Preconditions for the development of Russian Arctic export, coastal (cabotage) transportation and project cargo for the arctic demand

The article considers the concept and description of the Northern Sea Route (NSR), the main prerequisites for the development of Russian Arctic export by using the NSR. The concept and analysis of coastal shipping using Arctic vessels and the predictive conclusions on possible Arctic projects are also presented in the article. Systems for the development of Russian Arctic export, coastal transportation, and project cargo for Arctic demand include freight transport systems by rail and sea transport fleet. The purpose of this article is to analyze the data of transport systems, as well as to identify key prospects for the development of this system in Russia, taking into account a new concept – the Northern Sea Transport Corridor. According to the fact that it is a national transport corridor of the Russian Federation, the development of the cargo traffic is mainly connected with the Arctic exploration projects

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Lateglacial–Holocene environments and human occupation in the Upper Lena region of Eastern Siberia derived from sedimentary and zooarchaeological data from Lake Ochaul

In the current study, different geochemical and biological proxies, including pollen, non-pollen palynomorphs, ostracods and molluscs, from an AMS radiocarbon-dated sediment core from Lake Ochaul (54°14′N, 106°28′E; 641 m a.s.l.) are presented and discussed. Ochaul is a fresh-water lake and an archaeological site situated ca. 100 km northwest of Lake Baikal in the upper reaches of the Lena River. The 260-cm-long sedimentary record presented here spans the Lateglacial–Holocene interval, between ca. 13,500 cal yr BP and the present. The reconstructions of the postglacial vegetation and lake system development are discussed along with the regional climate dynamics and the hemispheric-scale environmental changes. During the Allerød interstadial the region around Lake Ochaul was dominated by sparse taiga forests. Cooling during the Younger Dryas led to a more open tundra landscape where trees formed patchy forest stands in climatically favourable environments. This facilitated a rapid spread of forests at the onset of the Early Holocene during which the study region was probably characterized by seasonally dry climate controlled by the interplay of higher insolation, lower global sea levels and remaining ice sheets in the North Atlantic region. After thermal and moisture optimum conditions and a maximum spread of forests during the Middle Holocene, continuous cooling and a trend to more open forests landscapes marked the Late Holocene. These long-term trends were interrupted by several relatively short episodes of change in the vegetation and algal records, which coincide with short-term (centennial-scale) Northern Hemisphere cooling/drying phases. This shows that the regional vegetation reacted sensitively to these climate oscillations. Six AMS radiocarbon dates of bone material of large herbivorous animals from the Ochaul archaeological site located at the northern shore of the lake provide important information about prehistoric hunter-gatherers and indicate that activities at the site took place at ca. 27,780–27,160 cal yr BP (95% probability range) as well as during the Mesolithic (ca. 8850–8450 cal yr BP), Early, Middle and Late Neolithic (between ca. 6840 and 5490 cal yr BP) and the Iron Age (ca. 2120–1930 cal yr BP). Our results demonstrate that despite major environmental transformations following the Last Glacial Maximum, Lake Ochaul and the Malaya Anga River valley remained attractive for large herbivores and for prehistoric hunter-gatherers, even during the Middle Neolithic cultural “hiatus” (ca. 6660–6060 cal yr BP) in Cis-Baikal, as documented by the published archaeological records

WUSCHEL-RELATED HOMEOBOX5 gene expression and interaction of CLE peptides with components of the systemic control add two pieces to the puzzle of autoregulation of nodulation

In legumes, the symbiotic nodules are formed as a result of dedifferentiation and reactivation of cortical root cells. A shoot-acting receptor complex, similar to the Arabidopsis (Arabidopsis thaliana) CLAVATA1 (CLV1)/CLV2 receptor, regulating development of the shoot apical meristem, is involved in autoregulation of nodulation (AON), a mechanism that systemically controls nodule number. The targets of CLV1/CLV2 in the shoot apical meristem, the WUSCHEL (WUS)-RELATED HOMEOBOX (WOX) family transcription factors, have been proposed to be important regulators of apical meristem maintenance and to be expressed in apical meristem "organizers." Here, we focus on the role of the WOX5 transcription factor upon nodulation in Medicago truncatula and pea (Pisum sativum) that form indeterminate nodules. Analysis of temporal WOX5 expression during nodulation with quantitative reverse transcription-polymerase chain reaction and promoter-reporter fusion revealed that the WOX5 gene was expressed during nodule organogenesis, suggesting that WOX genes are common regulators of cell proliferation in different systems. Furthermore, in nodules of supernodulating mutants, defective in AON, WOX5 expression was higher than that in wild-type nodules. Hence, a conserved WUS/WOX-CLV regulatory system might control cell proliferation and differentiation not only in the root and shoot apical meristems but also in nodule meristems. In addition, the link between nodule-derived CLE peptides activating AON in different legumes and components of the AON system was investigated. We demonstrate that the identified AON component, NODULATION3 of pea, might act downstream from or beside the CLE peptides during AON

