Where Are You From? An Investigation into the Intersectionality of Accent Strength and Nationality Status on Perceptions of Non-native Speakers in Britain

We explore how interpersonal and intergroup perceptions are affected by a non-native speaker’s accent strength and the status of their home country. When nationality information was absent (Study 1), natives who heard a strong (vs. weak) accent rated the speaker as warmer but immigrants as a group as more threatening. This result was replicated when the speaker’s nationality was familiar (Study 2) but in this study, country status further shaped accent-based perceptions: the strong (vs. weak) accented speaker evoked more positive interpersonal perceptions when her country status was low, but more negative intergroup perceptions when her country status was high. When the status of the speaker’s nationality was manipulated (Study 3), we replicated the interpersonal perceptions found in Study 1 and the intergroup perceptions found in Study 2. Findings support a holistic approach to investigating perceptions of non-native speakers: one that considers nationality as well as accent strength

Prologue: Language Challenges in the 21st Century

As immigration and mobility increases, so do interactions between people from different linguistic backgrounds. Yet while linguistic diversity offers many benefits, it also comes with a number of challenges. In seven empirical articles and one commentary, this Special Issue addresses some of the most significant language challenges facing researchers in the 21st century: the power language has to form and perpetuate stereotypes, the contribution language makes to intersectional identities, and the role of language in shaping intergroup relations. By presenting work that aims to shed light on some of these issues, the goal of this Special Issue is to (a) highlight language as integral to social processes and (b) inspire researchers to address the challenges we face. To keep pace with the world’s constantly evolving linguistic landscape, it is essential that we make progress toward harnessing language’s power in ways that benefit 21st century globalized societies

Obedience as “Engaged Followership”:A Review and Research Agenda

Milgram’s Obedience to Authority (OtA) studies have long been understood as demonstrating that people are prone to blindly follow the orders of authority. More recently, we have proposed an engaged followership model of obedience, which suggests that a person’s willingness to go along with the requests of an authority figure is predicated on their identification with that person and/or the cause they represent. In this paper, we present a review of our rationale for this perspective and take stock of the current evidence we have to support it. We also highlight gaps in this evidence, and set out an agenda for future research

High definition systems in Japan

The successful implementation of a strategy to produce high-definition systems within the Japanese economy will favorably affect the fundamental competitiveness of Japan relative to the rest of the world. The development of an infrastructure necessary to support high-definition products and systems in that country involves major commitments of engineering resources, plants and equipment, educational programs and funding. The results of these efforts appear to affect virtually every aspect of the Japanese industrial complex. The results of assessments of the current progress of Japan toward the development of high-definition products and systems are presented. The assessments are based on the findings of a panel of U.S. experts made up of individuals from U.S. academia and industry, and derived from a study of the Japanese literature combined with visits to the primary relevant industrial laboratories and development agencies in Japan. Specific coverage includes an evaluation of progress in R&D for high-definition television (HDTV) displays that are evolving in Japan; high-definition standards and equipment development; Japanese intentions for the use of HDTV; economic evaluation of Japan's public policy initiatives in support of high-definition systems; management analysis of Japan's strategy of leverage with respect to high-definition products and systems

The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis

Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact on the structure and expression of host chromatin by the human retrovirus HTLV-1. We show that HTLV-1 disrupts host chromatin structure by forming loops between the provirus and the host genome; certain loops depend on the critical chromatin architectural protein CTCF, which we recently discovered binds to the HTLV-1 provirus. We show that the provirus causes two distinct patterns of abnormal transcription of the host genome in cis: bidirectional transcription in the host genome immediately flanking the provirus, and clone-specific transcription in cis at non-contiguous loci up to >300 kb from the integration site. We conclude that HTLV-1 causes insertional mutagenesis up to the megabase range in the host genome in >104 persistently-maintained HTLV-1+ T-cell clones in vivo

Engaged followership and toxic science:Exploring the effect of prototypicality on willingness to follow harmful experimental instructions

Drawing on the ‘engaged followership’ reinterpretation of Milgram's work on obedience, four studies (three pre-registered) examine the extent to which people's willingness to follow an experimenter's instructions is dependent on the perceived prototypicality of the science they are supposedly advancing. In Studies 1, 2 and 3, participants took part in a study that was described as advancing either ‘hard’ (prototypical) science (i.e., neuroscience) or ‘soft’ (non-prototypical) science (i.e., social science) before completing an online analogue of Milgram's ‘Obedience to Authority’ paradigm. In Studies 1 and 2, participants in the neuroscience condition completed more trials than those in the social science condition. This effect was not replicated in Study 3, possibly because the timing of data collection (late 2020) coincided with an emphasis on social science's importance in controlling COVID-19. Results of a final cross-sectional study (Study 4) indicated that participants who perceived the study to be more prototypical of science found it more worthwhile, reported making a wider contribution by taking part, reported less dislike for the task, more happiness at having taken part, and more trust in the researchers, all of which indirectly predicted greater followership. Implications for the theoretical understanding of obedience to toxic instructions are discussed

Bioinformatics advances in saliva diagnostics

There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create a data management system and web resource constructed to support human salivaomics research. To maximize the utility of the SKB for retrieval, integration and analysis of data, we have developed the Saliva Ontology and SDxMart. This article reviews the informatics advances in saliva diagnostics made possible by the Saliva Ontology and SDxMart

Mapping the strand-specific transcriptome of fission yeast

Pervasive genome-wide transcription is widespread in eukaryotic cells, but key features of the transcriptome have yet to be fully characterized. a new study using antibody-based detection of RNA-DNA duplexes on tiling arrays now reveals a complex, strand-specific transcriptional world in fission yeast

Questioning authority: New perspectives on Milgram’s ‘obedience’ research and its implications for intergroup relations

Traditionally, Milgram's 'obedience' studies have been used to propose that 'ordinary people' are capable of inflicting great harm on outgroup members because they are predisposed to follow orders. According to this account, people focus so much on being good followers that they become unaware of the consequences of their actions. Atrocity is thus seen to derive from inattention. However recent work in psychology, together with historical reassessments of Nazi perpetrators, questions this analysis. In particular, forensic re-examination of Milgram's own findings, allied to new psychological and historical research, supports an “engaged follower” analysis in which the behaviour of perpetrators is understood to derive from identification with, and commitment to, an ingroup cause that is believed to be noble and worthwhile

MAPU 2.0: high-accuracy proteomes mapped to genomes

The MAPU 2.0 database contains proteomes of organelles, tissues and cell types measured by mass spectrometry (MS)-based proteomics. In contrast to other databases it is meant to contain a limited number of experiments and only those with very high-resolution and -accuracy data. MAPU 2.0 displays the proteomes of organelles, tissues and body fluids or conversely displays the occurrence of proteins of interest in all these proteomes. The new release addresses MS-specific problems including ambiguous peptide-to-protein assignments and it provides insight into general functional features on the protein level ranging from gene ontology classification to comprehensive SwissProt annotation. Moreover, the derived proteomic data are used to annotate the genomes using Distributed Annotation Service (DAS) via EnsEMBL services. MAPU 2.0 is a model for a database specifically designed for high-accuracy proteomics and a member of the ProteomExchange Consortium. It is available on line at http://www.mapuproteome.com