THE STUDY OF PARTITION COEFFICIENT OCTANOL/WATER FOR 3-(2-ALCHYLSULFANYL-6-BENZOTHIAZOLYLAMINOMETHYL)-2- BENZOXAZOLTIONE AS PHOTOSYNTHESIS INHIBITORS

It is well known that  benzoxazole derivatives have a wide range of biological activities. Recently, it was shown that the derivatives of benzoxazoltione, substituted at an amino group inhibit photosynthesis in chloroplasts and algae such as Chlorela vulgaris. It was observed that the inhibitory effect decreases with increasing lipophilicity of substances in the series. The lipophilicity or hydrophilicity are expressed by the partition coefficient, which is a very important factor that characterize the pharmacokinetic profile of a chemical compound. We studied the structural descriptors that contribute to the biological activity of substances. For a series of nine substances, results show that descriptors CSAA, CSEV and TFES appear to be responsible for the inhibitory activity of these substances

THE CORRELATION STUDIES OF ANTIMYCOBACTERIAL ACTIVITY FOR A NUMBER OF DERIVATIVES OF 4-CARBOXAMIDE

In order to produce a desired physiological effect, substances have to cross cell membranes. The ability of a chemical compound to cross membranes is influenced primarily by the partition coefficient. This is a physical-chemical factor that directly influence the pharmacokinetic profile of the drug and indirect its pharmacodynamic profile. The paper is a QSAR study carried out on a class of substituted of carboxamide, having antimycobacterial activity against the atypical mycobacterial strains and that these compounds are inhibitors of the photosynthesis process. The purpose of such a study is to link the chemical structures of the compounds represented by a set of molecular descriptors with biological activity exhibited by them, expressed as IC50. Identifying these descriptors leads to information of the changes induced by  the presence and nature of different chemical groups in the molecule, which allows optimization of analyzed biological activity

DETECTION OF HEAVY METALS FROM MOLLUSCS SHELLS

This work presents aspects regarding some heavy metals (Cd, Pb, Cu and Zn) concentration in shells of different molluscs (Mytilus galloprovincialis, Rapana thomasiana, Mya arenaria, Scapharca) collected from the Romanian Black Sea Coast. The heavy metals were analysed using atomic absorption spectrometry

INVESTIGATION OF HEAVY METALS FROM SOME ALIMENTARY PRODUCTS

The presence in high amount of organic pollutants and heavy metals in environmentrepresents a potential danger for human health and for environment too. This workpresents aspects regarding the pollution with heavy metals (Cd, Pb, Cu and Zn) of some food products: caw milk, caw cheese and caw meat. The samples analysed were collected from some housekeeping of Lumina (Constanta). The heavy metals were analysed using atomic absorption spectrometry