Active gas features in three HSC-SSP CAMIRA clusters revealed by high angular resolution analysis of MUSTANG-2 SZE and XXL X-ray observations

International audienceWe present results from simultaneous modelling of high angular resolution GBT/MUSTANG-2 90 GHz Sunyaev–Zel’dovich effect (SZE) measurements and XMM-XXL X-ray images of three rich galaxy clusters selected from the HSC-SSP Survey. The combination of high angular resolution SZE and X-ray imaging enables a spatially resolved multicomponent analysis, which is crucial to understand complex distributions of cluster gas properties. The targeted clusters have similar optical richnesses and redshifts, but exhibit different dynamical states in their member galaxy distributions: a single-peaked cluster, a double-peaked cluster, and a cluster belonging to a supercluster. A large-scale residual pattern in both regular Compton-parameter y and X-ray surface brightness distributions is found in the single-peaked cluster, indicating a sloshing mode. The double-peaked cluster shows an X-ray remnant cool core between two SZE peaks associated with galaxy concentrations. The temperatures of the two peaks reach ∼20–30 keV in contrast to the cool core component of ∼2 keV, indicating a violent merger. The main SZE signal for the supercluster is elongated along a direction perpendicular to the major axis of the X-ray core, suggesting a minor merger before core passage. The and y distributions are thus perturbed at some level, regardless of the optical properties. We find that the integrated Compton y parameter and the temperature for the major merger are boosted from those expected by the weak-lensing mass and those for the other two clusters show no significant deviations, which is consistent with predictions of numerical simulations

Comparative study of young people's response to anti-smoking messages

Smoking prevalence increases rapidly with age, with the majority of people taking it up during their teenage years (Walker et al. 2001). Research conducted into young teenagers and smoking in 1998 indicated that less than 1% of 11-year-olds were regular smokers compared with over one-fifth (21%) of 15-year-olds (Higgins 1998). This evidence indicates that if young people do not begin smoking before the age of 20 they are unlikely ever to start. Targeting young people before smoking initiation in their early teens may therefore be critical to reducing smoking rates. Mass-media campaigns can play an important role in reaching large numbers of young people directly with prevention messages and are a powerful influence on individuals' awareness, knowledge and understanding of health and social issues (Pierce et al. 1991; Backer et al. 1992; Bandura 1994; Reid 1996; Mudde & De Vries 1999). When used as part of a comprehensive tobacco control programme, they have been successful in several countries in reducing the uptake of smoking by young people and encouraging cessation (Flynn et al. 1992, 1994; Sly & Heald 1999; Sly et al. 2001a, 2001b, 2002; Andrews et al. 2004). There is considerable debate, however, as to which is the most suitable message theme for reducing smoking among young people. This paper examines the rationale for, and the potential impact of, three appeals: 'fear appeals', 'social norms' and 'industry manipulation'. Evidence exists suggesting that both social norms and industry manipulation messages have worked well in influencing young people's smoking attitudes and behaviour in the United States (Sly & Heald 1999; Sly et al. 2001a, 2001b, 2002) and that fear appeals have worked with Australian adults (Donovan et al. 1999; Tan et al. 2000). There is a lack of research, however, pertaining to how young people in England may respond to anti-smoking message themes and the transferability of these appeals to different cultural contexts. Also, little is known about whether different message types have a differential impact among young people; for example, are particular types of young people more receptive to particular messages? This paper therefore first considers the existing evidence base and relevant theoretical principles before focusing on qualitative research conducted with young people in England to explore their response to different types of message themes

