Bioequivalence of three florfenicol preparations in broilers

This study was aimed to determine the bioequivalence of three different preparations of florfenicol using non-drugged broiler chickens. A total of 28 broiler chickens aging 30-day were divided into four equal groups; these were Group I, II, III, and IV. The birds of Group I (for effective substance) were given intravenous (i.v.) administration of florfenicol dosed at 40 mg/kg body weight (b.wt.). The birds of Group II (for reference drug), Group III (for test-1 drug), and Group IV (for test-2 drug) received florfenicol preparations with water (dosed at 40 mg/kg b.wt.) through intracrop administration. Blood samples were collected periodically from the birds of all four groups, and blood plasma was separated. Levels of florfenicol and its metabolite (florfenicol amine) in the plasma were measured by High Performance Liquid Chromatography (HPLC). In this study, the limit of detection (LOD) for florfenicol and florfenicol amine were recorded as 0.017 and 0.78 ?g/mL, respectively. On the other hand, the recovery of florfenicol and florfenicol amine were 83.4-84.6 and 82.2-83.8%, respectively. Based on the values of area under the curve (AUC), maximum concentration (Cmax), and time to maximum concentration (Tmax), test-1 drug was found to be acceptable, whereas test-2 drug was remained below the acceptable limits (80-125%) of AUC and Cmax. Thus, it was concluded that test-1 drug was bioequivalent as compared to the reference drug

Arsenic residues in grey mullets caught in Lake Van

in this study, pollution caused by arsenic residues in grey mullets (Chalcarburnus tarichii, Pallas 1811) living in Van lake were investigated

Heavy metal levels in mussels (Unio stevenianus krynicki) obtained from Van Lake

The aim of this study was to evaluate heavy metal levels in mussels (Unio stevenianus Krynicki) obtained from Van Lake. A total of 120 samples representing each of the four seasons was collected between 01.01.1994 and 01.01.1995. The organic parts of the samples were ashed with a mixture of magnesium oxide and magnesium nitrate according to the dry ashing method and arsenic residues were measured by silver diethyldithyocarbamate in UV spectrophotometer; copper, cadmium, zinc and lead levels were also determined using an atomic absorption spectrophotometer. In the analysis of the 120 samples for residues of heavy mettals, the average values were found to be: 1.43+/-0.81 ppm for lead, 0.09+/-0.02 ppm for cadmium, 5.83+/-0.73 ppm for copper, 15.93+/-3.26 ppm for zinc and 0.06+/-0.05 ppm for arsenic