Phycosem Marine Agronomy: prácticas externas en empresa

[Resumen]: El presente informe se centra en describir el conjunto de tareas, actividades y procesos que he desarrollado en la empresa Phycosem Marine Agronomy, S.L., durante mis cuatro meses de trabajo. El objetivo de la realización de prácticas en esta empresa es adquirir las competencias profesionales necesarias para trabajar en un laboratorio, conocer el funcionamiento de una instalación dedicada al cultivo de macroalgas marinas, desarrollar habilidades prácticas en la acuicultura marina y aplicar los conocimientos adquiridos en el máster en Acuicultura.Traballo fin de mestrado (UDC.CIE). Acuicultura. Curso 2020/202

Hacia el paradigma biopsicosocial: el Arte como herramienta en entornos de Salud

En este trabajo de investigación nos proponemos realizar una aproximación teórica analizando cuáles son las herramientas que desde el Arte se nos ofrecen para trabajar en entornos de Salud. En la primera parte, se traza un recorrido teórico por las aportaciones más relevantes que desde la neurociencia hasta el arteterapia posibilitan trabajar con la partes del cerebro sano, frente al enfoque del paradigma médico occidental que se ocupa del trabajo con la parte del cerebro enfermo. De cómo las emociones y el hemisferio derecho cerebral intervienen en la generación de respuestas racionales ante estímulos externos. De cómo el arteterapia puede posibilitar un entorno terapéutico para contribuir al restablecimiento de la Salud, o en su defecto la mejora de los aspectos emocionales y/o relacionales que tienen que ver con el rol de enfermo. En definitiva, siguiendo las recomendaciones de la Organización Mundial de la Salud, se trata de alcanzar un estado de bienestar físico, psíquico y social como concepto de Salud, a través del uso del Arte como estrategia terapéutica. En la segunda parte del trabajo se describen los dos grandes paradigmas en investigación, y se analizan para intentar hallar una estrategia metodológica que pueda ser aplicada en las intervenciones que se raelizan de Arte en contextos de Salud, para acotar procedimientos arteterapéuticos y obtener resultados medibles, comparables y verificables.Peris Roca, ME. (2013). Hacia el paradigma biopsicosocial: el Arte como herramienta en entornos de Salud. http://hdl.handle.net/10251/35458.Archivo delegad

A Parametric Computational Study of RC Building Structures under Corner-Column Removal Situations

