Concentrated solar thermoelectric generators

Solar thermoelectric generators (STEGs) are solid state heat engines that generate electricity from concentrated sunlight. In this paper, we develop a novel detailed balance model for STEGs and apply this model to both state-of-the-art and idealized materials. This model uses thermoelectric compatibility theory to provide analytic solutions to device efficiency in idealized materials with temperature-dependent properties. The results of this modeling allow us to predict maximum theoretical STEG efficiencies and suggest general design rules for STEGs. With today's materials, a STEG with an incident flux of 100 kW m^(−2) and a hot side temperature of 1000 °C could achieve 15.9% generator efficiency, making STEGs competitive with concentrated solar power plants. Future developments will depend on materials that can provide higher operating temperatures or higher material efficiency. For example, a STEG with zT = 2 at 1500 °C would have an efficiency of 30.6%

Effective thermal conductivity in thermoelectric materials

Thermoelectric generators (TEGs) are solid state heat engines that generate electricity from a temperature gradient. Optimizing these devices for maximum power production can be difficult due to the many heat transport mechanisms occurring simultaneously within the TEG. In this paper, we develop a model for heat transport in thermoelectric materials in which an “effective thermal conductivity” (κ_eff) encompasses both the one dimensional steady-state Fourier conduction and the heat generation/consumption due to secondary thermoelectric effects. This model is especially powerful in that the value of κeff does not depend upon the operating conditions of the TEG but rather on the transport properties of the TE materials themselves. We analyze a variety of thermoelectric materials and generator designs using this concept and demonstrate that κ_(eff) predicts the heat fluxes within these devices to 5% of the exact value

Method for welding an article and terminating the weldment within the perimeter of the article

An article is welded, as in weld repair of a defect, by positioning a weld lift-off block at a location on the surface of the article adjacent to the intended location of the end of the weldment on the surface of the article. The weld lift-off block has a wedge shape including a base contacting the surface of the article, and an upper face angled upwardly from the base from a base leading edge. A weld pool is formed on the surface of the article by directly heating the surface of the article using a heat source. The heat source is moved relative to the surface of the article and onto the upper surface of the weld lift-off block by crossing the leading edge of the wedge, without discontinuing the direct heating of the article by the heat source. The heating of the article with the heat source is discontinued only after the heat source is directly heating the upper face of the weld lift-off block, and not the article

A comparison of resting state functional magnetic resonance imaging to invasive electrocortical stimulation for sensorimotor mapping in pediatric patients

Localizing neurologic function within the brain remains a significant challenge in clinical neurosurgery. Invasive mapping with direct electrocortical stimulation currently is the clinical gold standard but is impractical in young or cognitively delayed patients who are unable to reliably perform tasks. Resting state functional magnetic resonance imaging non-invasively identifies resting state networks without the need for task performance, hence, is well suited to pediatric patients. We compared sensorimotor network localization by resting state fMRI to cortical stimulation sensory and motor mapping in 16 pediatric patients aged 3.1 to 18.6 years. All had medically refractory epilepsy that required invasive electrographic monitoring and stimulation mapping. The resting state fMRI data were analyzed using a previously trained machine learning classifier that has previously been evaluated in adults. We report comparable functional localization by resting state fMRI compared to stimulation mapping. These results provide strong evidence for the utility of resting state functional imaging in the localization of sensorimotor cortex across a wide range of pediatric patients

On the role of the corpus callosum in interhemispheric functional connectivity in humans

Resting state functional connectivity is defined in terms of temporal correlations between physiologic signals, most commonly studied using functional magnetic resonance imaging. Major features of functional connectivity correspond to structural (axonal) connectivity. However, this relation is not one-to-one. Interhemispheric functional connectivity in relation to the corpus callosum presents a case in point. Specifically, several reports have documented nearly intact interhemispheric functional connectivity in individuals in whom the corpus callosum (the major commissure between the hemispheres) never develops. To investigate this question, we assessed functional connectivity before and after surgical section of the corpus callosum in 22 patients with medically refractory epilepsy. Section of the corpus callosum markedly reduced interhemispheric functional connectivity. This effect was more profound in multimodal associative areas in the frontal and parietal lobe than primary regions of sensorimotor and visual function. Moreover, no evidence of recovery was observed in a limited sample in which multiyear, longitudinal follow-up was obtained. Comparison of partial vs. complete callosotomy revealed several effects implying the existence of polysynaptic functional connectivity between remote brain regions. Thus, our results demonstrate that callosal as well as extracallosal anatomical connections play a role in the maintenance of interhemispheric functional connectivity

Popular Conceptions of Nationhood in Old and New European Member States: Partial Support for the Ethnic-Civic Framework

