27 research outputs found
c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines
- Author
- A Gartland
- A Liedert
- A Trümper
- AE Grigoriadis
- BM Wice
- C Kaebisch
- C Meier
- CJ Dixon
- D Xie
- DB Henriksen
- DB Henriksen
- DB Henriksen
- DJ Drucker
- E Velázquez
- EL Pacheco-Pantoja
- Elda Leonor Pacheco-Pantoja
- IR Orriss
- IR Orriss
- J Kim
- J Parker
- James A. Gallagher
- Jane P. Dillon
- JE Koch
- JV Zhang
- KA Buckley
- M-C Beauvieux
- MC Bunck
- MJ Hayton
- Peter J. M. Wilson
- RJ Bollag
- S Sasaki-Hamada
- S Sasaki-Hamada
- S Susini
- T Inhoff
- T Tsuboi
- WB Bowler
- William D. Fraser
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 20/07/2016
- Field of study
It is widely accepted that the c-Fos gene has a role in proliferation and differentiation of bone cells. ATP-induced c-Fos activation is relevant to bone homeostasis, because nucleotides that are present in the environment of bone cells can contribute to autocrine/paracrine signalling. Gut hormones have previously been shown to have an effect on bone metabolism. In this study, we used the osteoblastic Saos-2 cell line transfected with a c-Fos-driven reporter stimulated with five gut hormones: glucose inhibitory peptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), ghrelin and obestatin, in the presence or absence of ATP. In addition, TE-85 cells were used to determine the time course of c-Fos transcript induction following stimulation with GLP-1, and GLP-2 with or without ATP, using reverse transcription qPCR. The significant results from the experiments are as follows: higher level of c-Fos induction in presence of GIP, obestatin (p = 0.019 and p = 0.011 respectively), and GIP combined with ATP (p < 0.001) using the luciferase assay; GLP-1 and GLP-2 combined with ATP (p = 0.034 and p = 0.002, respectively) and GLP-2 alone (p < 0.001) using qPCR. In conclusion, three of the gut peptides induced c-Fos, providing a potential mechanism underlying the actions of these hormones in bone which can be directed or enhanced by the presence of ATP
Circulating microRNAs as potential diagnostic biomarkers for osteoporosis
- Author
- A Bedene
- A Svedbom
- A Turchinovich
- A Zimmer
- AD Anastasilakis
- AJ Wijnen van
- BP Lewis
- C Guay
- C Sanchez
- C Seeliger
- DTK Phuong
- E Hernlund
- EL Pacheco-Pantoja
- EM Rosset
- F Massicotte
- H Dweep
- H Gu
- H Li
- I Bab
- J Peppel van de
- JB Lian
- KJ Livak
- L He
- L Panach
- M Bruderer
- MJ Oursler
- MM Cohen Jr.
- MP Yavropoulou
- MV Kuleshov
- N Harvey
- N Ludwig
- NH Kulkarni
- P Garmilla-Ezquerra
- R Kocijan
- R Kong
- S Chowdhari
- S Pradervand
- S Seitz
- S Weilner
- SC Manolagas
- T Komori
- TS Lisse
- U Heilmeier
- Z Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 24/05/2018
