Investigació i gènere a la Universitat Jaume I 2016

Actes del II Congrès d’Investigació i Gènere a la Universitat Jaume I, celebrat l’11 de maig de 2016 a la Universitat Jaume I.La igualtat de dones i homes, tot i ser un principi jurídic universal recollit en normes internacionals i nacionals i que es troba en la base dels sistemes democràtics, és difícil d'aconseguir. Per això hi ha un consens generalitzat sobre la necessitat d'impulsar actuacions transversals i accions positives en tots els àmbits. És en aquest context en el qual van sorgir, entre altres mesures, l'obligatorietat legal de crear plans d'igualtat en organitzacions amb més de 250 treballadors (Llei orgànica 3/2007 per a la igualtat efectiva de dones i homes) i en el cas concret de les universitats espanyoles, de considerar-les part de la seua estructura d'organització segons s'estableix en la disposició addicional dotzena de la Llei orgànica 4/2007, de 12 d'abril, d'universitats. La Universitat Jaume I presenta en aquesta publicació les actes del II Congrés d’Investigació i Gènere que van tenir lloc a l'UJI i que inclouen treballs de final de grau i de màster, tesis doctorals, projectes d'investigació i activitat docent de grau

Puntos de sutura

Se muestra y explica cómo poner puntos de sutura a pacientes.Departamento de Enfermerí

Canalización de vía venosa periférica

Se explica y muestra el proceso de canalización de vía venosa periférica a pacientes.Departamento de Enfermerí

Bomba volumétrica

Se explica y muestra cómo usar una bomba volumétrica para suministrar suero a pacientes.Departamento de Enfermerí

Sondaje nasogástrico

Se explica y muestra como realizar un sondaje nasogástrico a pacientes.Departamento de Enfermerí

Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs

Producción CientíficaTumor cells undergo a critical remodeling of intracellular Ca2+ homeostasis that contribute to important cancer hallmarks. Store-operated Ca2+ entry (SOCE), a Ca2+ entry pathway modulated by mitochondria, is dramatically enhanced in colon cancer cells. In addition, most cancer cells display the Warburg effect, a metabolic switch from mitochondrial metabolism to glycolysis that provides survival advantages. Accordingly, we investigated mitochondria control of store-operated currents (SOCs) in two cell lines previously selected for representing human normal colonic cells and colon cancer cells. We found that, in normal cells, mitochondria are important for SOCs activity but they are unable to prevent current inactivation. In contrast, in colon cancer cells, mitochondria are dispensable for SOCs activation but are able to prevent the slow, Ca2+-dependent inactivation of SOCs. This effect is associated to increased ability of tumor cell mitochondria to take up Ca2+ due to increased mitochondrial potential (ΔΨ) linked to the Warburg effect. Consistently with this view, selected non-steroidal anti-inflammatory drugs (NSAIDs) depolarize mitochondria, inhibit mitochondrial Ca2+ uptake and promote SOC inactivation, leading to inhibition of both SOCE and cancer cell proliferation. Thus, mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells and this effect is counteracted by selected NSAIDs providing a mechanism for cancer chemoprevention.Ministerio de Economía, Industria y Competitividad (grant BFU2015-70131R)Junta de Castilla y León (grant VA145U13

Invasive Disease vs Urinary Antigen-Confirmed Pneumococcal Community-Acquired Pneumonia

Background: The burden of pneumococcal disease is measured only through patients with invasive pneumococcal disease. The urinary antigen test (UAT) for pneumococcus has exhibited high sensitivity and specificity. We aimed to compare the pneumococcal pneumonias diagnosed as invasive disease with pneumococcal pneumonias defined by UAT results. Methods: A prospective observational study of consecutive nonimmunosuppressed patients with community-acquired pneumonia was performed from January 2000 to December 2014. Patients were stratified into two groups: invasive pneumococcal pneumonia (IPP) defined as a positive blood culture or pleural fluid culture result and noninvasive pneumococcal pneumonia (NIPP) defined as a positive UAT result with negative blood or pleural fluid culture result. Results: We analyzed 779 patients (15%) of 5,132, where 361 (46%) had IPP and 418 (54%) had NIPP. Compared with the patients with IPP, those with NIPP presented more frequent chronic pulmonary disease and received previous antibiotics more frequently. Patients with IPP presented more severe community-acquired pneumonia, higher levels of inflammatory markers, and worse oxygenation at admission; more pulmonary complications; greater extrapulmonary complications; longer time to clinical stability; and longer length of hospital stay compared with the NIPP group. Age, chronic liver disease, mechanical ventilation, and acute renal failure were independent risk factors for 30-day crude mortality. Neither IPP nor NIPP was an independent risk factor for 30-day mortality. Conclusions: A high percentage of confirmed pneumococcal pneumonia is diagnosed by UAT. Despite differences in clinical characteristics and outcomes, IPP is not an independent risk factor for 30-day mortality compared with NIPP, reinforcing the importance of NIPP for pneumococcal pneumonia

Invasive Disease vs Urinary Antigen-Confirmed Pneumococcal Community-Acquired Pneumonia

Background: The burden of pneumococcal disease is measured only through patients with invasive pneumococcal disease. The urinary antigen test (UAT) for pneumococcus has exhibited high sensitivity and specificity. We aimed to compare the pneumococcal pneumonias diagnosed as invasive disease with pneumococcal pneumonias defined by UAT results. Methods: A prospective observational study of consecutive nonimmunosuppressed patients with community-acquired pneumonia was performed from January 2000 to December 2014. Patients were stratified into two groups: invasive pneumococcal pneumonia (IPP) defined as a positive blood culture or pleural fluid culture result and noninvasive pneumococcal pneumonia (NIPP) defined as a positive UAT result with negative blood or pleural fluid culture result. Results: We analyzed 779 patients (15%) of 5,132, where 361 (46%) had IPP and 418 (54%) had NIPP. Compared with the patients with IPP, those with NIPP presented more frequent chronic pulmonary disease and received previous antibiotics more frequently. Patients with IPP presented more severe community-acquired pneumonia, higher levels of inflammatory markers, and worse oxygenation at admission; more pulmonary complications; greater extrapulmonary complications; longer time to clinical stability; and longer length of hospital stay compared with the NIPP group. Age, chronic liver disease, mechanical ventilation, and acute renal failure were independent risk factors for 30-day crude mortality. Neither IPP nor NIPP was an independent risk factor for 30-day mortality. Conclusions: A high percentage of confirmed pneumococcal pneumonia is diagnosed by UAT. Despite differences in clinical characteristics and outcomes, IPP is not an independent risk factor for 30-day mortality compared with NIPP, reinforcing the importance of NIPP for pneumococcal pneumonia

Implementación del Atlas Digital de Petrografía de Rocas Ígneas Volcánicas como herramienta docente en la asignatura de Petrología Ígnea y Metamórfica (3º Geología, UA)

La presente red docente tuvo por objetivo principal facilitar el aprendizaje de la Petrografía de rocas volcánicas mediante la generación de contenidos e imágenes relativos a los principales tipos de rocas volcánicas, haciendo principal hincapié en los aspectos petrográficos (texturas, composición mineral y clasificación). Para ello se creó una página web para facilitar fotografías de láminas delgadas vistas al microscopio petrográfico, con sus respectivas descripciones. El recurso objeto de trabajo en esta red es el Atlas Digital de Petrografía de Rocas Ígneas Volcánicas (PIM), dirigido a promover la autonomía durante el estudio del alumnado a través del uso de ambientes virtuales, así como facilitar material que le permita profundizar en su formación. Estos contenidos se enmarcan dentro de la docencia de la asignatura Petrología Ígnea y Metamórfica (3er curso del Grado en Geología de la Universidad de Alicante). Se ha realizado una evaluación de la acción/experiencia, a través de la percepción por parte de estudiantes y docentes, de la implementación del citado recurso, de modo que ha permitido valorar la calidad y facilidad de manejo de esta herramienta. Resultado de la encuesta también se han puesto de manifiesto posibles mejoras de la estructuración de la web, así como incrementar algunos contenidos