A Quali-quantitative evaluation approach to pedodiversity by multivariate analysis: introduction to the concept of "pedocharacter"

A model has been developed for the interpretation of the complexity of pedological systems; this is referred to as “pedocharacter”. The main aim of the model was to reduce the variables able to define soils and their relationships with the environment through the following quali-quantitative approach: i) definition of a fair number of qualitative characters; and ii) development of an analytic function, defined as “Land Relevance of the Factor”

Building Information Modeling and Geographic Information System: Integrated Framework in Support of Facility Management (FM)

Currently, the management of public real estate stocks is one of the most challenging activities. In this case, facility management emerges as a strategic but complex discipline that requires a great amount of integrated and structured data and information of heterogeneous origin and nature. Starting from this premise, this paper focuses on how FM discipline can be supported by Building Information Modeling (BIM) and Geographic Information System (GIS) integrated methodologies and tools achieving high levels of effectiveness and efficiency in public building stock management. This led to the definition and development of a framework that mainly takes advantage of open-source tools (e.g., Quantum Geographic Information System—QGIS, and Dynamo) and non-proprietary data exchange formats like the COBie (Construction Operations Building Information Exchange) international standard. This methodological framework is capable of integrating different but strongly complementary tools, data, information, and expert knowledge for a multiscale approach. The methodology presented in this paper does not provide for an integral transfer of BIM data to the GIS platform but leads instead to an effective bidirectional integration between the two informative systems, by properly relating them and allowing for an easy switch from one system database to the other. The findings of experimental applications of the methodological approach to the former Macciotta pediatric hospital, a healthcare building owned by the University of Cagliari, are presented and discussed. Finally, the analysis about potentials and criticalities of the developed methodological framework aims to trigger the widest future development and dissemination of this research

Pedotechniques strategies to improve soil resilience against the impact of irrigation by municipal wastewater: using zeolitized tuffs as soil amendments

A research was started aiming at evaluating the possible use of natural zeolites as exchange conditioners to improve and make durable the soil resilience against the adverse effects of the use of anomalous wastewater, for irrigation purposes. To satisfy such aims, two zeolitized tuffs (ZTs), viz. a Neapolitan yellow tuff (NYT) and a clinoptilolite bearing tuff (ZCL), were tested as pedotechnical materials to improve soil resilience against the impact of treatment by a ‘dirty’ municipal wastewater (DMW)

Zeolitized tuffs in pedotechnique for quarry restoration: evaluation of phytonutritional efficiency in ^AUP model horizons

A study was started aiming at assessing the suitability of zeolitized tuff as optimal mineral Human Transported Materials (HTMs) in pedotechnologies for quarry restoration

Asenapine Effects On Peroxidation and Calcium Movements in HL-1 Cells

Introduction Bipolar patients are at higher risk for cardiovascular morbidity and mortality than their counterparts in the general population. In a recent in vitro study, Asenapine, a new antipsychotic for the treatment of mania/mixed mania, was found to keep physiological endothelial function by activation of eNOS-related NO release and to protect endothelial cells against peroxidation by interference with mitochondria, apoptosis and cell survival. Objectives To examine the cardiac protective effects elicited by Asenapine against peroxidation and on the Ca2+ movements. Methods In HL-1 that had undergone oxidative stress by 20 min hydrogen peroxide the effects of 30 min pre-treatment with Asenapine on survival and proliferation will be examined. In Fura-2AM loaded HL-1 we will next analyze the effects of Asenapine on Ca2+ movements and the related involvement of cAMP/PKA and PLC pathways, CaMKII, L and T type Ca2+ channels and 5HT1A receptors. The role of 'capacitative” Ca2+ entry, plasma-membrane Ca2+ pump inhibitor (PMCA) and Na+/Ca2+ exchanger will be analyzed. Changes of membrane potential caused by interference with K+ channels will be examined, as well. Results We expect to find a proliferative and anti-peroxidative effect of Asenapine in HL-1 cells. Asenapine could also affect Ca2+ movements through cAMP/PKA and PLC-dependent signalling and the involvement of 5HT1A receptors. The effects of Asenapine could also be related to changes of plasma membrane by interference with K+ channels and the modulation of PMCA activity and Na+/Ca2+ exchanger. Conclusions We expect to further confirm the protective effect of Asenapine against peroxidative injuries.Implications will be discusse

Antibiotics or No Antibiotics, That Is the Question: An Update on Efficient and Effective Use of Antibiotics in Dental Practice

The antimicrobial resistance (AMR) phenomenon is an emerging global problem and is induced by overuse and misuse of antibiotics in medical practice. In total, 10% of antibiotic prescriptions are from dentists, usually to manage oro-dental pains and avoid postsurgical complications. Recent research and clinical evaluations highlight new therapeutical approaches with a reduction in dosages and number of antibiotic prescriptions and recommend focusing on an accurate diagnosis and improvement of oral health before dental treatments and in patients' daily lives. In this article, the most common clinical and operative situations in dental practice, such as endodontics, management of acute alveolar abscesses, extractive oral surgery, parodontology and implantology, are recognized and summarized, suggesting possible guidelines to reduce antibiotic prescription and consumption, maintaining high success rates and low complications rates. Additionally, the categories of patients requiring antibiotic administration for pre-existing conditions are recapitulated. To reduce AMR threat, it is important to establish protocols for treatment with antibiotics, to be used only in specific situations. Recent reviews demonstrate that, in dentistry, it is possible to minimize the use of antibiotics, thoroughly assessing patient's conditions and type of intervention, thus improving their efficacy and reducing the adverse effects and enhancing the modern concept of personalized medicine