- Field of study
Osteoporosis is the most common age-related bone disease worldwide and is usually clinically asymptomatic until the first fracture happens. MicroRNAs are critical molecular regulators in bone remodelling processes and are stabilised in the blood. The aim of this project was to identify circulatory microRNAs associated with osteoporosis using advanced PCR arrays initially and the identified differentially-expressed microRNAs were validated in clinical samples using RT-qPCR. A total of 161participants were recruited and 139 participants were included in this study with local ethical approvals prior to recruitment. RNAs were extracted, purified, quantified and analysed from all serum and plasma samples. Differentially-expressed miRNAs were identified using miRNA PCR arrays initially and validated in 139 serum and 134 plasma clinical samples using RT-qPCR. Following validation of identified miRNAs in individual clinical samples using RT-qPCR, circulating miRNAs, hsa-miR-122-5p and hsa-miR-4516 were statistically significantly differentially-expressed between non-osteoporotic controls, osteopaenia and osteoporosis patients. Further analysis showed that the levels of these microRNAs were associated with fragility fracture and correlated with the low bone mineral density in osteoporosis patients. The results show that circulating hsa-miR-122-5p and hsa-miR-4516 could be potential diagnostic biomarkers for osteoporosis in the future
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
- Abdallah J
- Abdul Ghani R
- Abdul Kadir K
- Abdullah R
- Abejuela Z
- Abouglila K
- Abraham O
- Abrahamsen I
- Abraira Munoz Ld
- Abramowitz M
- Abusnana S
- Accini Mendoza Jl
- Acosta I
- Agafyina A
- Agarwal R
- Agarwal Rajiv
- Aggarwal N
- Agra J
- Ahmed F
- Ahuad Guerrero Ra
- Aiello J
- Ainsworth P
- Aizenberg D
- Akiyama H
- Akright L
- Akyea-Djamson A
- Al-Karadsheh A
- Alamartine E
- Alappan R
- Albisu Jp
- Ali N
- Ali Z
- Alicic R
- Allison Dc
- Alvarez Garcia P
- Alvarisqueta A
- Alves da Costa Fa
- Amerena J
- Amigo A
- Amodeo C
- Andreeva V
- Andreotti Turatti La
- Angelescu Lm
- Angelova A
- Anghel V
- Antic S
- Aoki H
- Aquitania G
- Arauz-Pacheco C
- Arcos E
- Arfeen S
- Arif A
- Aronson R
- Arutchelvam V
- Arvind M
- Asano A
- Asmarats Mercadal L
- Atray N
- August P
- Avendano J
- Avram Ri
- Awad A
- Babikova J
- Badat A
- Bajaj H
- Baker J
- Bakris G
- Bakris George
- Barbarash O
- Barna O
- Barnard M
- Barnhill P
- Barranco E
- Barrera C
- Barrios C
- Bartaskova D
- Bartolacci I
- Barton P
- Barysheva O
- Beacom M
- Behara V
- Bellary S
- Belo D
- Belobradkova J
- Bentley-Lewis R
- Benusova O
- Berenguer R
- Berli Ma
- Bermudez L
- Bernardo M
- Bhushan Rs
