Análise teórica de formas e métodos para o desenvolvimento sustentável de da sociedade

The article is devoted to the theoretical analysis of forms and methods for social enterprise sustainable development. They analyzed the system of an effective functioning of social enterprises. It was shown that one of the key tasks of social sphere regional development improvement is the use of intensive growth factors.El artículo está dedicado al análisis teórico de formas y métodos para el desarrollo sostenible de la empresa social. Analizaron el sistema de un funcionamiento efectivo de las empresas sociales. Se demostró que una de las tareas clave de la mejora del desarrollo regional de la esfera social es el uso de factores de crecimiento intensivos.O artigo é dedicado à análise teórica de formas e métodos para o desenvolvimento sustentável das empresas sociais. Eles analisaram o sistema de um funcionamento eficaz das empresas sociais. Mostrou-se que uma das principais tarefas da melhoria do desenvolvimento regional na esfera social é o uso de fatores de crescimento intensivos

Political management of youth students’ electoral participation in Russia: topical issues

Electoral participation is the most accessible way for citizens to influence the political course of the country. This determines the relevance of the chosen research topic. In the course of the study, the authors found that a set of measures, aimed at changing the order of organization and conduct of voting in Russia, contributed to an increase in the effectiveness of the electoral process and the interest of the youth audience in political activity. The purpose of this study is to identify modern mechanisms of political management of electoral participation of student youth in Russia. The objectives of this study are to study the interest of student youth in the implementation of socio-political activities, as well as to identify the features of electoral behavior of student youth in Russia. The research was conducted using such methods as: classical analysis of documents, the method of comparative analysis and the survey conducted in the form of a questionnaire using the Google.forms resource. The results of the author’s sociological research “Political activity of youth as a factor of electoral participation in Russia” show that students are willingly interested in socio-political activities and express their interest in the development of civic initiative. In the course of the study we found a growing interest among students in a new, for Russia, form of political participation – political volunteering

Probing a Complex of Cytochromecand Cardiolipin by Magnetic Circular Dichroism Spectroscopy: Implications for the Initial Events in Apoptosis

Oxidation of cardiolipin (CL) by its complex with cytochrome c (cyt c) plays a crucial role in triggering apoptosis. Through a combination of magnetic circular dichroism spectroscopy and potentiometric titrations, we show that both the ferric and ferrous forms of the heme group of a CL:cyt c complex exist as multiple conformers at a physiologically relevant pH of 7.4. For the ferric state, these conformers are His/Lys- and His/OH–-ligated. The ferrous state is predominantly high-spin and, most likely, His/–. Interconversion of the ferric and ferrous conformers is described by a single midpoint potential of -80 ± 9 mV vs SHE. These results suggest that CL oxidation in mitochondria could occur by the reaction of molecular oxygen with the ferrous CL:cyt c complex in addition to the well-described reaction of peroxides with the ferric form

Цифровизация административных процедур в Республике Беларусь

Развитие цифровых технологий приобретает всё большую значимость. Происходит дигитализация всех сфер общества, в том числе и сферы государственного управления. В статье раскрывается актуальность развития цифровизации административных процедур

Age changes of blood microcirculation in students and sportsmen under the influence of physical training

Age specifi c features of blood microcircula詛 on reac誛 vity in students and athletes (freestyle wrestling at the level of candidates for a master of sports) are studied for 18 to 21 years under the infl uence of a dosed physical training. Signifi cant diff erences in the values of the most parameters characterizing the microcircula萋 on of blood at rest were observed between the 4 age groups under examina裻 on, both in students and athletes with diff erent levels of the microcircula萋 on index, and it was shown that the contribu詻 on of ac詻 ve modula脫 ons of the blood fl ow to the forma裻 on of its profi le is more important. Regular exercise changes the age dependence of the level of muscle 詻 ssue perfusion, as well as the amplitude of blood fl ow fl uctua詻 ons in 裻 ssues. Essen裻 al diff erences in the eff ect of physical training on the eff ec譋 veness of microcircula譋 on in stu- dents and athletes have been established, depending on the value of the microcircula誛 on index. The results indicate the need to take into account the hierarchy of regulatory mechanisms in the selec荫 on of the intensity of physical training, as well as the possibility of a targeted eff ect on respiratory-pulse modula講 on in the microvasculature and, consequently, on their ra譛 o, by means of dosed physical training

Improving the efficiency of using fixed assets and their influence on regional development

 The article is devoted to the study of the problem of increasing the efficiency of the use of fixed production assets and their influence on the development of the region. The study of the efficiency indicators of the region's production potential is one of the key tasks of improving the regional development of the region's production base. The solution to the problem consists in strengthening the orientation toward the increasingly full use of intensive factors of economic growth. Activities to implement these tasks are among the least capital-intensive ways to develop regional production infrastructure. At the same time, along with a low capital intensity of product growth, a significant increase in labor productivity and a decrease in current production costs are ensured

Social sphere development regularities in regional reproduction in Russia

The article is devoted to the theoretical analysis of social enterprise development in the reproduction process. As a method, the social sphere has analyzed the system of enterprise effective functioning. As a result, one of the key tasks of the regional reproduction process improvement is the effective development of the social sphere. In conclusion, a necessary condition for the rational combination of sectoral and regional aspects of social infrastructure development planning is the division of the country territory into region

