Simulation and design of nonlinear material structures for energy and biomedical devices

The project's main objective is the development of mathematical models and solutions of the models for simulation and design of some modern nonlinear material structures for energy and biomedical devices. One of the challenges in modeling the structural behavior of the materials is that they cannot be modeled accurately by the theory of linear elasticity or common linearization theory even at small strains for not having a well-defined yield stress point

On the global solvability of a class of fourth-order nonlinear boundary value problems

ABSTRACT. This paper is concerned with the global solvability of a class of fourth-order nonlinear boundary value problems that govern the deformation of an elastic beam which is acted upon by axial compression, lateral forces and is in contact with a semi-infinite medium acting as a foundation For certain ranges of the acting axial compression force, the solvability of the equations follows from the coerciVity of their linear parts. Beyond these ranges this coercivity is lost It is shown here that the coercivity which ensures the global solvability can be generated by the nonlinear parts ofthe equations for a certain type offoundation. KEY WORDS AND PHRASES: Global solvability, fourth-order nonlinear boundary value problems, homogeneous nonlinearity, Leray-Schauder fixed point theorem, coercivity 1991 AMS SUBJECT CLASSIFICATION CODES: 49G99, 73H05, 73K15

Infection Isolation Location Rather than Specific Species Correlates with Different Adherence Strength, While Biofilm Density Remains Static in Clinically Isolated Candida and Arthroconidial Yeasts

In order to colonize and infect the host, arthroconidial yeasts must avoid being killed by host defense. Formation of biofilms on implanted devices allows the fungi to avoid host responses and to disseminate into the host. To better study the mechanisms of infections by arthroconidial yeast, the adherence and biofilm formation were assayed on patient samples collected for 10 years. In clinical samples adherence varies within particular species, but relative adherence is constant for those samples isolated from the same infection site. Here we document for the first time in vitro biofilm formation on clinically relevant catheter material for Trichosporon dohaense, T. ovoides, T. japonicum, T. coremiiforme, Cutaneotrichosporon mucoides, Cutaneotrichosporon cutaneum, Galactomyces candidus, and Magnusiomyces capitatus. Analysis of biofilm biomass assays found that biofilm mass changes less than 2-fold, regardless of the species. Our results reinforce the idea that most pathogenic fungi can form biofilms and that biofilm formation is a source of systemic infections.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Phenolic profiling and bioactivity assessment of in vitro propagated Psidium cattleianum Sabine: A promising study

Psidium cattleianum Sabine (strawberry guava) is an evergreen shrub that is grown as a fruiting hedge and has received significant consideration in the food and pharmaceutical disciplines. This study aims to set a promising protocol for in vitro propagation of P. cattleianum, along with profiling the phenolic content of the original plant (OP), induced callus (IC), and regenerated plantlets (RP) extracts, ultimately, evaluating their anti-inflammatory, antioxidant, and anticancer potential. Seeds were treated with commercial bleaching, HCl, and H2O2 to enhance the germination percentage and minimize the contamination percentage. Culturing sterilized leaf explants onto Murashige and Skoog (MS) medium supplemented with benzyl adenine (BA), 2,4-dichloro phenoxy acetic acid, and kinetin showed the best callus induction, while supplementation of MS media with BA, adenine sulfate, naphthalene acetic acid, and gibberellic acid activated regeneration. Augmentation of MS media with indol-3-butyric acid recorded the maximum rooting percentage. Finally, the obtained rooted shoots were successfully acclimatized in sand and peat moss soil. HPLC-MS/MS profiles of OP, RP, and IC showed a variety of phenolic metabolites. IC extract decreased the viability of MCF-7, HepG2, and K-562 cancer cell lines. Also, OP exhibits strong antioxidant activity. P. cattleianum and its RP are profound sources of phenolic compounds promoted for promising applications in the food and pharmaceutical industries