314 research outputs found
Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1
- Author
- A Patgiri
- B Ibarra-Molero
- BN Bullock
- BR Brooks
- BW Ozanne
- CN Pace
- D Aud
- D Derossi
- D Krylov
- D Seebach
- D Wang
- D Wang
- D Wang
- D Wang
- DA Guarracino
- David P. Fairlie
- DH Appella
- DP Fairlie
- DP Fairlie
- E Vives
- EF Wagner
- EK OâShea
- EK OâShea
- EK OâShea
- F Bernal
- F Bernal
- GH Bird
- GH Bird
- Gloria Ruiz-GĂłmez
- Huy N. Hoang
- J Liu
- JD Tyndall
- JK Judice
- JM Dixon
- JM Mason
- JM Mason
- JM Mason
- JM Mason
- JN Glover
- Jody M. Mason
- Jose M. Sanchez-Ruiz
- LD Walensky
- LD Walensky
- LK Henchey
- LM Johnson
- NE Shepherd
- NE Shepherd
- NE Shepherd
- P Lavigne
- PS Kutchukian
- R Eferl
- R Zenz
- RE Moellering
- RN Chapman
- RO Crooks
- RS Harrison
- S Baek
- SM Fuchs
- T Wiseman
- TA Libermann
- Tara Rao
- Timothy A. Hill
- YW Kim
- YW Kim
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/03/2013
- Field of study
Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners. However, short synthetic peptides with sequences corresponding to such protein epitopes are unstructured in water and promiscuously bind to proteins with low affinity and specificity. Here we combine structural stability and target specificity of proteins, with low cost and rapid synthesis of small molecules, towards meeting the significant challenge of binding coiled coil proteins in transcriptional regulation. By iteratively truncating a Jun-based peptide from 37 to 22 residues, strategically incorporating i-->i+4 helix-inducing constraints, and positioning unnatural amino acids, we have produced short, water-stable, alpha-helical peptides that bind cFos. A three-dimensional NMR-derived structure for one peptide (24) confirmed a highly stable alpha-helix which was resistant to proteolytic degradation in serum. These short structured peptides are entropically pre-organized for binding with high affinity and specificity to cFos, a key component of the oncogenic transcriptional regulator Activator Protein-1 (AP-1). They competitively antagonized the cJunâcFos coiled-coil interaction. Truncating a Jun-based peptide from 37 to 22 residues decreased the binding enthalpy for cJun by ~9 kcal/mol, but this was compensated by increased conformational entropy (TDS †7.5 kcal/mol). This study demonstrates that rational design of short peptides constrained by alpha-helical cyclic pentapeptide modules is able to retain parental high helicity, as well as high affinity and specificity for cFos. These are important steps towards small antagonists of the cJun-cFos interaction that mediates gene transcription in cancer and inflammatory diseases
Identification of a Bacteria-produced Benzisoxazole with Antibiotic Activity against Multi-drug Resistant Acinetobacter baumannii
- Author
- A Chaker
- A Ć ali
- AP Magiorakos
- AR Vasquez
- AY Hsu
- B Green
- BL Deng
- BP Nichols
- CM Moore
- CM Shivaprasad
- DT Gallagher
- EC Meng
- EF Pettersen
- F Dosselaere
- GC Leite
- H Braberg
- H Imai
- HelenW Boucher
- HW Boucher
- I Goic-Barisic
- IG Young
- J Gao
- JC Saunders
- JEJ Mills
- JM Andrews
- K Matsushita
- KE Whalen
- KM Herrmann
- KP Rakesh
- L BrÀuer
- L Davis
- L Dijkshoorn
- L Wessjohann
- LL Maragakis
- LS Munoz-Price
- M Anand
- M Beganovic
- M Hamada
- M Jain
- M Siebert
- M Siebert
- MJ Holden
- MK OâShea
- MR Sivala
- N Ashwini
- N Smith
- NJ Hrib
- O Trott
- P Khedekar
- P Weiden
- PR Rhomberg
- R Bax
- R Meganathan
- RA Laskowski
- S Aiello
- S Chandra
- S-S Han
- SA Marshall
- SS Purohit
- T Maxson
- UPC Tran
- W Wierenga
- Y Uto
- Y Uto
- Y Yakupogullari
- ZA Qureshi
- Publication venue
- DigitalCommons@URI
- Publication date
- 01/02/2021
- Field of study