- Bijata-Bronisz R
- Bilyk Sd
- Bin Shudim Ss
- Biscoveanu M
- Bompoint Severine
- Bonadonna R
- Bordonava A
- Borot S
- Botsyurko V
- Bowman-Stroud C
- Brandon D
- Breedt J
- Bregman R
- Brenner Barry M
- Brenner Bm
- Brusco O
- Buganova I
- Bull Scott
- Burst V
- Busch R
- Busegeanu Mm
- Calella P
- Camelo Sanches Fc
- Canaan Y
- Canani Lh
- Cannon Christopher P
- Cannon Cp
- Cantero Mc
- Capuano George
- Caringal C
- Cariou B
- Cartasegna Lr
- Castellino P
- Cercos E
- Cereto Castro F
- Ceriello A
- Chacra Ar
- Chae Dw
- Chang Ct
- Chang T
- Chapin L
- Charytan David M
- Charytan Dm
- Che Yusof Md
- Cheifetz A
- Chen E
- Chen N
- Chen Q
- Cherney D 3rd
- Chertow G
- Cheung Nw
- Chilito A
- Chiovato L
- Chizhov D
- Cho Ym
- Chouinard G
- Christensen T
- Christiano C
- Christofides E
- Chu Pei-Ling
- Chuang Lm
- Chuateco C
- Cif A
- Cigarran Guldris S
- Coffee L
- Cohen K
- Cohen R
- Cohen S
- Cohen-Stein D
- Coloma Gc
- Colombo H
- Comia Rs
- Commendatore V
- Conway J
- Cook C
- Correa Rotter Jr
- Cosma D
- Cournoyer S
- Coyne D
- Crisan C
- Cruz Jb
- Csecsei G
- Csiky B
- Cuadrado J
- Culak J
- Cuneo Ca
- Cunha Borges Jl
- Cunha V\ueancio Sa
- Cusumano Am
- D'Avila D
- da Silva Franco Rj
- Daboul N
- Danos P
- Daroza G
- Darwish R
- Daswani A
- David C
- Davies E
- Davies M
- Davies S
- Dawson A
- De Brouwer K
- de Carvalho Contieri Fl
- De Cosmo S
- De Nicola L
- De Serres S
- de Souza Portes E
- de Souza P
- de Zeeuw D
- de Zeeuw Dick
- Deak L
- Deboni Lm
- Deck K
- Deepak D
- Delos Santos L
- Demian Ld
- Derosa G
- Desouza C
- Destree M
- Dev D
- Dhillon M
- Di Carlo A
- Di Cianni G
- Diaz Escalante T
- Diaz Ruiz Jea
- Dimitrov S
- Distiller L
- Distiller L
- Djordjevic M
- Dobronravov V
- Dohnalova L
- Dominquez Lopez M
- Douthat Wg
- Dran Rd
- Drasnar T
- Dreval A
- Droste C
- Dua S
- Dub\ue9 F
- Dudar I
- Dudas M
- Dussol B
- Dzupina A
- Dzuponova J
- Eder F
- Edwards Robert
- Edwin Fm
- Egido de Los Rios J
- El Kossi M
- El-Shahawy M
- Elosegui Am
- English P
- Enriquez Sosa Fe
- Ervin J
- Esquenazi A
- Evans J
- Faghih M
- Farias E
- Faulmann G
- Fauvel Jp
- Ferariu Ie
- Ferkl R
- Fern\ue1ndez Montenegro Ma
- Fernandez Fresnedo G
- Fernandez Mf
- Feuerstein J
- Filho Ff
- Finkelstein H
- Fishbane S
- Flores Lozano F
- Flota Cervera Lf
- Fragale G
- Frasc\ue0 G
- Fraser D
- Fraser I
- Frenk Baron P
- Fretes Jo
- Frias J
- Fuiano G
- Fulcher G
- Fulop P
- Fushtey I
- G\uf3rriz Jl
- Gaglia J
- Galan Serrano A
- Galindo-Ramos E
- Galphin C
- Gambaro G
- Gan Cl
- Gan S
- Garcia Ballesteros C
- Garcia Ortiz Lh
- Garcia I
- Garcia Nh
- Garibotto G
- Gastaldi A
- Gaupsiene E
- Gelersztein E
- Geloneze Neto B
- Genadieva V
- Genova-Hristova G
- George S
- Ghazi A
- Giorda C
- Glenny Ja
- Glinkina I
