5 research outputs found
Colonial Institutions, Slavery, Inequality, and Development: Evidence from São Paulo, Brazil
The implication of property rights for joint agriculture timber productivity in the Brazilian Amazon
El a?ai mejora la enfermedad de h?gado graso no alcoh?lico (NAFLD) inducida por la fructosa.
Introduction: the excessive consumption of fructose can cause liver damage, characteristic of non-alcoholic fatty liver disease (NAFLD) associated with changes in lipid metabolism and antioxidant defenses. A?ai, the fruit of Euterpe oleracea Mart., has demonstrated numerous biological
activities, including anti-inflammatory, antioxidant, and lipid metabolism modulating action.
Objective: we evaluated the benefits of a?ai supplementation on liver damage caused by replacing starch with fructose in rats.
Methods: thirty male Fischer rats were divided into two groups, the control group (C, 10 animals), which consumed a standard diet (AIN-93M),
and the fructose (F, 20 animals) group, which consumed a diet containing 60% of fructose. After eight weeks, 10 animals from the fructose group
received 2% of lyophilized a?ai, and were called the a?ai fructose group (FA). The animals were fed ad libitum with these diets for another ten
weeks. Serum, hepatic and fecal lipid profile, antioxidant enzymes and carbonylated protein were assessed and histopathological characterization
of the liver was performed.
Results: a?ai promoted the reduction of ALT activity in relation to the fructose group (F), reduced alkaline phosphatase to a level similar to that
of the control group (C) in relation to the fructose group (F), and reduced catalase activity. The fruit also increased the ratio of total/oxidized
glutathione (GSH/GSSG) and reduced the degree of macrovesicular steatosis and the number of inflammatory cells.
Conclusion: the replacement of starch by fructose during this period was effective in promoting NAFLD. A?ai showed attenuating effects on
some markers of hepatic steatosis and inflammation.Introducci?n: el consumo excesivo de fructosa puede causar da?o hep?tico, caracter?stico de la enfermedad hep?tica grasa no alcoh?lica
(EHGNA), asociada con cambios en el metabolismo de los l?pidos y defensas antioxidantes. El a?ai, fruto del Euterpe oleracea Mart., ha demostrado desempe?ar numerosas actividades biol?gicas, incluidas acciones antiinflamatorias, antioxidantes y moduladoras del metabolismo lip?dico.
Objetivo: se evaluaron los beneficios de la suplementaci?n con a?ai en el da?o hep?tico causado por la sustituci?n del almid?n por fructosa
en ratas.
M?todos: se distribuyeron 30 ratas Fischer macho en dos grupos: 10 ratas en el grupo control (C), que consum?a una dieta est?ndar (AIN-93M),
y 20 ratas en el grupo fructosa (F), que consum?a una dieta que conten?a un 60% de fructosa. Despu?s de ocho semanas, diez animales del
grupo fructosa recibieron un 2% de a?ai liofilizado, por lo que pasaron a integrar el grupo a?ai fructosa (FA). Los animales fueron alimentados
ad libitum con estas dietas durante otras diez semanas. Se analizaron el perfil lip?dico hep?tico y fecal, las enzimas antioxidantes y la prote?na
carbonilada, y se realiz? la caracterizaci?n histopatol?gica del h?gado.
Resultados: el a?ai promovi? la reducci?n de la actividad de ALT en relaci?n al grupo de fructosa (F) y la reducci?n de la fosfatasa alcalina a
niveles similares a los hallados en el grupo control (C) en relaci?n con el grupo de fructosa (F). El fruto tambi?n aument? la proporci?n de glutati?n
total/oxidado (GSH/GSSG) y redujo el grado de esteatosis macrovesicular y el n?mero de c?lulas inflamatorias.
Conclusi?n: la sustituci?n de almid?n por fructosa durante este periodo fue eficaz en la promoci?n de NAFLD. El a?ai mostr? efectos atenuantes
en algunos marcadores de esteatosis hep?tica y de inflamaci?n