780 research outputs found
X-ray bright active galactic nuclei in massive galaxy clusters III: New insights into the triggering mechanisms of cluster AGN
We present the results of a new analysis of the X-ray selected Active
Galactic Nuclei (AGN) population in the vicinity of 135 of the most massive
galaxy clusters in the redshift range of 0.2 < z < 0.9 observed with Chandra.
With a sample of more than 11,000 X-ray point sources, we are able to measure,
for the first time, evidence for evolution in the cluster AGN population beyond
the expected evolution of field AGN. Our analysis shows that overall number
density of cluster AGN scales with the cluster mass as .
There is no evidence for the overall number density of cluster member X-ray AGN
depending on the cluster redshift in a manner different than field AGN, nor
there is any evidence that the spatial distribution of cluster AGN (given in
units of the cluster overdensity radius r_500) strongly depends on the cluster
mass or redshift. The scaling relation we measure is
consistent with theoretical predictions of the galaxy merger rate in clusters,
which is expected to scale with the cluster velocity dispersion, , as or . This consistency suggests that AGN in
clusters may be predominantly triggered by galaxy mergers, a result that is
further corroborated by visual inspection of Hubble images for 23
spectroscopically confirmed cluster member AGN in our sample. A merger-driven
scenario for the triggering of X-ray AGN is not strongly favored by studies of
field galaxies, however, suggesting that different mechanisms may be primarily
responsible for the triggering of cluster and field X-ray AGN.Comment: 21 Pages, 8 figures, 5 tables. Submitted to MNRAS. Comments are
welcome, and please request Steven Ehlert for higher resolution figure
Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder
We investigated the contractile roles of M2 and M3 muscarinic receptors in urinary bladder from streptozotocin-treated mice. Wild-type and M2 muscarinic receptor knockout (M2 KO) mice were given a single injection of vehicle or streptozotocin (125 mg kg−1) 2–24 weeks prior to bladder assays. The effect of forskolin on contractions elicited to the muscarinic agonist, oxotremorine-M, was measured in isolated urinary bladder (intact or denuded of urothelium). Denuded urinary bladder from vehicle-treated wild-type and M2 KO mice exhibited similar contractile responses to oxotremorine-M, when contraction was normalized relative to that elicited by KCl (50 mM). Eight to 9 weeks after streptozotocin treatment, the EC50 value of oxotremorine-M increased 3.1-fold in urinary bladder from the M2 KO mouse (N = 5) compared to wild type (N = 6; P < 0.001). Analogous changes were observed in intact bladder. In denuded urinary bladder from vehicle-treated mice, forskolin (5 µM) caused a much greater inhibition of contraction in M2 KO bladder compared to wild type. Following streptozotocin treatment, this forskolin effect increased 1.6-fold (P = 0.032). At the 20- to 24-week time point, the forskolin effect increased 1.7-fold for denuded as well as intact bladders (P = 0.036, 0.01, respectively). Although streptozotocin treatment inhibits M3 receptor-mediated contraction in denuded urinary bladder, muscarinic contractile function is maintained in wild-type bladder by enhanced M2 contractile function. M2 receptor activation opposes forskolin-induced relaxation of the urinary bladder, and this M2 function is enhanced following streptozotocin treatment
X-ray Bright Active Galactic Nuclei in Massive Galaxy Clusters II: The Fraction of Galaxies Hosting Active Nuclei
We present a measurement of the fraction of cluster galaxies hosting X-ray
bright Active Galactic Nuclei (AGN) as a function of clustercentric distance
scaled in units of . Our analysis employs high quality Chandra X-ray
and Subaru optical imaging for 42 massive X-ray selected galaxy cluster fields
spanning the redshift range of . In total, our study involves
176 AGN with bright () optical counterparts above a keV flux
limit of . When excluding
central dominant galaxies from the calculation, we measure a cluster-galaxy AGN
fraction in the central regions of the clusters that is times lower
that the field value. This fraction increases with clustercentric distance
before becoming consistent with the field at . Our data
exhibit similar radial trends to those observed for star formation and
optically selected AGN in cluster member galaxies, both of which are also
suppressed near cluster centers to a comparable extent. These results strongly
support the idea that X-ray AGN activity and strong star formation are linked
through their common dependence on available reservoirs of cold gas.Comment: 9 Pages, 4 Figures, accepted for publication in MNRAS, please contact
Steven Ehlert ([email protected]) with any querie
Probing the extreme realm of AGN feedback in the massive galaxy cluster, RX J1532.9+3021
We present a detailed Chandra, XMM-Newton, VLA and HST analysis of one of the
strongest cool core clusters known, RX J1532.9+3021 (z=0.3613). Using new, deep
90 ks Chandra observations, we confirm the presence of a western X-ray cavity
or bubble, and report on a newly discovered eastern X-ray cavity. The total
mechanical power associated with these AGN-driven outflows is (22+/-9)*10^44
erg/s, and is sufficient to offset the cooling, indicating that AGN feedback
still provides a viable solution to the cooling flow problem even in the
strongest cool core clusters. Based on the distribution of the optical
filaments, as well as a jet-like structure seen in the 325 MHz VLA radio map,
we suggest that the cluster harbours older outflows along the north to south
