05 eV. For M< T_r < M/100, i.e., when kination stops to dominate at a time which is not much later than when leptogenesis takes place, the efficiency of the process, defined as the ratio between the produced lepton asymmetry and the amount of CP violation in the RHN decay, can be larger than in the standard scenario of radiation domination. This possibility is limited to the case when the neutrino mass scale is larger than about 0.01 eV. The super--weak wash--out regime is obtained for T_r << M/100, and includes the case when T_r is close to the nucleosynthesis temperature ~ 1 MeV. Irrespective of T_r, we always find a sufficient window above the electroweak temperature T ~ 100 GeV for the sphaleron transition to thermalize, so that the lepton asymmetry can always be converted to the observed baryon asymmetry.Comment: 13 pages, 8 figure

Fundamental limitations on "warp drive" spacetimes

"Warp drive" spacetimes are useful as "gedanken-experiments" that force us to confront the foundations of general relativity, and among other things, to precisely formulate the notion of "superluminal" communication. We verify the non-perturbative violation of the classical energy conditions of the Alcubierre and Natario warp drive spacetimes and apply linearized gravity to the weak-field warp drive, testing the energy conditions to first and second order of the non-relativistic warp-bubble velocity. We are primarily interested in a secondary feature of the warp drive that has not previously been remarked upon, if it could be built, the warp drive would be an example of a "reaction-less drive". For both the Alcubierre and Natario warp drives we find that the occurrence of significant energy condition violations is not just a high-speed effect, but that the violations persist even at arbitrarily low speeds. An interesting feature of this construction is that it is now meaningful to place a finite mass spaceship at the center of the warp bubble, and compare the warp field energy with the mass-energy of the spaceship. There is no hope of doing this in Alcubierre's original version of the warp-field, since by definition the point in the center of the warp bubble moves on a geodesic and is "massless". That is, in Alcubierre's original formalism and in the Natario formalism the spaceship is always treated as a test particle, while in the linearized theory we can treat the spaceship as a finite mass object. For both the Alcubierre and Natario warp drives we find that even at low speeds the net (negative) energy stored in the warp fields must be a significant fraction of the mass of the spaceship.Comment: 18 pages, Revtex4. V2: one reference added, some clarifying comments and discussion, no physics changes, accepted for publication in Classical and Quantum Gravit

The quantum inequalities do not forbid spacetime shortcuts

A class of spacetimes (comprising the Alcubierre bubble, Krasnikov tube, and a certain type of wormholes) is considered that admits `superluminal travel' in a strictly defined sense. Such spacetimes (they are called `shortcuts' in this paper) were suspected to be impossible because calculations based on `quantum inequalities' suggest that their existence would involve Planck-scale energy densities and hence unphysically large values of the `total amount of negative energy' E_tot. I argue that the spacetimes of this type may not be unphysical at all. By explicit examples I prove that: 1) the relevant quantum inequality does not (always) imply large energy densities; 2) large densities may not lead to large values of E_tot; 3) large E_tot, being physically meaningless in some relevant situations, does not necessarily exclude shortcuts.Comment: Minor corrections and addition