184 research outputs found
Optical control of electron spin coherence in CdTe/(Cd,Mg)Te quantum wells
Optical control of the spin coherence of quantum well electrons by short
laser pulses with circular or linear polarization is studied experimentally and
theoretically. For that purpose the coherent electron spin dynamics in a
n-doped CdTe/(Cd,Mg)Te quantum well structure was measured by time-resolved
pump-probe Kerr rotation, using resonant excitation of the negatively charged
exciton (trion) state. The amplitude and phase shifts of the electron spin beat
signal in an external magnetic field, that are induced by laser control pulses,
depend on the pump-control delay and polarization of the control relative to
the pump pulse. Additive and non-additive contributions to pump-induced signal
due to the control are isolated experimentally. These contributions can be well
described in the framework of a two-level model for the optical excitation of
the resident electron to the trion.Comment: 15 pages, 18 figure
Categoricity Spectra for Rigid Structures
Β© 2016 by University of Notre Dame. For a computable structure M, the categoricity spectrum is the set of all Turing degrees capable of computing isomorphisms among arbitrary computable copies of M. If the spectrum has a least degree, this degree is called the degree of categoricity of M. In this paper we investigate spectra of categoricity for computable rigid structures. In particular, we give examples of rigid structures without degrees of categoricity
Spin dynamics of electrons and holes in InGaAs/GaAs quantum wells at milliKelvin temperatures
The carrier spin dynamics in a n-doped (In,Ga)As/GaAs quantum well has been
studied by time-resolved Faraday rotation and ellipticity techniques in the
temperature range down to 430 milliKelvin. These techniques give data with very
different spectral dependencies, from which nonetheless consistent information
on the spin dynamics can be obtained, in agreement with theoretical
predictions. The mechanisms of long-lived spin coherence generation are
discussed for the cases of trion and exciton resonant excitation. We
demonstrate that carrier localization leads to a saturation of spin relaxation
times at 45 ns for electrons below 4.5 K and at 2 ns for holes below 2.3 K. The
underlying spin relaxation mechanisms are discussed.Comment: 8 pages, 8 figure
Coherent spin relaxation in molecular magnets
Numerical modelling of coherent spin relaxation in nanomagnets, formed by
magnetic molecules of high spins, is accomplished. Such a coherent spin
dynamics can be realized in the presence of a resonant electric circuit coupled
to the magnet. Computer simulations for a system of a large number of
interacting spins is an efficient tool for studying the microscopic properties
of such systems. Coherent spin relaxation is an ultrafast process, with the
relaxation time that can be an order shorter than the transverse spin dephasing
time. The influence of different system parameters on the relaxation process is
analysed. The role of the sample geometry on the spin relaxation is
investigated.Comment: Latex file, 22 pages, 7 figure
Phosphate-modified CpG oligonucleotides induce in vitro maturation of human myeloid dendritic cells
