Partículas codificadas

La presente invención se refiere a una partícula codificada. Específicamente, la partícula codificada según la presente invención, comprende: a) al menos un núcleo metálico; b) un agente de marcaje unido a la superficie de dicho núcleo metálico, proporcionando un núcleo metálico marcado; c) una capa externa de un material inerte que encapsula a dicho núcleo metálico marcado; y d) al menos una biomolécula directamente o indirectamente unida a dicha capa externa. Además, la presente invención se refiere a un método para la preparación de una partícula codificada. Además, la presente invención se refiere a un método para la preparación de una microesfera y a la microesfera obtenida por el método. Además, la presente invención se refiere a un método para detectar materiales biológicos. Adicionalmente, la presente invención se refiere al uso de una partícula codificadaPeer reviewedUniversidad de VigoB1 Patente sin examen previ

Partículas codificadas

La presente invención se refiere a una partícula codificada. Específicamente, la partícula codificada según la presente invención, comprende: a) al menos un núcleo metálico; b) un agente de marcaje unido a la superficie de dicho núcleo metálico, proporcionando un núcleo metálico marcado; c) una capa externa de un material inerte que encapsula a dicho núcleo metálico marcado; y d) al menos una biomolécula directamente o indirectamente unida a dicha capa externa. Además, la presente invención se refiere a un método para la preparación de una partícula codificada. Además, la presente invención se refiere a un método para la preparación de una microesfera y a la microesfera obtenida por el método. Además, la presente invención se refiere a un método para detectar materiales biológicos. Adicionalmente, la presente invención se refiere al uso de una partícula codificadaPeer reviewedUniversidad de VigoB1 Patente sin examen previ

Silicon particles as trojan horses for potential cancer therapy

[EN] Background: Porous silicon particles (PSiPs) have been used extensively as drug delivery systems, loaded with chemical species for disease treatment. It is well known from silicon producers that silicon is characterized by a low reduction potential, which in the case of PSiPs promotes explosive oxidation reactions with energy yields exceeding that of trinitrotoluene (TNT). The functionalization of the silica layer with sugars prevents its solubilization, while further functionalization with an appropriate antibody enables increased bioaccumulation inside selected cells. Results: We present here an immunotherapy approach for potential cancer treatment. Our platform comprises the use of engineered silicon particles conjugated with a selective antibody. The conceptual advantage of our system is that after reaction, the particles are degraded into soluble and excretable biocomponents. Conclusions: In our study, we demonstrate in particular, specific targeting and destruction of cancer cells in vitro. The fact that the LD50 value of PSiPs-HER-2 for tumor cells was 15-fold lower than the LD50 value for control cells demonstrates very high in vitro specificity. This is the first important step on a long road towards the design and development of novel chemotherapeutic agents against cancer in general, and breast cancer in particular.The authors acknowledge financial support from the following projects FIS2009-07812, MAT2012-35040, PROMETEO/2010/043, CTQ2011-23167, CrossSERS, FP7 MC-IEF 329131, and HSFP (project RGP0052/2012) and Medcom Tech SA. Xiang Yu acknowledges support by the Chinese government (CSC, Nr. 2010691036).Fenollosa Esteve, R.; Garcia-Rico, E.; Alvarez, S.; Alvarez, R.; Yu, X.; Rodriguez, I.; Carregal-Romero, S.... (2014). Silicon particles as trojan horses for potential cancer therapy. 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Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

Joint Observation of the Galactic Center with MAGIC and CTA-LST-1

MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes (IACTs), designed to detect very-high-energy gamma rays, and is operating in stereoscopic mode since 2009 at the Observatorio del Roque de Los Muchachos in La Palma, Spain. In 2018, the prototype IACT of the Large-Sized Telescope (LST-1) for the Cherenkov Telescope Array, a next-generation ground-based gamma-ray observatory, was inaugurated at the same site, at a distance of approximately 100 meters from the MAGIC telescopes. Using joint observations between MAGIC and LST-1, we developed a dedicated analysis pipeline and established the threefold telescope system via software, achieving the highest sensitivity in the northern hemisphere. Based on this enhanced performance, MAGIC and LST-1 have been jointly and regularly observing the Galactic Center, a region of paramount importance and complexity for IACTs. In particular, the gamma-ray emission from the dynamical center of the Milky Way is under debate. Although previous measurements suggested that a supermassive black hole Sagittarius A* plays a primary role, its radiation mechanism remains unclear, mainly due to limited angular resolution and sensitivity. The enhanced sensitivity in our novel approach is thus expected to provide new insights into the question. We here present the current status of the data analysis for the Galactic Center joint MAGIC and LST-1 observations