One of the most influential theories in the study of nationalism has been the ethnic-East/civic-West framework developed by Hans Kohn. Using the 2002 Eurobarometer survey on national identity and building on earlier survey studies, this article examines whether the Kohn framework is valid at the level of popular understandings of nationhood. It scrutinizes the framework both conceptually - do people define nationhood in civic or ethnic terms? - and regionally - is the East indeed more ethnic than the West and the West more civic than the East? It will show that identity markers cluster in a political, a cultural and an ethnic dimension. Respondents do not see these dimensions as competing sources of nationhood, however. The article further lends some support for the regional component of the framework. Lastly, it argues that it is the intensity of national identifications rather than their qualitative nature (ethnic-civic) that correlates with xenophobia. © 2006 Taylor & Francis

Real-time motion analytics during brain MRI improve data quality and reduce costs

Head motion systematically distorts clinical and research MRI data. Motion artifacts have biased findings from many structural and functional brain MRI studies. An effective way to remove motion artifacts is to exclude MRI data frames affected by head motion. However, such post-hoc frame censoring can lead to data loss rates of 50% or more in our pediatric patient cohorts. Hence, many scanner operators collect additional 'buffer data', an expensive practice that, by itself, does not guarantee sufficient high-quality MRI data for a given participant. Therefore, we developed an easy-to-setup, easy-to-use Framewise Integrated Real-time MRI Monitoring (FIRMM) software suite that provides scanner operators with head motion analytics in real-time, allowing them to scan each subject until the desired amount of low-movement data has been collected. Our analyses show that using FIRMM to identify the ideal scan time for each person can reduce total brain MRI scan times and associated costs by 50% or more

Response to “Comment on ‘Effective thermal conductivity in thermoelectric materials’” [J. Appl. Phys. 113, 204904 (2013)]

It is commonly claimed that achieving maximum power from a thermoelectric generator necessitates electrical load matching conditions instead of the operating condition derived for maximum generator efficiency. Here, we explain why the electrical load matching claim for maximum power in a design optimization is flawed and show that the load condition derived for maximum efficiency always produces more power. Finally, we consider a CPM generator, and prove that the electrical condition for maximum efficiency is indeed the electrical condition for maximum power, maximum power density, maximum power/cost of thermoelectric material, and maximum power/weight of thermoelectric material, when the leg length of the thermoelectric generator is a design variable

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types of the adult pancreas. We show that a subpopulation of Pdx1-expressing cells is susceptible to oncogenic K-Ras-induced transformation without tissue injury, whereas insulin-expressing endocrine cells are completely refractory to transformation under these conditions. However, chronic pancreatic injury can alter their endocrine fate and allow them to serve as the cell of origin for exocrine neoplasia. These results suggest that one mechanism by which inflammation and/or tissue damage can promote neoplasia is by altering the fate of differentiated cells that are normally refractory to oncogenic stimulation.National Cancer Institute (U.S.) (Cancer Center Support (Core) Grant, P30 CA14051)National Institutes of Health (U.S.) (grant 1 PO1 CA117969 01)American Cancer Society (ACS Research Professor)Anna Fuller FundMassachusetts Institute of Technology (Daniel K. Ludwig Foundation Cancer Research Professor)Howard Hughes Medical Institute (Investigator

Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase

This paper describes the performance of junctions based on self-assembled monolayers (SAMs) as the functional element of a half-wave rectifier (a simple circuit that converts, or rectifies, an alternating current (AC) signal to a direct current (DC) signal). Junctions with SAMs of 11-(ferrocenyl)-1-undecanethiol or 11-(biferrocenyl)-1-undecanethiol on ultraflat, template-stripped Ag (AgTS) bottom electrodes, and contacted by top electrodes of eutectic indium–gallium (EGaIn), rectified AC signals, while similar junctions based on SAMs of 1-undecanethiol—SAMs lacking the ferrocenyl terminal group—did not. SAMs in these AC circuits (operating at 50 Hz) remain stable over a larger window of applied bias than in DC circuits. AC measurements, therefore, can investigate charge transport in SAM-based junctions at magnitudes of bias inaccessible to DC measurements. For junctions with SAMs of alkanethiols, combining the results from AC and DC measurements identifies two regimes of bias with different mechanisms of charge transport: (i) low bias (|V| 1.3 V), at which Fowler–Nordheim (FN) tunneling dominates. For junctions with SAMs terminated by Fc moieties, the transition to FN tunneling occurs at |V| ≈ 2.0 V. Furthermore, at sufficient forward bias (V > 0.5 V), hopping makes a significant contribution to charge transport and occurs in series with direct tunneling (V 2.0 V) until FN tunneling activates (V 2.0 V). Thus, for Fc-terminated SAMs at forward bias, three regimes are apparent: (i) direct tunneling (V = 0–0.5 V), (ii) hopping plus direct tunneling (V ≈ 0.5–2.0 V), and (iii) FN tunneling (V 2.0 V). Since hopping does not occur at reverse bias, only two regimes are present over the measured range of reverse bias. This difference in the mechanisms of charge transport at forward and reverse bias for junctions with Fc moieties resulted in large rectification ratios (R > 100) and enabled half-wave rectification.Chemistry and Chemical Biolog