The emergence of multi-drug resistant pathogenic bacteria represents a serious and growing threat to national healthcare systems. Most pressing is an immediate need for the development of novel antibacterial agents to treat Gram-negative multi-drug resistant infections, including the opportunistic, hospital-derived pathogen, Acinetobacter baumannii. Herein we report a naturally occurring 1,2-benzisoxazole with minimum inhibitory concentrations as low as 6.25âÎŒgâmlâ1 against clinical strains of multi-drug resistant A. baumannii and investigate its possible mechanisms of action. This molecule represents a new chemotype for antibacterial agents against A. baumannii and is easily accessed in two steps via de novo synthesis. In vitro testing of structural analogs suggest that the natural compound may already be optimized for activity against this pathogen. Our results demonstrate that supplementation of 4-hydroxybenzoate in minimal media was able to reverse 1,2-benzisoxazoleâs antibacterial effects in A. baumannii. A search of metabolic pathways involving 4-hydroxybenzoate coupled with molecular modeling studies implicates two enzymes, chorismate pyruvate-lyase and 4-hydroxybenzoate octaprenyltransferase, as promising leads for the target of 3,6-dihydroxy-1,2-benzisoxazole
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Recall of a live and personally experienced eyewitness event by adults with autism spectrum disorder
- Author
- A Farrant
- A Lee
- A Mizuno
- A North
- AG OâShea
- AJO Whitehouse
- American Psychiatric Association
- Amina Memon
- AN Meltzoff
- Anna Lambrechts
- C Lord
- C Millward
- CH Salmond
- CS Symons
- D Allen
- D Wechsler
- D Williams
- Dermot M. Bowler
- DJ Hare
- DL Williams
- DM Bowler
- DM Bowler
- DM Bowler
- DM Bowler
- DM Bowler
- DM Williams
- DZ Wojcik
- E McCrory
- EF Loftus
- EL Hill
- EL Hill
- FIM Craik
- FZ Ambery
- HA Henderson
- Home Office
- J Boucher
- J Boucher
- J Engelkamp
- J Engelkamp
- J Russell
- J Russell
- JA Summers
- JR Petersilia
- K Maras
- KA Loveland
- Katie L. Maras
- KL Maras
- KL Maras
- L Bennetto
- L Crane
- L Crane
- L Goddard
- M Bruck
- MR Woodbury-Smith
- MR Woodbury-Smith
- NJ Minshew
- P Howlin
- RR Jordan
- S Baron-Cohen
- S Dunphy-Lelii
- S Hala
- S Hashtroudi
- SB Gaigg
- SB Klein
- SB Klein
- SE Lind
- SE Lind
- SE Lind
- T Zalla
- TW Wilson
- X Ming
- Publication venue
- Publication date
- 01/01/2013
- Field of study
The aim of the present study was to (a) extend previous eyewitness research in autism spectrum disorder (ASD) using a live and personally experienced event; (b) examine whether witnesses with ASD demonstrate a facilitative effect in memory for self- over other-performed actions; (c) explore source monitoring abilities by witnesses with ASD in discriminating who performed which actions within the event. Eighteen high-functioning adults with ASD and 18 age- and IQ-matched typical counterparts participated in a live first aid scenario in which they and the experimenter each performed a number of actions. Participants were subsequently interviewed for their memory of the event using a standard interview procedure with free recall followed by questioning. The ASD group recalled just as many correct details as the comparison group from the event overall, however they made more errors. This was the case across both free recall and questioning phases. Both groups showed a self-enactment effect across both interview phases, recalling more actions that they had performed themselves than actions that the experimenter had performed. However, the ASD group were more likely than their typical comparisons to confuse the source of self-performed actions in free recall, but not in questioning, which may indicate executive functioning difficulties with unsupported test procedures. Findings are discussed in terms of their theoretical and practical implications
Evolving missions and university entrepreneurship:Academic spin-offs and graduate start-ups in the entrepreneurial society
- Author
- A Fayolle
- A Fayolle
- A Geuna
- A Huyghe
- A Lockett
- A Lockett
- AD Heher
- AN Link
- B Honig
- C Gouriéroux
- C Leitch
- Chiara Marzocchi
- D Audretsch
- D Mowery
- D Siegel
- D Siegel
- DC Mowery
- DF Kuratko
- DH Hsu
- DS Siegel
- DS Siegel
- DTI
- E Rasmussen
- EF Damsgaard
- European Commission
- F Kitagawa
- F Kitagawa
- F Rossi
- F Rossi
- F Vught van
- F Vught van
- FJ Calzonetti
- FJ Greene
- FT Rothaermel
- Fumi Kitagawa
- GD Libecap
- GD Markman
- H Bergmann
- H Goldstein
- J Bercovitz
- J Niosi
- J-P BĂ©chard
- JM Wooldridge
- JM Wooldridge
- K Ismail
- K Smith
- KM Eisenhardt
- M Abreu
- M Abreu
- M Abreu
- M Bertanha
- M Feldman
- M Guerrero
- M Guerrero
- M Mars
- M Perkmann
- M SĂĄnchez-Barrioluengo
- M Wright
- M Wright
- Mabel SĂĄnchez-Barrioluengo
- N Hewitt-Dundas
- Ocasio
- P Braunerhjelm
- P DâEste
- R Lambert
- R Lester
- RD Ireland
- RP OâShea
- RT Harrison
- SA Shane
- SD Dodd