Cleft lip and palate in Scotland : a survey

The aim of the survey was to assess midwives' experiences and knowledge of cleft lip and/or palate (CL+/-P), confidence in supporting the families and giving feeding advice, and to identify areas for input from the cleft team. In order to do so, questionnaires were sent to maternity units across Scotland. The results were as follows: 206 questionnaires were returned (42 per cent response rate). Forty one per cent of the midwives had helped a baby with CL+/-P to be born; 23 per cent knew the incidence of CL+/-P; 33 per cent were aware of the stages in treating CL+/- P; 99 per cent were aware that feeding difficulties are a potential complication. When asked about offering support to the families, 70 per cent were not confident and 60 per cent were not confident at giving feeding advice. Regarding cleft team input, 65 per cent would like a training day, 45 per cent requested small group teaching, 50 per cent would like a website and 57 per cent would like printed literature. Our recommendations are to implement training, for midwives, along with supporting websites and literature

Factors that affect the food choices made by girls and young women, from minority ethnic groups, living in the UK

Lower birth weight, often found in infants from minority ethnic groups, may be partly because of the disproportionate representation of ethnic minority groups in low-income areas. To develop an intervention, to improve the nutritional intake of young women from populations at risk of low-birth-weight babies, which would be culturally sensitive and well received by the intended recipients, a community development approach was used to investigate factors that might influence food choice and the nutritional intake of girls and young women from ethnic minority groups. Methods Focus group discussions were conducted across the UK, to explore factors that might affect the food choices of girls and young women of African and South Asian decent. The data was analysed using deductive content analysis (Qual. Soc. Res., 1, 2000, 1). Discussions were around the broad themes of buying and preparing food, eating food and dietary changes, and ideas for an intervention to improve diet. Results? The focus group discussions indicated that all the communities took time, price, health and availability into consideration when making food purchases. The groups were also quite similar in their use of ‘Western’ foods which tended to be of the fast food variety. These foods were used when there was not enough time to prepare a ‘traditional’ meal. Conclusion Many issues that affect the food choice of people who move to the UK are common within different ethnic groups. The idea of a practical intervention based on improving cooking skills was popular with all the groups

Weak-lensing Mass Calibration of ACTPol Sunyaev–Zel’dovich Clusters with the Hyper Suprime-Cam Survey

International audienceWe present weak-lensing measurements using the first-year data from the Hyper Suprime-Cam Strategic Survey Program on the Subaru telescope for eight galaxy clusters selected through their thermal Sunyaev–Zel’dovich (SZ) signal measured at 148 GHz with the Atacama Cosmology Telescope Polarimeter experiment. The overlap between the two surveys in this work is 33.8 square degrees, before masking bright stars. The signal-to-noise ratio of individual cluster lensing measurements ranges from 2.2 to 8.7, with a total of 11.1 for the stacked cluster weak-lensing signal. We fit for an average weak-lensing mass distribution using three different profiles, a Navarro–Frenk–White profile, a dark-matter-only emulated profile, and a full cosmological hydrodynamic emulated profile. We interpret the differences among the masses inferred by these models as a systematic error of 10%, which is currently smaller than the statistical error. We obtain the ratio of the SZ-estimated mass to the lensing-estimated mass (the so-called hydrostatic mass bias 1−b) of , which is comparable to previous SZ-selected clusters from the Atacama Cosmology Telescope and from the Planck Satellite. We conclude with a discussion of the implications for cosmological parameters inferred from cluster abundances compared to cosmic microwave background primary anisotropy measurements

A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium.

Part of the substantial unexplained familial aggregation of breast cancer may be due to interactions between common variants, but few studies have had adequate statistical power to detect interactions of realistic magnitude. We aimed to assess all two-way interactions in breast cancer susceptibility between 70,917 single nucleotide polymorphisms (SNPs) selected primarily based on prior evidence of a marginal effect. Thirty-eight international studies contributed data for 46,450 breast cancer cases and 42,461 controls of European origin as part of a multi-consortium project (COGS). First, SNPs were preselected based on evidence (P 10(-10)). In summary, we observed little evidence of two-way SNP interactions in breast cancer susceptibility, despite the large number of SNPs with potential marginal effects considered and the very large sample size. This finding may have important implications for risk prediction, simplifying the modelling required. Further comprehensive, large-scale genome-wide interaction studies may identify novel interacting loci if the inherent logistic and computational challenges can be overcome

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10−8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility