The First Impact Factor of the European Journal of Therapeutics

Dear Colleagues, The statement made by Journal Citation Reports on 26 July 2022, it was reported that some important updates in the journal metrics will be published in 2023 [1]. The most striking of these changes was that the journal impact factor would now be calculated, including journals from the Arts and Humanities Citation Index (AHCI) and the Emerging Sources Citation Index (ESCI). On 28 June 2023, the current metrics of the journals indexed in the Web of Science were shared by the Journal Citation Reports for 2022 [2]. As it is known, the European Journal of Therapeutics is indexed in the ESCI and is included in the Category of Medicine, General & Internal. Therefore, the impact factor was calculated for the European Journal of Therapeutics for the first time. According to the report recently announced by Journal Citation Reports, the impact factor of the European Journal of Therapeutics for 2022 is 0.3 (Fig. 1) [3]. In addition, the European Journal of Therapeutics ranks ninetieth among one hundred fifty-seven (90/157) in the Category of Medicine, General & Internal, and ESCI-indexed journals [4]. Although the first impact factor declared for the European Journal of Therapeutics is 0.3 is not a bad value, it is an inevitable reality that it should be better. On the other hand, in previous editorials [5, 6], it was reported that the articles accepted in the European Journal of Therapeutics were now published as Accepted / Early Views Articles quickly [6]. In addition, it was stated that the editorial team was enriched with many internationally important academicians in their fields [5]. Moreover, there will be various revisions and improvements planned to be made to the journal's publication policy in the near future. We think these improvements may play an essential role in increasing the impact factor of the European Journal of Therapeutics in the long term. Yours sincerel

Editorial: From the Incoming Editors of the European Journal of Therapeutics (Eur J Ther)

Dear Colleagues, We are delighted to share the new issue (June 2023, volume 29, Issue 2) of the European Journal of Therapeutics (Eur J Ther). Furthermore, we are honored to be appointed as the New Editor-in-Chief and New Deputies Editor-in-Chief of Eur J Ther, the international publication of the Gaziantep University Faculty of Medicine published since 1990. First, we would like to thank the previous Editor-in-Chief, Prof. M. Murat Sucu, and his team for their hard work during their tenure. They significantly increased its contribution to the field and international reputation by further developing the journal. In addition, we would like to express our gratitude to all the editors, authors, referees, and technical team who have contributed to the journal since 1990, when our journal first started being published. Unfortunately, due to the change of publishing house, there were some technical problems and interruptions on the web page of Eur J Ther in the first few months of 2023. So, we regret to inform you that there are delays in the evaluation stages of some manuscripts sent to the journal. However, we would like to let you know that from now on, your valuable works submitted to Eur J Ther will be evaluated as quickly as possible. In addition, we would like to announce that all articles accepted for publication in our journal, which is considered an essential innovation, will be published on the web page of our journal as Early View / Accepted Articles in a short time. This innovation will expedite the citation process for your publications. As the New Editor-in-Chief and New Deputies Editor-in-Chief, we aim to increase the quality and visibility of Eur J Ther and to improve its indexes. We want to remind you that the journal’s target audience is researchers, physicians, and health professionals interested in or working in all medical and dental disciplines. Therefore, we request you submit your valuable research to Eur J Ther to contribute to the development and content of the journal. Sincerely yours

Evaluation of the diagnostic value of platelet indices in pediatric acute appendicitis

Objective: Abdominal examination findings in pediatric acute appendicitis (AA) significantly vary by age. Therefore, grading systems have been developed for diagnosing pediatric appendicitis, and laboratory and radiological findings have an important role in this diagnosis. However, there is a need to develop new parameters for diagnosing AA. This study aimed to investigate the diagnostic value of platelet indices in AA. Methods: This retrospective, observational study included 207 pediatric patients who were admitted to the Emergency Department and operated on for AA. The patients were divided into three groups on the basis of their surgical and histopathological findings (non-AA, uncomplicated AA, and complicated AA). Results: There was no significant difference in the mean platelet volume/platelet count (MPV/PC) ratio among the groups. The white blood cell (WBC) count and the MPV/PC ratio showed a significant negative relationship (r = −0.239). The specificity for MPV was 61.8% and the sensitivity was 68.8%. Receiver operating curve analysis of WBC and MPV showed significance for diagnosing AA. Conclusion: There is a negative, but weak, relationship between the WBC count and the MPV/PC ratio. However, the MPV/PC ratio could be a useful parameter for diagnosing pediatric AA according to receiver operating curve analysis. © The Author(s) 2020

