ГЕНЕТИЧЕСКИЙ ПОЛИМОРФИЗМ АРОМАТАЗЫ У ПАЦИЕНТОК С СЕРОЗНЫМ РАКОМ ЯИЧНИКОВ В РЕСПУБЛИКЕ БЕЛАРУСЬ

The aim of the present research was to study the frequency of the distribution of variants of gene polymorphism of aromatase (СYP19A1) in Belarusian patients with serous ovarian cancer. This population established the influence of gene polymorphism rs10046 with the risk of serous ovarian cancer in women older than 50 years: CT genotype in a group of patients with serous ovarian cancer was met significantly less than in the control group (OR = 0.58; 95 % CI: 0.37–0.91; p = 0.023).В работе изучена частота распределения полиморфных вариантов гена ароматазы у белорусских пациенток с серозным раком яичников. В данной популяции пациентов установлена связь генетического полиморфизма rs10046 с риском развития серозного рака яичников у женщин старше 50 лет: генотип СТ в группе пациенток встречался достоверно реже (OR = 0,58; 95 % CI: 0,37–0,91; р = 0,023)

КВАНТОВОХИМИЧЕСКОЕ И ЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕ РЕАКЦИЙ НУКЛЕОФИЛЬНОГО ЗАМЕЩЕНИЯ В РЯДУ N-АЛКИЛ-3-НИТРО-1,2,4-ТРИАЗОЛОВ

Reactions of nucleophilic substitution of nitro group in N-alkyl-3-nitro-1,2,4-triazoles have been studied both experimentally and theoretically using DFT method. The standard enthalphy and Gibbs free energy of alkoxylation reactions of N-alkyl-3-nitro-1,2,4-triazoles in gas phase and aqueous solution have been calculated. The calculation results show that nucleophilic substitution reactions of N-alkyl-3-nitro-1,2,4-triazoles with alcohols and alcoholate anions are thermodynamically possible both in gas phase and in aqueous solution. Computed activation energies for reactions of N-alkyl-3-nitro-1,2,4-triazoles with methanol decrease in the series of ΔG≠S(for 1-isomer) >> ΔG≠S(for 4-isomer) > ΔG≠S(for 2-isomer). The calculation results are in good agreement with experimental data.С использованием современных квантовохимических и экспериментальных методов исследованы процессы нуклеофильного замещения нитрогруппы в ряду N-алкил-3-нитро-1,2,4-триазолов. Проведены расчеты стандартных энтальпий и энергий Гиббса реакций алкоксилирования N-алкил-3-нитро-1,2,4-триазолов в газовой и водной фазах. Согласно выполненным расчетам, реакции нуклеофильного замещения N-алкил-3-нитро-1,2,4-триазолов со спиртами и алкоголят-анионами термодинамически возможны как в газовой фазе, так и в водном растворе. На примере изомерных N-этил-3-нитро-1,2,4-триазолов показано, что расчетные значения энергии Гиббса активации реакций с метиловым спиртом в водном растворе уменьшаются в ряду ΔG≠S(для 1-изомера) >> ΔG≠S(для 4-изомера) > ΔG≠S(для 2-изомера). Результаты расчетов хорошо согласуются с данными экспериментального исследования процессов нуклеофильного замещения нитрогруппы в молекулах N-алкил-3-нитро-1,2,4-триазолов

The clinical relevance of oliguria in the critically ill patient : Analysis of a large observational database

Funding Information: Marc Leone reports receiving consulting fees from Amomed and Aguettant; lecture fees from MSD, Pfizer, Octapharma, 3 M, Aspen, Orion; travel support from LFB; and grant support from PHRC IR and his institution. JLV is the Editor-in-Chief of Critical Care. The other authors declare that they have no relevant financial interests. Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.publishersversionPeer reviewe

Continuity of Economic Education of Managers-to-be

The paper considers the problem of methodological and methodic continuity of reading economic subjects to future managers. The common content of economic subjects is based on the similar functions of the theory of economics and other economic sciences. The author presents the means of forming an integral understanding of economic issues on the example of teaching theory of economics, logistics, marketing, anti-crisis managementВ статье рассматривается проблема методологической и методической преемственности преподавания и изучения дисциплин экономического блока образовательной подготовки будущих менеджеров. Содержательное единство экономических дисциплин основано на общности функций экономической теории и других экономических наук. На примере изучения экономической теории, логистики, маркетинга, антикризисного управления демонстрируются возможности формирования у студентов целостного представления о проблемах экономического развития общества и управлении экономико

PREHARVEST SPROUTING RESISTANCE IN SPRING BREAD WHEAT CARRYING CHROMOSOME 6Agi(6D) FROM Agropyron intermedium

A significant adverse effect of chromosome 6Agi(6D)-from Agropyron intermedium on preharvest sprouting resistance was foundin inbredlines (F7–F10 or senior) andnear-isogeniclines of red-grain andwhite-grain common spring wheat. The red-grain recombinant inbredlines, carrying this substitution chromosome, varied significantly in this trait, probably, owing to the genetic background effect. The causes of the adverse effect of chromosome 6Agi(6D) from Agropyron intermedium on preharvest sprouting resistance are unknown

Seismological characteristics of the earth's crust of southeastern part of the Phennoscandinavian shield (Russia)

He deep structure of the Arkhangelsk region - Karelia border area was studied by generalizing earlier data, obtained by RWM, DSS and ECWM, and the results of new geological studies carried out by the Institute of Geology, Karelian Research Centre, RAS. The associated results of seismic (RWM, DSS, ECWM) research and other geophysical and geological data are discussed. This integrated approach makes it possible to reveal all principal differences in the seismic parameters of the upper crust in the section interval from the surface to a depth of 5- 7 km and their variation pattern that are due to geological-structural characteristics at the modern erosion section level. An increase in wave velocity near the surface is assumed to be connected with the presence of highly metamorphosed complexes or mafic-ultramafic magmatic rocks. Seismic parameters in the depth range 7-12 to 25-30 km are stable over the entire territory studied, and depth-dependent variations in velocity (maximum velocity in the upper and middle portions of the crust is not more than 6,2-6,5km/s) show an inversion pattern. The rock composition of the Earth's crust to a depth of 25-30 km is assumed to differ negligibly from that of the upper part of the section. A hypothesis of the nature of the crust-mantle transition layer in the region as a relict of the crystallized head portion of a Palaeoproterozoic Windy Belt plume is put forward. The evolution of the region's crust and the directions of large-scale movements in it are shown in general terms