Actors on the Scene: Immune Cells in the Myeloma Niche

Two mechanisms are involved in the immune escape of cancer cells: the immunoediting of tumor cells and the suppression of the immune system. Both processes have been revealed in multiple myeloma (MM). Complex interactions between tumor plasma cells and the bone marrow (BM) microenvironment contribute to generate an immunosuppressive milieu characterized by high concentration of immunosuppressive factors, loss of effective antigen presentation, effector cell dysfunction, and expansion of immunosuppressive cell populations, such as myeloid-derived suppressor cells, regulatory T cells and T cells expressing checkpoint molecules such as programmed cell death 1. Considering the great immunosuppressive impact of BM myeloma microenvironment, many strategies to overcome it and restore myeloma immunosurveillance have been elaborated. The most successful ones are combined approaches such as checkpoint inhibitors in combination with immunomodulatory drugs, anti-monoclonal antibodies, and proteasome inhibitors as well as chimeric antigen receptor (CAR) T cell therapy. How best to combine anti-MM therapies and what is the optimal timing to treat the patient are important questions to be addressed in future trials. Moreover, intratumor MM heterogeneity suggests the crucial importance of tailored therapies to identify patients who might benefit the most from immunotherapy, reaching deeper and more durable responses

A consensus document on definition and diagnostic criteria for orthorexia nervosa

Purpose: Since the term orthorexia nervosa (ON) was coined from the Greek (ὀρθός, right and ὄρεξις, appetite) in 1997 to describe an obsession with “correct” eating, it has been used worldwide without a consistent definition. Although multiple authors have proposed diagnostic criteria, and many theoretical papers have been published, no consensus definition of ON exists, empirical primary evidence is limited, and ON is not a standardized diagnosis. These gaps prevent research to identify risk and protective factors, pathophysiology, functional consequences, and evidence-based therapeutic treatments. The aims of the current study are to categorize the common observations and presentations of ON pathology among experts in the eating disorder field, propose tentative diagnostic criteria, and consider which DSM chapter and category would be most appropriate for ON should it be included. Methods: 47 eating disorder researchers and multidisciplinary treatment specialists from 14 different countries across four continents completed a three-phase modified Delphi process, with 75% agreement determined as the threshold for a statement to be included in the final consensus document. In phase I, participants were asked via online survey to agree or disagree with 67 statements about ON in four categories: A–Definition, Clinical Aspects, Duration; B–Consequences; C–Onset; D–Exclusion Criteria, and comment on their rationale. Responses were used to modify the statements which were then provided to the same participants for phase II, a second round of feedback, again in online survey form. Responses to phase II were used to modify and improve the statements for phase III, in which statements that met the predetermined 75% of agreement threshold were provided for review and commentary by all participants. Results: 27 statements met or exceeded the consensus threshold and were compiled into proposed diagnostic criteria for ON. Conclusions: This is the first time a standardized definition of ON has been developed from a worldwide, multidisciplinary cohort of experts. It represents a summary of observations, clinical expertise, and research findings from a wide base of knowledge. It may be used as a base for diagnosis, treatment protocols, and further research to answer the open questions that remain, particularly the functional consequences of ON and how it might be prevented or identified and intervened upon in its early stages. Although the participants encompass many countries and disciplines, further research will be needed to determine if these diagnostic criteria are applicable to the experience of ON in geographic areas not represented in the current expert panel. Level of evidence_ Level V: opinions of expert committee

A high-resolution view of the filament of gas between Abell 399 and Abell 401 from the Atacama Cosmology Telescope and MUSTANG-2

We report a significant detection of the hot intergalactic medium in the filamentary bridge connecting the galaxy clusters Abell 399 and Abell 401. This result is enabled by a low-noise, high-resolution map of the thermal Sunyaev–Zeldovich signal from the Atacama Cosmology Telescope (ACT) and Planck satellite. The ACT data provide the 1.65 arcmin resolution that allows us to clearly separate the profiles of the clusters, whose centres are separated by 37 arcmin, from the gas associated with the filament. A model that fits for only the two clusters is ruled out compared to one that includes a bridge component at >5σ. Using a gas temperature determined from Suzaku X-ray data, we infer a total mass of (3.3±0.7)×1014M⊙ associated with the filament, comprising about 8 per cent of the entire Abell 399–Abell 401 system. We fit two phenomenological models to the filamentary structure; the favoured model has a width transverse to the axis joining the clusters of ∼1.9Mpc⁠. When combined with the Suzaku data, we find a gas density of (0.88±0.24)×10−4cm−3⁠, considerably lower than previously reported. We show that this can be fully explained by a geometry in which the axis joining Abell 399 and Abell 401 has a large component along the line of sight, such that the distance between the clusters is significantly greater than the 3.2Mpc projected separation on the plane of the sky. Finally, we present initial results from higher resolution (12.7 arcsec effective) imaging of the bridge with the MUSTANG-2 receiver on the Green Bank Telescope