- SG Walter
- Shah
- T Astebro
- TC Ambos
- WW Powell
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/07/2017
- Field of study
A recent call has urged to broaden the conceptualization of university entrepreneurship in order to appreciate the heterogeneity of contexts and actors involved in the process of entrepreneurial creation. A gap still persists in the understanding of the variety of ventures generated by different academic stakeholders, and the relationships between these entrepreneurial developments and university missions, namely, teaching and research. This paper addresses this particular gap by looking at how university teaching and research activities influence universitiesâ entrepreneurial ventures such as academic spin-offs and graduate start-ups. Empirically, we analyse the English higher education sector, drawing on institutional data at the university level. First, we explore the ways in which teaching and research activities are configured, and secondly, we examine how such configurations relate to academic spin-offs and graduate start-ups across different universities over time. Our findings suggest, first, that the evolution of USOs and graduate start-ups exhibit two different pathways over time; and second, that teaching and research both affect entrepreneurial ventures but their effect is different.JRC.B.4-Human Capital and Employmen
Bats in the anthropogenic matrix: Challenges and opportunities for the conservation of chiroptera and their ecosystem services in agricultural landscapes
- Author
- A Estrada
- A Estrada
- A Estrada
- A Estrada
- A Frey-Ehrenbold
- A Guillén
- A Kurta
- A Medina
- A Rainho
- A Schmidt
- A Valiente-Banuet
- A Vargas Espinoza
- AA Castro-Luna
- AG Power
- AL Walsh
- AL Walsh
- B Maas
- B Verboom
- Bea Maas
- Bradley Law
- BS Bennett
- C Arellano-Sota
- C Cleveland
- C Drescher
- C Flaquer
- C GarcĂa Estrada
- C GarcĂa-Estrada
- C Numa
- C Sirami
- C Srinivasulu
- C Stechert
- C Wilson
- CA Hallmann
- CA Harvey
- CA Harvey
- CD Mendenhall
- Christoph F. J. Meyer
- CL Noer
- CM Davy
- D Faria
- D Faria
- D Faria
- D Faria
- D Fukuda
- D Russo
- D Russo
- D Tilman
- D. Tilman
- DA Rambaldini
- David Tilman
- DB Sasse
- DH White
- DP Bebber
- DR Clark
- DR Clark
- DR Clark
- DR Clark
- DR Clark
- DS Karp
- E Fuentes-Montemayor
- E Pineda
- EB Morrison
- EF Lambin
- EL Clare
- F Bellec Le
- F Bontadina
- F LisĂłn
- F LisĂłn
- F Mayen
- F Randrianandrianina
- G Jones
- G LesiĆski
- G Robertson
- GF McCracken
- I Perfecto
- J Fischer
- J Fischer
- J Fischer
- J Fuller
- J Hanspach
- J Jong de
- J Loos
- J Russ
- J Vandermeer
- J Weiss
- JA Foley
- JG Boyles
- JG Boyles
- JJ Storm
- JL Reid
- JL Sedlock
- JO Whitaker Jr
- JP Sluijs Van der
- K Bohmann
- K Kannan
- K Senthilkumar
- K Williams-Guillén
- K Williams-Guillén
- K Williams-Guillén
- KL Boughey
- KM Schmidt
- L Lopez-Hoffman
- L Wickramasinghe
- L Wickramasinghe
- LE Henderson
- LF Lumsden
- LF Lumsden
- LJ Farrow
- LJ Thomson
- LMS Aguiar
- M Dietz
- M Egger
- M Ekman
- M Lundy
- M Weerd Van
- MB Kalka
- MJO Pocock
- MK Obrist
- ML Thies
- NC Downs
- NM Furey
- P Federico
- P LĂłpez del Toro
- P Prokop
- P Stahlschmidt
- P Stahlschmidt
- PE Lentini
- PJ Taylor
- PJ Taylor
- PJ Taylor
- R Arlettaz
- R Arlettaz
- R Arlettaz
- R Arlettaz
- R GarcĂa-Morales
- R Medellin
- RA Saldaña Våzquez
- RE Swanepoel
- RL Clawson
- RS Defries
- S Bayat
- S Bumrungsri
- S Bumrungsri
- S Bumrungsri
- S Graf
- SD Gehrt
- Sheema Abdul Aziz
- SR Brechin
- SR Tuttle
- Surendra Kumar Yadav
- T Miura
- T Tscharntke
- T Tscharntke
- TC Wanger
- TH Kunz
- TH Kunz
- TH Ricketts
- Thomas H. Kunz
- Thomas O. McShane
- Tigga Kingston
- TJ OâShea
- TJ OâShea
- TL Mildenstein
- W Leelapaibul
- W Quarles
- WE Conner
- WF Laurance
- Y Lee
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2016
- Field of study
Intensification in land-use and farming practices has had largely negative effects on bats, leading to population declines and concomitant losses of ecosystem services. Current trends in land-use change suggest that agricultural areas will further expand, while production systems may either experience further intensification
