1,779 research outputs found
Nucleon electromagnetic form factors from lattice QCD using a nearly physical pion mass
We present lattice QCD calculations of nucleon electromagnetic form factors
using pion masses = 149, 202, and 254 MeV and an action with
clover-improved Wilson quarks coupled to smeared gauge fields, as used by the
Budapest-Marseille-Wuppertal collaboration. Particular attention is given to
removal of the effects of excited state contamination by calculation at three
source-sink separations and use of the summation and generalized
pencil-of-function methods. The combination of calculation at the nearly
physical mass = 149 MeV in a large spatial volume ( = 4.2)
and removal of excited state effects yields agreement with experiment for the
electric and magnetic form factors and up to = 0.5
GeV.Comment: v2: published version; 30 pages, 25 figures, 6 table
Quark Contributions to Nucleon Momentum and Spin from Domain Wall fermion calculations
We report contributions to the nucleon spin and momentum from light quarks
calculated using dynamical domain wall fermions with pion masses down to 300
MeV and fine lattice spacing a=0.084 fm. Albeit without disconnected diagrams,
we observe that spin and orbital angular momenta of both u and d quarks are
opposite, almost canceling in the case of the d quark, which agrees with
previous calculations using a mixed quark action. We also present the full
momentum dependence of n=2 generalized form factors showing little variation
with the pion mass.Comment: 7 pages, 5 figures, NT-LBNL-11-020, MIT-CTP-4323. Presented at the
29th International Symposium on Lattice Field Theory (Lattice 2011), Squaw
Valley, California, 10-16 Jul 201
Nucleon Electromagnetic Form Factors from Lattice QCD using 2+1 Flavor Domain Wall Fermions on Fine Lattices and Chiral Perturbation Theory
We present a high-statistics calculation of nucleon electromagnetic form
factors in lattice QCD using domain wall quarks on fine lattices, to
attain a new level of precision in systematic and statistical errors. Our
calculations use lattices with lattice spacing a=0.084 fm for
pion masses of 297, 355, and 403 MeV, and we perform an overdetermined analysis
using on the order of 3600 to 7000 measurements to calculate nucleon electric
and magnetic form factors up to 1.05 GeV. Results are shown
to be consistent with those obtained using valence domain wall quarks with
improved staggered sea quarks, and using coarse domain wall lattices. We
determine the isovector Dirac radius , Pauli radius and
anomalous magnetic moment . We also determine connected contributions
to the corresponding isoscalar observables. We extrapolate these observables to
the physical pion mass using two different formulations of two-flavor chiral
effective field theory at one loop: the heavy baryon Small Scale Expansion
(SSE) and covariant baryon chiral perturbation theory. The isovector results
and the connected contributions to the isoscalar results are compared with
experiment, and the need for calculations at smaller pion masses is discussed.Comment: 44 pages, 40 figure
The band structure of BeTe - a combined experimental and theoretical study
Using angle-resolved synchrotron-radiation photoemission spectroscopy we have
determined the dispersion of the valence bands of BeTe(100) along ,
i.e. the [100] direction. The measurements are analyzed with the aid of a
first-principles calculation of the BeTe bulk band structure as well as of the
photoemission peaks as given by the momentum conserving bulk transitions.
Taking the calculated unoccupied bands as final states of the photoemission
process, we obtain an excellent agreement between experimental and calculated
spectra and a clear interpretation of almost all measured bands. In contrast,
the free electron approximation for the final states fails to describe the BeTe
bulk band structure along properly.Comment: 21 pages plus 4 figure
Polyhedral units and network connectivity in calcium aluminosilicate glasses from high-energy x-ray diffraction
Structure factors for Cax/2AlxSi1-xO2 glasses (x=0,0.25,0.5,0.67) extended to
a wave vector of magnitude Q= 40 1/A have been obtained by high-energy x-ray
diffraction. For the first time, it is possible to resolve the contributions of
Si-O, Al-O and Ca-O coordination polyhedra to the experimental atomic pair
distribution functions (PDF). It has been found that both Si and Al are
four-fold coordinated and so participate in a continuous tetrahedral network at
low values of x. The number of network breaking defects in the form of
non-bridging oxygens (NBO's) increases slowly with x until x=0.5 (NBO's ~ 10%
at x=0.5). By x=0.67 the network breaking defects become significant as
evidenced by the significant drop in the average coordination number of Si. By
contrast, Al-O tetrahedra remain free of NBO's and fully integrated in the
Al/Si-O network for all values of x. Calcium maintains a rather uniform
coordination sphere of approximately 5 oxygen atoms for all values of x. The
results suggest that not only Si/Al-O tetrahedra but Ca-O polyhedra, too, play
a role in determining the glassy structure
Nucleon Generalized Parton Distributions from Full Lattice QCD
We present a comprehensive study of the lowest moments of nucleon generalized
parton distributions in N_f=2+1 lattice QCD using domain wall valence quarks
and improved staggered sea quarks. Our investigation includes helicity
dependent and independent generalized parton distributions for pion masses as
low as 350 MeV and volumes as large as (3.5 fm)^3, for a lattice spacing of
0.124 fm. We use perturbative renormalization at one-loop level with an
improvement based on the non-perturbative renormalization factor for the axial
vector current, and only connected diagrams are included in the isosinglet
channel.Comment: 40 pages, 49 figures; Revised chiral extrapolations in sections A-K,
main conclusions unchange
Impact of Mucositis on Absorption and Systemic Drug Exposure of Isavuconazole
ABSTRACT
Isavuconazonium sulfate is the water-soluble prodrug of isavuconazole. Population analyses have demonstrated relatively predictable pharmacokinetic (PK) behavior in diverse patient populations. We evaluated the impact of mucositis on the oral isavuconazole exposure using population PK modeling. This study included patients treated in two phase 3 trials of isavuconazole, SECURE for treatment of invasive aspergillosis (IA) and other filamentous fungi and VITAL for patients with mucormycosis, invasive fungal disease (IFD) caused by other rare fungi, or IA and renal impairment. Mucositis was reported by site investigators and its impact on oral bioavailability was assessed. Use of the oral formulation was at the discretion of the investigator. Patients with plasma samples collected during the use of isavuconazonium sulfate were included in the construction of population PK model. Of 250 patients included, 56 patients had mucositis at therapy onset or as an adverse event during oral isavuconazole therapy. Levels of oral bioavailability were comparable, at 98.3% and 99.8%, respectively. The average drug exposures (average area under the curve [AUC
ave
]) calculated from either the mean or median parameter estimates were not different between patients with and without mucositis. Mortality and overall clinical responses were similar between patients receiving oral therapy with and without mucositis. We found that isavuconazole exposures and clinical outcomes in this subset of patients with mucositis who were able to take oral isavuconazonium sulfate were comparable to those in patients without mucositis, despite the difference in oral bioavailability. Therefore, mucositis may not preclude use of the oral formulation of isavuconazonium sulfate.
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Nucleon structure from mixed action calculations using 2+1 flavors of asqtad sea and domain wall valence fermions
We present high statistics results for the structure of the nucleon from a
mixed-action calculation using 2+1 flavors of asqtad sea and domain wall
valence fermions. We perform extrapolations of our data based on different
chiral effective field theory schemes and compare our results with available
information from phenomenology. We discuss vector and axial form factors of the
nucleon, moments of generalized parton distributions, including moments of
forward parton distributions, and implications for the decomposition of the
nucleon spin.Comment: 68 pages, 47 figures. Main revision points: improved discussion of
chiral fits and systematic uncertainties, several minor refinements. Accepted
for publication in Phys.Rev.
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