A STUDY ON COMPETITIVENESS OF READY-MADE GARMENTS FOR EXPORT-LED ECONOMIC GROWTH IN BANGLADESH: ISSUES AND CHALLENGES

Abstract: Bangladesh achieved remarkable economic development in the last few decades, and the ready-made garment (RMG) industry played a vital role in this regard. The future economic development of the country depends on the success and continuation of such industrial sectors for export-led growth of the country. Considering the importance of the export-led economic growth strategy, this study assessed the global competitiveness of this industry. Michael Porter’s Diamond model of national competitiveness is used as the main analytical framework to assess the sources of competitiveness. A SWOT analysis is also conducted to identify future challenges and critical success factor for the continuing contribution of the industry. The study followed a mixed method approach to investigate the research questions. Secondary literature, consisting mainly of reports and documents from government and the private sector, were collected to comprehend the contemporary industry. A survey of 199 respondents from 150 RMG factories was conducted to assess effects and relative weights of different factors included in the National Diamond model and to understand the basis of the competitiveness of the RMG industry of Bangladesh. A further 30 face-to-face interviews with representatives from five different stakeholder groups including international buyers were conducted to get further explanations and insights of different factors of importance for achieving and maintaining the competitiveness of the RMG industry of Bangladesh. The findings of the study reveal that not all the dimensions of Porter’s National Diamond model contributed to the competitiveness of the RMG industry. Among the four main National Diamond dimensions, the RMG industry of Bangladesh appeared to enjoy competitiveness without having a favorable demand condition in the domestic market. The other three main dimensions—i.e., the factor conditions, related and support industries, and industry strategy, structure and rivalry—mostly played conducive roles in the development of the RMG industry in Bangladesh and provided the impetus to achieve competitive advantage in the global market. However, within factor conditions, the availability of a large unskilled workforce, strategic locations and reasonable infrastructure acted as sources of competitive advantage despite some limitations including a lack of highly skilled mid-level RMG professionals, limited access to adequate financing, and deficiencies in R&D activities. Similarly, regarding related and support industries, a large number of backward-linkage knitwear industries positively contributed towards competitiveness, though industry respondents indicated an absence of well-developed clusters as a limitation compared to other countries. In the case of industry strategy, structure and rivalry, collaborative actions by the industry association regarding compliance issues, as well as collective responses to buyers’ needs, were identified as sources of competitive advantage, while sub-contracting to non-compliant factories and a lack of systematic R&D (e.g., an absence of a common e-platform) were considered as limitations. The findings indicate that the positive impact of favorable factors of those three dimensions (factor conditions, related and support industries, and industry strategy, structure and rivalry) were relatively stronger than the negative impacts, and contribute to the achievement of competitive advantage of the industry. Other than the four main factors, the study also found that government support has played a significant role in the development of the RMG industry in Bangladesh. The government provided these supports through various policy initiatives, financial incentives, and the negotiation of favorable trade agreements including tariff and import-quota free access to the European Union under the Generalized System of Preference (GSP) scheme. The study also recognized that three chance events greatly influenced the development of the RMG industry of Bangladesh and positively affected growth in the sector: a quota system levied against traditional RMG exporters (e.g. South Korea, Hong Kong) in the 1970s; the Multi-Fibre Arrangement (MFA) that governed world trade in textiles and garments from 1974 to 1994 and provided beneficial access for Bangladeshi exporters; and compliance issues raised after the 2013 Rana Plaza garment factory catastrophe. The findings further highlight the importance of Porter’s double, multiple and rough diamond propositions in maintaining the continuous growth and development of the RMG industry in Bangladesh. It also briefly points out the potential impact of current COVID -19 pandemic on the RMG industry of Bangladesh. Finally, it proposes further research avenues to advance knowledge on competitiveness from different perspectives along with policy implications for the RMG sector of Bangladesh

Molecular docking study of Zingiber officinale Roscoe compounds as a mumps virus nucleoprotein inhibitor