(particularly in developing nations) or become more environmentally friendly (especially in Europe). In this chapter, we review the existing literature on how agricultural management affects the bat assemblages and the behavior of individual bat species, as well as the literature on provision of ecosystem services by bats (pest insect suppression and pollination) in agricultural systems. Bats show highly variable responses to habitat conversion, with no significant change in species
richness or measures of activity or abundance. In contrast, intensification within agricultural systems (i.e., increased agrochemical inputs, reduction of natural structuring elements such as hedges, woods, and marshes) had more consistently negative
effects on abundance and species richness. Agroforestry systems appear to mitigate negative consequences of habitat conversion and intensification, often having higher abundances and activity levels than natural areas. Across biomes, bats play key roles in limiting populations of arthropods by consuming various agricultural pests. In tropical areas, bats are key pollinators of several commercial fruit species. However, these substantial benefits may go unrecognized by farmers, who sometimes associate bats with ecosystem disservices such as crop raiding. Given the importance of bats for global food production, future agricultural management should focus on âwildlife-friendlyâ farming practices that allow more bats to exploit and persist
in the anthropogenic matrix so as to enhance provision of ecosystem services. Pressing research topics include (1) a better understanding of how local-level versus
landscape-level management practices interact to structure bat assemblages,
(2) the effects of new pesticide classes and GM crops on bat populations, and (3) how increased documentation and valuation of the ecosystem services provided by bats could improve attitudes of producers toward their conservation
Production of dust by massive stars at high redshift
- Author
- A Beelen
- A Borghesi
- A Burrows
- A Cucchiara
- A Elmhamdi
- A Elmhamdi
- A Gal-Yam
- A Gal-Yam
- A Heger
- A Heger
- A Karakas
- A Laor
- A Omont
- A Omont
- A Pastorello
- A Pastorello
- A Pastorello
- A Pastorello
- A Pipino
- A Renzini
- A Wachter
- A. C. Andersen
- AA Miller
- AA Zijlstra
- AGGM Tielens
- AI Karakas
- AJT Poelarends
- AM Hofmeister
- AM Soderberg
- AP Jones
- AP Jones
- AP Jones
- AP Jones
- AS Ferrarotti
- AS Ferrarotti
- AS Ferrarotti
- AV Filippenko
- AV Filippenko
- B Donn
- B Ercolano
- BB Nath
- BEK Sugerman
- BG Elmegreen
- BJ Williams
- BM Tinsley
- BT Draine
- BT Draine
- BT Draine
- BT Draine
- BT Draine
- BW OâShea
- C Breuck De
- C Charbonnel
- C Gall
- C Gall
- C Helling
- C JĂ€ger
- C JĂ€ger
- C JĂ€ger
- C JĂ€ger
- C JĂ€ger
- C JĂ€ger
- C Koike
- C Koike
- C Koike
- C Koike
- C Koike
- C Koike
- C Ledoux
- C McKee
- C Trundle
- C Vlahakis
- C. Gall
- CF McKee
- CJ Stockdale
- CL Carilli
- CL Carilli
- CL Fryer
- CM Baugh
- CM Raiteri
- CM Sharp
- D Fabian
- D Feder
- D Ishihara
- D Maoz
- D Schaerer
- DA Green
- DA Perley
- DA Riechers
- DC Hines
- DC Hines
- DD Clayton
- DD Clayton
- DD Clayton
- DD Clayton
- DH Hughes
- DH Wooden
- DJ Benford
- DJ Hunter
- DJ Mortlock
- DK Sahu
- DW Silvia
- E Carlo Di
- E Dartois
- E Dwek
- E Dwek
- E Dwek
- E Dwek
- E Dwek
- E Dwek
- E Dwek
- E Lagadec
- E Lagadec
- E Sedlmayr
- E Vassiliadis
- ED Palik
- EE Salpeter
- EF Erickson
- EM Levesque
- EM Levesque
- EO Ofek
- F Bertoldi
- F Bertoldi
- F Calura
- F Cernuschi
- F DâAntona
- F DâAntona
- F Herwig
- F Hoyle
- F Kemper
- F Mannucci
- F Matteucci
- F Molster
- F Patat
- F Rouleau
- F Walter
- FJ Molster
- FJ Molster
- FJ Molster
- FJ Molster
- FL Schöier
- FS Kitaura
- G Chabrier
- G Chabrier
- G Chabrier
- G Meynet
- G Pascoli
- G Schaller
- G Umana
- GC Sloan
- GC Sloan
- GH Bowen
- GH Rieke
- GR Knapp
- H Bartko
- H Gail
- H Gail
- H Gail
- H Hirashita
- H Maness
- H Mutschke
- H Olofsson
- H Olofsson
- H Umeda
- HA Thronson Jr
- HL Gomez
- HL Gomez
- HL Morgan
- HL Morgan
- HP Gail
- I Cherchneff
- I Cherchneff
- I Cherchneff
- I Cherchneff
- I Cherchneff
- I Cherchneff
- I Iben Jr
- I Iben Jr
- I McDonald
- I McDonald
- I Robson
- I Sakon
- IJ Danziger
- J Dabringhausen
- J Dorschner
- J Dorschner
- J Dorschner
- J Hjorth
- J MaĂz-ApellĂĄniz
- J Puls
- J Rho
- J Rho
- J Scalo
- J Scalo
- J Tumlinson
- J VinkĂł
- J Whelan
- J. Hjorth
- JC Lattanzio
- JC Weingartner
- JE Andrews
- JE Andrews
