Effet des injections répétées de gadodiamide sur le métabolisme cérébelleux chez le rat mesuré in vivo par 1H SRM

International audienc

Detection of cerebellar hyperintensity on unenhanced MR images at 7T after cumulative injections of gadodiamide in healthy rats

National audienc

Detection of cerebellar hyperintensity on unenhanced MR images at 7T after cumulative injections of gadodiamide in healthy rats

International audienc

Perinatal Bisphenol A exposure induces sex-specific modifications in lipid profil of mice liver

National audienc

Une exposition périnatale aux dérivés dichlorés du Bisphénol A altère le métabolisme et la microarchitecture hippocampique : étude par IRM et 1H SRM chez la souris

International audienc

Etude comparée de la quantification de spectres 1H in vivo par Eretic digital, LC Model, AMARES et QUEST

International audienc

Wideband black-blood late gadolinium enhancement imaging for improved myocardial scar assessment in patients with cardiac implantable electronic devices.

Wideband phase-sensitive inversion recovery (PSIR) late gadolinium enhancement (LGE) enables myocardial scar imaging in implantable cardioverter defibrillators (ICD) patients, mitigating hyperintensity artifacts. To address subendocardial scar visibility challenges, a 2D breath-hold single-shot electrocardiography-triggered black-blood (BB) LGE sequence was integrated with wideband imaging, enhancing scar-blood contrast. Wideband BB, with increased bandwidth in the inversion pulse (0.8-3.8 kHz) and T <sub>2</sub> preparation refocusing pulses (1.6-5.0 kHz), was compared with conventional and wideband PSIR, and conventional BB, in a phantom and sheep with and without ICD, and in six patients with cardiac devices and known myocardial injury. ICD artifact extent was quantified in the phantom and specific absorption rate (SAR) was reported for each sequence. Image contrast ratios were analyzed in both phantom and animal experiments. Expert radiologists assessed image quality, artifact severity, and scar segments in patients and sheep. Additionally, histology was performed on the sheep's heart. In the phantom, wideband BB reduced ICD artifacts by 62% compared to conventional BB while substantially improving scar-blood contrast, but with a SAR more than 24 times that of wideband PSIR. Similarly, the animal study demonstrated a considerable increase in scar-blood contrast with wideband BB, with superior scar detection compared with wideband PSIR, the latter confirmed by histology. In alignment with the animal study, wideband BB successfully eliminated severe ICD hyperintensity artifacts in all patients, surpassing wideband PSIR in image quality and scar detection. Wideband BB may play a crucial role in imaging ICD patients, offering images with reduced ICD artifacts and enhanced scar detection