Final Report of the Commission on Presidential Disability and the Twenty-Fifth Amendment

This Report examines the Twenty-Fifth Amendment to identify potential difficulties in presidential succession and makes recommendations

Synthesis of an alkylmagnesium amide and interception of a ring-opened isomer of the important utility amide 2,2,6,6-tetramethylpiperidide (TMP)

Two new magnesium complexes containing the important utility amide 2,2,6,6-tetramethylpiperidide (TMP) have been synthesised. Treating the magnesium bis(alkyl) reagent (Me3SiCH2)2Mg with a molar equivalent of TMP(H) in hydrocarbon medium produces the dimeric alkylmagnesium amide complex [(Me3SiCH2)Mg(μ-TMP)]22, which was isolated in high yield. X-ray crystallography revealed that 2 was an unsymmetrical dimer as unusually the two TMP ligands adopt different conformations – one a chair, the other a twisted boat. Solution studies (multinuclear NMR and DOSY NMR spectroscopies) show that 2 undergoes a monomerisation and Schlenk equilibrium in d8-THF. When (Me3SiCH2)2Mg was reacted with two molar equivalents of TMP(H) in hydrocarbon medium [in an effort to prepare Mg(TMP)2] a crystalline sample of a surprising product, a tetranuclear triheteroanionic amide-alkoxide-amidoalkene [(TMP)Mg(μ-TMP){μ-N(H)C(Me)2CH2CH2CH2C(Me) = CH2}Mg(μ-OCH2SiMe3)]23 was obtained. Complex 3 contains two unexpected anions, namely the alkoxide produced via oxygen insertion into a Mg–C bond, and the primary amidoalkene which is produced via ring opening of the TMP anion

Casimir interaction between a microscopic dipole oscillator and a macroscopic solenoid

We discuss the interaction between a microscopic electric dipole oscillator and a long solenoid which are separated by a small distance. The solenoid belongs to a simple RLC circuit and the zero point and thermal current fluctuations within the solenoid coils are taken into account. We describe how they affect the equilibrium state and the excited states of the oscillator, thus providing a description of the Casimir interaction of the system. We calculate the modification in the lifetime of the oscillator excited states as a function of the parameters of the circuit, the dipole orientation, and the distance between the dipole and the solenoid. The Casimir force between the solenoid and the electric dipole is calculated, and it is shown that this Casimir interaction always exists, that is, it occurs even when the macroscopic current in the solenoid is zero. We suggest experiments which can exhibit these effects related to the electromagnetic interactions between atoms or molecules and simple circuits

The Stakes in Bayh-Dole: Public Values Beyond the Pace of Innovation

Evaluation studies of the Bayh-Dole Act are generally concerned with the pace of innovation or the transgressions to the independence of research. While these concerns are important, I propose here to expand the range of public values considered in assessing Bayh-Dole and formulating future reforms. To this end, I first examine the changes in the terms of the Bayh-Dole debate and the drift in its design. Neoliberal ideas have had a definitive influence on U.S. innovation policy for the last thirty years, including legislation to strengthen patent protection. Moreover, the neoliberal policy agenda is articulated and justified in the interest of “competitiveness.” Rhetorically, this agenda equates competitiveness with economic growth and this with the public interest. Against that backdrop, I use Public Value Failure criteria to show that values such as political equality, transparency, and fairness in the distribution of the benefits of innovation, are worth considering to counter the “policy drift” of Bayh-Dole

Symposium: The Adequacy of the Presidential Succession System in the 21st Century, Part 2

Symposium. Panel: Robert E. Gilbert, Rose McDermott, Akhil Amar, and Senator Birch Bayh. Moderated by William F. Baker. Fordham University School of Law, April 16, 2010. Aired on C-SPAN.https://ir.lawnet.fordham.edu/twentyfifth_amendment_photos/1002/thumbnail.jp

Symposium: The Adequacy of the Presidential Succession System in the 21st Century, Part 3

Symposium. Panel: Joel K. Goldstein, Dean John D. Feerick, Benton Becker, James E. Fleming, and Senator Birch Bayh. Moderated by Robert Kaczorowski. Fordham University School of Law, April 16, 2010. Aired on C-SPAN.https://ir.lawnet.fordham.edu/twentyfifth_amendment_photos/1003/thumbnail.jp

Longitudinal Changes in Body Composition in Patients After Initiation of Hemodialysis Therapy: Results From an International Cohort

ObjectiveIn patients with advanced kidney disease, metabolic and nutritional derangements induced by uremia interact and reinforce each other in a deleterious vicious circle. Literature addressing the effect of dialysis initiation on changes in body composition (BC) is limited and contradictory. The aim of this study was to evaluate changes in BC in a large international cohort of incident hemodialysis patients.MethodsA total of 8,227 incident adult end-stage renal disease patients with BC evaluation within the initial first 6 months of baseline, defined as 6 months after renal replacement therapy initiation, were considered. BC, including fat tissue index (FTI) and lean tissue index (LTI), were evaluated by Body Composition Monitor (BCM, Fresenius Medical Care, Bad Homburg, Germany). Exclusion criteria at baseline were lack of a BCM measurement before or after baseline, body mass index (BMI) < 18.5 kg/m2, presence of metastatic solid tumors, treatment with a catheter, and prescription of less or more than 3 treatments per week. Maximum follow-up was 2 years. Descriptive analysis was performed comparing current values with the baseline in each interval (delta analysis). Linear mixed models considering the correlation structure of the repeated measurements were used to evaluate factors associated with different trends in FTI and LTI.ResultsBMI increased about 0.6 kg/m2 over 24 months from baseline. This was associated with increase in FTI of about 0.95 kg/m2 and a decrease in LTI of about 0.4 kg/m2. Female gender, diabetic status, and low baseline FTI were associated with a significant greater increase of FTI. Age > 67 years, diabetes, male gender, high baseline LTI, and low baseline FTI were associated with a significant greater decrease of LTI.ConclusionsWith the transition to hemodialysis, end-stage renal disease patients presented with distinctive changes in BC. These were mainly associated with gender, older age, presence of diabetes, low baseline FTI, and high baseline LTI. BMI increases did not fully represent the changes in BC