Denudation of the Côte d'Ivoire-Ghana transform margin from apatite fission tracks.

Apatite fission track analysis of samples from the shoulder (marginal ridge) of the Côte d'Ivoire-Ghana transform continental margin reveal a cooling of the margin between 85 and 65 Ma for the central and eastern parts of the ridge. All samples were heated in situ during sedimentary burial with a temperature >120 °C, except for two samples located in the eastern part which were heated between 105 and 120 °C. For the first time, age/depth diagram along a transform margin shows a shape involving erosion starting at the bottom of the continental slope, then stepping backwards towards the edge of the slope. This retrogressive erosion can result from the deepening of the lithospheric plate sliding along the transform margin, from thick continental crust to thin continental crust, and finally to oceanic crust. This process could be at the origin of the shoulder uplift by flexural response to the important crustal discharge (>2 km)

Vers un développement territorial durable : Critères pour la localisation optimale des nouvelles activités

editorial reviewedLe travail produit par la CPDT (Lepur-ULiège et CREAT-UCLouvain) vise à mettre en place une analyse multicritère visant à « filtrer » les disponibilités foncière à l'urbanisation inscrites au sein des plans de secteur de l'ensemble du territoire wallon au travers d’un ensemble de critères qui sont soit des contraintes (exemple : zones Natura 2000, aléa d'inondation...), soit des potentialités (exemple: la structure spatiale du SDER, l’accessibilité des lieux...). Le résultat constitue un outil opérationnel pour les autorités communales et régionales en charge de la planification du territoire et les bureaux d'études qui les conseillent en vue de prioriser les sites urbanisables qui le méritent ou au contraire, en vue de préserver de l'urbanisation ceux qui présentes le plus de contraintes et/ou le moins de potentialités.Recherche CPDT 2007-2008 Identification des localisations optimales des activités économiques locales et Expertise 2007-2008 Evaluation des besoins en Zone d'activités économiques6. Clean water and sanitation7. Affordable and clean energy9. Industry, innovation and infrastructure11. Sustainable cities and communities13. Climate action15. Life on lan

Cell density dependent stimulation of PAI-1 and hyaluronan synthesis by TGF-[béta] in orbital fibroblasts

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First results of the Swiss Household Panel – Covid-19 Study

To get more insight into how people were affected by and fared during the first wave of the Covid-19 pandemic, the Swiss Household Panel launched an additional Covid-19 Survey among participating households. It was fielded between May and June 2020, right after the strictest regulations ended, but numerous restrictions were still in place. This paper presents the main findings of this study with respect to a wide variety of domains: the occurrence of Covid-19 infections in people’s networks, changes with respect to work, finances, time use, family life, following education from home, health and wellbeing, worries, social networks and social cohesion, and the evaluation of the political measures taken by the federal government

Characteristics of Hyaluronan Synthesis Inhibition by 4-Methylumbelliferone in Orbital Fibroblasts

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Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema

Background: Numerous genes have been associated with the three most common allergic diseases (asthma, allergic rhinitis or eczema) but these genes explain only a part of the heritability. In the vast majority of genetic studies, complex phenotypes such as co- morbidity of two of these diseases, have not been considered. This may partly explain missing heritability. Objective: To identify genetic variants specifically associated with the co-morbidity of asthma-plus-eczema. Methods: We first conducted a meta-analysis of four GWAS (Genome-Wide Association Study) of the combined asthma-plus-eczema phenotype (total of 8807 European-ancestry subjects of whom 1208 subjects had both asthma and eczema). To assess whether the association with SNP(s) was specific to the co- morbidity, we also conducted a meta-analysis of homogeneity test of association according to disease status (“asthma-plus-eczema” vs. the presence of only one disease “asthma only or eczema only”). We then used a joint test by combining the two test statistics from the co-morbidity-SNP association and the phenotypic heterogeneity of SNP effect meta-analyses. Results: Seven SNPs were detected for specific association to the asthma-plus-eczema co-morbidity, two with significant and five with suggestive evidence using the joint test after correction for multiple testing. The two significant SNPs are located in the OCA2 gene (Oculocutaneous Albinism II), a new locus never detected for significant evidence of association with any allergic disease. This gene is a promising candidate gene, because of its link to skin and lung diseases, and to epithelial barrier and immune mechanisms. Conclusion: Our study underlines the importance of studying sub-phenotypes as co-morbidities to detect new susceptibility genes

Eye Tricks

Catalog for the exhibition Eye Tricks held at the Seton Hall University Walsh Gallery, November 12 - December 15, 2007. Curated by Jeanne Brasile and Jason Marquis. Includes the essay Illusion / Elusion by Jason Marquis. Includes color illustrations

Eye Tricks

Catalog for the exhibition Eye Tricks held at the Seton Hall University Walsh Gallery, November 12 - December 15, 2007. Curated by Jeanne Brasile and Jason Marquis. Includes the essay Illusion / Elusion by Jason Marquis. Includes color illustrations

Genome-wide interaction study of early-life smoking exposure on time-to-asthma onset in childhood

Background: Asthma, a heterogeneous disease with variable age of onset, results from the interplay between genetic and environmental factors. Early-life tobacco smoke (ELTS) exposure is a major asthma risk factor. Only a few genetic loci have been reported to interact with ELTS exposure in asthma. Objective: Our aim was to identify new loci interacting with ELTS exposure on time-to-asthma onset (TAO) in childhood.Methods: We conducted genome-wide interaction analyses of ELTS exposure on time-to-asthma onset in childhood in five European-ancestry studies (totaling 8,273 subjects) using Cox proportional-hazard model. The results of all five genome-wide analyses were meta-analyzed.Results: The 13q21 locus showed genome-wide significant interaction with ELTS exposure (P=4.3x10-8 for rs7334050 within KLHL1 with consistent results across the five studies). Suggestive interactions (P<5x10-6) were found at three other loci: 20p12 (rs13037508 within MACROD2; P=4.9x10-7), 14q22 (rs7493885 near NIN; P=2.9x10-6) and 2p22 (rs232542 near CYP1B1; P=4.1x10-6). Functional annotations and the literature showed that the lead SNPs at these four loci influence DNA methylation in the blood and are located nearby CpG sites reported to be associated with exposure to tobacco smoke components, which strongly support our findings.Conclusion and Clinical Relevance: We identified novel candidate genes interacting with ELTS exposure on time-to-asthma onset in childhood. These genes have plausible biological relevance related to tobacco smoke exposure. Further epigenetic and functional studies are needed to confirm these findings and to shed light on the underlying mechanisms