3,128 research outputs found
Confronting and Understanding Factors of Teacher Turnover: A Deep-rooted Phenomenon Employing an Autoethnographic Perspective
This qualitative autoethnographic study explores the phenomenon of teacher turnover as it relates to the researcher’s specific contexts and personal experiences. Through the acts of journaling, coaching, and narrative writing, teachers can better understand influences of culture on their beliefs, values, attitudes, and decisions – especially in regards to actions of movement from one setting to another. The findings indicate that beliefs, values, attitudes, and decisions are learned through a school’s culture, and they can change depending on perspective. The findings also indicate that there is power in dialogue – even for teachers who never felt they had influence or a voice at all
Advanced Cyberinfrastructure for Science, Engineering, and Public Policy
Progress in many domains increasingly benefits from our ability to view the
systems through a computational lens, i.e., using computational abstractions of
the domains; and our ability to acquire, share, integrate, and analyze
disparate types of data. These advances would not be possible without the
advanced data and computational cyberinfrastructure and tools for data capture,
integration, analysis, modeling, and simulation. However, despite, and perhaps
because of, advances in "big data" technologies for data acquisition,
management and analytics, the other largely manual, and labor-intensive aspects
of the decision making process, e.g., formulating questions, designing studies,
organizing, curating, connecting, correlating and integrating crossdomain data,
drawing inferences and interpreting results, have become the rate-limiting
steps to progress. Advancing the capability and capacity for evidence-based
improvements in science, engineering, and public policy requires support for
(1) computational abstractions of the relevant domains coupled with
computational methods and tools for their analysis, synthesis, simulation,
visualization, sharing, and integration; (2) cognitive tools that leverage and
extend the reach of human intellect, and partner with humans on all aspects of
the activity; (3) nimble and trustworthy data cyber-infrastructures that
connect, manage a variety of instruments, multiple interrelated data types and
associated metadata, data representations, processes, protocols and workflows;
and enforce applicable security and data access and use policies; and (4)
organizational and social structures and processes for collaborative and
coordinated activity across disciplinary and institutional boundaries.Comment: A Computing Community Consortium (CCC) white paper, 9 pages. arXiv
admin note: text overlap with arXiv:1604.0200
The redesign and re-evaluation of an internet-based telerehabilitation system for the assessment of dysarthria in adults
A previous study revealed that reliable assessment of dysarthria was feasible. However, that study also revealed a number of system limitations and suggested that technological enhancements and improvements in study design and clinical assessment protocols were needed before validity and reliability of assessment of dysarthria via telerehabilitation could be confirmed. In the current study, improvements in technology, study design, and clinical assessment protocols were implemented in order to re-examine the validity and reliability of assessing and diagnosing dysarthria via the telerehabilitation medium. The aim of this study was to explore the validity and reliability of assessing dysarthria using both formal standardized and informal assessments via a purpose-built telerehabilitation system. Twenty-four participants with an acquired dysarthria were assessed simultaneously via telerehabilitation and face-to-face (FTF) on a battery of assessments. A custom-built telerehabilitation system enabled real-time telerehabilitation assessment over a 128 Kbps Internet connection. Data analysis included an analysis of strength of agreement between the two methods using percentage agreement and weighted Κ statistics. Inter-rater and intrarater reliability were also examined for both the FTF and telerehabilitation-led assessments. Good strength of agreement was found between the FTF and telerehabilitation assessment methods. High intrarater and inter-rater reliability within both the FTF and telerehabilitation assessment methods supported these findings. Participants reported high overall satisfaction in the telerehabilitation environment. This study describes the improvements made to the telerehabilitation system reported previously and confirms that valid and reliable assessment of dysarthria using both standardized and informal assessments over the Internet is possible using this system
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Reproductive Coercion and Relationship Abuse Among Adolescents and Young Women Seeking Care at School Health Centers.
