EPR before EPR: a 1930 Einstein-Bohr thought experiment revisited

In 1930 Einstein argued against consistency of the time-energy uncertainty relation by discussing a thought experiment involving a measurement of mass of the box which emitted a photon. Bohr seemingly triumphed over Einstein by arguing that the Einstein's own general theory of relativity saves the consistency of quantum mechanics. We revisit this thought experiment from a modern point of view at a level suitable for undergraduate readership and find that neither Einstein nor Bohr was right. Instead, this thought experiment should be thought of as an early example of a system demonstrating nonlocal "EPR" quantum correlations, five years before the famous Einstein-Podolsky-Rosen paper.Comment: 11 pages, revised, accepted for publication in Eur. J. Phy

Promoting post-stroke recovery through focal or whole body vibration: criticisms and prospects from a narrative review

Objective: Several focal muscle vibration (fMV) and whole body vibration (WBV) protocols have been designed to promote brain reorganization processes in patients with stroke. However, whether fMV and WBV should be considered helpful tools to promote post-stroke recovery remains still largely unclear. Methods: We here achieve a comprehensive review of the application of fMV and WBV to promote brain reorganization processes in patients with stroke. By first discussing the putative physiological basis of fMV and WBV and then examining previous observations achieved in recent randomized controlled trials (RCT) in patients with stroke, we critically discuss possible strength and limitations of the currently available data. Results: We provide the first systematic assessment of fMV studies demonstrating some improvement in upper and lower limb functions, in patients with chronic stroke. We also confirm and expand previous considerations about the rather limited rationale for the application of current WBV protocols in patients with chronic stroke. Conclusion: Based on available information, we propose new recommendations for optimal stimulation parameters and strategies for recruitment of specific stroke populations that would more likely benefit from future fMV or WBV application, in terms of speed and amount of post-stroke functional recovery

P02.99: Assessment of fetal lung maturity in a non‐invasive fashion

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Barium alginate capsules for 3D immobilisation of living cells: morphology, membrane properties and permeability

Encapsulation in a barium alginate membrane is a promising strategy to obtain a three dimensional culture of living cells: membrane properties are crucial for a realistic clinical application. A one-step encapsulation technique, recently developed for controlled release of boar semen, was employed to prepare barium alginate and protamine-alginate membranes: permeability to two model molecules (haemoglobin and glucose) was evaluated. Capsules were evaluated for technological properties and scanning electron microscopy was used to examine the external morphology of the capsules and the 3D distribution of the cells within the core. The results indicate that 3D arrangement and cell shape are maintained, capsule dimensions and mechanical properties can be modulated, as well as their permeability to model molecules such as haemoglobin and glucose

Transport in strongly-coupled graphene-LaAlO3/SrTiO3 hybrid systems

We report on the transport properties of hybrid devices obtained by depositing graphene on a LaAlO3/SrTiO3 oxide junction hosting a 4 nm-deep two-dimensional electron system. At low graphene-oxide inter-layer bias the two electron systems are electrically isolated, despite their small spatial separation, and very efficient reciprocal gating is shown. A pronounced rectifying behavior is observed for larger bias values and ascribed to the interplay between electrostatic depletion and tunneling across the LaAlO3 barrier. The relevance of these results in the context of strongly-coupled bilayer systems is discussed.Comment: 10 pages, 3 figure

Internal Time Formalism for Spacetimes with Two Killing Vectors

The Hamiltonian structure of spacetimes with two commuting Killing vector fields is analyzed for the purpose of addressing the various problems of time that arise in canonical gravity. Two specific models are considered: (i) cylindrically symmetric spacetimes, and (ii) toroidally symmetric spacetimes, which respectively involve open and closed universe boundary conditions. For each model canonical variables which can be used to identify points of space and instants of time, {\it i.e.}, internally defined spacetime coordinates, are identified. To do this it is necessary to extend the usual ADM phase space by a finite number of degrees of freedom. Canonical transformations are exhibited that identify each of these models with harmonic maps in the parametrized field theory formalism. The identifications made between the gravitational models and harmonic map field theories are completely gauge invariant, that is, no coordinate conditions are needed. The degree to which the problems of time are resolved in these models is discussed.Comment: 36 pages, Te

The effect of RU486 administered during the proliferative and secretory phase of the cycle on the bleeding pattern, hormonal parameters and the endometrium

