60 research outputs found
Fecal Metaproteomics Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following Lifestyle-Induced Weight Loss
Gut microbiota-mediated inflammation promotes obesity-associated low-grade inflammation, which represents a hallmark of metabolic syndrome. To investigate if lifestyle-induced weight loss (WL) may modulate the gut microbiome composition and its interaction with the host on a functional level, we analyzed the fecal metaproteome of 33 individuals with metabolic syndrome in a longitudinal study before and after lifestyle-induced WL in a well-defined cohort. The 6-month WL intervention resulted in reduced BMI (â13.7%), improved insulin sensitivity (HOMA-IR, â46.1%), and reduced levels of circulating hsCRP (â39.9%), indicating metabolic syndrome reversal. The metaprotein spectra revealed a decrease of human proteins associated with gut inflammation. Taxonomic analysis revealed only minor changes in the bacterial composition with an increase of the families Desulfovibrionaceae, Leptospiraceae, Syntrophomonadaceae, Thermotogaceae and Verrucomicrobiaceae. Yet we detected an increased abundance of microbial metaprotein spectra that suggest an enhanced hydrolysis of complex carbohydrates. Hence, lifestyle-induced WL was associated with reduced gut inflammation and functional changes of human and microbial enzymes for carbohydrate hydrolysis while the taxonomic composition of the gut microbiome remained almost stable. The metaproteomics workflow has proven to be a suitable method for monitoring inflammatory changes in the fecal metaproteome
Data compression for the First G-APD Cherenkov Telescope
The First Geiger-mode Avalanche photodiode (G-APD) Cherenkov Telescope (FACT)
has been operating on the Canary island of La Palma since October 2011.
Operations were automated so that the system can be operated remotely. Manual
interaction is required only when the observation schedule is modified due to
weather conditions or in case of unexpected events such as a mechanical
failure. Automatic operations enabled high data taking efficiency, which
resulted in up to two terabytes of FITS files being recorded nightly and
transferred from La Palma to the FACT archive at ISDC in Switzerland. Since
long term storage of hundreds of terabytes of observations data is costly, data
compression is mandatory. This paper discusses the design choices that were
made to increase the compression ratio and speed of writing of the data with
respect to existing compression algorithms.
Following a more detailed motivation, the FACT compression algorithm along
with the associated I/O layer is discussed. Eventually, the performances of the
algorithm is compared to other approaches.Comment: 17 pages, accepted to Astronomy and Computing special issue on
astronomical file format
Calibration and performance of the photon sensor response of FACT -- The First G-APD Cherenkov telescope
The First G-APD Cherenkov Telescope (FACT) is the first in-operation test of
the performance of silicon photo detectors in Cherenkov Astronomy. For more
than two years it is operated on La Palma, Canary Islands (Spain), for the
purpose of long-term monitoring of astrophysical sources. For this, the
performance of the photo detectors is crucial and therefore has been studied in
great detail. Special care has been taken for their temperature and voltage
dependence implementing a correction method to keep their properties stable.
Several measurements have been carried out to monitor the performance. The
measurements and their results are shown, demonstrating the stability of the
gain below the percent level. The resulting stability of the whole system is
discussed, nicely demonstrating that silicon photo detectors are perfectly
suited for the usage in Cherenkov telescopes, especially for long-term
monitoring purpose
FACT -- The G-APD revolution in Cherenkov astronomy
Since two years, the FACT telescope is operating on the Canary Island of La
Palma. Apart from its purpose to serve as a monitoring facility for the
brightest TeV blazars, it was built as a major step to establish solid state
photon counters as detectors in Cherenkov astronomy. The camera of the First
G-APD Cherenkov Telesope comprises 1440 Geiger-mode avalanche photo diodes
(G-APD), equipped with solid light guides to increase the effective light
collection area of each sensor. Since no sense-line is available, a special
challenge is to keep the applied voltage stable although the current drawn by
the G-APD depends on the flux of night-sky background photons significantly
varying with ambient light conditions. Methods have been developed to keep the
temperature and voltage dependent response of the G-APDs stable during
operation. As a cross-check, dark count spectra with high statistics have been
taken under different environmental conditions. In this presentation, the
project, the developed methods and the experience from two years of operation
of the first G-APD based camera in Cherenkov astronomy under changing
environmental conditions will be presented.Comment: Proceedings of the Nuclear Science Symposium and Medical Imaging