direction. The jet of the central AGN is therefore either precessing or
sloshing-induced motions have caused the outflows to change directions. There
are also hints of an X-ray depression to the north aligned with the 325 MHz
jet-like structure, which might represent the highest redshift ghost cavity
discovered to date. We further find evidence of a cold front (r=65kpc) that
coincides with the outermost edge of the western X-ray cavity and the edge of
the radio mini-halo. The common location of the cold front with the edge of the
radio mini-halo supports the idea that the latter originates from electrons
being reaccelerated due to sloshing induced turbulence. Alternatively, its
coexistence with the edge of the X-ray cavity may be due to cool gas being
dragged out by the outburst. We confirm that the central AGN is highly
sub-Eddington and conclude that a >10^10M_Sun or a rapidly spinning black hole
is favoured to explain both the radiative-inefficiency of the AGN and the
powerful X-ray cavities.Comment: Accepted for publication to ApJ (minor corrections), 16 pages, 16
figures, 5 tables. Full resolution at http://www.stanford.edu/~juliehl/M1532
Pathology Associated with AAV Mediated Expression of Beta Amyloid or C100 in Adult Mouse Hippocampus and Cerebellum
Accumulation of beta amyloid (Ab) in the brain is a primary feature of Alzheimer’s disease (AD) but the exact molecular mechanisms by which Ab exerts its toxic actions are not yet entirely clear. We documented pathological changes 3 and 6 months after localised injection of recombinant, bi-cistronic adeno-associated viral vectors (rAAV2) expressing human Ab40- GFP, Ab42-GFP, C100-GFP or C100V717F-GFP into the hippocampus and cerebellum of 8 week old male mice. Injection of all rAAV2 vectors resulted in wide-spread transduction within the hippocampus and cerebellum, as shown by expression of transgene mRNA and GFP protein. Despite the lack of accumulation of Ab protein after injection with AAV vectors, injection of rAAV2-Ab42-GFP and rAAV2- C100V717F-GFP into the hippocampus resulted in significantly increased microgliosis and altered permeability of the blood brain barrier, the latter revealed by high levels of immunoglobulin G (IgG) around the injection site and the presence of IgG positive cells. In comparison, injection of rAAV2-Ab40-GFP and rAAV2-C100-GFP into the hippocampus resulted in substantially less neuropathology. Injection of rAAV2 vectors into the cerebellum resulted in similar types of pathological changes, but to a lesser degree. The use of viral vectors to express different types of Ab and C100 is a powerful technique with which to examine the direct in vivo consequences of Ab expression in different regions of the mature nervous system and will allow experimentation and analysis of pathological AD-like changes in a broader range of species other than mouse
Multipartite Entanglement and Frustration
Some features of the global entanglement of a composed quantum system can be
quantified in terms of the purity of a balanced bipartition, made up of half of
its subsystems. For the given bipartition, purity can always be minimized by
taking a suitable (pure) state. When many bipartitions are considered, the
requirement that purity be minimal for all bipartitions can engender conflicts
and frustration arises. This unearths an interesting link between frustration
and multipartite entanglement, defined as the average purity over all
(balanced) bipartitions.Comment: 15 pages, 7 figure
ixpeobssim: a Simulation and Analysis Framework for the Imaging X-ray Polarimetry Explorer
ixpeobssim is a simulation and analysis framework, based on the Python
programming language and the associated scientific ecosystem, specifically
developed for the Imaging X-ray Polarimetry Explorer (IXPE). Given a source
model and the response functions of the telescopes, it is designed to produce
realistic simulated observations, in the form of event lists in FITS format,
containing a strict super-set of the information provided by standard IXPE
level-2 files. The core ixpeobssim simulation capabilities are complemented by
a full suite of post-processing applications, allowing for the implementation
of complex, polarization-aware analysis pipelines, and facilitating the
inter-operation with the standard visualization and analysis tools
traditionally in use by the X-ray community. We emphasize that, although a
significant part of the framework is specific to IXPE, the modular nature of
the underlying implementation makes it potentially straightforward to adapt it
to different missions with polarization capabilities.Comment: 12 pages, 6 figures. Accepted for publication on SoftwareX; source
code available at https://github.com/lucabaldini/ixpeobssi
Higher education and unemployment in Europe : an analysis of the academic subject and national effects
This paper examines the impact of an academic degree and field of study on short and long-term unemployment across Europe (EU15). Labour Force Survey (LFS) data on over half a million individuals are utilised for that purpose. The harmonized LFS classification of level of education and field of study overcomes past problems of comparability across Europe. The study analyses (i) the effect of an academic degree at a European level, (ii) the specific effect of 14 academic subjects and (iii) country specific effects. The results indicate that an academic degree is more effective on reducing the likelihood of short-term than long-term unemployment. This general pattern even though it is observed for most of the academic subjects its levels show significant variation across disciplines and countries
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