Accelerators in Silicon Valley

In this book Silicon Valley expert Peter Ester describes how these 'schools of startup entrepreneurship' operate and how they empower startups. He interviewed over twenty Silicon Valley accelerators. They are analyzed in terms of mission, selection policy, technology focus, target groups, program features, funding, mentoring and training, and startup showcases. What can Europe and other regions and countries learn from how Silicon Valley accelerators help startups to become successful companies? This book gives the answer. Accelerators in Silicon Valley is a book for entrepreneurs, startup founders, policymakers, practitioners, scholars, and students who share a fascination for building the new startup economy

The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71

<p>Abstract</p> <p>Background</p> <p>The FF domain is conserved across all eukaryotes and usually acts as an adaptor module in RNA metabolism and transcription. <it>Saccharomyces cerevisiae </it>encodes two FF domain proteins, Prp40, a component of the U1 snRNP, and Ypr152c, a protein of unknown function. The structure of Prp40, its relationship to other proteins within the U1 snRNP, and its precise function remain little understood.</p> <p>Results</p> <p>Here we have investigated the essentiality and interaction properties of the FF domains of yeast Prp40. We show that the C-terminal two FF domains of Prp40 are dispensable. Deletion of additional FF domains is lethal. The first FF domain of Prp40 binds to U1 protein Luc7 in yeast two-hybrid and GST pulldown experiments. FF domains 2 and 3 bind to Snu71, another known U1 protein. Peptide array screens identified binding sites for FF1-2 within Snu71 (NDVHY) and for FF1 within Luc7 (ϕ[FHL] × [KR] × [GHL] with ϕ being a hydrophobic amino acid).</p> <p>Conclusion</p> <p>Prp40, Luc7, and Snu71 appear to form a subcomplex within the yeast U1snRNP. Our data suggests that the N-terminal FF domains are critical for these interactions. Crystallization of Prp40, Luc7, and Snu71 have failed so far but co-crystallization of pairs or the whole tri-complex may facilitate crystallographic and further functional analysis.</p

Mobility in Europe: Analysis of the 2005 Eurobarometer Survey on Geographical and Labour Market Mobility

The European Commission has designated the year 2006 as 'European Year of Workers' Mobility'. The purpose of the initiative is to inform EU citizens of the benefits and the costs of both geographical mobility and job or labour market mobility; the realities of working in another country or changing job or career; and the rights they are entitled to as migrant workers. The initiative also aims to promote the exchange of good practice between public authorities and institutions, the social partners and the private sector, and to promote greater study of the scale and nature of geographical and job mobility within the Union

A freirianian global legacy: a dialogue with Peter Roberts

In the phase of the proposed and expected discussions for the debate on Freire's thought on the occasion of the centenary of its birth, this text sought to establish a dialogue with one of the researchers who have, over decades, established a whole scientific, academic and social journey. , having as one of the contributions of reflection the work of the Brazilian teacher Paulo Freire. Thus, an interview was carried out with Professor Peter Roberts, whose production has crossed borders and broadened the discussion with and of Freire's thought. Peter Roberts is a professor at the University of Canterbury, Christchurch, New Zealand, in the field of Education. The objective of the interview, therefore, was to highlight the work of Paulo Freire in the focus of academic works carried out by Professor Peter Roberts, either establishing dialogic bridges between Freire and other authors, or looking forward to new paths that update Freire's thought.En la fase de las discusiones propuestas y esperadas para el debate sobre el pensamiento de Freire con motivo del centenario de su nacimiento, este texto buscó entablar un diálogo con uno de los investigadores que, a lo largo de décadas, ha constituido todo un conjunto científico, académico y itinerario social., teniendo como uno de los aportes de reflexión la obra del maestro brasileño Paulo Freire. Así, se realizó una entrevista al profesor Peter Roberts, cuya producción ha traspasado fronteras y ha ampliado la discusión con y del pensamiento de Freire. Peter Roberts es profesor en la Universidad de Canterbury, Christchurch, Nueva Zelanda, en el campo de la educación. El objetivo de la entrevista, por tanto, era destacar el trabajo de Paulo Freire en el foco de trabajos académicos realizados por el&nbsp; profesor Peter Roberts, ya sea estableciendo puentes dialógicos entre Freire y otros autores, o buscando nuevos caminos que actualicen el pensamiento de Freire.Em fase das discussões propostas e esperadas para o debate do pensamento freireano em ocasião do centenário de seu nascimento, buscou-se neste texto estabelecer um diálogo com um dos pesquisadores que têm, ao longo de décadas, estabelecido toda uma caminhada científica, acadêmica e social, tendo como um dos aportes de reflexão a obra do professor brasileiro Paulo Freire. Assim, foi realizada entrevista com o professor Peter Roberts, cuja produção tem atravessado fronteiras e alargado a discussão com e do pensamento freireano. Peter Roberts é professor na University of Canterbury, em Christchurch, na Nova Zelândia, na área de Educação. O objetivo da entrevista, portanto, foi realçar a obra de Paulo Freire no enfoque dos trabalhos acadêmicos realizados pelo professor Peter Roberts, quer estabelecendo pontes dialógicas de Freire com outros autores, quer perspectivando novos caminhos que atualizam o pensamento freireano

Datenbankenunterstützung für das Protein-Protein-Docking: ein effizienter und robuster Feature-Index

In der vorliegenden Arbeit schlagen wir eine Architektur für ein Dockingsystem vor, das zu einem gegebenen Anfrageprotein alle möglichen Dockingpartner und deren zugehörige Konstellationen in einer Proteindatenbank sucht. Die einzelnen Filter- und Bewertungsschritte dieses Dockingsystems sollen durch den Einsatz räumlicher Zugriffsstrukturen unterstützt werden. Hier behandeln wir insbesondere die Verwendung eines effizienten und robusten Feature-Index. Dieser dient dazu, aus dem Raum aller möglichen Konstellationen von Partnerproteinen aus der Datenbank gute Kandidatenvorschläge zu ermitteln. Dazu werden im Vorfeld die Proteinoberflächen regionalisiert, in einem k-dimensionalen Raum von Kennzahlen beschrieben und in einer k-dimensionalen räumlichen Indexstruktur verwaltet. Für die Docking-Suche wird das Anfrageprotein analog regionalisiert, und zusätzlich werden seine Kennzahlen komplementiert, so daß zum Komplement ähnliche Regionen als mögliche Docking-Stellen im Index gefunden werden können. In den nachfolgenden Filterschritten des Dockingsystems wird unter anderem das räumliche Passen genauer überprüft