A signomial programming approach for binary image restoration by penalized least squares

The authors present a novel optimization approach, using signomial programming (SP), to restore noise-corrupted binary and grayscale images. The approach requires the minimization of a penalized least squares functional over binary variables, which has led to the design of various approximation methods in the past. In this brief, we minimize the functional as a SP problem which is then converted into a reversed geometric programming (GP) problem and solved using standard GP solvers. Numerical experiments show that the proposed approach restores both degraded binary and grayscale images with good accuracy, and is over 20 times faster than the positive semidefinite programming approach. © 2007 IEEE.published_or_final_versio

Aberration-aware robust mask design with level-set-based inverse lithography

Optical proximity correction (OPC) is one of the most widely used Resolution Enhancement Techniques (RET) in mask designs. Conventional OPC is often designed for a set of nominal imaging parameters without giving sufficient attention to the process variations caused by aspherical wavefront leaving the exit pupil of the lithography system. As a result, the mask designed may deliver poor performance with process variations. In this paper, we first describe how a general point spread function (PSF) with wave aberration can degrade the output pattern quality, and then show how the wave aberration function can be incorporated into an inverse imaging framework for robust input mask pattern design against aberrations. A level-set-based time-dependent model can then be applied to solve it with appropriate finite difference schemes. The optimal mask gives more robust performance against either one specific type of aberration or a combination of different types of aberrations. © 2010 SPIE.published_or_final_versionThe Photomask and Next-Generation Lithography Mask Technology XVII, Yokohama, Japan, 13-14 April 2010. in Proceedings of SPIE, 2010, v. 7748, article no. 77481U, p. 1-

Robust level-set-based inverse lithography

Level-set based inverse lithography technology (ILT) treats photomask design for microlithography as an inverse mathematical problem, interpreted with a time-dependent model, and then solved as a partial differential equation with finite difference schemes. This paper focuses on developing level-set based ILT for partially coherent systems, and upon that an expectation-orient optimization framework weighting the cost function by random process condition variables. These include defocus and aberration to enhance robustness of layout patterns against process variations. Results demonstrating the benefits of defocus-aberration-aware level-set based ILT are presented. © 2011 Optical Society of America.published_or_final_versio

A total variation regularization based super-resolution reconstruction algorithm for digital video

Super-resolution (SR) reconstruction technique is capable of producing a high-resolution image from a sequence of low-resolution images. In this paper, we study an efficient SR algorithm for digital video. To effectively deal with the intractable problems in SR video reconstruction, such as inevitable motion estimation errors, noise, blurring, missing regions, and compression artifacts, the total variation (TV) regularization is employed in the reconstruction model. We use the fixed-point iteration method and preconditioning techniques to efficiently solve the associated nonlinear Euler-Lagrange equations of the corresponding variational problem in SR. The proposed algorithm has been tested in several cases of motion and degradation. It is also compared with the Laplacian regularization-based SR algorithm and other TV-based SR algorithms. Experimental results are presented to illustrate the effectiveness of the proposed algorithm.£.published_or_final_versio

The role of mass spectrometry in hepatocellular carcinoma biomarker discovery

Hepatocellular carcinoma (HCC) is the main liver malignancy and has a high mortality rate. The discovery of novel biomarkers for early diagnosis, prognosis, and stratification purposes has the potential to alleviate its disease burden. Mass spectrometry (MS) is one of the principal technologies used in metabolomics, with different experimental methods and machine types for different phases of the biomarker discovery process. Here, we review why MS applications are useful for liver cancer, explain the MS technique, and briefly summarise recent findings from metabolomic MS studies on HCC. We also discuss the current challenges and the direction for future research

A study of time variability of surface currents at a point in Monterey Bay.

