Women in the U.S. Military: Growing Share, Distinctive Profile

The women who serve in today's military differ from the men who serve in a number of ways. Compared with their male counterparts, a greater share of military women are black and a smaller share are married. Also, women veterans of the post-9/11 era are less likely than men to have served in combat and more likely to be critical of the wars in Iraq and Afghanistan. In other ways, however, military women are not different from military men: they are just as likely to be officers; they joined the armed services for similar reasons; and post-9/11 veterans of both sexes have experienced a similar mix of struggles and rewards upon returning to civilian life. Since 1973, when the United States military ended conscription and established an all-volunteer force, the number of women serving on active duty has risen dramatically. The share of women among the enlisted ranks has increased seven-fold, from 2% to 14%, and the share among commissioned officers has quadrupled, from 4% to 16%.Department of Defense policy prohibits the assignment of women to any "unit below brigade level whose primary mission is direct ground combat." While this policy excludes women from being assigned to infantry, special operations commandos and some other roles, female members of the armed forces may still find themselves in situations that require combat action, such as defending their units if they come under attack.2This report explores the changing role of women in the military using several data sources. Two Department of Defense publications -- Population Representation in the Military Forces, FY2010 and Demographics 2010: Profile of the Military Community -- provide the overall trends in military participation by gender, as well as demographic and occupational profiles of male and female military personnel. The report also draws on data from two surveys of military veterans: a Pew Research Center survey of a nationally representative sample of 1,853 veterans conducted July 28-Sept. 4, 2011, and the July 2010 Current Population Survey (CPS) Veterans Supplement (n=9,739 veterans)

For Many Injured Veterans, A Lifetime of Consequences

One out of every ten veterans alive today was seriously injured at some point while serving in the military, and three-quarters of those injuries occurred in combat. For many of these 2.2 million wounded warriors, the physical and emotional consequences of their wounds have endured long after they left the military, according to a Pew research Center survey of a nationally representative sample of 1,853 veterans conducted from July 18 to Sept. 4, 2011.Veterans who suffered major service-related injuries are more than twice as likely as their more fortunate comrades to say they had difficulties readjusting to civilian life. They are almost three times as likely as other veterans to report they have suffered from post-traumatic stress (PTS). And they are less likely in later life to be in overall good health or to hold full-time jobs

Patient Health Questionnaire-9 scores do not accurately estimate depression prevalence: individual participant data meta-analysis.

OBJECTIVES: Depression symptom questionnaires are not for diagnostic classification. Patient Health Questionnaire-9 (PHQ-9) scores ≥10 are nonetheless often used to estimate depression prevalence. We compared PHQ-9 ≥10 prevalence to Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (SCID) major depression prevalence and assessed whether an alternative PHQ-9 cutoff could more accurately estimate prevalence. STUDY DESIGN AND SETTING: Individual participant data meta-analysis of datasets comparing PHQ-9 scores to SCID major depression status. RESULTS: A total of 9,242 participants (1,389 SCID major depression cases) from 44 primary studies were included. Pooled PHQ-9 ≥10 prevalence was 24.6% (95% confidence interval [CI]: 20.8%, 28.9%); pooled SCID major depression prevalence was 12.1% (95% CI: 9.6%, 15.2%); and pooled difference was 11.9% (95% CI: 9.3%, 14.6%). The mean study-level PHQ-9 ≥10 to SCID-based prevalence ratio was 2.5 times. PHQ-9 ≥14 and the PHQ-9 diagnostic algorithm provided prevalence closest to SCID major depression prevalence, but study-level prevalence differed from SCID-based prevalence by an average absolute difference of 4.8% for PHQ-9 ≥14 (95% prediction interval: -13.6%, 14.5%) and 5.6% for the PHQ-9 diagnostic algorithm (95% prediction interval: -16.4%, 15.0%). CONCLUSION: PHQ-9 ≥10 substantially overestimates depression prevalence. There is too much heterogeneity to correct statistically in individual studies

The β-Catenin/T-Cell Factor/Lymphocyte Enhancer Factor Signaling Pathway Is Required for Normal and Stress-Induced Cardiac Hypertrophy

In cells capable of entering the cell cycle, including cancer cells, β-catenin has been termed a master switch, driving proliferation over differentiation. However, its role as a transcriptional activator in terminally differentiated cells is relatively unknown. Herein we utilize conditional, cardiac-specific deletion of the β-catenin gene and cardiac-specific expression of a dominant inhibitory mutant of Lef-1 (Lef-1Δ20), one of the members of the T-cell factor/lymphocyte enhancer factor (Tcf/Lef) family of transcription factors that functions as a coactivator with β-catenin, to demonstrate that β-catenin/Tcf/Lef-dependent gene expression regulates both physiologic and pathological growth (hypertrophy) of the heart. Indeed, the profound nature of the growth impairment of the heart in the Lef-1Δ20 mouse, which leads to very early development of heart failure and premature death, suggests β-catenin/Tcf/Lef targets are dominant regulators of cardiomyocyte growth. Thus, our studies, employing complementary models in vivo, implicate β-catenin/Tcf/Lef signaling as an essential growth-regulatory pathway in terminally differentiated cells