- Gnudi L
- Godlevska O
- Godoy Jorquera Jg
- Goldenberg R
- Golovchenko O
- Gomes M
- Gomez Rangel Jd
- Gomez O
- Gonzalez Colaso Pdc
- Gonzalez Martinez Fj
- Gonzalez Orellana Ra
- Gonzalez A
- Gonzalez E
- Gonzalez Jp
- Gopalakrishnan N
- Gorelick P
- Gorson D
- Gourdy P
- Govender R
- Govender V
- Gowda A
- Goycoa C
- Goykhman S
- Gracious N
- Greco B
- Greene T
- Greene Tom
- Greloni Gc
- Grineva E
- Grubb S
- Guinsburg A
- Gulati R
- Gunstone A
- Gupta A
- Gupta M
- Gyrina O
- Haase Fp
- Hadjadj S
- Halciakova K
- Hall T
- Haller H
- Halmagyi I
- Hammoud J
- Hancu N
- Handelsman S
- Hanif W
- Hansraj A
- Harcsa E
- Harris R
- Hartman I
- Hawley C
- Heerspink Hiddo J L
- Heerspink Hjl
- Henein S
- Hermida S
- Hernandez Triana E
- Herrera Jimenez Le
- Hershon K
- Hettiarachchi M
- Higuera Jd
- Hillis G
- Hiser D
- Holman R
- Home P
- Hon G
- Hotlos L
- Hristozov K
- Hsia Tl
- Hsieh Ch
- Hudson M
- Hufert K
- Hwang Sj
- Ignjatovic J
- Iitsuka T
- Ilavska A
- Irizar Santana Ss
- Ismail M
- Jackson A
- Jacob R
- Jaffer S
- Jaime M
- Jain D
- Jamal A
- Januszewicz A
- Januzzi J
- Jardine M
- Jardine Meg J
- Jardine Mj
- Jeong Ik
- Jerwan-Keim R
- Jha V
- Ji L
- Jimenez Florez F
- Jimeno C
- Jodar Gimeno Je
- Johnson A
- Johnson D
- Joseph F
- Joshi M
- Juncos Li
- Jurgens J
- Kaczmarek B
- Kajiyama S
- Kamenov Z
- Kaminska A
- Kashine S
- Kasner S
- Kaupke C
- Kawada T
- Kazmirchuk A
- Keightley G
- Keitel E
- Keltai K
- Kendereski A
- Keresztesi S
- Kern E
- Kerr Saraiva Jf
- Keshavamurthy Cb
- Khandwala H
- Khanna R
- Khirmanov V
- Khitan Z
- Khullar D
- Kim S
- Kim Sg
- Kim Yh
- Kiss K
- Kissela B
- Klein A
- Klokocnikova V
- Klyver Mi
- Kodera T
- Kohara Sk
- Koizumi M
- Kolansky D
- Kolesnyk I
- Kolesnyk M
- Kolmakova E
- Komisarenko I
- Kong Wy
- Kong Y
- Kono H
- Konyves L
- Koppolu D
- Kopyt N
- Koroleva T
- Korzh O
- Koundurdjiev A
- Kovar R
- Kovesdy C
- Koyama K
- Kozloviene D
- Kraft F
- Krane V
- Kravchun N
- Krishna G
- Krishnan S
- Kropp J
- Krynski F
- Kumar A
- Kumar J
- Kumar N
- Kumeda Y
- Kumwenda M
- Kurtz Lisboa Hr
- Kusnir J
- Kvitkova L
- Kwon Hs
- Kwon Mj
- Lalic K
- Lalic N
- Lam Sw
- Lanchiotti Pv
- Lane W
- Lastuvka J
- Latiff G
- Laviada Molina H
- Lawrence M
- Lazuka L
- Le Meur Y
- Lee Bw
- Lee J
- Lee Ly
- Lee Mk
- Legun O
- Lehrner L
- Leia C
- Leiter L
- Lentz J
- Leon de la Fuente Ra
- Levin A
- Levin Adeera
- Levinson D
- Lewis D
- Li D
- Li N
- Li W
- Li X
- Lim Sk
- Lim-Abrahan Ma
- Limos A
- Lin Cc
- Lin G
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- Lin P
- Lindley R
- Liss K
- Liu J
- Loh Cl
- Lombard L
- Lozanov L
- Lu W
- Lu Yc
- Lukac M
- Luna Ceballos Ri
- Macdougall I
- Maddux A
- Madej A
- Madore F
- Mah Pm
- Mahaffey Kenneth W.