The geomagnetic electrokinetograph (GEK) was used to measure surface currents near the center of Monterey Bay during six separate 24-hour periods from May through July, 1972. An average of 244 current vectors were derived for each cruise. The mean currents from these cruises are all southerly and ranged from 4.1 cm/sec to 20.4 cm/sec. The average of these mean currents is 12.1 cm/sec toward 163 °T. These values were compared with individual currents derived from dynamic topographies from the same period. Diurnal and semi-diurnal variations of the current were studied after subjecting the data to a fourier analysis. It was concluded that there must be at least an indirect coupling of the ocean currents with the semi-diurnal tide at the data point. The diurnal component also is important; it may be tidal or inertial, or merely related to the passage of the sun.http://archive.org/details/studyoftimevaria00howtLieutenant, United States NavyApproved for public release; distribution is unlimited

In search of multipolar order on the Penrose tiling

Based on Monte Carlo calculations, multipolar ordering on the Penrose tiling, relevant for two-dimensional molecular adsorbates on quasicrystalline surfaces and for nanomagnetic arrays, has been analyzed. These initial investigations are restricted to multipolar rotors of rank one through four - described by spherical harmonics Ylm with l=1...4 and restricted to m=0 - positioned on the vertices of the rhombic Penrose tiling. At first sight, the ground states of odd-parity multipoles seem to exhibit long-range multipolar order, indicated by the appearance of a superstructure in the form of the decagonal Hexagon-Boat-Star tiling, in agreement with previous investigations of dipolar systems. Yet careful analysis establishes that long-range multipolar order is absent in all cases investigated here, and only short-range order exists. This result should be taken as a warning for any future analysis of order in either real or simulated arrangements of multipoles on quasiperiodic templates

Motivations of women who organized others for prostitution: Evidence from a female prison in China

This article discusses women’s involvement in sex work management – an offence defined under section 358 of the 1997 Chinese Criminal Law and one of the re-emerged areas of illegality following the economic reforms since 1978. It first provides the historical context, legislative background and relevant sections of the Chinese vice laws so as to help make sense of the data obtained. Then it discusses the methodological issues before presenting the empirical findings to explore the socio-demographic profile of the incarcerated female sex work organizers who participated in this study and their motivations for organizing others for prostitution. Based on empirical data, this article explores the impact of social conditions on female offenders in China’s reform era and also the effects of the anti-prostitution policy in the country. Moreover, through a Chinese case study, it makes contributions to broader scholarship on the sex trade regulation. It concludes with a couple of implications for policy and practice

Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population

BACKGROUND: Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern China. In addition to environmental factors such as Epstein-Barr virus infection and diet, genetic susceptibility has been reported to play a key role in the development of this disease. The x-ray repair cross-complementing group 1 (XRCC1) gene is important in DNA base excision repair. We hypothesized that two common single nucleotide polymorphisms of XRCC1 (codons 194 Arg→Trp and 399 Arg→Gln) are related to the risk of NPC and interact with tobacco smoking. METHODS: We sought to determine whether these genetic variants of the XRCC1 gene were associated with the risk of NPC among the Cantonese population in a hospital-based case control study using polymerase chain reaction-restriction fragment length polymorphism analysis. We conducted this study in 462 NPC patients and 511 healthy controls. RESULTS: After adjustment for sex and age, we found a reduced risk of developing NPC in individuals with the Trp194Trp genotype (OR = 0.48; 95% CI, 0.27–0.86) and the Arg194Trp genotype (OR = 0.79; 95% CI, 0.60–1.05) compared with those with the Arg194Arg genotype. Compared with those with the Arg399Arg genotype, the risk for NPC was not significantly different in individuals with the Arg399Gln genotype (OR = 0.82; 95% CI, 0.62–1.08) and the Gln399Gln genotype (OR = 1.20; 95% CI, 0.69–2.06). Further analyses stratified by gender and smoking status revealed a significantly reduced risk of NPC among males (OR = 0.32; 95% CI, 0.14–0.70) and smokers (OR = 0.34; 95% CI, 0.14–0.82) carrying the XRCC1 194Trp/Trp genotype compared with those carrying the Arg/Arg genotype. No association was observed between Arg399Gln variant genotypes and the risk of NPC combined with smoking and gender. CONCLUSION: Our findings suggest that the XRCC1 Trp194Trp variant genotype is associated with a reduced risk of developing NPC in Cantonese population, particularly in males and smokers. Larger studies are needed to confirm our findings and unravel the underlying mechanisms

Differential Conservation and Divergence of Fertility Genes boule and dazl in the Rainbow Trout

10.1371/journal.pone.0015910PLoS ONE61