Myeloid dendritic cells (DCs) play an important role in the immune response; therefore, the search for compounds that can effectively activate DCs is a needful goal. This study was aimed to investigate the effect of synthetic CpG oligodeoxynucleotides (CpG-ODN) on the maturation and allostimulatory activity of myeloid DCs in comparison with other PAMP and DAMP molecules. For the research, we synthesized known CpG-ODN class C (SD-101 and D-SL03) containing thiophosphate internucleotide groups, and their original phosphate-modified analogues (SD-101M and D-SL03M) with mesylphosphoramide internucleotide groups (M = ΞΌ-modification). The effects of CpG-ODN and other activators were evaluated on DCs generated from blood monocytes in the presence of GM-CSF and IFN-Ξ± (IFN-DC) or IL-4 (IL4-DC). Evaluation of the intracellular TLR-9 expression showed that both types of DCs (IFN-DC and IL4-DC) contained on average 52 and 80 % of TLR-9-positive cells, respectively. The CpG-ODNs studied enhanced the allostimulatory activity of IFN-DCs, and the effect of ΞΌ-modified CpG-ODNs was higher than that of CpG-ODNs with thiophosphate groups. The stimulating effect of CpG-ODN at a dose of 1.0 ΞΌg/ml was comparable (for D-SL03, D-SL03M, SD-101) with or exceeded (for SD-101M) the effect of LPS at a dose of 10 ΞΌg/ml. At the same time, IFN-DCs were characterized by greater sensitivity to the action of CpG-ODNs than IL4-DCs. The enhancement of DC allostimulatory activity in the presence of CpG-ODNs was associated with the induction of final DC maturation, which was confirmed by a significant decrease in the number of CD14+DC, an increase in mature CD83+DC and a trend towards an increase in CD86+DC. Interestingly, the characteristic ability of LPS to enhance the expression of the co-stimulatory molecule OX40L on DCs was revealed only for the ΞΌ-analogue SD-101M. In addition, CpG-ODNs (SD-101 and SD-101M) had a stimulatory effect on IFN-Ξ³ production comparable to the action of LPS. The data obtained indicate a stimulating effect of CpG-ODN on the maturation and allostimulatory activity of human myeloid DCs, which is more pronounced for ΞΌ-modified analogs
ΠΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π·Π½ΠΎΡΡΠΈ Π½Π°Π·Π°Π»ΡΠ½ΡΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠ² β Π½ΠΎΠ²ΡΠΉ, ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΠΉ ΡΠ΅ΡΡ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΌΡΠΊΠΎΠ²ΠΈΡΡΠΈΠ΄ΠΎΠ·Π°
An attempt was undertaken to evaluate peculiarities of biophysical phenotype of the basic cystic fibrosis (CF) defect in 21 cystic fibrosis patients from 5 to 41 years old. CF patients have demonstrated markedly more negative potential difference (NPD) across nasal epithelium than 15 patients of non-CF control group. The mean NPD of C F patients was 44.7Β±2.2 mV (range -32.5 to -68.9 mV), in the control group it was 17.2Β±1.8 mV. The method of the nasal PD measuring is acceptable and rapidly performed and may provide an additional tool for CF diagnosing.ΠΡΠ»Π° ΠΏΡΠ΅Π΄ΠΏΡΠΈΠ½ΡΡΠ° ΠΏΠΎΠΏΡΡΠΊΠ° ΠΎΡΠ΅Π½ΠΈΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π±ΠΈΠΎΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π½ΠΎΡΠΈΠΏΠ° ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ Π΄Π΅ΡΠ΅ΠΊΡΠ° ΠΌΡΠΊΠΎΠ²ΠΈΡΡΠΈΠ΄ΠΎΠ·Π° Ρ 21 Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 5 Π»Π΅Ρ Π΄ΠΎ 41 Π³ΠΎΠ΄Π°. Π£ Π»ΠΈΡ, ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ
ΠΌΡΠΊΠΎΠ²ΠΈΡΡΠΈΠ΄ΠΎΠ·ΠΎΠΌ, Π±ΡΠ»ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠ΅ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΠ΅ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ ΡΠ°Π·Π½ΠΎΡΡΠΈ Π½Π°Π·Π°Π»ΡΠ½ΡΡ
ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠ² (nasal Potential Difference β NPD), ΡΠ΅ΠΌ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΡΡΡΠ°Π΄Π°ΡΡΠΈΡ
Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
(Π₯ΠΠΠ) ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ. Π‘ΡΠ΅Π΄Π½ΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ NPD Π² Π³ΡΡΠΏΠΏΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΌΡΠΊΠΎΠ²ΠΈΡΡΠΈΠ΄ΠΎΠ·ΠΎΠΌ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ -44,7Β±2,2 ΠΌΠ (ΠΎΡ-32,5 ΠΌΠ Π΄ΠΎ -68,9 ΠΌΠ), Π² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ -17,2Β±1,8 ΠΌΠ (ΠΎΡ-6,8 ΠΌΠ Π΄ΠΎ -30,2 ΠΌΠ). ΠΠ΅ΡΠΎΠ΄ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ NPD ΡΠ²Π»ΡΠ΅ΡΡΡ Π»Π΅Π³ΠΊΠΎ ΠΈ Π±ΡΡΡΡΠΎ Π²ΡΠΏΠΎΠ»Π½ΠΈΠΌΡΠΌ, ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°Π½ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΡΠ° Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΌΡΠΊΠΎΠ²ΠΈΡΡΠΈΠ΄ΠΎΠ·Π°
