Additional file 1: of Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility

Supplemental Data: Table S1. The clinical characteristics of samples in each JIA cohort. Table S2. Genome-wide significant associations at the HLA locus (p < 5×10-8 in the discovery cohort).Table S3. Association results for top SNPs in known JIA associated genes PTPN22, IL2RA, ANTXR2. TableS4. The most significantly associated SNPs at CXCR4 locus on chromosome 2q22.1. Table S5 . Genomewideassociation results for imputed SNPs (p < 1×10-4 in combined analysis) in the vicinity of CXCR4 in our JIA cohort. Table S6. Primers used in Sanger sequencing validation of rare variants at CXCR4 locus. Figure S1. Genome-wide association results for JIA. Figure S2. Regional association plot for the 2q22.1 region. Figure S3. CXCR4 tissue-specific gene expression levels. Figure S4. CXCR4 expression levels stratified by SNP genotype. (DOC 466 kb