- Mahaffey Kw
- Maheshwari H
- Major L
- Malaver N
- Malberti F
- Malek Marin T
- Mandayam S
- Mandreoli M
- Manisha S
- Mankovskyy B
- Mannucci E
- Manocha Ab
- Mao H
- Marar I
- Marasaev V
- Marchetta N
- Margaritov V
- Martin Del Camp Blanco B
- Martinka E
- Martynyuk L
- Mascaro D
- Maxeiner S
- Mazur S
- Mcguire Dk
- Mcmahon A
- Medina Fari\uf1a M
- Mehta B
- Meininger G
- Meininger Gary
- Mele P
- Middleton J
- Milagres R
- Mileder M
- Miyauchi S
- Mizuyama K
- Mkrtumyan A
- Mlodawska-Choluj D
- Molina de Salazar Di
- Molnar M
- Montenegro Junior R
- Mookadam M
- Morales Franco G
- Morales Portillo C
- Mordujovich J
- Moreda R
- Moreira de Brito C
- Moreira Diaz Jp
- Moreno Loza Ot
- Morren F
- Morugova T
- Mostovoy Y
- Moustafa M
- Mu\uf1oz Lopez Mendoza M
- Mu\uf1oz Torres M
- Mucsi J
- Muirhead N
- Mujica Trenche S
- Munar Vila Ma
- Munteanu M
- Mustieles Rocha C
- Nagibovich G
- Nagibovich O
- Nam Ms
- Narayanan M
- Narvarte J
- Nassar T
- Navickas A
- Nazario Sabbag \uc2r
- Nazzer Hissa M
- Neal B
- Neal Bruce
- Nedogoda S
- Negru D
- Newman G
- Ng Ks
- Ngcakani N
- Nichol B
- Nicholls K
- Nicol P
- Nicolai S
- Nieto Iglesias J
- Niiya T
- Nik Ahmad Nnf
- Nisnisan J
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- Noonan P
- Noronha I
- Nortje H
- Nossuli Ak
- Novoa Pa
- Nowicki M
- Nowicki M
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- O'Shaughnessy A
- Obialo C
- Obrador Vera G
- Obrador G
- Ochodnicka Z
- Oh Kh
- Oishi H
- Olelewe S
- Oliver M
- Onaca Ag
- Oosthuizen H
- Orio Si
- Orlowska-Kowalik G
- Oroszlan T
- Orozco Castellanos R
- Orsi E
- Ory I
- Osipova I
- Ota S
- Otreras F
- Ounadjela S
- Oviedo A
- Packham D
- Padron J
- Panarotto D
- Pankhaniya R
- Pantoja Perez J
- Paragh G
- Parfrey P
- Park Cy
- Park Sh
- Parker R
- Paschen B
- Pashkovska N
- Patel D
- Patel G
- Patel N
- Pavon H
- Pecoits Filho R
- Pecoits-Filho R
- Pella D
- Penfornis A
- Peralta Calcaneo J
- Pereira Ma
- Pererva L
- Perez Vera M
- Perez A
- Perez C
- Peringat J
- Perkovic V
- Perkovic Vlado
- Perlman A
- Pertseva T
- Pesickova S
- Peterfai E
- Peterka K
- Petrica L
- Petro G
- Pettis K
- Pharr W
- Philip S
- Phillips A
- Piatti P
- Pichette V
- Pillay-Ramaya L
- Plassmann G
- Plaza Mv
- Pollock C
- Pollock Carol
- Popa Ar
- Popenda G
- Popovic-Radinovic V
- Portoles Perez Jm
- Prasad N
- Proietto J
- Prozesky H
- Pumprla J
- Purighalla R
- Quesada Sim\uf3n Ma
- Quesada-Suarez L
- Rabasa-Lhoret R
- Raduan Ra
- Raffaele P
- Railey M
- Ramirez Roca La
- Ramos Jc
- Ramtoola S
- Ranetti Ae
- Rangelov R
- Ranjan R
- Raskina T
- Rastogi S
- Ratnasingam V
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- Reddy J
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- Rendell M
- Resk Jh
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- Rewerska B
- Reyes Rosano Ma
- Rheeder P
- Rich L
- Rista L
- Roberts A
- Robinson M
- Rodriguez Papini N
- Rodriguez Pattzi H
- Rodriguez H
- Roger S
- Rosas Guzman J
- Rosas S
- Rose L
- Rosero R
- Rosivall L
- Roussel R
- Rucker Joerg Ie
- Rychl\uedk I
- Rychlik I
- S\ue1nchez Arenales Ja
- Saaveddra Sanchez Sb
- Saavedra Gajardo V
- Saba F
- Sakakibara T
- Sala J
- Salazar Ma
- Samoylov O
- Samoylova Y
- Sanchez Mijangos Jh
- Sanchez Polo Jv
- Sankaram R
- Santoro D
- Santos F
- Santos Jc
- Saporito W
- Sarin R
- Sasso Fc
- Satyanarayana Rk
- Saudek F
- Saulnier Pj
- Saxena M
- Sazonova O
- Scharfstein D
- Schiavi Lb
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- Schmidt M
- Schreiman R
- Schuch T
- Scott D
- Scott R
- Scotton As
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- Sekkarie M
- Sennik D
- Sensenbrenner J
- Serafinceanu C
- Serrano Sanson P
- Serviddio G