Local pedagogical history in training bachelors of education

The main aim of the study is to investigate the issues of pedagogy and technology of local history studies applied in training Bachelors of Education at a pedagogical University. The authors describe results of experimental work carried out at Stary Oskol branch of Belgorod State National Research University and approbation of local pedagogical history technology. Regarding the methods used in the study, we consider the training system containing local history concepts is made up by the following components: the training process, educational activities and research, teacher’s internship, extracurricular and outreach activitie

Исследование роли хориоидеи и хрусталика в развитии первичного закрытия угла передней камеры

PURPOSE. To study the role of the choroid and lens in the development of primary anterior chamber angle closure.MATERIAL AND METHODS. The study included 90 patients aged 47 to 80 years (30 with primary angle closure (PAC), 30 with suspected primary angle closure (PACs), and 30 in the control group) who underwent swept source optical coherence tomography (SS-OCT). The following parameters were analyzed: subfoveolar choroidal thickness (SFCT), intraocular pressure (IOP), axial length (AL), anterior chamber depth (ACD), lens vault (LV), iris curvature (ICurv) and iris thickness (IT750), angle opening distance (AOD500, AOD750), and trabecular-iris space area (TISA500, TISA750).RESULTS. SFCT in PAC (341±59 µm) and PACs (340±51 µm) was higher than in the control group (257.0±37.0 µm, p<0.05). In PAC and PACs, the correlations of SFCT with age, AL, LV, ICurv, IT750 were revealed (p<0.05 for each), as well as correlations of LV with age, IOP, ACD, ICurv, IT750, AOD500, AOD750, TISA500, TISA750 were found (p<0.05 for each). The correlation of SFCT with IOP was determined only in PAC (p=-0.476; p=0.008).CONCLUSION. The increase in the choroidal thickness in macula in both PACs and PAC compared with the controls, as well as the correlations of subfoveolar choroidal thickness with lens vault and iris parameters suggest the involvement of the choroid in the pathogenesis of primary angle closure disease (PACD). The correlations of lens vault with IOP, as well as the parameters of anterior chamber and iris indicate the prevailing role of the lens in the development of PACD and the need for its early replacement.ЦЕЛЬ. Изучить роль хориоидеи и хрусталика в развитии первичного закрытия угла передней камеры.МАТЕРИАЛ И МЕТОДЫ. Исследование включало 90 пациентов (30 с первичным закрытием угла [ПЗУ], 30 – с подозрением на первичное закрытие угла [ППЗУ], 30 – контроль) в возрасте от 47 до 80 лет, которым проведена оптическая когерентная томография Swept Source (SS-OCT; optical coherence tomography). Анализируемые параметры: толщина субфовеолярной хориоидеи (ТХф), внутриглазное давление (ВГД), передне-задняя ось (ПЗО), глубина передней камеры (ГПК), высота свода хрусталика (LV, lens vault), кривизна радужки (ICurv) и ее толщина (IT750; iris thickness), дистанция открытия угла (AOD500, AOD750; angle opening distance), иридотрабекулярное пространство (TISA500, TISA750; trabecular-iris space area).РЕЗУЛЬТАТЫ. ТХф при ПЗУ (341±59 мкм) и ППЗУ (340±51 мкм) была выше, чем в контроле (257,0±37,0 мкм, p<0,05). При ПЗУ и ППЗУ выявлены корреляции ТХф с возрастом, AL, LV, ICurv, IT750 (все p<0,05), а также установлены корреляции LV с возрастом, ВГД, ACD, ICurv, IT750, AOD500, AOD750, TISA500, TISA750 (все p<0,05). Только при ПЗУ отмечалась корреляция ТХф с ВГД (p=-0,476; p=0,008).ЗАКЛЮЧЕНИЕ. Увеличение ТХф по сравнению с контролем как при ППЗУ, так и при ПЗУ, а также корреляции ТХф с LV и параметрами радужки предполагают участие хориоидеи в патогенезе заболевания первичного закрытия угла (ЗПЗУ). Корреляции LV с ВГД, параметрами передней камеры и радужки свидетельствуют о доминирующей роли хрусталика в формировании ЗПЗУ и необходимости ранней его замены

Magnetostimulated Chandges of Microhardness in Potassium Acid Phthalate Crystals

A decrease in microhardness along the (010) cleavage in potassium acid phthalate single crystals by 15--18% after the application of a permanent magnetic field was revealed for the first time. It is shown that the effect revealed is of the volume character. The role of interlayer water in the processes stimulated by a magnetic field is studied., Interlayer water plays does not cause the observed changes it only plays the part of an indicator of these changes in potassium acid phthalate crystals in a magnetic field. It is established that microhardness in the (100) plane of the crystal in an applied a magnetic field first increases by 12--15% and then remains constant in time within the accuracy of the experiment. The possibility of varying the crystal structure of potassium acid phthalate crystals by applying magnetic fields inducing rearrangement in the system of hydrogen bonds or in the defect structure is discussed.Comment: 6 pages, 7 figure