[EN] Building progressive collapse is currently one of the hottest topics in the structural engineering field. Most of the research carried out to date on this topic has been focused on the structural analysis of the failure of one or more columns in a building to determine the Alternative Load Paths (ALPs) the structure can activate. Past research was mainly focused on extreme situations with high loads and large structural deformations and, to a lesser extent, research looked at lower loads used in design accidental situations, which requires a different set of assumptions in the analysis. This paper describes a study aimed at analysing accidental design situations in corner-column removal scenarios in reinforced concrete (RC) building structures and evaluating the available real ALPs in order to establish practical recommendations for design situations that could be taken into account in future design codes. A wide parametric computational analysis was carried out with advanced Finite Element (FE) models which the authors validated by full¿scale tests on a purpose¿built building structure. The findings allowed us to: (i) establish design recommendations, (ii) demonstrate the importance of Vierendeel action and (iii) recommend Dynamic Amplification Factors (DAFs) for design situations.This research was funded by Fundacion BBVA-Becas Leonardo a Investigadores y Creadores Culturales 2017; the Spanish Ministry of Economy, Industry and Competitiveness, grant number BIA2017-88322-R-AR; Generalitat Valenciana/Fons Social Europeu, grant number APOSTD/2019/101 and Universitat Politecnica de Valencia, grant number PAID-10-17. This work is also part of the project "Extension of theoretical models against progressive collapse for tall and supertall concrete buildings", funded by the Engineering Physical Science Research Council (EPSRC) of the UK as part of an Impact Acceleration Account (IAA) held at the University of Surrey (grant number EP/K008153/1), and a continuation of two research projects also funded by EPSRC of the UK (grant ref: EP/K503939 and grant ref: EP/K008153/1).Buitrago, M.; Bertolesi, E.; Garzón-Roca, J.; Sagaseta, J.; Adam, JM. (2020). A Parametric Computational Study of RC Building Structures under Corner-Column Removal Situations. Applied Sciences. 10(24):1-27. https://doi.org/10.3390/app10248911S1271024Adam, J. M., Parisi, F., Sagaseta, J., & Lu, X. (2018). Research and practice on progressive collapse and robustness of building structures in the 21st century. Engineering Structures, 173, 122-149. doi:10.1016/j.engstruct.2018.06.082Kiakojouri, F., De Biagi, V., Chiaia, B., & Sheidaii, M. R. (2020). Progressive collapse of framed building structures: Current knowledge and future prospects. Engineering Structures, 206, 110061. doi:10.1016/j.engstruct.2019.110061Stephen, D., Lam, D., Forth, J., Ye, J., & Tsavdaridis, K. D. (2019). An evaluation of modelling approaches and column removal time on progressive collapse of building. Journal of Constructional Steel Research, 153, 243-253. doi:10.1016/j.jcsr.2018.07.019Eren, N., Brunesi, E., & Nascimbene, R. (2019). Influence of masonry infills on the progressive collapse resistance of reinforced concrete framed buildings. Engineering Structures, 178, 375-394. doi:10.1016/j.engstruct.2018.10.056Zhang, L., Li, H., & Wang, W. (2020). Retrofit Strategies against Progressive Collapse of Steel Gravity Frames. Applied Sciences, 10(13), 4600. doi:10.3390/app10134600Biagi, V. D., Kiakojouri, F., Chiaia, B., & Sheidaii, M. R. (2020). A Simplified Method for Assessing the Response of RC Frame Structures to Sudden Column Removal. Applied Sciences, 10(9), 3081. doi:10.3390/app10093081Yu, J., Luo, L., & Li, Y. (2018). Numerical study of progressive collapse resistance of RC beam-slab substructures under perimeter column removal scenarios. Engineering Structures, 159, 14-27. doi:10.1016/j.engstruct.2017.12.038Bermejo, M., Santos, A. P., & Goicolea, J. M. (2017). Development of Practical Finite Element Models for Collapse of Reinforced Concrete Structures and Experimental Validation. Shock and Vibration, 2017, 1-9. doi:10.1155/2017/4636381Fu, Q., & Tan, K.