Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future.

The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages, pharynx, larynx, and lung. Exposure to ambient air throughout the lifespan imposes vulnerability of the respiratory system to environmental challenges that can contribute toward development of disease. The importance of the respiratory system to human health is supported by statistics from the Centers for Disease Control and Prevention; in 2015, chronic lower respiratory diseases were the third leading cause of death in the United States. In light of the significant mortality associated with respiratory conditions that afflict all ages of the human population, this review will focus on basic and preclinical research conducted in nonhuman primate models of respiratory disease. In comparison with other laboratory animals, the nonhuman primate lung most closely resembles the human lung in structure, physiology, and mucosal immune mechanisms. Studies defining the influence of inhaled microbes, pollutants, or allergens on the nonhuman primate lung have provided insight on disease pathogenesis, with the potential for elucidation of molecular targets leading to new treatment modalities. Vaccine trials in nonhuman primates have been crucial for confirmation of safety and protective efficacy against infectious diseases of the lung in a laboratory animal model that recapitulates pathology observed in humans. In looking to the future, nonhuman primate models of respiratory diseases will continue to be instrumental for translating biomedical research for improvement of human health

"So speak the voices"

Thesis (M.A.)--Boston University, 1948. This item was digitized by the Internet Archive

Implementing Strategic Buyer-supplier Alliances For Product Development

This study is concerned with the successful implementation of alliances as a way of creating competitive advantage. As managers in technology intensive industries try to meet the challenges of rising costs, shortened product lives, and intense competition, they are turning to strategic alliances. Alliances allow a firm to specialize in those activities of the value chain that are essential to its competitive advantage, while entrusting other activities to their partner firms. Much of the past research on strategic alliances has focused on the characteristics of, and motivations for, alliances. There has been little work on how alliances are implemented. This study examines the successful management of strategic alliances for product development.;The purpose was to: (1) develop a synthesized model of alliance management, (2) empirically test the model using data collected from alliance managers, and (3) identify determinants of successful alliance management and performance. The study, as part of an integrated multi-method research program, included a literature review, pilot study, model development, data collection, and model testing. The results of the literature review and pilot study were the basis for the development of the strategic alliance management model. Data to test the model was collected from managers in North American firms involved in thirty-eight product development alliances. The model was tested using Partial Least Squares (PLS) with data collected by questionnaires. The model explains approximately 61 percent of the observed variance in strategic performance.;Based on the results of the study, recommendations are made to practicing managers involved in product development alliances. Essentially three sets of activities, or steps, make up successful alliances, and managers can take specific actions to manage these steps. These activities are initiating, maintenance, and building actions. In evaluating alliance performance, managers can assess operational and strategic performance. Following these guidelines should help managers realize productive and successful product development alliances

Social criticism in the novels, plays, and representative short stories of John Galsworthy.

Thesis (Ph.D)--Boston Universit

Influence of inclination error in sedimentary rocks on the Triassic and Jurassic apparent pole wander path for North America and implications for Cordilleran tectonics

Because of paleomagnetic inclination error (I error) in sedimentary rocks, we argue that previous estimates of Triassic and Jurassic paleolatitudes of the North American craton have generally been too low, the record being derived mostly from sedimentary rocks. Using results from all major cratons, we construct a new composite apparent pole wander (APW) path for Triassic through Paleogene based on 69 paleopoles ranging in age from 243 to 43 Ma. The poles are from igneous rocks and certain sedimentary formations corrected for I error brought into North American coordinates using plate tectonic reconstructions. Key features of the new APW path are a 25° northward progression from 230 to 190 Ma to high latitudes (off northernmost Siberia) where the pole lingers until 160 Ma, a jump to the Aleutians followed by a hook in western Alaska by ~145 Ma that leads to the 130-60 Ma stillstand, after which the pole moves to its present position. As an example of the application of this new path we use paleomagnetic results to determine that southern Wrangellia and Stikinia (W/S), the two most westerly terranes in the Canadian Cordillera, lay 630 to 1650 km farther south than at present relative to the craton during the Late Triassic and Early Jurassic. This is consistent with an exotic Tethyan origin as paleontological and mantle geochemical evidences imply. During the Late Triassic through Early Cretaceous, W/S moved northward more slowly than the craton, implying oblique sinistral net convergence over this 130 Myr interval. This was followed by dextral shear in latest Cretaceous through Eocene

Future benefits and applications of intelligent on-board processing to VSAT services

The trends and roles of VSAT services in the year 2010 time frame are examined based on an overall network and service model for that period. An estimate of the VSAT traffic is then made and the service and general network requirements are identified. In order to accommodate these traffic needs, four satellite VSAT architectures based on the use of fixed or scanning multibeam antennas in conjunction with IF switching or onboard regeneration and baseband processing are suggested. The performance of each of these architectures is assessed and the key enabling technologies are identified

An analysis of the interface between evolutionary algorithm operators and problem features for water resources problems. A case study in water distribution network design

Open Access articleEvolutionary Algorithms (EAs) have been widely employed to solve water resources problems for nearly two decades with much success. However, recent research in hyperheuristics has raised the possibility of developing optimisers that adapt to the characteristics of the problem being solved. In order to select appropriate operators for such optimisers it is necessary to first understand the interaction between operator and problem. This paper explores the concept of EA operator behaviour in real world applications through the empirical study of performance using water distribution networks (WDN) as a case study. Artificial networks are created to embody specific WDN features which are then used to evaluate the impact of network features on operator performance. The method extracts key attributes of the problem which are encapsulated in the natural features of a WDN, such as topologies and assets, on which different EA operators can be tested. The method is demonstrated using small exemplar networks designed specifically so that they isolate individual features. A set of operators are tested on these artificial networks and their behaviour characterised. This process provides a systematic and quantitative approach to establishing detailed information about an algorithm's suitability to optimise certain types of problem. The experiment is then repeated on real-world inspired networks and the results are shown to fit with the expected results.Engineering and Physical Sciences Research Council (EPSRC

Producers' Use of Crop Borders for Management of Potato Virus Y (PVY) in Seed Potatoes

Potato virus Y (PVY) is a very serious problem throughout most major seed potato producing states. Seed potato producers in Minnesota and North Dakota were surveyed in early 2005 to assess their perception of the profitability and risks associated with using crop borders to manage PVY in seed lots. Five of the 23 producers responding (a 25% response rate) said they had used crop borders in 2004. These 23 producers entered 152 seed lots into state seed certification programs. On average, producers had less than 0.1 seed lots rejected for PVY based on summer inspection. The average number of seed lots rejected in winter trials was 1.7. Of the 152 seed lots, these producers said they had entered into state seed certification programs, they reported detailed information on 108 lots. Generations 1 and 2 were the most likely generations to be protected by a crop border. Of these 108 seed lots, 104 passed summer inspection for PVY. Seventy-four percent of the 89 lots sent in for the winter test were reported to have passed. The use of crop borders was significant in explaining whether a seed lot had passed the winter test or not. Thirty-one (97%) of the 32 seed lots that were planted within a crop border passed the winter test while 31 (54%) of the 57 seed lots that were not planted with a crop border passed the winter test. No relationship was found between the choice of border crop and passing the winter test. Producers also were asked to state their agreement or disagreement with several statements regarding their knowledge and opinions on use of crop borders.Crop Production/Industries,

Tests of concrete and reinforced concrete column footings

Thesis (B.S.)--University of Illinois, 1911.Typescript