Seventeen healthy women aged 24-45 years with regular menstrual periods, proven fertility and not using steroidal contraceptives or IUD were recruited for the study. The volunteers were followed during one control, one treatment and one follow-up cycle. Daily morning urine samples were obtained during the control and the treatment cycle. The samples were analysed with regard to pregnanediol glucuronide (P2-G), oestrone glucuronide (E1-G), oestradiol (E2), progesterone (P4), LH and creatinine. During the entire 3-month study the subjects kept a record of uterine bleeding and side effects. The subjects received 50 mg RU486 daily either on cycle days 7-10 (n = 7) or on cycle days 20-23 (n = 10). An endometrial biopsy was taken on cycle day 10 in the first group and on cycle days 21-28 in the second group of patients. Treatment during the proliferative phase caused significant prolongation of the cycle length due to a delay of the oestrogen and LH surge. However, once the oestrogen concentration started to increase, the remaining part of the cycle was normal. The length of the follow-up cycle was similar to that of the control cycle. The morphology of the endometrium did not differ from control samples taken from untreated women at the same time of the cycle. All ovulating women (n = 9) treated in the mid-luteal phase started to bleed on the 3rd to 4th day of the treatment. In four of these women the bleeding was scanty and followed by a menstrual-like bleeding at expected time, while in the remaining five volunteers the treatment bleeding was heavier and not followed by a new bleeding until a month later. The duration of the secretory phase was 16.5 ± 1.3 days in women with two bleeding episodes and 11.8 ± 1.9 days in women with one bleeding episode (P < 0.05). The hormonal parameters were similar in both groups up to the start of the treatment. In the patients with one bleeding episode, the treatment was associated with a reduction in progesterone concentration, while in the patients with two bleeding episodes the progesterone concentration remained elevated until the second bleeding episode. Light microscopic examination of the endometrium revealed unique changes in the endometrial morphology. The results indicate that RU486 acts mainly on the endometrium but a direct or indirect effect on the corpus luteum cannot be excluded. The age of the corpus luteum may be of importance for its susceptibility to RU486 treatmen

Fast UPLC/PDA determination of squalene in Sicilian P.D.O. pistachio from Bronte: optimization of oil extraction method and analytical characterization

A fast reversed-phase UPLC method was developed for squalene determination in Sicilian pistachio samples that entry in the European register of the products with P.D.O. In the present study the SPE procedure was optimized for the squalene extraction prior to the UPLC/PDA analysis. The precision of the full analytical procedure was satisfactory and the mean recoveries were 92.8 + 0.3 % and 96.6 + 0.1 % for 25 and 50 mg L-1 level of addition, respectively. Selected chromatographic conditions allowed a very fast squalene determination; in fact it was well separated in ~ 0.54 min with good resolution. Squalene was detected in all the pistachio samples analyzed and the levels ranged from 55.45 to 226.34 mg . kg-1. Comparing our results with those of other studies it emerges that squalene contents in P.D.O. Sicilian pistachio samples, generally, were higher than those measured for other samples of different geographic origins

Chemical abundances and radial velocities in the extremely metal-poor galaxy DDO 68

We present chemical abundances and radial velocities of six HII regions in the extremely metal-poor star-forming dwarf galaxy DDO 68. They are derived from deep spectra in the wavelength range 3500 - 10,000 {\AA}, acquired with the Multi Object Double Spectrograph (MODS) at the Large Binocular Telescope (LBT). In the three regions where the [O III]$\lambda$4363 {\AA} line was detected, we inferred the abundance of He, N, O, Ne, Ar, and S through the "direct" method. We also derived the oxygen abundances of all the six regions adopting indirect method calibrations. We confirm that DDO 68 is an extremely metal-poor galaxy, and a strong outlier in the luminosity - metallicity relation defined by star-forming galaxies. With the direct-method we find indeed an oxygen abundance of 12+log(O/H)=7.14$\pm$0.07 in the northernmost region of the galaxy and, although with large uncertainties, an even lower 12+log(O/H)=6.96$\pm$0.09 in the "tail". This is, at face value, the most metal-poor direct abundance detection of any galaxy known. We derive a radial oxygen gradient of -0.06$\pm$0.03 dex/kpc (or -0.30 dex $R_{25}^{-1}$) with the direct method, and a steeper gradient of -0.12$\pm$0.03 dex/kpc (or -0.59 dex $R_{25}^{-1}$) from the indirect method. For the $\alpha$-element to oxygen ratios we obtain values in agreement with those found in other metal-poor star-forming dwarfs. For nitrogen, instead, we infer much higher values, leading to log(N/O)$\sim-1.4$, at variance with the suggested existence of a tight plateau at $-1.6$ in extremely metal poor dwarfs. The derived helium mass fraction ranges from Y=0.240$\pm$0.005 to Y=0.25$\pm$0.02, compatible with standard big bang nucleosynthesis. Finally, we measured HII region radial velocities in the range 479$-$522 km/s from the tail to the head of the "comet", consistent with the rotation derived in the HI.Comment: Accepted for publication in MNRA