8 research outputs found
Early Phototherapy at Lower Total Serum Bilirubin Can Decrease Auditory Neuropathy Disorder
Biliary pseudolithiasis during ceftriaxone therapy in children
Background: Ceftriaxone is almost widely used in the treatment of
pediatric infection and this is accompanied by some complications. The
aim of this study was to determine the incidence of abnormal
ultrasonography findings of gallbladder (pseudolithiasis or sludge)
during ceftriaxon therapy and its relation to fasting, sex and G6PD
deficiency. Methods: This quasi-experimental survey was done in
Amirkola Children's Hospital, Babol, Iran. First ultrasonography was
done before initiation of ceftriaxone therapy and it was repeated 24-48
hours after therapy and in the 5th, 7th, 10th and 14th day after the
treatment. If abnormal finding was seen, ultrasonography was done
weekly in the first two weeks until the side effect disappeared. Data
was collected and analyzed by SPSS software. Findings: Of all 108
patients, who were between 3 months to 10 years old, 20 cases had
abnormal findings in gallbladder (2 sludges and 18 pseudolithiases).
Length of fasting before ceftriaxone therapy had a positive relation
with possibility of stone formation (p<0.005), but age, sex,
duration of therapy and G6PD deficiency were not related (p<0.05).
In four cases pseudolithiasis was formed after only 1-2 doses of
ceftriaxone. Shortest and longest periods of resolution of
complications were 1 and 17 days respectively after
formation.Conclusion: Incidence of pseudolithiasis or sludge formation
during ceftriaxone therapy was 18.5% and fasting had a great effect on
these complications