Evaluation of forensic cases admitted to Cumhuriyet University hospital

AMAÇ: Bu çalışmada; adli olguların demografik özellikleri ile adli olgu profilinin ortaya çıkarılması yanı sıra; hekimlerin adli rapor düzenleme aşamasında standardizasyonunun sağlanmasının adli tıp uygulamaları ve yargılama aşamasındaki öneminin vurgulanması amaçlandı. GEREÇ ve YÖNTEM: Bu çalışma; 01.01.2006-31.12.2006 tarihleri arasında Cumhuriyet Üniversitesi Tıp Fakültesi Adli TıpAnabilim Dalı'na adli rapor düzenlenmesi için adli makamlardan gönderilen olguların hastane dosyaları ile adli raporlarının retrospektif olarak incelenmesiyle yapılmıstır. Olguların tıbbi ve adli kayıtları; cinsiyet, yaş, olay türü, olay tarihi, olay yeri, gönderilen makam, yaralanan vücut bölgesi, tedavi olduğu servis, zehirlenme ve cinsel saldırı yönünden, ayrıca adli rapordaki sonuç raporları yönünden değerlendirilerek benzer çalışmalarla karşılastırıldı. BULGULAR: 1,296 olgunun %76.8'i erkekti. Olguların çoğunlukla genç ve orta yaş grubunda olduğu belirlendi. Adli olguların özellikle ağustos ayında (%10.9) daha yoğun olduğu ve çoğunlukla acil serviste (%29.9) tanı ve tedavi sonrası taburcu edildikleri saptandı.Yaşamsal tehlikeye neden olacak yaralanma oranı ise %17.4 olarak tespit edildi. Yaralanmaların en sık (%44.6) baş-boyun bölgesinde olduğu, %30.8 ile trafik kazalarının adli olguların önemli bir kısmını olusşturduğu gözlendi. SONUÇ: Hekim güvenliği ve hasta mağduriyetinin önlenmesi açısından adli olguların özellikle raporlama aşamasının daha özenli yapılması için mezuniyet sonrası adli tıp eğitimi ve adli tıp uzmanları ile koordineli çalışma gereklidir.OBJECTIVE: The aim of this study is to reveal demographic properties and profile of forensic cases in addition to emphasize the importance of forensic report standardization in forensic medical practises and judicial process. MATERIALS and METHODS: This study, were reviewed retrospectively hospital files and forensic reports of cases who have been sent to Cumhuriyet University Medical Faculty Department of Forensic Medicine from by judicial authorities for organizing the forensic reports between the dates 01.01.2006-31.12.2006. The medical and judicial data that were evaluated according to gender, age, event type, event date, event location, sent to the authorities, injuring the body regions, the treatment services, intoxication, sexual assaults and also the results of forensic reports were compared with similar studies. RESULTS: Among 1.296 patients 76.8% were men. Most of the cases were young and middle aged group. Forensic cases were higher in number especially in August (10.9%) and discharged following diagnosis and treatment in emergency services (29.9%). Injuries with vital severity were identified as 17.4%. Injuries were most frequent (44.6%) at head-neck region and a significant ratio of forensic cases were caused by traffic accidents (%30.8). CONCLUSION: As a conclusion; to protect physcian and patients' rights, to control forensic reports more carefully, a coordinated study with forensic medical specialists is required during post graduation education of forensics

Procalcitonin and other acute phase reactants in patients with chronic obstructive pulmonary disease exacerbation