- JJ Eldridge
- JJ Eldridge
- JJ Eldridge
- JJ Eldridge
- JJ Eldridge
- JK Truelove
- JL Johnson
- JL Prieto
- JM Scalo
- JM Winters
- JP Anderson
- JR Maund
- JR Maund
- JR Maund
- JR Maund
- JS Doane
- JS Gallagher III
- JS Mathis
- JT Loon van
- K Davidson
- K Iwamoto
- K Justtanont
- K Kawara
- K Kifonidis
- K Liffman
- K Lodders
- K Maguire
- K Nomoto
- K Nomoto
- K Nomoto
- K Nomoto
- K Sandstrom
- K Weis
- KG Isaak
- KI Nomoto
- KJ Borkowski
- KM Pitman
- KM Pitman
- KS Kawabata
- L Decin
- L Decin
- L Dunne
- L Dunne
- L Dunne
- L Greggio
- L Greggio
- L Mattsson
- L Mattsson
- L Origlia
- L Origlia
- L Siess
- L Siess
- LA Willson
- LB Hoek van den
- LB Lucy
- LB Lucy
- LJ Smith
- M Elvis
- M Fink
- M Fraser
- M Frenklach
- M Frenklach
- M Hanner
- M Herant
- M Herant
- M Livio
- M Matsuura
- M Matsuura
- M Nagashima
- M Pettini
- M Pozzo
- M Pozzo
- M Schwarzschild
- M Tegmark
- MA Leitch-Devlin
- MAT Groenewegen
- MAT Groenewegen
- MAT Groenewegen
- MD Lehnert
- MG Edmunds
- MJ MichaĆowski
- ML Boyer
- ML Norman
- MR Krumholz
- MS Yun
- MT Botticella
- N Bastian
- N Elias-Rosa
- N Scoville
- N Smith
- N Smith
- N Smith
- N Smith
- N Smith
- N Smith
- N Smith
- N Smith
- N Smith
- N Yoshida
- N Yoshida
- N Yoshida
- N Yoshida
- NR Tanvir
- O Fox
- O Krause
- O Krause
- P Bouchet
- P Kroupa
- P Marigo
- P Massey
- P Massey
- P Todini
- P Ventura
- P Woitke
- PA Crowther
- PA Mazzali
- PB Alton
- PR Schwartz
- R Bandiera
- R Chary
- R Davé
- R Gautschy-Loidl
- R Gehrz
- R Kotak
- R Kotak
- R Kotak
- R Kotak
- R Maiolino
- R Pakmor
- R Salvaterra
- R Schneider
- R Schneider
- R Valiante
- R Wang
- R Wesson
- RA Chevalier
- RA Chevalier
- RB Larson
- RB Larson
- RF Webbink
- RG Arendt
- RH Hildebrand
- RJ Bouwens
- RJ Foley
- RJ Ivison
- RM Crockett
- RM Crockett
- RM Crockett
- RM Wagner
- RS Priddey
- RS Priddey
- RW Goodrich
- S Benetti
- S Bianchi
- S Ekström
- S Höfner
- S Höfner
- S Höfner
- S Höfner
- S Höfner
- S Höfner
- S Mattila
- S Mattila
- S Nakano
- S Ramstedt
- S Ramstedt
- S StanimiroviÄ
- S Wanajo
- S Zeidler
- S Zhukovska
- SD Dyk Van
- SD Dyk Van
- SD Dyk Van
- SD Murray
- SD Ryder
- SE Woosley
- SE Woosley
- SJ Smartt
- SJ Smartt
- SJ Smartt
- SK Ballero
- SP Reynolds
- SP Reynolds
- SV Marchenko
- T Abel
- T Blöcker
- T Blöcker
- T Douvion
- T Douvion
- T Henning
- T Henning
- T Karlsson
- T Kozasa
- T Kozasa
- T Moriya
- T Nozawa
- T Nozawa
- T Nozawa
- T Posch
- T Shigeyama
- T Szalai
- T Temim
- T Yoshida
- TA Thompson
- TC Beers
- TD Brandt
- TH Greif
- TL Daulton
- TL Wilson
- U Maio
- V Bromm
- V Bromm
- V Bromm
- V Bromm
- V Mennella
- V Orofino
- V Ossenkopf
- W Baade
- W Freudling
- W Hillebrandt
- W Nowotny
- W Nowotny
- WD Arnett
- WP Blair
- WP Blair
- WPS Meikle
- WW Duley
- WW Tian
- X Fan
- X Wang
- X Yang
- Y Chu
- Y Juarez
- Y Li
- YC Pei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2011
- Field of study
The large amounts of dust detected in sub-millimeter galaxies and quasars at
high redshift pose a challenge to galaxy formation models and theories of
cosmic dust formation. At z > 6 only stars of relatively high mass (> 3 Msun)
are sufficiently short-lived to be potential stellar sources of dust. This
review is devoted to identifying and quantifying the most important stellar
channels of rapid dust formation. We ascertain the dust production efficiency
of stars in the mass range 3-40 Msun using both observed and theoretical dust
yields of evolved massive stars and supernovae (SNe) and provide analytical
expressions for the dust production efficiencies in various scenarios. We also
address the strong sensitivity of the total dust productivity to the initial
mass function. From simple considerations, we find that, in the early Universe,
high-mass (> 3 Msun) asymptotic giant branch stars can only be dominant dust
producers if SNe generate <~ 3 x 10^-3 Msun of dust whereas SNe prevail if they
are more efficient. We address the challenges in inferring dust masses and
star-formation rates from observations of high-redshift galaxies. We conclude
that significant SN dust production at high redshift is likely required to
reproduce current dust mass estimates, possibly coupled with rapid dust grain
growth in the interstellar medium.Comment: 72 pages, 9 figures, 5 tables; to be published in The Astronomy and