Conference (IEEE-NSS/MIC), 201
Der diskrete Charme der Bourgeoisie - Ein Beitrag zur Soziologie des modernen WirtschaftsbĂŒrgertums
Entgegen der These der Auflösungserscheinungen des BĂŒrgertums stellt der Autor die Annahme auf den PrĂŒfstand, dass wir es nach wie vor mit gesellschaftlichen Fraktionierungen bĂŒrgerlicher Lebensweisen zu tun haben. Am Beispiel autobiographischer Schriften von deutschen Topmanagern stellt der Text ein modernes VerstĂ€ndnis des WirtschaftsbĂŒrgertums vor, das organisational (durch die Karrieremechanismen der Organisation) und institutionell (im Feld der Wirtschaft) verankert ist. Die moderne Sozialformation des WirtschaftsbĂŒrgertums ist nur noch auf der Grundlage von Organisationen denkbar. Sie lĂ€sst sich, jenseits von Klasse und Stand, als Positionselite beschreiben. Anhand der Autobiographien lĂ€sst sich die Reproduktion dieser Elite auf Basis einer engen VerknĂŒpfung zwischen familialer Herkunft, an organisationale Karrieren gebundene Leistungsbereitschaft und hoher formaler Bildung nachzeichnen. Die Abgrenzung in der Statusreproduktion zwischen Bildungs- und WirtschaftsbĂŒrgertum weist der Autor am jeweiligen VerhĂ€ltnis zur Bildung nach; zwar können beide einen hohen Bildungsgrad in Form von Bildungspatenten nachweisen, doch im Falle des WirtschaftsbĂŒrgertums herrscht ein instrumentelles VerhĂ€ltnis zur Bildung vor. Der hohe Bildungsgrad folgt hier dem BedĂŒrfnis, den Status mittels formaler Bildung abzusichern und damit die Gefahr der eigenen Austauschbarkeit - als Personal der Organisation - zu kompensieren. Der Text macht auĂerdem generationale Effekte sichtbar; insbesondere indem er darlegt, inwieweit der "moderne Manager" einerseits in der Betonung seines Status seinen VorgĂ€ngern gleicht und sich doch gleichzeitig in der Art der UnternehmensfĂŒhrung abgrenzt - indem er bspw. die Managementkonzepte seiner Zeit aufgreift
Spin dynamics in semiconductors
This article reviews the current status of spin dynamics in semiconductors
which has achieved a lot of progress in the past years due to the fast growing
field of semiconductor spintronics. The primary focus is the theoretical and
experimental developments of spin relaxation and dephasing in both spin
precession in time domain and spin diffusion and transport in spacial domain. A
fully microscopic many-body investigation on spin dynamics based on the kinetic
spin Bloch equation approach is reviewed comprehensively.Comment: a review article with 193 pages and 1103 references. To be published
in Physics Reports
Calibration and performance of the photon sensor response of FACT - the first G-APD Cherenkov telescope
The First G-APD Cherenkov Telescope (FACT) is the first in-operation test of the performance of silicon photo detectors in Cherenkov Astronomy. For more than two years it is operated on La Palma, Canary Islands (Spain), for the purpose of long-term monitoring of astrophysical sources. For this, the performance of the photo detectors is crucial and therefore has been studied in great detail. Special care has been taken for their temperature and voltage dependence implementing a correction method to keep their properties stable. Several measurements have been carried out to monitor the performance. The measurements and their results are shown, demonstrating the stability of the gain below the percent level. The resulting stability of the whole system is discussed, nicely demonstrating that silicon photo detectors are perfectly suited for the usage in Cherenkov telescopes, especially for long-term monitoring purpose.A. Biland, T. Bretz, J. BuĂ, V. Commichau, L. Djambazov, D. Dorner, S. Einecke, D. Eisenacher, J. Freiwald, O. Grimm, H. von Gunten, C. Haller, C. Hempfling, D. Hildebrand, G. Hughes, U. Horisberger, M.L. Knoetig, T. KrĂ€henbĂŒhl, W. Lustermann, E. Lyard, K. Mannheim, K. Meier, S. Mueller, D. Neise, A.-K. Overkemping, A. Paravac, F. Pauss, W. Rhode, U. Röser, J.-P. Stucki, T. Steinbring, F. Temme, J. Thaele, P. Vogler, R. Walter and Q. Weitze
Design and Operation of FACT -- The First G-APD Cherenkov Telescope
The First G-APD Cherenkov Telescope (FACT) is designed to detect cosmic
gamma-rays with energies from several hundred GeV up to about 10 TeV using the
Imaging Atmospheric Cherenkov Technique. In contrast to former or existing
telescopes, the camera of the FACT telescope is comprised of solid-state
Geiger-mode Avalanche Photodiodes (G-APD) instead of photomultiplier tubes for
photo detection. It is the first full-scale device of its kind employing this
new technology. The telescope is operated at the Observatorio del Roque de los
Muchachos (La Palma, Canary Islands, Spain) since fall 2011. This paper
describes in detail the design, construction and operation of the system,
including hardware and software aspects. Technical experiences gained after one
year of operation are discussed and conclusions with regard to future projects
are drawn.Comment: Corresponding authors: T. Bretz and Q. Weitze
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