Background: Mumps virus (MuV) can trigger severe infections, such as parotitis, epididymo-orchitis, and meningitis. The effectiveness of MuV vaccine administration has been proven, but current outbreaks warrant the development of antivirals against MuV. Zingiber officinale var. Roscoe or ginger is often used as an alternative remedy. Currently, there are no known in vitro or in vivo studies that investigate ginger as an MuV antiviral. Purpose: This study aims to evaluate the antiviral potency of the bioactive compounds in Zingiber officinale var. Roscoe against MuV. Methods: Antiviral activity screening was conducted by druglikeness analysis, antiviral probability, molecular docking, and molecular dynamic simulation. Results: As an antiviral, 6-shogaol from Zingiber officinale var. Roscoe has potency against MuV. It has a good binding affinity and can establish interactions with the binding domain of the target protein by forming hydrogen, Van der Waals, and alkyl bonds. Conclusion: The complex of 6-shogaol_NP was predicted to be volatile but stable for triggering inhibitory activity. However, these results must be proved by in vivo and in vitro approaches to strengthen the scientific evidence

Bioactive compounds screening of Rafflesia sp. and Sapria sp. (Family: Rafflesiaceae) as anti-SARS-CoV-2 via tetra inhibitors: An in silico research

Context: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread, causing a global pandemic with diverse symptoms and increased risk of mortality. Various symptoms and comorbidities contribute to a higher likelihood of death in patients. Additionally, existing antiviral drugs have shown incomplete efficacy. Rafflesia sp. and Sapria sp. are parasitic plants with potential medical applications as anti-SARS-CoV-2 agents. Aims: To evaluate the bioactive compounds derived from Rafflesia sp. and Sapria sp. as dual inhibitors against SARS-CoV-2. Methods: Ligand samples were obtained from the PubChem database. Target proteins essential for SARS-CoV-2 entry were obtained from the RCSB PDB. The antiviral potential of the bioactive compounds was evaluated using the Pass Online webserver. The bioactivity and inhibitory potential of selected ligands were analyzed using the SwissADME and Molinspiration web servers. In addition, a specific docking method was performed using PyRx software to determine binding activity and molecular interactions. Results: Computational analysis revealed that leucoanthocyanidin, ellagic acid, and catechin functioned as dual inhibitors, targeting angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), furin, and cathepsin L for antiviral activity. However, valrubicin and diminazene, serving as control drugs for ACE2 and furin, respectively, demonstrated the most effective results through this mechanism. Further studies are required to validate these findings. Conclusions: The combination of bioactive compounds derived from Rafflesia sp. and Sapria sp. shows potential antiviral activity through a dual inhibitor mechanism involving leucoanthocyanidin, ellagic acid, and catechin, which target SARS-CoV-2 proteins, namely ACE2, TMPRSS2, furin, and cathepsin L

Garcinoxanthones from Garcinia mangostana L. against SARS-CoV-2 infection and cytokine storm pathway inhibition: A viroinformatics study

Context: Mangosteen (Garcinia mangostana L.) is used in traditional medicine as an antibacterial, antioxidant, and anti-inflammatory. Aims: To determine the molecular mechanism and potential of garciniaxanthone derivate compounds from G. mangostana as SARS-CoV-2 antiviral and prevent cytokine storm through in silico approach. Methods: Ligand and protein samples were obtained from databases such as PubChem and Protein Databank, then drug-likeness analysis using Lipinski, Ghose, Veber, Egan, and Muege rules on SwissADME server, prediction of antiviral probability through PASSOnline server. Furthermore, molecular docking simulation with PyRx v1.0 software (Scripps Research, USA) with an academic license, identification of interactions and chemical bond positions of ligands on the target by PoseView server, 3D visualization of PyMOLv.2.5.2 software (Schrödinger, Inc., USA) with an academic license, molecular dynamics simulation for molecular stability prediction by CABS-flex v2.0 server, target prediction of antiviral candidate compounds by SwissTargetPrediction server, pathway analysis through STRING v11.5 database, and toxicity by ProTox-II server were used. Results: Garciniaxanthone C from G. mangostana was found to be a drug-like molecule with low toxicity. This can be a candidate for SARS-Cov-2 antiviral through inhibitor activity on two viral enzymes consisting of Mpro and replicase with a binding affinity value that is more negative than other garciniaxanthone derivates and is stable. Garciniaxanthone C is predicted to bind and inhibit pro-inflammatory proteins that trigger cytokine storms, such as NFKB1 and PTGS2. Conclusions: Garciniaxanthone derivative compounds from G. mangostana may be candidates for SARS-CoV-2 antiviral and preventing cytokine storm through garciniaxanthone C activity