The aim of this study was to investigate the correlation between procalcitonin and other acute phase reactants, and also analyze their relationship with clinical situation in chronic obstructive pulmonary disease (COPD) acute exacerbations.Materials and methods: The study was made with 122 acute COPD exacerbated patients, who were admitted to emergency service. Patients with below 0.25 ng/ml PCT value included Group 1, and the patients with PCT values ≥ 0.25 ng/ml Group 2. Serum procalcitonin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) values and white blood cell (WBC) counts were measured. Also, patients hospitalization time and mortality rates were recorded and compared with PCT.Results: Patients were divided in 3 groups according to their clinical diagnosis; Pneumonia (n=27), Mycoplasma-Chlamydia pneumonia (n=11) and the patients with only COPD exacerbation(n=84). Mean PCT values according to the groups were 9.47 ± 8.1 ng/ml, 0.41 ± 0.2 ng/ml, and 0.21 ± 0.05 ng/ml respectively. The relationship between PCT with CRP and white blood cell has been found between significiant (p=0.001, p=0.005 respectively), whereas the relationship between PCT and ESR was nonsignificant (p=0.55). Procalcitonin and CRP had a positive correlation with the hospitalization time (p=0.034, p=0.022 respectively). The mean ± standard error of PCT for the patients who died was 28.3 ± 27.5 ng/ml, and the difference between patients who died or were discharged was statistically significant (p= 0.012).Conclusion: PCT can be a useful indicator for morbidity and prognosis in COPD patients

Matrix metalloproteinase-9, neuron-specific enolase, S100 B and tau protein levels in the patients with carbon monoxide poisoning

Background: S100B, NSE, MMP-9, and Tau protein levels increase in cases causing hypoxic cell damage. The diagnosis of the severity of carbon monoxide (CO) poisoning in the early period of these parameters was studied. Material and Methods: COHb level measurement was made using a signal capture CO-pulse oximeter (Masimo's SET Rainbow, Masimo's Co, USA) at the first admission of the patients. Then, COHb levels were confirmed by arterial blood gas(ABG) analysis. The patients were divided into two groups as mild and moderate-severe, according to their Glasgow coma scores (GCS) [Mild (14–15); Moderate (9–13) or Severe (3–8)]. The control group was composed of 16 healthy and non-smoking volunteers. Results: The serum S100B protein and MMP-9 values at 0 hr of admission in the hospital and 3hr of treatment were not significantly different in the patient group as compared to the control group. Tau protein levels were significantly higher in the patient group at 0 and 3 hours (p> 0.05) as compared to healthy person. Conclusion: There was no relationship between CO poisoning and MMP-9 and S100B protein levels. NSE and Tau protein were significantly higher in the patient group than the control group. Tau protein may be more useful marker as compared to neuron-specific enolase.Firat University Scientific Research Projects Management Uni

Welcome to the December 2023 Issue (Vol:29, No:4) and Current News of the European Journal of Therapeutics

Dear Colleagues, In this editorial, we would like to share with you important developments in the European Journal of Therapeutics (Eur J Ther). First of all, as the editorial team, we would like you to know that we hold frequent meetings to benefit our esteemed colleagues and continue to work with great devotion in line with our goal of taking the journal further. We have previously shared with you that we have applied to many indexes. It is with great pleasure that we would like to inform you that in the last few months, more of our index applications have been approved. Index Copernicus, as a result of this application, the ICV 2022 value of our journal was determined to be 100 (approved 2023-10-31) [1] BASE (Bielefeld Academic Search Engine) (approved 2023-11-30) [2] Sherpa Romeo (approved 2023-09-27) [3] MIAR (approved 2023-10-16) [4] All indexes in our journal are currently included on the journal web page [5]. As the editorial team, we would like to inform you that we have determined a policy on this issue for our journal [6], taking into account the recommendations of important international ethics committees such as the Committee on Publication Ethics (COPE) [7] and the World Association of Medical Editors (WAME) [8], which have recently become a trendy topic of discussion about AI chatbots and academic studies prepared with the support of such tools. As you know, when our journal was founded in 1990 [9], it was published in two yearly issues. It is an essential responsibility for us to carry our journal, which continued its publication life with three issues a year in 2009 [10] and four issues a year in 2014 [11]. With your valuable support, we would like to announce that we will increase our journal to 6 issues a year as of 2024 (February, April, June, August, October and December) with the rapidly growing progress of our journal. Unfortunately, we cannot share the names of the referees who made significant contributions to our journal in 2023 due to the changes in the article submission interface during the year and the inaccessibility of some data in the previous interface. However, we would like to emphasize again that we are grateful to all of them for their valuable contributions. Moreover, to expand our journal's referee list, we would like to remind you that competent academics who volunteer in this regard can fill out the “Become a Reviewer for the European Journal of Therapeutics” form [12]. Finally, we would like to point out that we have strengthened our editorial team with an academician competent in dentistry, Fatih Sari, DDS, PhD. Fatih Sari, DDS, PhD, is a new Editorial Board Member of the Eur J Ther. Dr. Sari is an Associate Professor in the Department of Prosthodontics at the Gaziantep University Faculty of Dentistry. He is a Vice Dean of the Faculty of Dentistry and Head of Clinical Departments. Dr. Sari is a prosthodontist and a member of the Turkish Dental Association. He has experience in implant-supported fixed prostheses, Cad/Cam applications and dental materials. We look forward to being able to offer you a large number of high-quality and valuable articles over the coming year. In addition, we would like to thank the readers, authors and reviewers of the Eur J Ther for their continuous support. Sincerely yours