ObjectiveTo investigate demographic differences and evaluate how reproductive coercion and relationship abuse influences young females' care-seeking and sexual health behaviors.MethodsWe conducted a secondary analysis of cross-sectional baseline survey data from sexually active female students (aged 14-19 years) who sought care from school health centers. Outcomes included recent (previous 3 months) reproductive coercion, physical or sexual adolescent relationship abuse, and nonpartner sexual violence victimization. Cluster-adjusted χ tests compared demographics and generalized linear mixed models estimated associations among reproductive coercion, adolescent relationship abuse (physical and sexual abuse in romantic relationships), and care-seeking and sexual health behaviors.ResultsOf 550 sexually active high school females, 12% reported recent reproductive coercion and 17% reported physical or sexual adolescent relationship abuse, with no significant demographic differences. Prevalence of recent nonpartner sexual violence was 17%. There were no observed significant differences in care-seeking behaviors among those with recent reproductive coercion compared with those without. Physical or sexual adolescent relationship abuse was associated with increased odds of seeking testing or treatment for sexually transmitted infections (adjusted odds ratio [aOR] 2.08, 95% CI 1.05-4.13). Females exposed to both adolescent relationship abuse and reproductive coercion had higher odds of having a partner who was 5 or more years older (aOR 4.66, 95% CI 1.51-14.4), having two or more recent sexual partners (aOR 3.86, 95% CI 1.57-9.48), and using hormonal contraception only (aOR 3.77, 95% CI 1.09-13.1 vs hormonal methods with condoms).ConclusionAlmost one in eight females experienced recent reproductive coercion. We did not observe significant demographic differences in reproductive coercion. Partner age and number of sexual partners may elevate risk for abusive relationships. Relationship abuse is prevalent among high school students seeking care, with no clear pattern for case identification. By failing to identify factors associated with harmful partner behaviors, our results support universal assessment for reproductive coercion and relationship abuse among high school-aged adolescents, involving education, resources, and harm-reduction counseling to all patients.Clinical trial registrationClinicalTrials.gov, NCT01678378
Listening to the Voices of Teacher Candidates to Design Content Area Literacy Courses
While teacher candidates take courses which prepare them to deliver content in secondary content area classrooms, they often lack the knowledge necessary to help their future students learn discipline-specific information through the use of literacy strategies. In many cases, content area teacher candidates do not view themselves as literacy educators, believing instead that English teachers or elementary level educators are responsible for developing the reading and writing skills of students. However, development as teachers of literacy is possible. Through a content area literacy course taken as part of a teacher preparation program, secondary content area teacher candidates reported changes in their perceptions of and willingness to use literacy strategies to improve the learning outcomes of their students. Through pre-course and post-course surveys, teacher candidates reported an expanded understanding of the importance of literacy in the development of content knowledge
Intercalative Stacking: A Critical Feature of DNA Charge-Transport Electrochemistry
In electrochemistry experiments on DNA-modified electrodes, features of the redox probe that determine efficient charge transport through DNA-modified surfaces have been explored using methylene blue (MB^+) and Ru(NH_3)_6^(3+) as DNA-binding redox probes. The electrochemistry of these molecules is studied as a function of ionic strength to determine the necessity of tight binding to DNA and the number of electrons involved in the redox reaction; on the DNA surface, MB^+ displays 2e^-/1H^+ electrochemistry (pH 7) and Ru(NH^3)_6^(3+) displays 1e^- electrochemistry. We examine also the effect of electrode surface passivation and the effect of the mode (intercalation or electrostatic) of MB^+ and Ru(NH_3)_6^(3+) binding to DNA to highlight the importance of intercalation for reduction by a DNA-mediated charge-transport pathway. Furthermore, in experiments in which MB^+ is covalently linked to the DNA through a σ-bonded tether and the ionic strength is varied, it is demonstrated that intercalative stacking rather than covalent σ-bonding is essential for efficient reduction of MB^+. The results presented here therefore establish that efficient charge transport to the DNA-binding moiety in DNA films requires intercalative stacking and is mediated by the DNA base pair array