Managing diversity

Bangladesh has seen little of the flow of foreign direct investment (FDI) to the third world in the wake of the globalisation of the world economy, and this is its own fault, writes Quamrul Alam and Mohammad Emdad Ullah Mian

Money magnet misery

Bangladesh has seen little of the flow of foreign direct investment (FDI) to the third world in the wake of the globalisation of the world economy, and this is its own fault, writes Quamrul Alam and Mohammad Emdad Ullah Mian. Copyright 2006 Quamrul Alam and Mohammad Emdad Ullah Mian. No part of this article may be reproduced by any means without the written consent of the publisher

Prediction of Aflatoxin-B1 (AFB1) Molecular Mechanism Network and Interaction to Oncoproteins Growth Factor in Hepatocellular Carcinoma

Aflatoxin-B1 (AFB1) is a common contaminant for staple foods during the storage process. Chronic exposure to AFB1 is widely known to induce the development of hepatocellular carcinoma (HCC). However, there is a lack of understanding of AFBi role in HCC mechanism. This research aims to identify protein(s) in HCC that might interact with AFB1 and to predict the pathway effected by AFB1. Analyses were performed using bioinformatics tools. SMILES notation of AFB1 was submitted into Swiss Target Prediction. Interaction among predicted proteins were analyzed by using STRING. The 3D structure of target protein was constructed by homology modeling. Reverse docking was performed, and the result was ranked based on binding affinity score. Furthermore, protein interaction network was constructed and analyzed by using Cytoscape. Results showed that three protein groups were predicted as target of AFB1, such as kinases, phosphatases, and G protein-coupled receptor with probability of 46.7%, 20%, and 6.7%, respectively. Seven proteins of kinases were strongly related to HCC, including RAF1, MAPK1, MAPK3, AKT1, EGFR, GSK3B, and mTOR. Reverse docking considered the AKT1-AFB1 as the most potential complex with the lowest affinity score -10.2 kcal.mol-1. It has hydrophobic bonds in Trp80, Val270, Tyr272, Asp292, Thr211, Leu210, Leu264, and Lys268 residues, whereas hydrogen bond in Ser205 residues. Moreover, further analysis demonstrated that interaction of AKT1-AFB1 is related to the metastasis pathway in HCC mechanism

Rhamnopyranoside-Based Fatty Acid Esters as Antimicrobials: Synthesis, Spectral Characterization, PASS, Antimicrobial, and Molecular Docking Studies

The most widely used and accessible monosaccharides have a number of stereogenic centers that have been hydroxylated and are challenging to chemically separate. As a result, the task of regioselective derivatization of such structures is particularly difficult. Considering this fact and to get novel rhamnopyranoside-based esters, DMAP-catalyzed di-O-stearoylation of methyl α-l-rhamnopyranoside (3) produced a mixture of 2,3-di-O- (4) and 3,4-di-O-stearates (5) (ratio 2:3) indicating the reactivity of the hydroxylated stereogenic centers of rhamnopyranoside as 3-OH > 4-OH > 2-OH. To get novel biologically active rhamnose esters, di-O-stearates 4 and 5 were converted into six 4-O- and 2-O-esters 6–11, which were fully characterized by FT-IR, 1H, and 13C NMR spectral techniques. In vitro antimicrobial assays revealed that fully esterified rhamnopyranosides 6–11 with maximum lipophilic character showed better antifungal susceptibility than antibacterial activity. These experimental findings are similar to the results found from PASS analysis data. Furthermore, the pentanoyl derivative of 2,3-di-O-stearate (compound 6) showed better antifungal functionality against F. equiseti and A. flavus, which were found to be better than standard antibiotics. To validate the better antifungal results, molecular docking of the rhamnose esters 4–11 was performed with lanosterol 14α-demethylase (PDB ID: 3LD6), including the standard antifungal antibiotics ketoconazole and fluconazole. In this instance, the binding affinities of 10 (−7.6 kcal/mol), 9 (−7.5 kcal/mol), and 7 (−6.9 kcal/mol) were better and comparable to fluconazole (−7.3 kcal/mol), indicating the likelihood of their use as non-azole type antifungal drugs in the future