-H. (2019). Numerical study on steel-concrete composite floor systems under corner column removal scenario. Structures, 21, 33-44. doi:10.1016/j.istruc.2019.06.003Mucedero, G., Perrone, D., Brunesi, E., & Monteiro, R. (2020). Numerical Modelling and Validation of the Response of Masonry Infilled RC Frames Using Experimental Testing Results. Buildings, 10(10), 182. doi:10.3390/buildings10100182Tohidi, M., & Janby, A. (2020). Finite-Element Modeling of Progressive Failure for Floor-to-Floor Assembly in the Precast Cross-Wall Structures. Journal of Structural Engineering, 146(6), 04020087. doi:10.1061/(asce)st.1943-541x.0002588Olmati, P., Sagaseta, J., Cormie, D., & Jones, A. E. K. (2017). Simplified reliability analysis of punching in reinforced concrete flat slab buildings under accidental actions. Engineering Structures, 130, 83-98. doi:10.1016/j.engstruct.2016.09.061Buitrago, M., Sagaseta, J., & Adam, J. M. (2020). Avoiding failures during building construction using structural fuses as load limiters on temporary shoring structures. Engineering Structures, 204, 109906. doi:10.1016/j.engstruct.2019.109906Buitrago, M., Sagaseta, J., & Adam, J. M. (2018). Effects of sudden failure of shoring elements in concrete building structures under construction. Engineering Structures, 172, 508-522. doi:10.1016/j.engstruct.2018.06.052Joshi, D. D., & Patel, P. V. (2018). Experimental study of precast dry connections constructed away from beam–column junction under progressive collapse scenario. Asian Journal of Civil Engineering, 20(2), 209-222. doi:10.1007/s42107-018-0099-zMa, F., Gilbert, B. P., Guan, H., Xue, H., Lu, X., & Li, Y. (2019). Experimental study on the progressive collapse behaviour of RC flat plate substructures subjected to corner column removal scenarios. Engineering Structures, 180, 728-741. doi:10.1016/j.engstruct.2018.11.043Yang, T., Han, Z., Deng, N., & Chen, W. (2019). Collapse Responses of Concrete Frames Reinforced with BFRP Bars in Middle Column Removal Scenario. Applied Sciences, 9(20), 4436. doi:10.3390/app9204436Faridmehr, I., & Hajmohammadian Baghban, M. (2020). An Overview of Progressive Collapse Behavior of Steel Beam-to-Column Connections. Applied Sciences, 10(17), 6003. doi:10.3390/app10176003Qian, K., & Li, B. (2019). Strengthening and Retrofitting Precast Concrete Buildings to Mitigate Progressive Collapse Using Externally Bonded GFRP Strips. Journal of Composites for Construction, 23(3), 04019018. doi:10.1061/(asce)cc.1943-5614.0000943Lin, K., Lu, X., Li, Y., & Guan, H. (2019). Experimental study of a novel multi-hazard resistant prefabricated concrete frame structure. Soil Dynamics and Earthquake Engineering, 119, 390-407. doi:10.1016/j.soildyn.2018.04.011Qian, K., Liang, S.-L., Feng, D.-C., Fu, F., & Wu, G. (2020). Experimental and Numerical Investigation on Progressive Collapse Resistance of Post-Tensioned Precast Concrete Beam-Column Subassemblages. Journal of Structural Engineering, 146(9), 04020170. doi:10.1061/(asce)st.1943-541x.0002714Zhou, Y., Hu, X., Pei, Y., Hwang, H.