Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Water adsorption and O-defect formation on Fe2O3(0001) surfaces

The stability and reactivity of the hematite, Fe2O3(0001) surface are studied by density functional theory including an on-site Coulomb term (DFT+U). Even under oxygen rich conditions, the metal-terminated surface is shown to be stable. On this surface termination, the isolated water molecule forms a heterolytically dissociated structure with the OH− group attached to a surface Fe3+ ion and the proton to a surface O2− ion. Dissociative adsorption is strongly enhanced at oxygen vacancy sites. Here, the OH− group fills the oxygen vacancy site. Dehydrogenation accompanied by defect healing is favoured compared to water desorption (178 kJ mol−1 compared to 236 kJ mol−1). The water adsorption energies (at 0 K) for the clean and defective surfaces are 100 kJ mol−1 and 288 kJ mol−1, respectively.Peer Reviewe

Transformation of the company’s HR management systems based on digital literacy measurement

Corporate culture in each company has its own particularities, which allows to assess the efficiency and sustainability of a given company, design its development strategy as well as the capacity to attain its strategic goals. The current study, based on the model of O’Reilly, Chatman and Caldwell, allowed to define the key problem, that is the absence of digital literacy on the part of the personnel of the studied hotel chain. The identified problem may become an impediment towards formation of the digital culture in the context of digital transformatio

Electronic and Magnetic Properties of The Graphene/RE/Ni(111) (RE: La, Yb) Intercalation-Like Interfaces: A DFT Analysis

The effect of the rare-earth (RE) metals (La and Yb) intercalation on the electronic and magnetic properties of the graphene/Ni(111) interface is studied using state-of-the-art density functional theory calculations. In both systems, the intercalation of RE leads to the dramatic decrease of the magnetic moments of the Ni-interface atoms and to the negligible moments of C-atoms in a graphene layer, compared to the parent graphene/Ni(111) system. At the same time, the significant n-doping of graphene together with a band-gap opening is observed in both cases of the RE intercalation with a position of the graphene Dirac point reaching E-D - E-F approximate to -1.53 eV. Also the large density of states is found in the vicinity of the Fermi level (E-F) along the M - K direction for the graphene-derived pi states which can be attributed to the joint effect of the intercalated RE and interface Ni atoms. These factors - increased density of states at E-F and absence of magnetism of C-atoms in a graphene layer - indicate the possibility of the observation of the superconductive state in graphene in the considered RE-based systems, which is important for the understanding of these and other electronics effects in the graphene-based systems

Gastronomic Tourism as a Way of Forming Impressions

Since the second half of the 2000s, gastronomic tourism has been the most dynamically growing segment of tourism around the world: up to 1/3 of the tourist’s expenses in the destination are expenses for food and beverage. The importance of gastronomy in the context of the experience economy has grown many times: gastronomy has ceased to be only a function of ensuring the tourist’s stay in the destination, along with accommodation and transport – it becomes the core of the tourist experience, a means of penetrating the history and culture of the destination, receiving the brightest and deepest emotions. Against the background of increasing globalization and ever-greater “seen” by the average tourist, there is a burning out of interest in traditional tourist activities; for example, sightseeing is no longer enough, and tourists require full immersion in the culture of the host country/region, and even more – they want to live a small life like a local, and gastronomic experiences that extend beyond the simple consumption of food are able to meet this exacting demand. The increasing tourist flows and the volume growth of public catering indicate the demand for the gastronomic component of tourism, which, in turn, can be one of the main ways to form impressions