The Clinical Significiance of Multimarker Index for Early Diagnosis Among the Patients Admitted to the Emergency Department with Suspected Stroke

Objective: Cerebrovascular diseases have a high rate in emergency services. We investigated the value of MMX in plasma for early diagnosis among the patients with suspected cerebrovascular disease and the correlation between the emergency, triage and neurology physician diagnoses. Material and Methods: It is a prospective study carried out with 83 patients. Pre-prepared forms were filled with the data about the patients. Samples of 1cc venous blood were measured for MMX and the results classified as normal or pathologic. The correlation between the results and physician diagnosis was investigated. Results: 44 (53%) of 83 patients were male, 39 (47%) were female. The average age was 69.1 (37-90) years. Neurology physician diagnosis, accepted as the gold standard, was compared with the triage, emergency physician diagnosis and MMX results by ROC curve analysis, and the difference was not significiant (p>0.05). When the diagnoses of the emergency physician were compared with the MMX results, the compatiblity for definite and probable strokes were 100% and 92.1%. The rates for triage physician were 100% and 96.4%. Conclusion: As a result of this study we can say that the stroke probablity is high if MMX is high in patients with suspected cerebrovascular disease, but more studies with large population groups are needed for specifity assessment

Stranger in the garden: Ricinus communis, 17 cases of intoxication

Introduction: Ricinus communis is used as a decoration in landscape gardening in Turkey. In industrialized countries, however, it is used in many sectors, including the chemical, pharmaceutical, and fertilizer sectors; it is also used in cosmetics and biodiesel fuel production. In this presentation, 17 patients who ingested R. communis seeds are examined. Cases: Seventeen patients who ate the seeds of an unknown plant that grows in their gardens came to the emergency department with nausea, vomiting, and stomach ache complaints 4 h after ingesting the seeds. All patients were admitted to the critical care unit, monitored, and started on supportive treatment. After the treatment, patients’ vital signs and laboratory parameters were stable. Seven patients were discharged the next day upon the regression of symptoms. The remaining 10 patients were successfully discharged 2 days after the treatment. There are cases in medical literature where consumption of one-half of a R. communis seed resulted in death. In our presentation, each patient consumed one to four (2.18 on average) R. communis seeds, and the symptoms were over within 2 days. The clinical course ended without any cases of death, and all patients were discharged in good condition. Conclusion: Emergency physicians have to know the clinical course and medical methods regarding intoxication due to oral consumption of toxic plants. Severe toxicity and even mortality can be observed with the ingestion of the seeds of the plant. Similar symptoms (nausea, vomiting, and abdominal pain) were observed in all our cases, but no mortality was observed

MUSHROOM POISONING: RETROSPECTIVE ANALYSIS OF 294 CASES

OBJECTIVE: The objective of this study was to present special clinical and laboratory features of 294 cases of mushroom poisoning