428 research outputs found
Plasma Nanoscience: from Nano-Solids in Plasmas to Nano-Plasmas in Solids
The unique plasma-specific features and physical phenomena in the
organization of nanoscale solid-state systems in a broad range of elemental
composition, structure, and dimensionality are critically reviewed. These
effects lead to the possibility to localize and control energy and matter at
nanoscales and to produce self-organized nano-solids with highly unusual and
superior properties. A unifying conceptual framework based on the control of
production, transport, and self-organization of precursor species is introduced
and a variety of plasma-specific non-equilibrium and kinetics-driven phenomena
across the many temporal and spatial scales is explained. When the plasma is
localized to micrometer and nanometer dimensions, new emergent phenomena arise.
The examples range from semiconducting quantum dots and nanowires, chirality
control of single-walled carbon nanotubes, ultra-fine manipulation of
graphenes, nano-diamond, and organic matter, to nano-plasma effects and
nano-plasmas of different states of matter.Comment: This is an essential interdisciplinary reference which can be used by
both advanced and early career researchers as well as in undergraduate
teaching and postgraduate research trainin
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Effect of head group and lipid tail oxidation in the cell membrane revealed through integrated simulations and experiments
We report on multi-level atomistic simulations for the interaction of reactive oxygen species (ROS) with the head groups of the phospholipid bilayer, and the subsequent effect of head group and lipid tail oxidation on the structural and dynamic properties of the cell membrane. Our simulations are validated by experiments using a cold atmospheric plasma as external ROS source. We found that plasma treatment leads to a slight initial rise in membrane rigidity, followed by a strong and persistent increase in fluidity, indicating a drop in lipid order. The latter is also revealed by our simulations. This study is important for cancer treatment by therapies producing (extracellular) ROS, such as plasma treatment. These ROS will interact with the cell membrane, first oxidizing the head groups, followed by the lipid tails. A drop in lipid order might allow them to penetrate into the cell interior (e.g., through pores created due to oxidation of the lipid tails) and cause intracellular oxidative damage, eventually leading to cell death. This work in general elucidates the underlying mechanisms of ROS interaction with the cell membrane at the atomic level
Unraveling the deposition mechanism in a-C:H thin-film growth : a molecular-dynamics study for the reaction behavior of C3 and C3H radicals with a-C:H surfaces
In this mol.-dynamics study, we present the simulated growth of thin a-C:H films using the Brenner [Phys. Rev. B 42, 9458 (1990)] potential. These simulations are relevant for the growth of thin films, grown using low-energy hydrocarbons. In this work, we investigate the reaction mechanisms of both the linear and the cyclic isomers of C3 and C3H on an a-C:H surface. We found that the cyclic species are always more reactive as compared to the linear species, due to their lower stability. The C3 species are found to be more reactive than the C3H species, due to steric hindrance of the H atom, shielding the C atom from the surface. The different mechanisms are discussed. The resulting film properties for different flux ratios of C3 and C3H have also been investigated. It is shown that films as deposited from C3 and C3H have a low d. and show low crosslinking. A clear change in microstructure is obsd. as the ratio between the cyclic and the linear species changes. These simulations provide insights into the reaction behavior of the investigated species, and how this influences the resulting film properties. [on SciFinder (R)
Evidence that Amphotericin B Mediates Reactivation of Latent Epstein-Barr Virus in Hodgkin's Lymphoma Allowing Cytotoxicity by Acyclovir
This brief communication focuses on aspects of a recent case report (Yonsei Med J 2005;46:425-30) on a full and sustained remission of Hodgkin's lymphoma (HL) after a single day of chemotherapy. A septic episode required stopping chemotherapy and starting amphotericin B and acyclovir. Remission evidence was seen within days of starting these. A review of research supporting the notion that amphotericin B can reactivate latent Epstein-Barr virus and thus allow acyclovir to kill infected HL cells is given. Experimental work is required to confirm or refute this possibility. If successful, amphotericin B and acyclovir treatment could be extended to other EBV-driven cancers such as Burkitt's lymphoma, nasopharyngeal carcinoma and the occasional EBV-related epithelial cancer of the breast, colon, prostate, and others
Light emission from dye-doped cholesteric liquid crystals at oblique angles: Simulation and experiment
Effect of head group and lipid tail oxidation in the cell membrane revealed through integrated simulations and experiments
ABSTRACT: We report on multi-level atomistic simulations for the interaction of reactive oxygen species (ROS) with the head groups of the phospholipid bilayer, and the subsequent effect of head group and lipid tail oxidation on the structural and dynamic properties of the cell membrane. Our simulations are validated by experiments using a cold atmospheric plasma as external ROS source. We found that plasma treatment leads to a slight initial rise in membrane rigidity, followed by a strong and persistent increase in fluidity, indicating a drop in lipid order. The latter is also revealed by our simulations. This study is important for cancer treatment by therapies producing (extracellular) ROS, such as plasma treatment. These ROS will interact with the cell membrane, first oxidizing the head groups, followed by the lipid tails. A drop in lipid order might allow them to penetrate into the cell interior (e.g., through pores created due to oxidation of the lipid tails) and cause intracellular oxidative damage, eventually leading to cell death. This work in general elucidates the underlying mechanisms of ROS interaction with the cell membrane at the atomic level
Study of liquid crystal in contact with aqueous solutions for detection of biomolecules (abstract)
Design, Synthesis and Discovery of N,N'-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication
The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structureâbased virtual screening approach using the ZIKV NS5âMTase. A novel series of molecules with a carbazoylâarylâurea structure has been discovered and a library of analogues has been synthesized. The new compounds inhibit ZIKV MTase with IC50 between 23â48â
ÎŒM. In addition, carbazoylâarylâureas also proved to inhibit ZIKV replication activity at micromolar concentration
Printed in Great Britain Genome sequence analysis of Tamana bat virus and its relationship with the genus Flavivirus
Tamana bat virus (TABV, isolated from the bat Pteronotus parnellii) is currently classified as a tentative species in the genus Flavivirus. We report here the determination and analysis of its complete coding sequence. Low but significant similarity scores between TABV and memberviruses of the genus Flavivirus were identified in the amino acid sequences of the structural, NS3 and NS5 genes. A series of cysteines located in the envelope protein and the most important enzymatic domains of the virus helicase/NTPase, methyltransferase and RNA-dependent RNA polymerase were found to be highly conserved. In the serine-protease domain, the catalytic sites were conserved, but variations in sequence were found in the putative substrate-binding sites, implying possible differences in the protease specificity. In accordance with this finding, the putative cleavage sites of the TABV polyprotein by the virus protease are substantially different from those of flaviviruses. The phylogenetic position of TABV could not be determined precisely, probably due to the extremely significant genetic divergence from other member-viruses of the family Flaviviridae. However, analysis based on both genetic distances and maximum-likelihood confirmed that TABV is more closely related to the flaviviruses than to the other genera. These findings have implications for the evolutionary history and taxonomic classification of the family as a whole : (i) the possibility that flaviviruses were derived from viruses infecting mammals rather than from mosquito viruses cannot be excluded ; (ii) using the current criteria for the definition of genera in the family Flaviviridae, TABV should be assigned to a new genus
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