680 research outputs found
Closed String Tachyons and Their Implications for Non-Supersymmetric Strings
Closed string tachyons have long been somewhat mysterious. We note that there
is often a regime in the classical moduli space in which one can systematically
compute the effective action for such fields. In this regime, the tachyon is
light, and cannot be integrated out. Instead, one must consider the combined
dynamics of gravitons, moduli, tachyons and other light fields. We compute the
action and find that the quartic term for the tachyon is positive in the field
definition where the tachyon has no derivative coupling to the radion. We study
the evolution of isotropic, homogeneous configurations and find that typically
the system is driven to regions where the calculation is no longer under
control.Comment: 10 pages, no figures, references adde
Fluctuation spectrum of fluid membranes coupled to an elastic meshwork: jump of the effective surface tension at the mesh size
We identify a class of composite membranes: fluid bilayers coupled to an
elastic meshwork, that are such that the meshwork's energy is a function
\textit{not} of the real microscopic membrane area ,
but of a \textit{smoothed} membrane's area , which corresponds to the
area of the membrane coarse-grained at the mesh size . We show that the
meshwork modifies the membrane tension both below and above the scale
, inducing a tension-jump . The
predictions of our model account for the fluctuation spectrum of red blood
cells membranes coupled to their cytoskeleton. Our results indicate that the
cytoskeleton might be under extensional stress, which would provide a means to
regulate available membrane area. We also predict an observable tension jump
for membranes decorated with polymer "brushes"
Responsible Use of Polyphosphoric Acid (PPA) Modification of Asphalt Binders
Polyphosphoric acid (PPA) has been used to chemically modify asphalt binders to improve high temperature rheological properties, without adversely affecting low temperature rheological properties, since the early 1970s.(1) Since the introduction of Superpave performance-grade (PG) binders, PPA has been used as an additive for adjusting rheological properties to meet PG specification parameters. PPA has also been used to modify asphalt binders that need an extended range between the high and low temperature performance requirements to meet PG specification limits. Since the early 1990s, PPA has also been used in combination with polymer modifiers in polymer modified asphalt binders to enhance the quality of paving grade asphalt binders. This report discusses use of PPA as an asphalt binder modifier and presents information on detection and quantification of PPA in asphalt binders.US Department of Transportation Federal Highway Administratio
Dissipation in Dynamics of a Moving Contact Line
The dynamics of the deformations of a moving contact line is studied assuming
two different dissipation mechanisms. It is shown that the characteristic
relaxation time for a deformation of wavelength of a contact line
moving with velocity is given as . The velocity
dependence of is shown to drastically depend on the dissipation
mechanism: we find for the case when the dynamics is governed
by microscopic jumps of single molecules at the tip (Blake mechanism), and
when viscous hydrodynamic losses inside the moving
liquid wedge dominate (de Gennes mechanism). We thus suggest that the debated
dominant dissipation mechanism can be experimentally determined using
relaxation measurements similar to the Ondarcuhu-Veyssie experiment [T.
Ondarcuhu and M. Veyssie, Nature {\bf 352}, 418 (1991)].Comment: REVTEX 8 pages, 9 PS figure
Gold/Silica biochips: applications to Surface Plasmon Resonance and fluorescence quenching
We report Gold/Silica biochips for low cost biosensor devices. Firstly, the
study of biochemical interactions on silica by means of Surface Plasmon
Resonance (SPR) is presented. Secondly, Gold/Silica biochips are employed to
reduce the strong quenching that occurs when a fluorophore is close to the gold
surface. Furthermore, the control of the Silica-like thickness allows
optimizing the distance between the metallic surface and the fluorophore in
order to enhance the fluorescent signal. These results represent the first
steps towards highly sensitive, specific and low cost biosensors based, for
example, on Surface Plasmon Coupled Emission (SPCE) techniques
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Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey.
Primary Immune Regulatory Disorders (PIRD) are an expanding group of diseases caused by gene defects in several different immune pathways, such as regulatory T cell function. Patients with PIRD develop clinical manifestations associated with diminished and exaggerated immune responses. Management of these patients is complicated; oftentimes immunosuppressive therapies are insufficient, and patients may require hematopoietic cell transplant (HCT) for treatment. Analysis of HCT data in PIRD patients have previously focused on a single gene defect. This study surveyed transplanted patients with a phenotypic clinical picture consistent with PIRD treated in 33 Primary Immune Deficiency Treatment Consortium centers and European centers. Our data showed that PIRD patients often had immunodeficient and autoimmune features affecting multiple organ systems. Transplantation resulted in resolution of disease manifestations in more than half of the patients with an overall 5-years survival of 67%. This study, the first to encompass disorders across the PIRD spectrum, highlights the need for further research in PIRD management
Uterine mullerian adenosarcoma with sarcomatous overgrowth fatal recurrence within two weeks of diagnosis: a case report
Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a rare variant of uterine sarcomas, associated with postoperative recurrence, metastases and a fatal outcome. The mean age at diagnosis is 54.5 years. A 37-year-old nullipara presented with irregular vaginal bleeding, a normal pelvic examination, and an initially negative ultrasound. Repeat ultrasound one month later revealed an 11-cm heterogeneous pelvic mass. She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Pathology confirmed uterine MASO. Computed tomography 2 weeks postoperatively showed a huge mass compatible with recurrence. Patient died 2 weeks later. MASO is rarely diagnosed in women in their 4th decade. This case stresses that these aggressive tumors should be considered in the differential of patients with vaginal bleeding and pelvic masses irrespective of their age
Graduates of Lebanese medical schools in the United States: an observational study of international migration of physicians
BACKGROUND: As healthcare systems around the world are facing increasing physician shortages, more physicians are migrating from low to high income countries. As an illustrative case of international migration of physicians, we evaluated the current number and historical trends of Lebanese medical graduates (LMG) in the US, and compared their characteristics to those of US medical graduates (USMG) and other international medical graduates (IMG). METHODS: We evaluated the number of LMG using the 2004 the American Medical Association Physicians' Professional Data (AMA-PPD) and then compared it to the number of graduates of other countries. We evaluated the historical trends using the 1978–2004 historical files of the AMA-PPD. We analyzed the characteristics of all LMG and compared them to a random sample of 1000 USMG and a random sample of 1000 IMG using the 2004 AMA-PPD. RESULTS: In 2004, there were 2,796 LMG in the US, constituting 1.3% of all IMG. Compared to other foreign countries contributing to the US physician workforce, Lebanon ranked 2nd after adjusting for country population size (about 4 million) and 21st overall. About 40% of those who graduated from Lebanese medical schools in the last 25 years are currently active physicians in the US. Since 1978, the number of LMG in the US showed a consistent upward trend at a rate of approximately 71 additional graduates per year. Compared with USMG and IMG, LMG were more likely to work in medical research (OR = 2.31; 95% Confidence Interval (CI) = 1.21; 4.43 and OR = 2.63; 95% CI = 1.34; 5.01, respectively) and to be board certified (OR = 1.43; 95% CI = 1.14; 1.78 and OR = 2.04; 95% CI = 1.65;2.53, respectively) and less likely to be in family practice (OR = 0.14; 95% CI = 0.10; 0.19 and OR = 0.18; 95% CI = 0.12; 0.26, respectively). CONCLUSION: Given the magnitude and historical trends of migration of LMG to the US, further exploration of its causes and impact is warranted. High income countries should consider the consequences of their human resources policies on both low income countries' and their own healthcare systems
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