Effectiveness of pantoprazole for the treatment of erosive and ulcerative gastroduodenal lesions in patients taking dual antiplatelet therapy after emergency PCI
The effectiveness of proton pump inhibitors (PPIs) in patients with erosive and ulcerative lesions of the upper gastrointestinal tract (GIT), receiving dual antiplatelet therapy, is poorly evaluated. Aim. To determine the efficacy of PPIs in treatment of erosive and ulcerative lesions of stomach and duodenum in patients receiving dual antiplatelet therapy with aspirin and clopidogrel after urgent percutaneous coronary intervention (PCI) related to acute coronary syndromes (ACS). Methods. The study included 42 patients, whom urgent PCI related to ACS was performed. Duodenal and gastric erosive and ulcer lesions were found with gastroduodenoscopy in all of patients. Biopsy of antrum mucosae were evaluated to detect Helicobacter pilory (Hp). Repeated gastroduodenoscopy was provided through a month. Patients received dual antiplatelet therapy with aspirin and clopidogrel, and pantoprazole 40 mg per day for prevention of erosive-ulcer complications. Results. By gastroduodenoscopy 10-14 days after ACS erosive gastritis or duodenitis was identified in 38 (90,5%) patients, gastric ulcer - in 4 (9.5%) patients. Hp infection was detected in 62% of cases (26 patients). Abdominal pain and/or dyspeptic syndromes were noted in 18 (42,9%) patients. After one month clinical signs of abdominal and dyspeptic syndromes were eliminated in all of patients. There were no bleeding from the upper GIT. Complete epithelization of gastric and duodenal lesions was achieved in 22 (52.4%) patients. A significant inverse correlation was found between endoscopic criteria of effectiveness and Hp infection (r = - 0,36, p = 0.021), endoscopic criteria of effectiveness and smoking (r = - 0,5, p = 0.002). Conclusion. The short course of pantoprazole for treatment of erosive and ulcerative gastric and duodenal lesions in patients taking dual antiplatelet therapy after ACS and urgent PCI is effective only in half of cases. Smoking cessation and eradication therapy in the presence of Hp infection can enhance the efficacy of treatment.ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² ΠΏΡΠΎΡΠΎΠ½Π½ΠΎΠΉ ΠΏΠΎΠΌΠΏΡ (ΠΠΠ) Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π·ΡΠΎΠ·ΠΈΠ²Π½ΠΎ-ΡΠ·Π²Π΅Π½Π½ΡΠΌΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡΠΌΠΈ Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΎΡΠ΄Π΅Π»ΠΎΠ² ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ-ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ° (ΠΠΠ’), ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΡΠΈΡ
Π΄Π²ΠΎΠΉΠ½ΡΡ Π°Π½ΡΠΈΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠ°ΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ, ΠΈΠ·ΡΡΠ΅Π½Π° Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ. Π¦Π΅Π»Ρ. ΠΡΠ΅Π½ΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠ°Π½ΡΠΎΠΏΡΠ°Π·ΠΎΠ»Π° ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΡΠΎΠ·ΠΈΠ²Π½ΠΎ-ΡΠ·Π²Π΅Π½Π½ΡΡ
ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈ ΠΠΠ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ»ΡΡΠ°ΡΡΠΈΡ
Π΄Π²ΠΎΠΉΠ½ΡΡ Π°Π½ΡΠΈΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠ°ΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ Π°ΡΠΏΠΈΡΠΈΠ½ΠΎΠΌ ΠΈ ΠΊΠ»ΠΎΠΏΠΈΠ΄ΠΎΠ³ΡΠ΅Π»Π΅ΠΌ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½ΡΡ
ΡΡΠ΅ΡΠΊΠΎΠΆΠ½ΡΡ
ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΡΡ
Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ² (Π§ΠΠ) Π² ΡΠ²ΡΠ·ΠΈ Ρ ΠΎΡΡΡΡΠΌΠΈ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΡΠΌΠΈ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°ΠΌΠΈ (ΠΠΠ‘). ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 42 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, ΠΊΠΎΡΠΎΡΡΠΌ Π² ΡΠ²ΡΠ·ΠΈ Ρ ΠΠΠ‘ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½ΠΎΠ΅ Π§ΠΠ. Π£ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΡΠΈ ΡΠΈΠ±ΡΠΎΠ³Π°ΡΡΡΠΎΠ΄ΡΠΎΠ΄Π΅Π½ΠΎΡΠΊΠΎΠΏΠΈΠΈ (Π€ΠΠΠ‘) Π²ΡΡΠ²Π»Π΅Π½Ρ ΡΡΠΎΠ·ΠΈΠ²Π½ΠΎ-ΡΠ·Π²Π΅Π½Π½ΡΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈ ΠΠΠ. ΠΠΈΠΎΠΏΡΠ°ΡΡ ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΉ Π°Π½ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ΄Π΅Π»Π° ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈΡΡ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Helicobacter pilory (ΠΡ). ΠΠΎΠ²ΡΠΎΡΠ½Π°Ρ Π€ΠΠΠ‘ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΡΠ΅ΡΠ΅Π· ΠΎΠ΄ΠΈΠ½ ΠΌΠ΅ΡΡΡ. ΠΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ Π½Π°Π·Π½Π°ΡΠ°Π»ΠΈ Π΄Π²ΠΎΠΉΠ½ΡΡ Π°Π½ΡΠΈΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠ°ΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ Π°ΡΠΏΠΈΡΠΈΠ½ΠΎΠΌ ΠΈ ΠΊΠ»ΠΎΠΏΠΈΠ΄ΠΎΠ³ΡΠ΅Π»Π΅ΠΌ, Π° Π΄Π»Ρ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΡΡΠΎΠ·ΠΈΠ²Π½ΠΎ-ΡΠ·Π²Π΅Π½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ - ΠΏΠ°Π½ΡΠΎΠΏΡΠ°Π·ΠΎΠ» 40 ΠΌΠ³ Π² ΡΡΡΠΊΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π€ΠΠΠ‘ ΡΠ΅ΡΠ΅Π· 10-14 Π΄Π½Π΅ΠΉ ΠΏΠΎΡΠ»Π΅ ΠΠΠ‘ Ρ 38 (90,5%) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π²ΡΡΠ²Π»Π΅Π½ ΡΡΠΎΠ·ΠΈΠ²Π½ΡΠΉ Π³Π°ΡΡΡΠΈΡ ΠΈΠ»ΠΈ Π΄ΡΠΎΠ΄Π΅Π½ΠΈΡ, Ρ 4 (9,5%) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² - ΡΠ·Π²Π° ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°. ΠΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ Π²ΡΡΠ²Π»Π΅Π½Π° Π² 62% ΡΠ»ΡΡΠ°Π΅Π² (26 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²). ΠΠ±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΡΠΉ Π±ΠΎΠ»Π΅Π²ΠΎΠΉ ΠΈ/ΠΈΠ»ΠΈ Π΄ΠΈΡΠΏΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌΡ ΠΎΡΠΌΠ΅ΡΠ΅Π½Ρ Ρ 18 (42,9%) Π±ΠΎΠ»ΡΠ½ΡΡ
. Π§Π΅ΡΠ΅Π· ΠΎΠ΄ΠΈΠ½ ΠΌΠ΅ΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π±ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΈ Π΄ΠΈΡΠΏΠ΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠ² ΡΡΡΡΠ°Π½Π΅Π½Ρ Ρ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΡΠΎΠ²ΠΎΡΠ΅ΡΠ΅Π½ΠΈΠΉ ΠΈΠ· Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΎΡΠ΄Π΅Π»ΠΎΠ² ΠΠΠ’ Π½Π΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ. ΠΠΎΠ»Π½Π°Ρ ΡΠΏΠΈΡΠ΅Π»ΠΈΠ·Π°ΡΠΈΡ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈ ΠΠΠ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΠ° Ρ 22 (52,4%) ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΡΡΠ²Π»Π΅Π½Π° Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½Π°Ρ ΠΎΠ±ΡΠ°ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅ΠΌ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΠΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ (Π³ = - 0,36, Ρ = 0,021), ΡΠ½Π΄ΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅ΠΌ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΠΊΡΡΠ΅Π½ΠΈΠ΅ΠΌ (Π³ = - 0,5, Ρ = 0,002). ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎΡΠΎΡΠΊΠΈΠΉ ΠΊΡΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΠ°Π½ΡΠΎΠΏΡΠ°Π·ΠΎΠ»ΠΎΠΌ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΡΠΎΠ·ΠΈΠ²Π½ΠΎ-ΡΠ·Π²Π΅Π½Π½ΡΡ
ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈ ΠΠΠ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΡΠΈΡ
Π΄Π²ΠΎΠΉΠ½ΡΡ Π°Π½ΡΠΈΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠ°ΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ΅Π½Π΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΠΠ‘ ΠΈ Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½ΠΎΠ³ΠΎ Π§ΠΠ, ΡΡΡΠ΅ΠΊΡΠΈΠ²Π΅Π½ Π»ΠΈΡΡ Π² ΠΏΠΎΠ»ΠΎΠ²ΠΈΠ½Π΅ ΡΠ»ΡΡΠ°Π΅Π². ΠΡΠΊΠ°Π· ΠΎΡ ΠΊΡΡΠ΅Π½ΠΈΡ ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΡΠ°Π΄ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ ΠΡ-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΠΌΠΎΠ³ΡΡ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ
The use of nonsteroidal anti-inflammatory drugs for the treatment of facial pain in practice
Studies have shown that the drug ibuprofen is effective for the relief of pain in the facial area, allowing the continuation of dental treatment. Clinical experience has shown that 87% of patients were satisfied with the result of pain relief.ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΈΠ±ΡΠΏΡΠΎΡΠ΅Π½ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²-Π½ΡΠΌΠΈ Π΄Π»Ρ ΠΊΡΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π±ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Π² Π»ΠΈΡΠ΅Π²ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΡΠΎΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠΏΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ 87% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π±ΡΠ»ΠΈ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠ΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠΌ ΡΠ½ΡΡΠΈΡ Π±ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°
Comparative morphological characteristics of the uteroplacental area in abnormal placentation
The aim. To carry out a comparative morphological characteristic of the uteroplacental area with abnormal placentation β pl. accreta, pl. increta, pl. percreta. Materials and methods. The study included 47 patients with atypical placentation; the comparison group included 10 healthy pregnant women with uterine scar after a previous caesarean section. A histological study of uteroplacental area samples was performed with hematoxylin and eosin, methylene blue staining. An immunohistochemical study with primary antibodies to cytokeratin 7 (CK7), Hif2a, vascular endothelial growth factor, Ξ±-SMA was carried out. The differences between the compared values were considered to be statistically significant at p < 0.05. The results of the study. Pl. accreta was determined in 12 (25.5 %), pl. increta β in 30 (63.9 %), pl. percreta β in 5 (10.6 %) patients. In all patients of the main group, the decidua was completely or partially absent in the area of abnormal placentation or was replaced by an uneven layer of fetal fibrinoid. Cases when placental villi unevenly penetrated into the thickness of myometrium in the form of βtonguesβ or βcovesβ bordered by fetal fibrinoid and often located intermuscularly were defined as pl. increta (n = 26). Cases with the placental villi ingrowth to the serous membrane were considered as pl. Β percreta (n Β = Β 5). In cases with deep variants of Β ingrowth (pl. increta and pl. percreta) (n = 31), the villi were visualized in the lumen of the vessels and the thinning of the lower uterine segment with the presence of stretched muscle bundles was revealed. Aseptic necrosis of Β the myometrium was Β found: in 2 (16.7 %) of 12 women with pl. accreta, in 26 (86.7 %) of 30 women with pl. increta and in 5 (100 %) women with pl. percreta. There were no areas of necrosis in the myometrium of the women of comparison group. Conclusion. The appearance and increase of myometrial necrosis zones in response to an increase in the depth of placental villus ingrowth were detected. Myometrial necrosis zones could be the cause of activation of angiogenic factors and an important stimulus for the development of abnormal vascularization in placenta accreta spectrum
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