Coloron Phenomenology
A flavor-universal extension of the strong interactions was recently proposed
in response to the apparent excess of high- jets in the inclusive jet
spectrum measured at the Tevatron. This paper studies the color octet of
massive gauge bosons (`colorons') that is present in the low-energy spectrum of
the model's Higgs phase. Constraints from searches for new particles decaying
to dijets and from measurements of the weak-interaction parameter imply
that the colorons must have masses greater than 870-1000 GeV. The implications
of recent Tevatron data and the prospective input from future experiments are
also discussed.Comment: 13 pages, 4 embedded Postscript figures, LaTeX, full postscript
version also available at http://smyrd.bu.edu/htfigs/htfigs.html rectified
confusing phrase at end of sub-section on 'dijets
HUNK phosphorylates EGFR to regulate breast cancer metastasis
Epidermal growth factor receptor (EGFR) is commonly over-expressed in metastatic breast cancer yet metastatic breast cancer is generally resistant to anti-EGFR therapies, and the mechanism for resistance to EGFR inhibitors in this setting is not fully understood. Hormonally up-regulated neu-associated kinase (HUNK) kinase is up-regulated in aggressive breast cancers and is thought to play a role in breast cancer metastasis. However, no studies have been conducted to examine a relationship between EGFR and HUNK in breast cancer metastasis. We performed a kinase substrate screen and identified that EGFR is phosphorylated by HUNK. Our studies show that HUNK phosphorylates EGFR at T654, enhancing receptor stability and downstream signaling. We found that increased phosphorylation of T654 EGFR correlates with increased epithelial to mesenchymal, migration and invasion, and metastasis. In addition, we found that HUNK expression correlates with overall survival and distant metastasis free survival. This study shows that HUNK directly phosphorylates EGFR at T654 to promote metastasis and is the first study to show that the phosphorylation of this site in EGFR regulates metastasis
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Nanoflow-nanospray mass spectrometry metabolomics reveals disruption of the urinary metabolite profiles of HIV-positive patients on combination antiretroviral therapy
Background: The use of combination antiretroviral therapy (cART) has substantially improved the outlook for patients with HIV infection. However, lifelong exposure to cART is also associated with adverse metabolic changes and an enhanced risk of renal, hepatic and cardiovascular dysfunction. This study investigated disruptions of the urinary metabolome of cART-exposed patients, thereby furthering our understanding of some of the side effects of pharmaceutical intervention.
Methods: HIV-positive patients were recruited from an HIV clinic and divided into cART-naive and cART-exposed groups. HIV-negative patients were recruited from a sexual health clinic. All 89 subjects were white males. Targeted biochemistry analyses were performed on plasma samples. Urine samples were collected following an overnight fast and analysed with a highly sensitive untargeted metabolomic method using nanoflow/nanospray liquid chromatography-time of flight mass spectrometry. Datasets were analysed using projection modelling to detect metabolite markers of cART exposure.
Results: Metabolites or parent compounds of all cART drugs were detected in urine extracts of all but one of the cART-exposed patients confirming adherence to the pharmaceutical regimen. Analysis of urine samples from patients on cART revealed significant reductions in selected bile acids, lipid, nucleoside and androgen metabolites. However, plasma concentrations of free or conjugated testosterone were unchanged indicating possible disruption of androgen transport or excretion in urine of patients on cART.
Conclusions: Discovery-based metabolomics reveals the potential to identify novel markers of cART intervention and metabolite disruption in HIV-positive patients, which may enable the efficacy, compliance and side effects of these pharmaceutical mixtures to be investigated
The structure of electroweak corrections due to extended gauge symmetries
This paper studies models with extended electroweak gauge sectors of the form
SU(2) x SU(2) x U(1) x [SU(2) or U(1)]. We establish the general behavior of
corrections to precision electroweak observables in this class of theories and
connect our results to previous work on specific models whose electroweak
sectors are special cases of our extended group.Comment: 18 pages, 2 figures; added a referenc
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