- Sessa H
- Shahinfar S
- Shakeel M
- Shamkhalova M
- Shanik M
- Shaw S
- Sheth S
- Sheu Wh
- Shinkov A
- Shutemova E
- Shwartz Y
- Sim\uf5es de Almeida R
- Simo Canonge R
- Simon G
- Singh B
- Sinha Ad
- Slompo Ramos C
- Smatanova I
- Smirnov I
- Smith Casabella T
- Smith S
- Soares Fel\uedcio J
- Solomon R
- Song W
- Sood V
- Soto Gonzalez A
- Soto Mb
- Sowinski D
- Sprague A
- Spry L
- Sreedhar R
- Sreelatha M
- Starzec A
- Steele A
- Stella A
- Stephens J
- Strzelecka A
- Suchinda P
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- Sultan S
- Sun J
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- Surampudi P
- Sussman S
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- Symonds R
- Takacs R
- Takai M
- Tamayo Y Orozco JA
- Tan A
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- Tangri N
- Tellez Chavez E
- Temelkova M
- Terns Riera M
- Terrelonge A
- Terront Lozano Ma
- Tesar V
- Thervet E
- Thimmaiah R
- Thom\ue9 F
- Thompson M
- Tibes Hachmann Jc
- Tinahones Madueno Fj
- Toarba C
- Tolentino M
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- Tomonaga O
- Topchii I
- Torshizi A
- Travis K
- Trespalacios F
- Trevisan R
- Trippe B
- Trueba P
- Tryshchuk N
- Tsang V
- Tseluyko V
- Tsujimoto M
- Tu P
- Turchin A
- Turcios Juarez E
- Turner W
- Twahirwa M
- Ulla Mr
- Updegrove J
- Urbanaviciene E
- Uriasyev O
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- Valdes Depeda A
- Valdez M
- Valenzuela A
- Valis M
- Vallejos A
- Van Buren P
- Vangel S
- Vannorsdall M
- Vargas Alonso Rd
- Varghese F
- Vasas S
- Vazelov E
- Vejar M
- Velasquez-Mieyer P
- Velichkova E
- Venegas Carrillo L
- Vengadasalam P
- Ventrapragada S
- Veronelli Am
- Villagordoa Mesa J
- Villarino A
- Villegas I
- Visco Ve
- Vizir V
- Vlasenko M
- von Ingersleben G
- Vorobyev S
- Vukotic G
- Vyasam Rc
- Wada T
- Wadud K
- Wahba M
- Wakasugi M
- Wakeling J
- Wakida Y
- Walker R
- Wang G
- Wang H
- Warren M
- Wassermann A
- Watanabe T
- Watson E
- Watson H
- Watts R
- Weiner D
- Weiner P
- Welker J
- Welsh J
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- Wheeler David C
- Wheeler Dc
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- Williams S
- Winocour P
- Wong Ac
- Woo V
- Yakov A
- Yamada M
- Yamada S
- Yanagida K
- Yanase T
- Yang J
- Yao C
- Yap Ye
- Yavin Yshai
- Ygpuara Mdl
- Yin A
- Yoiti Hayashida C
- Yoon Kh
- Yost L
- Young S
- Yu X
- Yumita W
- Yupanqui H
- Zaidman Cj
- Zalunardo N
- Zamarripa Escobedo R
- Zanata Petry Tb
- Zanella Mt
- Zaniewski-Singh M.
- Zanoli L
- Zaoui P
- Zateyshchikova A
- Zateyshshikov D
- Zaviriukha V
- Zemek S
- Zhang H
- Zhang Hong
- Zhao M
- Zheng H
- Zinman B
- Zinman Bernard
- Zlova T
- Zsom M
- Zub L
- Zykova T
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
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- Boyan Nonchev
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- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
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- Altaf Abdulmalik
- Altinel Yuksel
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- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
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- Alyami Ziyad
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- Alzerwi Nasser
- Amin Shivang
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- Ammendola Michele
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- Anastasiadou Sofia
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- Augestad Knut Magne
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- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
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- Shoukrie Shoukrie I. M.