-J., Chen, T., Yi, W., & Deng, L. (2020). Dynamic load test on progressive collapse resistance of fully assembled precast concrete frame structures. Engineering Structures, 214, 110675. doi:10.1016/j.engstruct.2020.110675Alshaikh, I. M. H., Bakar, B. H. A., Alwesabi, E. A. H., & Akil, H. M. (2020). Experimental investigation of the progressive collapse of reinforced concrete structures: An overview. Structures, 25, 881-900. doi:10.1016/j.istruc.2020.03.018Buitrago, M., Bertolesi, E., Calderón, P. A., & Adam, J. M. (2021). Robustness of steel truss bridges: Laboratory testing of a full-scale 21-metre bridge span. Structures, 29, 691-700. doi:10.1016/j.istruc.2020.12.005Buitrago, M., Bertolesi, E., Sagaseta, J., Calderón, P. A., & Adam, J. M. (2021). Robustness of RC building structures with infill masonry walls: Tests on a purpose-built structure. Engineering Structures, 226, 111384. doi:10.1016/j.engstruct.2020.111384Adam, J. M., Buitrago, M., Bertolesi, E., Sagaseta, J., & Moragues, J. J. (2020). Dynamic performance of a real-scale reinforced concrete building test under a corner-column failure scenario. Engineering Structures, 210, 110414. doi:10.1016/j.engstruct.2020.110414Osteraas, J. D. (2006). Murrah Building Bombing Revisited: A Qualitative Assessment of Blast Damage and Collapse Patterns. Journal of Performance of Constructed Facilities, 20(4), 330-335. doi:10.1061/(asce)0887-3828(2006)20:4(330)Bažant, Z. P., Le, J.-L., Greening, F. R., & Benson, D. B. (2008). What Did and Did Not Cause Collapse of World Trade Center Twin Towers in New York? Journal of Engineering Mechanics, 134(10), 892-906. doi:10.1061/(asce)0733-9399(2008)134:10(892)Sasani, M., Kazemi, A., Sagiroglu, S., & Forest, S. (2011). Progressive Collapse Resistance of an Actual 11-Story Structure Subjected to Severe Initial Damage. Journal of Structural Engineering, 137(9), 893-902. doi:10.1061/(asce)st.1943-541x.0000418Pearson, C., & Delatte, N. (2005). Ronan Point Apartment Tower Collapse and its Effect on Building Codes. Journal of Performance of Constructed Facilities, 19(2), 172-177. doi:10.1061/(asce)0887-3828(2005)19:2(172)Xiao, Y., Kunnath, S., Li, F. W., Zhao, Y. B., Lew, H. S., & Bao, Y. (2015). Collapse Test of Three-Story Half-Scale Reinforced Concrete Frame Building. ACI Structural Journal, 112(4). doi:10.14359/51687746Qian, K., Weng, Y.-H., & Li, B. (2018). Impact of two columns missing on dynamic response of RC flat slab structures. Engineering Structures, 177, 598-615. doi:10.1016/j.engstruct.2018.10.011Feng, P., Qiang, H., Ou, X., Qin, W., & Yang, J. (2019). Progressive Collapse Resistance of GFRP-Strengthened RC Beam–Slab Subassemblages in a Corner Column–Removal Scenario. Journal of Composites for Construction, 23(1), 04018076. doi:10.1061/(asce)cc.1943-5614.0000917Zhou, Y., Chen, T., Pei, Y., Hwang, H.-J., Hu, X., Yi, W., & Deng, L. (2019). Static load test on progressive collapse resistance of fully assembled precast concrete frame structure. Engineering Structures, 200, 109719. doi:10.1016/j.engstruct.2019.109719Gao, S., & Guo, L. (2015). Progressive collapse analysis of 20-storey building considering composite action of floor slab. International Journal of Steel Structures, 15(2), 447-458. doi:10.1007/s13296-015-6014-5Wang, F., Yang, J., & Shah, S. (2020). Effect of Horizontal Restraints on Progressive Collapse Resistance of Precast Concrete Beam-Column Framed Substructures. KSCE Journal of Civil Engineering, 24(3), 879-889. doi:10.1007/s12205-020-1035-9Zhang, H., Shu, G., & Pan, R. (2019). Failure Mechanism of Composite Frames Under the Corner Column-Removal Scenario. Journal of Failure Analysis and Prevention, 19(3), 649-664. doi:10.1007/s11668-019-00644-8Micallef, K., Sagaseta, J., Fernández Ruiz, M., & Muttoni, A. (2014). Assessing punching shear failure in reinforced concrete flat slabs subjected to localised impact loading. International Journal of Impact Engineering, 71, 17-33. doi:10.1016/j.ijimpeng.2014.04.00

