11,372 research outputs found
Statement of Clifford J. Ehrlich Before the Commission on the Future of Worker-Management Relations
Testimony_Ehrlich_022494.pdf: 352 downloads, before Oct. 1, 2020
Effects of space cabin environments on infection Final report, 19 Jul. 1965 - 18 Sep. 1966
Infection resistance and radiation effects on mice determined after varied exposures to space cabin environment and ambient condition
Longitudinal variations, the opposition effect and monochromatic albedos for Mars
Magnitude at zero phase, phase coefficient, and monochromatic albedo computed for Mars as function of wavelengt
Using molecular mechanics to predict bulk material properties of fibronectin fibers
The structural proteins of the extracellular matrix (ECM) form fibers with finely tuned mechanical properties matched to the time scales of cell traction forces. Several proteins such as fibronectin (Fn) and fibrin undergo molecular conformational changes that extend the proteins and are believed to be a major contributor to the extensibility of bulk fibers. The dynamics of these conformational changes have been thoroughly explored since the advent of single molecule force spectroscopy and molecular dynamics simulations but remarkably, these data have not been rigorously applied to the understanding of the time dependent mechanics of bulk ECM fibers. Using measurements of protein density within fibers, we have examined the influence of dynamic molecular conformational changes and the intermolecular arrangement of Fn within fibers on the bulk mechanical properties of Fn fibers. Fibers were simulated as molecular strands with architectures that promote either equal or disparate molecular loading under conditions of constant extension rate. Measurements of protein concentration within micron scale fibers using deep ultraviolet transmission microscopy allowed the simulations to be scaled appropriately for comparison to in vitro measurements of fiber mechanics as well as providing estimates of fiber porosity and water content, suggesting Fn fibers are approximately 75% solute. Comparing the properties predicted by single molecule measurements to in vitro measurements of Fn fibers showed that domain unfolding is sufficient to predict the high extensibility and nonlinear stiffness of Fn fibers with surprising accuracy, with disparately loaded fibers providing the best fit to experiment. This work shows the promise of this microstructural modeling approach for understanding Fn fiber properties, which is generally applicable to other ECM fibers, and could be further expanded to tissue scale by incorporating these simulated fibers into three dimensional network models
Truncated unity functional renormalization group for multiband systems with spin-orbit coupling
Although the functional renormalization group (fRG) is by now a
well-established method for investigating correlated electron systems, it is
still undergoing significant technical and conceptual improvements. In
particular, the motivation to optimally exploit the parallelism of modern
computing platforms has recently led to the development of the
"truncated-unity" functional renormalization group (TU-fRG). Here, we review
this fRG variant, and we provide its extension to multiband systems with
spin-orbit coupling. Furthermore, we discuss some aspects of the implementation
and outline opportunities and challenges ahead for predicting the ground-state
ordering and emergent energy scales for a wide class of quantum materials.Comment: consistent with published version in Frontiers in Physics (2018
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“Like a Withered Tree, Stripped of Its Foliage”: What the Roe Court Missed and Why it Matters
While it would certainly be too much to argue that a fuller exposition of the multi-dimensional origins of the nation’s criminal abortion laws by the Roe Court would have somehow prevented the emergence of the “pro-woman” antiabortion position, I nonetheless contend that if the Roe Court had exposed the gendered origins of our criminal abortion laws, the deep paternalism of the woman-protective approach may well have attracted more critical attention than it did prior to 2007 when the Supreme Court’s embrace of the abortion regret trope served to focus greater public and scholarly attention on this development. In short, this historic knowledge serves to sharpen our understanding of the longstanding link between the regulation of abortion and the effort to control women’s reproductive bodies, thus making it clear that antiabortion activism has never simply been about protecting the fetus.
This Article proceeds in three parts. In Part I, we take a close look at the physicians’ mid-nineteenth century campaign to criminalize abortion. Specifically, we will focus on 1) the launch of their campaign; 2) the physicians’ framing of their effort as a “bold and manly” appeal; 3) their focus on preserving and protecting women’s purity and divinely ordained maternal role; 4) their claim that abortion was rife with injurious impacts as embodied in the view that it marked the uterus with a “stamp of derangement”; and 5) the antiabortion physicians’ claim that abortion, as practiced by white, middle-class women, threatened the racial character of the nation. In Part II, we turn to the Court’s landmark decision in Roe v. Wade. Zeroing in on its examination of the historical underpinnings of the nation’s criminal abortion laws, we first take a look at what the Roe Court said about this history, followed by a discussion of what the Court missed—namely, its elision of the gendered and racialized tropes that permeated the physicians’ antiabortion campaign. In Part III, we examine the late twentieth-century emergence of the “pro-woman/pro-life” antiabortion argument. After consideration of the traditional fetal-centric “pro-life” position, we turn to the origins of this new frame. This discussion is followed by a comparison of the core themes of the nineteenth-century physicians’ campaign with the contemporary woman- protective antiabortion position. These themes include: 1) that abortion is incompatible with women’s true nature, 2) that meaningful consent is an impossibility, and 3) that abortion is inherently harmful to women. In conclusion, this Article circles back to the Roe Court’s narrow reading of the physicians’ campaign to argue that if the Roe Court had engaged in a more robust reading of this history, the gendered paternalism of the contemporary “pro-woman/pro-life” position would have been rendered far more visible as a discredited approach to pressing women into motherhood
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