Lateglacial–Holocene environments and human occupation in the Upper Lena region of Eastern Siberia derived from sedimentary and zooarchaeological data from Lake Ochaul

In the current study, different geochemical and biological proxies, including pollen, non-pollen palynomorphs, ostracods and molluscs, from an AMS radiocarbon-dated sediment core from Lake Ochaul (54°14′N, 106°28′E; 641 m a.s.l.) are presented and discussed. Ochaul is a fresh-water lake and an archaeological site situated ca. 100 km northwest of Lake Baikal in the upper reaches of the Lena River. The 260-cm-long sedimentary record presented here spans the Lateglacial–Holocene interval, between ca. 13,500 cal yr BP and the present. The reconstructions of the postglacial vegetation and lake system development are discussed along with the regional climate dynamics and the hemispheric-scale environmental changes. During the Allerød interstadial the region around Lake Ochaul was dominated by sparse taiga forests. Cooling during the Younger Dryas led to a more open tundra landscape where trees formed patchy forest stands in climatically favourable environments. This facilitated a rapid spread of forests at the onset of the Early Holocene during which the study region was probably characterized by seasonally dry climate controlled by the interplay of higher insolation, lower global sea levels and remaining ice sheets in the North Atlantic region. After thermal and moisture optimum conditions and a maximum spread of forests during the Middle Holocene, continuous cooling and a trend to more open forests landscapes marked the Late Holocene. These long-term trends were interrupted by several relatively short episodes of change in the vegetation and algal records, which coincide with short-term (centennial-scale) Northern Hemisphere cooling/drying phases. This shows that the regional vegetation reacted sensitively to these climate oscillations. Six AMS radiocarbon dates of bone material of large herbivorous animals from the Ochaul archaeological site located at the northern shore of the lake provide important information about prehistoric hunter-gatherers and indicate that activities at the site took place at ca. 27,780–27,160 cal yr BP (95% probability range) as well as during the Mesolithic (ca. 8850–8450 cal yr BP), Early, Middle and Late Neolithic (between ca. 6840 and 5490 cal yr BP) and the Iron Age (ca. 2120–1930 cal yr BP). Our results demonstrate that despite major environmental transformations following the Last Glacial Maximum, Lake Ochaul and the Malaya Anga River valley remained attractive for large herbivores and for prehistoric hunter-gatherers, even during the Middle Neolithic cultural “hiatus” (ca. 6660–6060 cal yr BP) in Cis-Baikal, as documented by the published archaeological records

High-resolution pollen record of the last 13,500 years derived from AMS radiocarbon dated sediments of Lake Ochaul in Cis-Baikal (Eastern Siberia)

A 260-cm-long section of a sediment core from Lake Ochaul (54°14'N, 106°28'E; 641 m a.s.l.), a freshwater lake in the Cis-Baikal region, ca. 100 km northwest of Lake Baikal, was analysed for pollen and non-pollen palynomorphs. This high-resolution AMS-dated record covers the Lateglacial and Holocene interval between ca. 13,500 cal yr BP and the present. A total of 84 samples from the Och18-II-1 and Och18-II-2 sections have been treated using dense media separation to extract pollen and non-pollen palynomorphs (e.g. fern and moss spores, Chironomidae remains, Botryococcus and Pediastrum green algae colonies) for further microscopic analysis

Rhizosphere Bacterium Rhodococcus sp. P1Y Metabolizes Abscisic Acid to Form Dehydrovomifoliol

The phytohormone abscisic acid (ABA) plays an important role in plant growth and in response to abiotic stress factors. At the same time, its accumulation in soil can negatively affect seed germination, inhibit root growth and increase plant sensitivity to pathogens. ABA is an inert compound resistant to spontaneous hydrolysis and its biological transformation is scarcely understood. Recently, the strain Rhodococcus sp. P1Y was described as a rhizosphere bacterium assimilating ABA as a sole carbon source in batch culture and affecting ABA concentrations in plant roots. In this work, the intermediate product of ABA decomposition by this bacterium was isolated and purified by preparative HPLC techniques. Proof that this compound belongs to ABA derivatives was carried out by measuring the molar radioactivity of the conversion products of this phytohormone labeled with tritium. The chemical structure of this compound was determined by instrumental techniques including high-resolution mass spectrometry, NMR spectrometry, FTIR and UV spectroscopies. As a result, the metabolite was identified as (4RS)-4-hydroxy-3,5,5-trimethyl-4-[(E)-3-oxobut-1-enyl]cyclohex-2-en-1-one (dehydrovomifoliol). Based on the data obtained, it was concluded that the pathway of bacterial degradation and assimilation of ABA begins with a gradual shortening of the acyl part of the molecule