Astrophysics Revie
Operation and performance of the ATLAS Tile Calorimeter in Run 1
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouelfadl 
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez 
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor 
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Arce ATH
- Ardell RE
- Arduh FA
- Argos FC
- Arguin J-
- Argyropoulos S
- Armadans R
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
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- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
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- Astalos R
- Astigarraga ME
- Atkin RJ
- Atkinson M
- Atlay NB
- Auerbach B
- Augsten K
- Avolio G
- Avramidou R
- Axen B
- Ayoub MK
- Azuelos G
- AÌlvarez Piqueras D
- AÌkesson TPA
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahilo JJL
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Baines JT
- Bajic M
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- Baker OK
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- Banerjee S
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- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M
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- Barklow T
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- Bartoldus R
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- Berger N
- Bergsten LJ
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- Bernardi G
- Bernius C
- Bernlochner FU
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- Berta P
- Bertella C
- Bertoli G
- Bertram IA
- Besjes GJ
- Bessidskaia Bylund O
- Bessner M
- Besson N
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- Bethke S
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- Bierwagen K
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- Billoud TRV
- Bindi M
- Bingul A
- Bini C
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- Bisanz T
- Biswal JP
- Bittrich C
- Bjergaard DM
- Black JE
- Black KM
- Blair RE
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blunier D
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Boldyrev AS
- Bolz AE
- Bomben M
- Bona M
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- Boonekamp M
- Borisov A
- Borissov G
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- Boumediene D
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- Boveia A
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- Bratzler U
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- Breaden Madden WD
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- Brock R
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- Brooks WK
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- Broughton JH
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- Bruckman de Renstrom PA
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- Bruno S
- Brunt BH
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- Buat Q
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- Buckley AG
- Budagov IA
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- Bullock D
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
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- Burke S
- Burmeister I
- Burr JTP
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- Buschmann E
- Bussey P
- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- BuÌhrer F
- BuÌscher D
- BuÌscher V
- Cabras G
- Cabrera UrbaÌn S
- Caforio D
- Cai H
- Cairo VMM
- Cakir I
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
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- Camacho Toro R
- Camarda S
- Camarri P
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- Caminal 
- Camincher C
- Campana S
- Campanelli M
- Camplani A
- Campoverde A
- Canale V
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- Cantero J
- Cao T
- Cao Y
- Capeans Garrido MDM
- Caprini I
- Caprini M
- Capua M
- Carbone RM
- Cardarelli R
- Cardillo FC
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- CarraÌ S
- Carrillo-Montoya GD
- Casadei D
- Casado MP
- Casha AF
- Casolino M
- Casper DW
- Castelijn R
- Castillo Gimenez V
- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Caudron J
- Cavaliere V
- Cavallaro E
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Celebi E
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- Cerda Alberich L