Nuevas aportaciones al Paleolítico superior medio de la Cova Beneito

En el presente trabajo se ofrecen por primera vez dataciones absoluta obtenidas para los niveles adscritos al Solutrense. Al mismo tiempo se avanza con carácter preliminar los datos tipológicos, sedimentológicos/paleoambientales y antropológicos aportados por las excavaciones recientes en el exterior del abrigo.En aquest treball s’ofereix per primera vegada les datacions absolutes obtingudes per als nivells adscrits al Solutrià. Així com també es mostra un avanç amb carácter preliminar de les dades tipològiques, sedimentològiques/paleoambientals i antropològiques aportades per les recents excavacions a l’exterior de l’abric

Looking twice at the gender equity index for public health impact

Background: It has been shown that gender equity has a positive impact on the everyday activities of people (decision making, income allocation, application and observance of norms/rules) which affect their health. Gender equity is also a crucial determinant of health inequalities at national level; thus, monitoring is important for surveillance of women’s and men’s health as well as for future health policy initiatives. The Gender Equity Index (GEI) was designed to show inequity solely towards women. Given that the value under scrutiny is equity, in this paper a modified version of the GEI is proposed, the MGEI, which highlights the inequities affecting both sexes. Methods: Rather than calculating gender gaps by means of a quotient of proportions, gaps in the MGEI are expressed in absolute terms (differences in proportions). The Spearman’s rank coefficient, calculated from country rankings obtained according to both indexes, was used to evaluate the level of concordance between both classifications. To compare the degree of sensitivity and obtain the inequity by the two methods, the variation coefficient of the GEI and MGEI values was calculated. Results: Country rankings according to GEI and MGEI values showed a high correlation (rank coef. = 0.95). The MGEI presented greater dispersion (43.8%) than the GEI (19.27%). Inequity towards men was identified in the education gap (rank coef. = 0.36) when using the MGEI. According to this method, many countries shared the same absolute value for education but with opposite signs, for example Azerbaijan (−0.022) and Belgium (0.022), reflecting inequity towards women and men, respectively. This also occurred in the empowerment gap with the technical and professional job component (Brunei:-0.120 vs. Australia, Canada Iceland and the U.S.A.: 0.120). Conclusion: The MGEI identifies and highlights the different areas of inequities between gender groups. It thus overcomes the shortcomings of the GEI related to the aim for which this latter was created, namely measuring gender equity, and is therefore of great use to policy makers who wish to understand and monitor the results of specific equity policies and to determine the length of time for which these policies should be maintained in order to correct long-standing structural discrimination against women.This research was funded by the Institute of Women, Spanish Ministry of Health, Social Services and Equality (Ref. 112–09) and has been presented orally in “Health and equity in all policies” (SEE-SESPAS), Madrid, October 6-7th 2011

Looking twice at the gender equity index for public health impact.

Background: It has been shown that gender equity has a positive impact on the everyday activities of people (decision making, income allocation, application and observance of norms/rules) which affect their health. Gender equity is also a crucial determinant of health inequalities at national level; thus, monitoring is important for surveillance of women’s and men’s health as well as for future health policy initiatives. The Gender Equity Index (GEI) was designed to show inequity solely towards women. Given that the value under scrutiny is equity, in this paper a modified version of the GEI is proposed, the MGEI, which highlights the inequities affecting both sexes. Methods: Rather than calculating gender gaps by means of a quotient of proportions, gaps in the MGEI are expressed in absolute terms (differences in proportions). The Spearman’s rank coefficient, calculated from country rankings obtained according to both indexes, was used to evaluate the level of concordance between both classifications. To compare the degree of sensitivity and obtain the inequity by the two methods, the variation coefficient of the GEI and MGEI values was calculated. Results: Country rankings according to GEI and MGEI values showed a high correlation (rank coef. = 0.95). The MGEI presented greater dispersion (43.8%) than the GEI (19.27%). Inequity towards men was identified in the education gap (rank coef. = 0.36) when using the MGEI. According to this method, many countries shared the same absolute value for education but with opposite signs, for example Azerbaijan (−0.022) and Belgium (0.022), reflecting inequity towards women and men, respectively. This also occurred in the empowerment gap with the technical and professional job component (Brunei:-0.120 vs. Australia, Canada Iceland and the U.S.A.: 0.120). Conclusion: The MGEI identifies and highlights the different areas of inequities between gender groups. It thus overcomes the shortcomings of the GEI related to the aim for which this latter was created, namely measuring gender equity, and is therefore of great use to policy makers who wish to understand and monitor the results of specific equity policies and to determine the length of time for which these policies should be maintained in order to correct long-standing structural discrimination against women

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

Mutations in TP53 gene play a pivotal role in tumorigenesis and cancer development. Here, we report that gain-of-function mutant p53 proteins inhibit the autophagic pathway favoring antiapoptotic effects as well as proliferation of pancreas and breast cancer cells. We found that mutant p53 significantly counteracts the formation of autophagic vesicles and their fusion with lysosomes throughout the repression of some key autophagy-related proteins and enzymes as BECN1 (and P-BECN1), DRAM1, ATG12, SESN1/2 and P-AMPK with the concomitant stimulation of mTOR signaling. As a paradigm of this mechanism, we show that atg12 gene repression was mediated by the recruitment of the p50 NF-\u3baB/mutant p53 protein complex onto the atg12 promoter. Either mutant p53 or p50 NF-\u3baB depletion downregulates atg12 gene expression. We further correlated the low expression levels of autophagic genes (atg12, becn1, sesn1, and dram1) with a reduced relapse free survival (RFS) and distant metastasis free survival (DMFS) of breast cancer patients carrying TP53 gene mutations conferring a prognostic value to this mutant p53-and autophagy-related signature. Interestingly, the mutant p53-driven mTOR stimulation sensitized cancer cells to the treatment with the mTOR inhibitor everolimus. All these results reveal a novel mechanism through which mutant p53 proteins promote cancer cell proliferation with the concomitant inhibition of autophagy

