Role of TMPRSS6 rs855791 (T > C) polymorphism with iron and ferritin in Iraqi adult patients with iron deficiency anemia

Our study aimed to investigate the association between TMPRSS6 polymorphism and risk of iron deficiency anemia. In this analytical (case and control) study, venous blood samples were taken from (100) subjects, (50) patients with iron deficiency anemia and (50) healthy volunteers as a control group. Hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), iron, and ferritin were measured. Genomic DNA was extracted by salting out method and the TMPRSS6 C/T polymorphism and AQP1 were analyzed using polymerase chain reaction (PCR). The results showed that the frequency of TT genotype of TMPRSS6 C/T polymorphism was higher in IDA patients. The results also showed significantly low Hb concentration, MCV, MCHC, MCH, iron, and ferritin in IDA patients when compared with normal individuals (P≤0.00). The well gene and mutant gene within the IDA patients were shown to have no interaction with the CBC parameters (Hb, MCV, MCHC, MCH and RBC). The frequency of TT genotype of AQP1 polymorphism was significantly higher with mutant gene in IDA patients in comparison with the controls. In conclusion, there were statistically significant association between TMPRSS6 C/T polymorphism and risk of IDA and the same as of AQP1gene among Iraqi patients in Baghdad state. Also, There were interactions observed between TMPRSS6 C/T genotypes and AQP1 with means of Hb, MCV, MCHC, MCH, and iron in IDA patients group when compared with normal individuals. But there were no statistically significant differences between well gene and mutant gene in IDA patients

Search for jet extinction in the inclusive jet-pT spectrum from proton-proton collisions at s=8 TeV

Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published articles title, journal citation, and DOI.The first search at the LHC for the extinction of QCD jet production is presented, using data collected with the CMS detector corresponding to an integrated luminosity of 10.7  fb−1 of proton-proton collisions at a center-of-mass energy of 8 TeV. The extinction model studied in this analysis is motivated by the search for signatures of strong gravity at the TeV scale (terascale gravity) and assumes the existence of string couplings in the strong-coupling limit. In this limit, the string model predicts the suppression of all high-transverse-momentum standard model processes, including jet production, beyond a certain energy scale. To test this prediction, the measured transverse-momentum spectrum is compared to the theoretical prediction of the standard model. No significant deficit of events is found at high transverse momentum. A 95% confidence level lower limit of 3.3 TeV is set on the extinction mass scale

Searches for electroweak neutralino and chargino production in channels with Higgs, Z, and W bosons in pp collisions at 8 TeV

Searches for supersymmetry (SUSY) are presented based on the electroweak pair production of neutralinos and charginos, leading to decay channels with Higgs, Z, and W bosons and undetected lightest SUSY particles (LSPs). The data sample corresponds to an integrated luminosity of about 19.5 fb(-1) of proton-proton collisions at a center-of-mass energy of 8 TeV collected in 2012 with the CMS detector at the LHC. The main emphasis is neutralino pair production in which each neutralino decays either to a Higgs boson (h) and an LSP or to a Z boson and an LSP, leading to hh, hZ, and ZZ states with missing transverse energy (E-T(miss)). A second aspect is chargino-neutralino pair production, leading to hW states with E-T(miss). The decays of a Higgs boson to a bottom-quark pair, to a photon pair, and to final states with leptons are considered in conjunction with hadronic and leptonic decay modes of the Z and W bosons. No evidence is found for supersymmetric particles, and 95% confidence level upper limits are evaluated for the respective pair production cross sections and for neutralino and chargino mass values

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