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
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- Cetin SA
- Chafaq A
- Chakraborty D
- Chan SK
- Chan WS
- Chan YL
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- Chapman JD
- Charlton DG
- Chau CC
- Chavez Barajas CA
- Che S
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- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
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- Cheplakov A
- Cheremushkina E
- Cherkaoui El Moursli R
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov MV
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- Christodoulou V
- Chu MC
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- Ciaccio A
- Ciaccio L
- Cinca D
- Cindro V
- CioaraÌ IA
- Ciocio A
- Cirotto F
- Citron ZH
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- Coimbra AEC
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- Conventi F
- Cooper-Sarkar AM
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- Correia AM
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- Costa MJ
- Costanzo D
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- CreÌpeÌ-Renaudin S
- Cristinziani M
- Croft V
- Crosetti G
- Cueto A
- Cuhadar Donszelmann T
- Cukierman AR
- Cunha 
- Curatolo M
- CuÌth J
- Czekierda S
- Czodrowski P
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- Da 
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- Dado T
- Dahbi S
- Dai T
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- Dandoy JR
- Daneri MF
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- Dao V
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- Dartsi O
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- Daubney T
- Davey W
- David C
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- Davydov Y
- Dawe E
- Dawson I
- De Asmundis R
- De Benedetti A
- De Castro S
- De Cecco S
- De Groot N
- de Jong P
- De la Torre H
- De Lorenzi F
- De Maria A
- De Moura 
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- De Salvo A
- De Sanctis U
- De Santo A
- De Vasconcelos Corga K
- De Vivie 
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- Debenedetti C
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- Dehghanian N
- Del Gaudio M
- Del Peso J
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- Delmastro M
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- Demichev M
- Denisov SP
- Denysiuk D
- Derendarz D
- Derkaoui JE
- Derue F
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- Deterre C
- Dette K
- Devesa MR
- Deviveiros PO
- Dewhurst A
- Dhaliwal S
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- Dubreuil A
- Duchovni E
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- Ducourthial A
- Ducu OA
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- Duffield EM
- Duflot L
- Dumancic M
- Dumitriu AE
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- Dunford M
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- Duran 
- Durglishvili A
- Duschinger D
- Dutta B
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- Dyndal M
- Dysch S
- Dziedzic BS
- Dâamen G
- DâAuria S
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- Dâonofrio A
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- Ecker KM
- Edgar RC
- Eifert T
- Eigen G
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- El Kosseifi R
- Ellajosyula V
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- Epland MB
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- Escobar C
- Esposito B
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- Etienvre AI
- Etzion E
- Evans H
- Ezhilov A
- Ezzi M
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- Faisca 
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- Falke PJ
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- Fawcett WJ
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- Fenyuk AB
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- Ferreira de Lima DE
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- Fiolhais MCN
- Fiorini L
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- Flaschel N
- Fleck I
- Fleischmann P
- Fletcher RRM
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- Flierl BM
- Flores Castillo LR
- Flores LM
- Fomin N
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- Formica A
- Forti AC
