Construction and Use Examples of Private Electronic Notary Service in Educational Institutions

People have many documents. For example, a variety of documents are prepared and used in public institutions. As the internet becomes widely available in recent years, paper documents are being replaced with electronic data, which are often distributed in the form of electronic data without being printed out. Similarly, in educational institutions, increasing number of documents are distributed in the form of electronic data. Such data are distributed through various routes and means, and prone to the risk of alteration in the process. Data may be protected against alteration, but it is difficult to completely prevent data alteration in the distribution process. Data can be generated with electronic signature that allows for the identification of data creator and possible alterations by third parties. This method is, however, not valid if the data becomes separated from the electronic signature, making the validation of data creator or data alterations difficult or impossible. In this paper, we describe the invention of a system that, even in cases where data is separated form the electronic signature, enables easy identification of possible data alterations by the electronic signature management. And we describe here an exploratory construction of private electronic notary service in university. We also add a review on the utilization method of private electronic notary service in universities

Ocular infestation by a juvenile leech, Myxobdella sinanensis in Japan

[Purpose] The case of ocular infestation by a leech is rare. We reported that Myxobdella sinanensis infests conjunctiva. [Observations] A 5-year-old girl presented with blood clots in the inner corner of the left eye, and a history bloody eye discharge and bloody tears for 5 days. She was prescribed 0.5% levofloxacin ophthalmic drops for conjunctival damage. However, her parent watched a worm moving in her conjunctiva while taking a bath. She presented again the same day, and a worm was found in the left eye of the lower conjunctival fornix and was adsorbed to the inner corner. We removed a worm under eye drop anesthesia, the next day the patient had no symptoms. We captured the worm, and it was identified morphologically and genetically as Myxobdella sinanensis. This was the first case reported of Myxobdella sinanensis be infestation in a human. [Conclusions and Importance] The ecological trait of Myxobdella sinanensis still did not remain clear, so this case report was helpful to find out a life cycle of Myxobdella sinanensis. As the outdoor population continues to increase, the cases of human parasites such as leech are expected to increase. When a patient with bloody eye discharge and bloody tears presents, we should carefully examine the conjunctiva and ocular surfaces, and interview recent history of exposure to stream water

Construction and Use Examples of Private Electronic Notary Service in Educational Institutions

People have many documents. For example, a variety of documents are prepared and used in public institutions. As the internet becomes widely available in recent years, paper documents are being replaced with electronic data, which are often distributed in the form of electronic data without being printed out. Similarly, in educational institutions, increasing number of documents are distributed in the form of electronic data. Such data are distributed through various routes and means, and prone to the risk of alteration in the process. Data may be protected against alteration, but it is difficult to completely prevent data alteration in the distribution process. Data can be generated with electronic signature that allows for the identification of data creator and possible alterations by third parties. This method is, however, not valid if the data becomes separated from the electronic signature, making the validation of data creator or data alterations difficult or impossible. In this paper, we describe the invention of a system that, even in cases where data is separated form the electronic signature, enables easy identification of possible data alterations by the electronic signature management. And we describe here an exploratory construction of private electronic notary service in university. We also add a review on the utilization method of private electronic notary service in universities

1994 Multi-site Broadband Seismic Observation at Sakurajima Volcano, Japan

Broadband observation of volcanic earthquakes has been recently conducted at many volcanoes. At the Sakurajima Volcano in Japan, one of the most active volcanoes all over the world, we conducted two broadband seismic observations successfully in last three years. However, they left some problems in terms of the number of observation sites and recording systems. This paper reports the outline of our third observation using three broadband seismometers (Streckeisen STS-II) with continuous recording at the Sakurajima Volcano from February 18 to March 28, 1994. This observation is distinguished from the previous two by the three stations operating continuously over the entire period. Although the Sakurajima Volcano had very low seismic activities during this observation period, we observed some kinds of volcanic earthquake, A-type and B-type earthquakes and volcanic tremors, particularly one series of interesting clone events

Misleading presentations in functional food trials led by contract research organizations were frequently observed in Japan : meta-epidemiological study