〈初期軍記〉における戦闘被害の表現-女の描かれ方をめぐって-

軍記・語り物研究会第374回例会(平成19年7月22日・於:法政大学)共同討議「初期軍記」研究の検証と展開-新たな「状況」と「変容」を探る-における基調報

Method based on data mining techniques for breast cancer recurrence analysis

Cancer is a constantly evolving disease, which affects a large number of people worldwide. Great efforts have been made at the research level for the development of tools based on data mining techniques that allow to detect or prevent breast cancer. The large volumes of data play a fundamental role according to the literature consulted, a great variety of dataset oriented to the analysis of the disease has been generated, in this research the Breast Cancer dataset was used, the purpose of the proposed research is to submit comparison of the J48 and randomforest, NaiveBayes and NaiveBayes Simple, SMO Poli-kernel and SMO RBF-Kernel classification algorithms, integrated with the Simple K-Means cluster algorithm for the generation of a model that allows the successful classification of patients who are or Non-recurring breast cancer after having previously undergone surgery for the treatment of said disease, finally the methods that obtained the best levels were SMO Poly-Kernel + Simple K-Means 98.5% of Precision, 98.5% recall, 98.5% TPRATE and 0.2% FPRATE. The results obtained suggest the possibility of using intelligent computational tools based on data mining methods for the detection of breast cancer recurrence in patients who had previously undergone surgery

Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer

15noBackground: Urothelial bladder cancers (UBCs) are distinct in two main molecular subtypes, namely basal and luminal type. Subtypes are also diverse in term of immune contexture, providing a rationale for patient selection to immunotherapy. Methods: By digital microscopy analysis of a muscle-invasive BC (MIBC) cohort, we explored the density and clinical significance of CD66b(+) tumor-associated-neutrophils (TAN) and CD3(+) T cells. Bioinformatics analysis of UBC datasets and gene expression analysis of UBC cell lines were additionally performed. Results: Basal type BC contained a significantly higher density of CD66b(+) TAN compared to the luminal type. This finding was validated on TCGA, GSE32894 and GSE124305 datasets by computing a neutrophil signature. Of note, basal-type MIBC display a significantly higher level of chemokines (CKs) attracting neutrophils. Moreover, pro-inflammatory stimuli significantly up-regulate CXCL1, CXCL2 and CXCL8 in 5637 and RT4 UBC cell lines and induce neutrophil chemotaxis. In term of survival, a high density of T cells and TAN was significantly associated to a better outcome, with TAN density showing a more limited statistical power and following a non-linear predicting model. Conclusions: TAN are recruited in basal type MIBC by pro-inflammatory CKs. This finding establishes a groundwork for a better understanding of the UBC immunity and its relevance.openopenMandelli, Giulio Eugenio; Missale, Francesco; Bresciani, Debora; Gatta, Luisa Benerini; Scapini, Patrizia; Caveggion, Elena; Roca, Elisa; Bugatti, Mattia; Monti, Matilde; Cristinelli, Luca; Belotti, Sandra; Simeone, Claudio; Calza, Stefano; Melocchi, Laura; Vermi, WilliamMandelli, Giulio Eugenio; Missale, Francesco; Bresciani, Debora; Gatta, Luisa Benerini; Scapini, Patrizia; Caveggion, Elena; Roca, Elisa; Bugatti, Mattia; Monti, Matilde; Cristinelli, Luca; Belotti, Sandra; Simeone, Claudio; Calza, Stefano; Melocchi, Laura; Vermi, Willia