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- Frost JA
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- Galea C
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- Gallas EJ
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- Gamboa 
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- GarciÌa Pascual JA
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- Gkialas I
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- Gorbounov PA
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- Gorini E
- GorisÌek A
- Goshaw AT
- Gostkin MI
- Gottardo CA
- Goudet CR
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- Goussiou AG
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- Janus M
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- Leisos A
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- Lindquist BE
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- Lipniacka A
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- Zwalinski L
- ZÌenisÌ T
- ZÌivkovicÌ L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The Tile Calorimeter is the hadron calorimeter covering the central region of the ATLAS experiment at the Large Hadron Collider. Approximately 10,000 photomultipliers collect light from scintillating tiles acting as the active material sandwiched between slabs of steel absorber. This paper gives an overview of the calorimeterâs performance during the years 2008â2012 using cosmic-ray muon events and protonâproton collision data at centre-of-mass energies of 7 and 8TeV with a total integrated luminosity of nearly 30 fbâ1. The signal reconstruction methods, calibration systems as well as the detector operation status are presented. The energy and time calibration methods performed excellently, resulting in good stability of the calorimeter response under varying conditions during the LHC Run 1. Finally, the Tile Calorimeter response to isolated muons and hadrons as well as to jets from protonâproton collisions is presented. The results demonstrate excellent performance in accord with specifications mentioned in the Technical Design Report
Search for supersymmetry in events with four or more leptons in âs =13 TeV pp collisions with ATLAS
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimine NI
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- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Ălvarez Piqueras D
- Ă kesson TPA
- Ć filigoj T
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb â1 of proton-proton collisions delivered by the Large Hadron Collider at s â =13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95% confidence level in simplified models of General Gauge Mediated supersymmetry, where higgsino masses are excluded up to 295 GeV. In R -parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46 TeV, 1.06 TeV, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively
Measurement of the tÂŻtZ and tÂŻtW cross sections in proton-proton collisions at âs=13âTeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexandre D
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
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- Zhemchugov A
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- Zobernig G
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- Ălvarez Piqueras D
- Ă kesson TPA
- Ć filigoj T
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
A measurement of the associated production of a top-quark pair (tÂŻt) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1ââfbâ1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The tÂŻtZ and tÂŻtW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are ÏtÂŻtZ=0.95±0.08stat±0.10systâpb and ÏtÂŻtW=0.87±0.13stat±0.14systâpb in agreement with the Standard Model predictions. The measurement of the tÂŻtZ cross section is used to set constraints on effective field theory operators which modify the tÂŻtZ vertex
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at â=13TeV
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- Zhemchugov A
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- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fbâ1 of sâ=13TeV protonâproton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38â0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
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