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

Una mirada prospectiva de la industria Risaraldense camino a la industria 4.0 : plan tecnológico 2020–2030 Centro de Diseño e Innovación Tecnológico Industrial

Se presenta el plan tecnológico del Centro de Diseño e Innovación Tecnológico Industrial del SENA para la vigencia 2002 - 2030. Comprende el análisis y diagnóstico de la industria risaraldense, sus necesidades y tendencias, con enfoque a la industria 4.0. Se provee información para: identificar tecnologías y ocupaciones emergentes que permitan anticipar la definición de perfiles de instructores, determinar requerimientos de modernización de infraestructura física y tecnológica del Centro de formación, actualizar, crear o eliminar programas de formación, establecer el tipo de formación, servicios tecnológicos e innovación que el centro de formación ofrecerá en un horizonte de 10 años e identificar los proyectos y actores estratégicos para el centro de formación.The technological plan of the SENA Industrial Technological Design and Innovation Center for the period 2002-2030 is presented. It includes the analysis and diagnosis of the Risaralda industry, its needs and trends, with a focus on industry 4.0. Information is provided to: identify emerging technologies and occupations that allow anticipating the definition of instructor profiles, determine modernization requirements of the physical and technological infrastructure of the Training Center, update, create or eliminate training programs, establish the type of training, services technology and innovation that the training center will offer over a 10-year horizon and identify projects and strategic actors for the training center.Fase I: análisis y diagnóstico estratégico -- Análisis externo del centro de formación -- Análisis interno del centro de formación -- Seguimiento al plan tecnológico inmediatamente anterior -- Cruce DOFA -- Vigilancia científico -tecnológica y competitiva especialidad energía eléctrica -- Vigilancia científico -tecnológica y competitiva especialidad electrónica y automatización -- Vigilancia científico -tecnológica y competitiva especialidad Mecánica Industrial -- Vigilancia científico -tecnológica y competitiva especialidad Informática, diseño y desarrollo de software -- Vigilancia científico -tecnológica y competitiva especialidad materiales para la industria -- Vigilancia científico -tecnológica y competitiva especialidad Automotor -- Vigilancia científico -tecnológica y competitiva especialidad Textil, confección y diseño -- Vigilancia científico -tecnológica y competitiva especialidad construcción e infraestructura -- Vigilancia científico -tecnológica y competitiva servicios tecnológicos -- Fase II: formulación estratégica -- Mapa de trayectoria tecnológica -- Validación con expertos -- Construcción de escenarios -- Formulación estratégica -- Métodos prospectivos utilizados -- Formulación estratégica -- Fase III: recomendaciones estratégicas -- Recomendaciones estratégicas especialidad energía eléctrica -- Recomendaciones estratégicas especialidad electrónica y automatización -- Recomendaciones estratégicas especialidad mecánica industrial -- Recomendaciones estratégicas especialidad Informática, diseño y desarrollo de software -- Recomendaciones estratégicas especialidad materiales para la industria -- Recomendaciones estratégicas especialidad Automotor -- Recomendaciones estratégicas especialidad Textil, confección y diseño -- Recomendaciones estratégicas especialidad construcción e infraestructura -- Recomendaciones estratégicas Sennova -- Servicios tecnológicos -- Introducción e información general -- Planteamiento de la necesidad u oportunidad -- Objetivos -- Desarrollo de la vigilancia científico-tecnológica -- Resultados de vigilancia tecnológica con base en análisis de patentes -- Identificación de tecnologías y sublíneas tecnológicas -- Comportamiento de los aceros -- Vigilancia normativa y regulatoria -- Vigilancia tecnológica -- Vigilancia competitiva -- Vigilancia comercial -- Resultados -- Conclusiones y recomendacionesna556 página