機能性食品の臨床試験を元にした広告への問題提起 --優良と誤認させる要素が多く含まれる--. 京都大学プレスリリース. 2024-03-01.[Objectives] The functional food market has experienced significant growth, leading to an uptick in clinical trials conducted by contract research organizations (CROs). Research focusing on CRO-managed trials and the communication of trial outcomes to the consumer market remains underexplored. This metaepidemiological study aims to evaluate the quality of randomized controlled trials (RCTs) facilitated by prominent CROs in Japan and to examine the quality of the representations used to convey their results to consumers. [Study Design and Setting] This study focused on the food trials that were registered in the University Hospital Medical Information Network Clinical Trial Registry or the International Clinical Trials Registry Platform by the top 5 CROs. Press releases of study results or advertisements of food products based on the study results were identified by conducting a Google search. The risk of bias in the RCT publications was independently assessed by 2 reviewers, who also evaluated the presence of “spin” in the abstracts and full texts. An assessment of “spin” in press releases/advertisements was undertaken. [Results] A total of 76 RCT registrations, 32 RCT publications, and 11 press releases/advertisements were included. Approximately 72% of the RCT publications exhibited a high risk of bias due to selective outcome reporting. “Spin” was present in the results of the abstract (72%), abstract conclusion (81%), full-text results (44%), and full-text conclusion (84%). “Spin” appeared in 73% of press releases/advertisements due to the selective outcome reporting. [Conclusion] Functional food presentations in Japan frequently contained “spin.” The Japanese government should more rigorously check whether food manufacturers report outcomes selectively

Peripheral platelet phagocytosis in an extremely low birth weight infant: a case report

A 768 g female neonate, born at 25 weeks' gestation, developed sepsis due to methicillin-resistant Staphylococcus epidermidis on day 14. Severe thrombocytopenia was observed, and hemophagocytic macrophages were identified in her peripheral blood smear. Cytokine profiles at the time of onset suggested that an inflammatory cytokine storm had activated lymphocytes and macrophages, leading to platelet phagocytosis. After administration of vancomycin for 14 days and immunoglobulin therapy, she improved without any complications. Considering the results of cytokine profiles, early intervention for infection may have prevented progression to hemophagocytic lymphohistiocytosis and reduced the severity of clinical symptoms

Investigation of biomarkers in a rare case of fulminant necrotizing enterocolitis in a preterm infant

We encountered a very rare case of fulminant necrotizing enterocolitis (F-NEC) in a preterm male baby. The course of NEC and sepsis in this case was clearly different from the usual course. After onset at 14 days of life, catheter-related bloodstream infection was first assumed, and antibiotics and γ-globulin administration were started. However, 12 hours after onset, the baby's abdominal distension increased remarkably, and his entire abdominal wall turned red to purple. Escherichia coli were isolated from the blood culture, but the catheter tip culture was negative. Exchange transfusion was performed 32 hours after onset, but no significant changes were observed in the baby's general condition, and he died 46 hours after onset. The acute phase reactants of CRP and α1-acid glycoprotein increased, but haptoglobin did not. Although IL-1β and TNFα increased as expected with sepsis, IL-6, IL-8, IL-10, and G-CSF however increased to a greater extent than expected. From the above, we diagnosed the development of intestinal necrosis as a result of widespread intestinal ischemia, and that sepsis was associated with this poor condition

High platelet reactivity is a predictor of left ventricular remodelling in patients with acute myocardial infarction

Aims Acute myocardial infarction (AMI) is associated with left ventricular remodelling (LVR), which leads to progressive heart failure. Platelets play a pivotal role in promoting systemic and cardiac inflammatory responses during the complex process of myocardial wound healing or repair following AMI. This study aimed to investigate the impact of platelet reactivity immediately after primary percutaneous coronary intervention (PCI) on LVR in AMI patients with ST-segment (STEMI) and nonST-segment elevation (NSTEMI). Methods and results This prospective, single-centre, observational study included 182 patients with AMI who underwent primary PCI (107 patient with STEMI and 75 patients with NSTEMI). Patients were administered a loading dose of aspirin plus prasugrel before the procedure, and platelet reactivity was assessed using the VerifyNow P2Y12 assay immediately after PCI. Echocardiography was performed before discharge and during the chronic phase (8 +/- 3 months after discharge). LVR was defined as a relative >= 20% increase in left ventricular end-diastolic volume index (LVEDVI). LVR in chronic phase was found in 34 patients (18.7%) whose platelet reactivity was significantly higher than those without LVR (259.6 +/- 61.5 and 213.1 +/- 74.8 P2Y12 reaction units [PRU]; P = 0.001). The occurrence of LVR did not differ between patients with STEMI and patients with NSTEMI (21.5% and 14.7%; P = 0.33). The optimal cut-off value of platelet reactivity for discriminating LVR was >= 245 PRU. LVEDVI significantly decreased at chronic phase in patients without high platelet reactivity (= d245 PRU) (P = 0.06). Multivariate logistic analysis showed that high platelet reactivity was an independent predictor of LVR after adjusting for LVEDVI before discharge (odds ratio, 4.13; 95% confidence interval, 1.85-9.79). Conclusions High platelet reactivity measured immediately after PCI was a predictor of LVR in patients with AMI during the chronic phase. The role of antiplatelet therapy on inflammation in the myocardium is a promising area for further research