Intensification of cattle ranching production systems: Socioeconomic and environmental synergies and risks in Brazil

Intensification of Brazilian cattle ranching systems has attracted both national and international attention due to its direct relation with Amazon deforestation on the one hand and increasing demand of the global population for meat on the other. Since Brazilian cattle ranching is predominantly pasture-based, we particularly focus on pasture management. We summarize the most recurrent opportunities and risks associated with pasture intensification that are brought up within scientific and political dialogues, and discuss them within the Brazilian context. We argue that sustainable intensification of pasturelands in Brazil is a viable way to increase agricultural output while simultaneously sparing land for nature. Since environmental degradation is often associated with low-yield extensive systems in Brazil, it is possible to obtain higher yields, while reversing degradation, by adopting practices like rotational grazing, incorporation of legumes and integrated crop-livestock-forestry systems. Technical assistance is however essential, particularly for small- and medium-scale farmers. Sound complementary policies and good governance must accompany these measures so that a ‘rebound effect’ does not lead to increased deforestation and other adverse social and environmental impacts. It is also important that animal welfare is not compromised. Although the discussion is presented with respect to Brazil, some aspects are relevant to other developing countries

A Hierarchical Taxonomy of Psychopathology Can Transform Mental Health Research

For more than a century, research on psychopathology has focused on categorical diagnoses. Although this work has produced major discoveries, growing evidence points to the superiority of a dimensional approach to the science of mental illness. Here we outline one such dimensional system—the Hierarchical Taxonomy of Psychopathology (HiTOP)—that is based on empirical patterns of co-occurrence among psychological symptoms. We highlight key ways in which this framework can advance mental-health research, and we provide some heuristics for using HiTOP to test theories of psychopathology. We then review emerging evidence that supports the value of a hierarchical, dimensional model of mental illness across diverse research areas in psychological science. These new data suggest that the HiTOP system has the potential to accelerate and improve research on mental-health problems as well as efforts to more effectively assess, prevent, and treat mental illness.FSW – Publicaties zonder aanstelling Universiteit Leide

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Food avoidance by breast feeding mothers in south east queensland

A group of 123 lactating mothers have been studied in Southeast Queensland, Australia. Seventy-three percent eliminated some foods from their own diets either to prevent problems or to treat existing conditions in their infants. The commonest food to be excluded was cabbage, followed by chocolate, other vegetables and fruit. A few mothers stopped taking cow’s milk or cow’s milk products. The mothers obtained this information from many sources including family, friends, books as well as health professionals. Avoidance of certain foods during lactation is a common practice. Mothers who avoided some foods had significantly greater weight loss between one and three months after delivery than those who ate a free diet, but maternal food restrictions had no significant effect on the weight gains of their infants

Methylation increases the open probability of the epithelial sodium channel in A6 epithelia

We used single channel methods on A6 renal cells to study the regulation by methylation reactions of epithelial sodium channels. 3-Deazaadenosine (3- DZA), a methyltransferase blocker, produced a 5-fold decrease in sodium transport and a 6-fold decrease in apical sodium channel activity by decreasing channel open probability (P(o)). 3-Deazaadenosine also blocked the increase in channel open probability associated with addition of aldosterone. Sodium channel activity in excised 'inside-out' patches usually decreased within 1-2 min; in the presence of S-adenosyl-L-methionine (AdoMet), activity persisted for 5-8 min. Sodium channel mean time open (t(open)) before and after patch excision was higher in the presence of AdoMet than in untreated excised patches but less than t(open) in cell-attached patches. Sodium channel activity in excised patches exposed to both AdoMet and GTP usually remained stable for more than 10 min, and P(o) and the number of active channels per patch were close to values in cell-attached patches from untreated cells. These findings suggest that a methylation reaction contributes to the activity of epithelial sodium channels in A6 cells and is directed to some regulatory element closely connected with the channel, whose activity also depends on the presence of intracellular GTP.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Partnership, flexible workplace practices and the realisation of mutual gains: evidence from the British WERS 2004 dataset

This paper examines the potential for workplace partnership to produce mutual gains through the implementation of high-performance, flexible-working initiatives. Using a large manager–employee matched dataset, originating in the British Workplace Employment Relations Survey (WERS 2004), it focuses upon a range of related workplace practices reported by manager and employees as available or in use in their establishment, to consider the extent to which their implementation is associated with mutual benefits (positive-sum), reported by both managers and employee respondents, or whether gains for one group occur at potential cost to another (zero-sum). Bivariate probit models allow measures of manager and employee-reported organisational outcomes to endogenously affect each other, first from a managerial perspective, second from an employee perspective and third from a combined managerial and employee perspective. The results highlight the significant potential for partnership agreements to deliver mutual gains, albeit within a narrower range of workplace practices than might be the case if the innovation package was designed with the primary interest of only one group in mind. Unsurprisingly, managers and employees were found to have different perspectives in relation to partnership arrangements, with the latter having the more realistic expectations of achievable outcomes. However, since partnership agreements, as defined by this paper, remain underdeveloped within UK workplaces, with only 8% of the sampled 23,000 employees benefiting from such workplace arrangements, the evidence advanced by this paper would indicate a potential scope for realisable gains deriving from well-designed, participatory forms of partnership

Ethnicity and Psychiatric Comorbidity in a National Sample: Evidence for Latent Comorbidity Factor Invariance and Connections with Disorder Prevalence

Purpose: Prevalence rates, and bivariate comorbidity patterns, of many common mental disorders differ significantly across ethnic groups. While studies have examined multivariate comorbidity patterns by gender and age, no studies to our knowledge have examined such patterns by ethnicity. Such an investigation could aid in understanding the nature of ethnicity-related health disparities in mental health and is timely given the likely implementation of multivariate comorbidity structures (i.e., internalizing and externalizing) to frame key parts of DSM-5. Methods: We investigated whether multivariate comorbidity of 11 common mental disorders, and their associated latent comorbidity factors, differed across five ethnic groups in a large, nationally representative sample (n = 43,093). We conducted confirmatory factor analyses and factorial invariance analyses in White (n = 24,507), Hispanic/Latino (n = 8,308), Black (n = 8,245), Asian/Pacific Islander (n = 1,332), and American Indian/Alaska Native (n = 701) individuals. Results: Results supported a two-factor internalizing-externalizing comorbidity factor model in both lifetime and 12-month diagnoses. This structure was invariant across ethnicity, but factor means differed significantly across ethnic groups. Conclusions: These findings, taken together, indicated that observed prevalence rate differences between ethnic groups reflect ethnic differences in latent internalizing and externalizing factor means. We discuss implications for classification (DSM-5 and ICD-11 meta-structure), health disparities research, and treatment