- Shrestha Rashmit
- Siboe Mark
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- Stogowski Piotr Tomasz
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- Stroumpoulis Konstantinos
- Su Yu-Xiong
- Suarez Sara Busto
- Subramani Yamini
- Subramaniam Sentilnathan
- Sue-Chue-Lam Colin
- Suer Muhammed Salih
- Sulaiman Bilal
- Sultania Mahesh
- Sundarraju Shalini
- Sungurtekin Hulya
- Suresh Sreelakshmi
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- Swed Sarya
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- Szabómihályová Katarína
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- Süleyman Marlen
- Tadic Boris
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- Tailor Bhavesh
- Taj Eldeen Samaher Taj Eldeen Hassan
- Takeda Flavio Roberto
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- Tawalbeh Ra'Fat
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- Techapongsatorn Suphakarn
- Teixeira Pedro
- Tejero-Pintor Francisco J.
- Tellez Karla Susana Martin
- Tellez Luis Garcia-Sancho
- Thaha Mohamed Adhnan
- Thakar Sumit
- Thaw May Htoo
- Theivendran Kanthan
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- Theochari Nikoletta
- Theodoropoulos George
- Theophilidou Elena
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- Thomas Bradley
- Thomas Jerin Jose
- Thuduvage Vasanthika
- Thumbadoo Ruben
- Tian Sarah
- Tidjane Anisse
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- Tomasicchio Giovanni
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- Trulson Alexander
- Trungu Sokol
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- Tucker Olga
- Tuech Jean Jacques
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- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
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- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Differential effects of adiponectin in osteoblast-like cells
- Author
- Avbersek-Luznik I
- Bowler WB
- Chen TH
- Deeg MA
- Deeg MA
- Ding PY
- Doran AC
- Díez JJ
- Elda L. Pacheco-Pantoja
- Elefteriou F
- English PJ
- Gallagher JA
- Gartland A
- Gregory P
- James A. Gallagher
- Konukoglu D
- Kress BC
- Laet CD
- Lewinson D
- Luo XH
- Luo XH
- Maahs DM
- Miller M
- Moss DW
- Napoli N
- Ohashi K
- Oshima K
- Pacheco-Pantoja EL
- Peirson SN
- Peter J. M. Wilson
- Raikwar NS
- Ricci TA
- Sadie-Van Gijsen H
- Schofield JN
- Seibel MJ
- Shinoda Y
- Sodi R
- Swarbrick MM
- Talbott SM
- Tietz NW
- Tu Q
- Wang Y
- Weyer C
- William D. Fraser
- Xing Y
- Yamauchi T
- Zeni SN
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Local application of statins in the treatment of experimental periodontal disease in rats
- Author
- Akbari G
- Almeida J
- Barsante MM
- Bianca Fernanda Espósito SANTOS
- Bradford MM
- Bradley AD
- Cunha-Cruz J
- Dalcico R
- Daniela Coelho de LIMA
- Ebersole JL
- Eduardo Quintão Manhanini SOUZA
- Fernandes LA
- Garcia VG
- Glassford SE
- Gueders MM
- Johnson JH
- Klausen B
- Krishna R
- Kurgan Ş
- Leandro Araújo FERNANDES
- Lindhe J
- Luan Z
- Masadeh M
- Maísa Ribeiro Pereira Lima BRIGAGÃO
- Mundy G
- Nassar CA
- Netzel-Arnett N
