5,913 research outputs found

    A dawn\u27s swim to the uninhabited island

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    Relationship science and interventions: Where we are and where we are going

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    Relationship distress and divorce often have profound effects on couples and their children. Relationship science has long sought to prevent and alleviate relationship distress; this chapter is a summary of many important recent developments in the field. Ongoing challenges in studying and assisting intimate relationships are also discussed

    Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons

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    Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about their input from other glutamatergic neurons. Here we show that these cells receive numerous contacts from nonprimary boutons that express the vesicular glutamate transporter 2 (VGLUT2), and form asymmetrical synapses on their dendrites and cell bodies. These synapses are significantly smaller than those formed by peptidergic afferents, but provide a substantial proportion of the glutamatergic synapses that the cells receive (over a third of those in laminae I–II and half of those in deeper laminae). Surprisingly, although the dynorphin precursor preprodynorphin (PPD) was only present in 4–7% of VGLUT2 boutons in laminae I–IV, it was found in 58% of the VGLUT2 boutons that contacted these cells. This indicates a highly selective targeting of the lamina III projection cells by glutamatergic neurons that express PPD, and these are likely to correspond to local neurons (interneurons and possibly projection cells). Since many PPD-expressing dorsal horn neurons respond to noxious stimulation, this suggests that the lamina III projection cells receive powerful monosynaptic and polysynaptic nociceptive input. Excitatory interneurons in the dorsal horn have been shown to possess IA currents, which limit their excitability and can underlie a form of activity-dependent intrinsic plasticity. It is therefore likely that polysynaptic inputs to the lamina III projection neurons are recruited during the development of chronic pain states

    Mapping the Evolution of "Clusters": A Meta-analysis

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    This paper presents a meta-analysis of the “cluster literature” contained in scientific journals from 1969 to 2007. Thanks to an original database we study the evolution of a stream of literature which focuses on a research object which is both a theoretical puzzle and an empirical widespread evidence. We identify different growth stages, from take-off to development and maturity. We test the existence of a life-cycle within the authorships and we discover the existence of a substitutability relation between different collaborative behaviours. We study the relationships between a “spatial” and an “industrial” approach within the textual corpus of cluster literature and we show the existence of a “predatory” interaction. We detect the relevance of clustering behaviours in the location of authors working on clusters and in measuring the influence of geographical distance in co-authorship. We measure the extent of a convergence process of the vocabulary of scientists working on clusters.Cluster, Life-Cycle, Cluster Literature, Textual Analysis, Agglomeration, Co-Authorship

    BRCA2 Mutations and Consequences for DNA Repair

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    Processes influencing visual awareness during motion-induced blindness

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    Visual illusions, such as motion-induced blindness, arise when the visual system, balancing speed and efficiency, summarizes the information it receives to form a percept. Motion-induced blindness (MIB) is characterized as the disappearance of a salient target when surrounded by a moving mask. Efforts to determine the mechanism have focused on the role of target characteristics on perceived disappearance by a coherently moving mask. In this dissertation, I take another approach, paying specific attention to the role of motion characteristics of the mask. In Experiments 1, 2, 3, and 4, I investigate whether the property of common fate influences target disappearance by manipulating coherence of the mask elements. Results showed that as mask coherence increased, perceived target disappearance decreased. This pattern was unaffected by the lifetime of the moving dots, the dot density of the motion stimulus, the target eccentricity, or the number of motion trajectories contained in the mask. The finding that motion coherence preferentially affected MIB prompted Experiments 5, 6, 7, and 8. Specifically, these experiments sought to investigate the spatial influence of mask motion on target disappearance. MIB was measured during conditions where opposing areas of motion coherence were confined locally surrounding the target or in more global areas across the display. The results revealed that motion coherence at more global locations, particularly at the area of fixation, had more influence on target disappearance compared to the coherence in proximity of the target and may reflect inability of the visual system to form a global motion pattern. The possibility that global motion may give rise to MIB, motivated the final research avenue. Experiment 9 addressed the possibility that variability in motion processing of the mask affects target disappearance. Specifically, the strength of motion processing was measured using the motion aftereffect. Results showed a strong connection between the amount of motion processing dedicated to the mask and the amount of MIB. As a whole, the findings show that motion processing, particularly during MIB, may be a driving force in our ability to perceive other objects in our environment
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