Acute puerperal uterine inversion: Case report

Acute puerperal uterine inversion is a rare but potentially fatal obstetric emergency in which the uterine fundus collapses into the uterine cavity. Maternal mortality is high unless the condition is recognised and quickly corrected. The duration of time elapsed from moment of diagnosis to that of correction, along with rapid resuscitation measures are of utmost importance in its prognosis. A recent case managed successfully is described followed by a short review of the literature

Subjective Causality

We show that it is possible to understand and identify a decision maker's subjective causal judgements by observing her preferences over interventions. Following Pearl [2000], we represent causality using causal models (also called structural equations models), where the world is described by a collection of variables, related by equations. We show that if a preference relation over interventions satisfies certain axioms (related to standard axioms regarding counterfactuals), then we can define (i) a causal model, (ii) a probability capturing the decision-maker's uncertainty regarding the external factors in the world and (iii) a utility on outcomes such that each intervention is associated with an expected utility and such that intervention $A$ is preferred to $B$ iff the expected utility of $A$ is greater than that of $B$. In addition, we characterize when the causal model is unique. Thus, our results allow a modeler to test the hypothesis that a decision maker's preferences are consistent with some causal model and to identify causal judgements from observed behavior

Partial Awareness

We develop a modal logic to capture partial awareness. The logic has three building blocks: objects, properties, and concepts. Properties are unary predicates on objects; concepts are Boolean combinations of properties. We take an agent to be partially aware of a concept if she is aware of the concept without being aware of the properties that define it. The logic allows for quantification over objects and properties, so that the agent can reason about her own unawareness. We then apply the logic to contracts, which we view as syntactic objects that dictate outcomes based on the truth of formulas. We show that when agents are unaware of some relevant properties, referencing concepts that agents are only partially aware of can improve welfare.Comment: Appears in AAAI-1

Dissenting Opinions in the WTO Appellate Body: Drivers of Their Issuance & Implications for the Institutional Jurisprudence

The Appellate Body (AB) of the WTO has issued over 140 reports but only eight separate opinions, four of which are genuinely dissenting. Such paucity, in fact, is the WTO’s implicit tradition inherited from GATT of prioritizing unanimous decisions, hoping they solidify the institution’s legitimacy and countries’ confidence in the system. But at the more individual level, an AB member’s decision to dissent is driven by multiple factors that have implications for the institution’s jurisprudence. First, the factors explain how the symbiotic relationship between an AB member and his or her nominating country – whose interests turn out to be closely intertwined – is affected according to the former’s personal preferences. Moreover, a subset of the factors – the so-called “evaluators” – can assess the doctrinal significance of dissents and illuminate how each of them is contributing to the WTO’s case law development

Measuring the delay time distribution of binary neutron stars. II. Using the redshift distribution from third-generation gravitational wave detectors network

We investigate the ability of current and third-generation gravitational wave (GW) detectors to determine the delay time distribution (DTD) of binary neutron stars (BNS) through a direct measurement of the BNS merger rate as a function of redshift. We assume that the DTD follows a power law distribution with a slope $\Gamma$ and a minimum merger time $t_{\rm min}$, and also allow the overall BNS formation efficiency per unit stellar mass to vary. By convolving the DTD and mass efficiency with the cosmic star formation history, and then with the GW detector capabilities, we explore two relevant regimes. First, for the current generation of GW detectors, which are only sensitive to the local universe, but can lead to precise redshift determinations via the identification of electromagnetic counterparts and host galaxies, we show that the DTD parameters are strongly degenerate with the unknown mass efficiency and therefore cannot be determined uniquely. Second, for third-generation detectors such as Einstein Telescope (ET) and Cosmic Explorer (CE), which will detect BNS mergers at cosmological distances, but with a redshift uncertainty inherent to GW-only detections ($\delta(z)/z\approx 0.1z$), we show that the DTD and mass efficiency can be well-constrained to better than 10\% with a year of observations. This long-term approach to determining the DTD through a direct mapping of the BNS merger redshift distribution will be supplemented by more near term studies of the DTD through the properties of BNS merger host galaxies at $z\approx 0$ (Safarzadeh & Berger 2019).Comment: 10 pages, Accepted to ApJ Letter

Embodied Metaphors and Creative “Acts”

Creativity is a highly sought after skill. To inspire people’s creativity, prescriptive advice in the form of metaphors abound: We are encouraged to think outside the box, to consider the problem on one hand, then on the other hand, and to put two and two together to achieve creative breakthroughs. These metaphors suggest a connection between concrete bodily experiences and creative cognition. Inspired by recent advances on body-mind linkages under the emerging vernacular of embodied cognition, we explored for the first time whether enacting metaphors for creativity enhances creative problem-solving. In five studies, findings revealed that both physically and psychologically embodying creative metaphors promote fluency, flexibility, and/or originality in problem-solving. Going beyond prior research that focused primarily on the kind of embodiment that primes preexisting knowledge, we provide the first evidence that embodiment can also activate cognitive processes conducive for generating previously unknown ideas and connections

The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma.

Intratumour heterogeneity (ITH) has become an important focus of cancer research in recent years. ITH describes the cellular variation that enables tumour evolution, including tumour progression, metastasis and resistance to treatment. The selection and expansion of genetically distinct treatment-resistant cancer cell clones provides one explanation for treatment failure. However, tumour cell variation need not be genetically encoded. In pancreatic ductal adenocarcinoma (PDAC) in particular, the complex tumour microenvironment as well as crosstalk between tumour and stromal cells result in exceptionally variable tumour cell phenotypes that are also highly adaptable. In this review we discuss four different types of phenotypic heterogeneity within PDAC, from morphological to metabolic heterogeneity. We suggest that these different types of ITH are not independent, but, rather, can inform one another. Lastly, we highlight recent findings that suggest how therapeutic efforts may halt PDAC progression by constraining cellular heterogeneity

Hole density dependence of effective mass, mobility and transport time in strained Ge channel modulation-doped heterostructures

We performed systematic low-temperature (T = 350 mK–15 K) magnetotransport measurements on the two-dimensional hole gas with various sheet carrier densities Ps = (0.57–2.1)×1012 cm–2 formed in the strained Ge channel modulation-doped (MOD) SiGe heterostructures grown on Si substrates. It was found that the effective hole mass deduced by temperature dependent Shubnikov–de Hass oscillations increased monotonically from (0.087±0.05)m0 to (0.19±0.01)m0 with the increase of Ps, showing large band nonparabolicity in strained Ge. In contrast to this result, the increase of the mobility with increasing Ps (up to 29 000 cm2/V s) was observed, suggesting that Coulomb scattering played a dominant role in the transport of the Ge channel at low temperatures. In addition, the Dingle ratio of the transport time to the quantum lifetime was found to increase with increasing Ps, which was attributed to the increase of remote impurity scattering with the increase of the doping concentration in MOD SiGe layers