- Pacheco-Pantoja EL
- Quinn M
- Sağlam M
- Sorsa T
- Ting M
- Vieira S
- Xu XC
- Zhang Y
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The Guerrero Composite Terrane of western Mexico: Collision and subsequent rifting in a supra-subduction zone
- Author
- Anderson
- Anderson
- Anderson
- Anderson
- Araujo
- Arredondo-Guerrero
- Barboza-Gudiñ
- Barboza-Gudiñ
- Benammi
- Bissig
- Cabral-Cano
- Campa
- Campa
- Campa
- Campa
- Campa
- Cantu-Chapa
- Centeno-Garcí
- Centeno-Garcí
- Centeno-Garcí
- Centeno-Garcí
- Centeno-Garcí
- Centeno-Garcia
- Chá
- Contreras-Montero
- Cuevas-Pé
- De Cserna
- Delgado
- Delgado
- Diaz-Salgado
- Dickinson
- Dickinson
- Eguiluz
- Elí
- Ferrusquí
- Fitz
- Freydier
- Freydier
- Freydier
- Garcí
- Gehrels
- Hall
- Keppie
- Keppie
- Ló
- Lapierre
- Lapierre
- Lawlor
- McDowell
- Mendoza
- Monod
- Monod
- Monod
- Mortensen
- Mullan
- Ortega-Gutié
- Ortega-Gutié
- Ortega-Gutié
- Ortega-Gutié
- Ortiz
- Ortiz-Herná
- Ortiz-Hernandez
- Ortiz-Hernandez
- Ortiz-Hernandez
- Pacheco
- Pantoja
- Pantoja
- Patchett
- Quintero-Legorreta
- Ranson
- Rosales-Lagarde
- Ruí
- Salinas-Prieto
- Schaaf
- Servais
- Silva-Romo
- Solari
- Talavera-Mendoza
- Talavera-Mendoza
- Talavera-Mendoza
- Tardy
- Tristá
- Urrutia-Fucugauchi
- Valencia-Moreno
- Valencia-Moreno
- Yañ
- Publication venue
- 'Geological Society of America'
- Publication date
- 01/01/2008
- Field of study
Role of Marrow Adipocytes in Regulation of Energy Metabolism and Bone Homeostasis
- Author
- A Bartelt
- A Bonomo
- A During
- A Elbaz
- A Ioan-Facsinay
- A Krings
- AL Gruver
- B Lecka-Czernik
- B Lecka-Czernik
- B Vandanmagsar
- BC Lee
- BJ Adler
- C Pararasa
- C Roggia
- D Kajimura
- D Naot
- D Naot
- E Zhao
- EL Pacheco-Pantoja
- EL Scheller
- G Matarese
- HS Berner
- I Iwamoto
- J Cornish
- J Jurimae
- Jian-ming Lin
- Jillian Cornish
- JJ Crossno
- KA Philbrick
- KE Barbour
- KE Barbour
- KJ Motyl
- L D'Amico
- L Gong
- LF Liu
- LH Dib
- M Wu
- N Busso
- O Ghali
- O Naveiras
- P Hardouin
- P Seale
- P Tontonoz
- RT Turner
- S Kapur
- S Post
- SP Weisberg
- T Akune
- T Baum
- T McLaughlin
- Tao Wang
- WP Cawthorn
- X Jiang
- Y Li
- Y Wan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Glucagon-like peptide-1 receptor agonist Liraglutide has anabolic bone effects in ovariectomized rats without diabetes.
- Author
- A Astrup
- A Dienelt
- A Mieczkowska
- A Papazafiropoulou
- AJ Garber
- AV Schwartz
- B Nuche-Berenguer
- B Nuche-Berenguer
- B Nuche-Berenguer
- B Nuche-Berenguer
- B Su
- Bei Tao
- BM Abdallah
- C Holscher
- C Sanz
- C Yamada
- CH Ko
- Christian Holscher
- DJ Drucker
- Dongmei Liu
- E Aoyama
- EL Pacheco-Pantoja
- G Mabilleau
- H Taipaleenmaki
- Hanxiao Sun
- Hongyan Zhao
- I Dicembrini
- JE Campbell
- JH Ellenbroek
- Jianmin Liu
- JingJia Yu
- JR Ussher
- JY Wu
- K Kazafeos
- Knudsen L Bjerre
- Lihao Sun
- Lin Zhao
- MA Nauck
- ML Bouxsein
- MS Molinuevo
- N Giuliani
- N Jaiswal
- N Panjwani
- Nan Lu
- PJ Larsen
- RJ Bollag
- T Akune
- T Komori
- T Nomiyama
- X Ma
- Xiaojing Wang
- Y Wittrant
- Z Tang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study