III Congresso Ibérico de Apicultura

As ameaças à sanidade das colónias – dos pesticidas às doenças, parasitas e predadores A genética e o melhoramento como ferramentas para uma melhor gestão e conservação da abelha ibérica Qualidade e inovação como fatores de promoção e diversificação das produções apícolas Novas ferramentas para uma apicultura cada vez mais competitiva

Abstracts & Selected Papers eBook : 4th International Research Forum on Guided Tours

The International Research Forum on Guided Tours had its roots in Sweden back in 2009 and every two years it has been bringing together different actors within the scope of Guided Tours. From academic to practical perspectives, each Forum has been rewarding its participants in intercultural, intellectual and professional terms. Bearing in mind that common aim, after the meetings in Sweden, the UK and the Netherlands, in 2015 the IRFGT headed southwest to Portugal. In Estoril, delegates were welcomed around springtime, from the 18th to the 21st March

XXI Encontro da Sociedade Portuguesa de Eletroquímica & XVIII Encontro Ibérico de Eletroquímica: livro de resumos

O XXI Encontro da Sociedade Portuguesa de Eletroquímica & XVIII Encontro Ibérico de Eletroquímica decorreu no Instituto Politécnico de Bragança, Portugal, de 14 a 17 de setembro de 2016. O Encontro permitiu aos participantes apresentar e discutir as suas linhas de trabalho em Eletroquímica bem como, desenvolver parcerias estratégicas com objetivos comuns, pensando também nos desafios que se avizinham no âmbito das políticas Europeias

Leachables from single-use systems and impact to product quality

Application of single-use (SU) systems for the manufacturing of biologics have increased significantly over the years and pose challenges for pharmaceutical processing in terms of leachables and their potential impact on product quality. Our small-scale stressed/accelerated studies (conducted at ≥ 25°C with elevated surface area to volume ratio) revealed increase in protein aggregation and sub-visible particles resulting from storage in disposable bags compare to other non-disposable storage containers (glass vials and stainless steel). Three classes of relevant leachable compounds are believed to potentially interact with protein and promote protein aggregation. We have repeatedly shown that some of the protein aggregates are dissociable by SDS and preventable by increasing polysorbate 20 levels (indicating hydrophobic leachable compounds). We have also observed covalent protein aggregates that are preventable by adding anti-oxidants (suggesting leachable compounds that promote strong protein crosslinking). Furthermore, we have observed protein aggregates that can be prevented by heat-treated bags prior to storage (indicating volatile compounds). In addition to protein aggregation observed in SU bioprocess bags, our lab-scale studies have shown that visible protein particles could form readily upon contact with gamma irradiated SU assemblies used for filling drug product (DP). Gamma-irradiated silicone tubing and lynx connectors (taken from assembly) generated substantial amount of particles (majority non-protein and some protein) that would not be acceptable if observed in the final DP. No apparent impact of formulation parameters have been found in these studies. Localized discoloration of silicone tubing was observed around areas with PVC cap (used as a guard on the pinch clamps) after gamma irradiation. Discoloration of silicone tubing can also be induced with heat regardless of PVC cap contact. Several extractable species were found in gamma-irradiated silicone tubing, and the origin of these extractable species is believed to be from the gamma irradiated assembly/packaging material rather than the tubing itself. The extractable species were comparable between the discolored and clear tubing. Furthermore, heat treatment of silicone tubing was effective at reducing these organic extractable species. Neither the extractable species nor discolored tubing has been shown to cause protein particles. Inconsistencies (from assembly to assembly) in the formation of these visible protein particles pose a challenge for further investigation into the mechanism. Meanwhile, a potential mitigation would be to incorporate a filter close to the filling nozzle into the SU assembly by SU manufacturer. Since these SU assemblies are used for filling DP, it is crucial that manufacturers produce products (may include non-fluid contact material) that are essentially free of extractables, leachables, and particles

Sociedad civil y democracia en América Latina: crisis y reinvención de la política

Sociedad Civil y Democracia en América Latina: crisis y reinvención de la política abre un debate urgente y necesa-rio sobre los desafíos que afectan a la gobernabilidad y la consolidación de la democracia en nuestro continente

Sociedade civil e democracia na América Latina: crise e reinvenção da política

Sociedade Civil e Democracia na América Latina: crise e reinvenção da política abre um debate urgente e necessário sobre os desafios que afetam a governabilidade e consolidação da democracia em nosso continente

Características Arquitectónicas a considerar en un Centro de Interpretación Vivencial que potencialice y promocione los recursos del bosque de protección Alto Mayo, Distrito de Pardo Miguel – Provincia de Rioja

El siguiente trabajo buscó darle un valor agregado a una las reservas naturales más hermosas que tenemos en el departamento de San Martín, y darle un plus que ayude a su preservación natural. Creando un recinto donde se pueda transmitir su importancia y el sin número de especies entre en flora y fauna que alberga. Busco que se vuelva un punto de visita obligatoria de turistas fomentando una nueva opción para el poblador de generar economía en sus hogares. El proceso de recopilación de información se inició a raíz de una necesidad, la necesidad de dar un valor agregado a esta belleza natural. La infraestructura de un CENTRO DE INTERPRETACIÓN VIVENCIAL, un lugar donde el poblador se llene de conociendo de las bondades de este lugar y disfrute de su estadía mientras dure su permanencia. Se profundizó a conocer lugares al rededor del mundo con esta misma perspectiva, “los análisis de casos exitosos”, también las encuestas dieron una idea de la visión del poblador con respecto al Bosque de Protección Alto Mayo. Arrojó los posibles ambientes podríamos adicionar a este recinto, ciñéndonos a los parámetros de la normatividad. Arrojando como idea un lugar que no solo sea dirigido al visitante sino al uso de los mismos pobladores donde puedan a través del uso de estos espacios, generar oportunidades de trabajo a los mismos pobladores de la zona y hacer un círculo de identidad con un lugar que les da una oportunidad de ayudar y que este lugar se auto sostenga con estos servicios

Atas do XVII Simpósio Internacional de Informática Educativa

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