Gamow-Teller strength distributions in Fe and Ni stable isotopes

We study Gamow-Teller strength distributions in some selected nuclei of particular Astrophysical interest within the iron mass region. The theoretical framework is based on a proton-neutron Quasiparticle Random Phase Approximation built on a deformed selfconsistent mean field basis obtained from two-body density-dependent Skyrme forces. We compare our results to available experimental information obtained from (n,p) and (p,n) charge exchange reactions.Comment: 11 pages, 3 figure

Isospin mixing and Fermi transitions: Selfconsistent deformed mean field calculations and beyond

We study Fermi transitions and isospin mixing in an isotopic chain 70-78 Kr considering various approximations that use the same Skyrme-Hartree-Fock single particle basis. We study Coulomb effects as well as the effect of BCS and quasiparticle random phase approximation (QRPA) correlations. A measure of isospin mixing in the approximate ground state is defined by means of the expectation value of the isospin operator squared in N=Z nuclei (which is generalized to N different from Z nuclei). Starting from strict Hartree-Fock approach without Coulomb, it is shown that the isospin breaking is negligible, on the order of a few per thousand for (N-Z)=6, increasing to a few percent with Coulomb. Pairing correlations induce rather large isospin mixing and Fermi transitions of the forbidden type (beta- for NZ). The enhancement produced by BCS correlations is compensated to a large extent by QRPA correlations induced by isospin conserving residual interactions that tend to restore isospin symmetry.Comment: 14 pages, 5 figures, to be published in Phys. Rev.

Modeling of the binodal curve of ionic liquid/salt aqueous systems

Ionic Liquid-based Aqueous Two Phase Systems (ILATPS) are an innovative technique to separate biomolecules that combines the advantages of liquid–liquid extraction and hydrophilic ionic liquids. Most ILATPS are based on ionic liquids and conventional inorganic salts, and the phase envelope, described by the binodal curve, is usually modeled by empirical equations that are used to determine the phase compositions and assess the ionic liquid recyclability. However, these empirical equations may provide a poor extrapolation ability or low accuracy at the extreme regions of the binodal curve or suffer from problems of convergence. Therefore, the aim of this work is the analysis of the binodal curve equations, comparing the models reported in the literature to describe ILATPS and proposing alternative equations to improve accuracy or to reduce the mathematical complexity. For this purpose, a database compiling binodal experimental data of 100 ILATPS has been built, so that the analysis could make it possible to obtain representative conclusions for all these systems. Several models were developed, and different statistical criteria were used to assess the advantages and disadvantages of each one of these models for the binodal curve. The results show that, when accuracy is critical, a proposed model with just an additional parameter reduced more than 25% the residual mean squared error (RMSE) with respect to the commonly used equation, without losing the statistical significance of the parameters. For complex problems where an explicit equation in both the concentration of ionic liquid and of salt is needed, the use of an explicit model developed with 3 adjusted parameters that kept high accuracy (R2 > 0.996 and RMSE < 0.66) is proposed. Finally, the analysis also revealed that a fitting method based on the minimization of relative errors is recommended to increase the accuracy of the binodal curve at high salt concentrations, which is the crucial region for assessing the recyclability of the ionic liquid.This work was developed in the scope of the project CICECO Aveiro Institute of Materials (Ref. FCT UID/CTM/50011/2013), financed by national funds through the FCT/MEC and co-financed by FEDER under the PT2020 Partnership Agreement. The authors also acknowledge FCT for the Post-doctoral grant SFRH/BPD/79263/2011 of S.P.M. Ventura

A numerical study of the overlap probability distribution and its sample-to-sample fluctuations in a mean-field model

In this paper we study the fluctuations of the probability distributions of the overlap in mean field spin glasses in the presence of a magnetic field on the De Almeida-Thouless line. We find that there is a large tail in the left part of the distribution that is dominated by the contributions of rare samples. Different techniques are used to examine the data and to stress on different aspects of the contribution of rare samples.Comment: 13 pages, 11 figure

The marginally stable Bethe lattice spin glass revisited

Bethe lattice spins glasses are supposed to be marginally stable, i.e. their equilibrium probability distribution changes discontinuously when we add an external perturbation. So far the problem of a spin glass on a Bethe lattice has been studied only using an approximation where marginally stability is not present, which is wrong in the spin glass phase. Because of some technical difficulties, attempts at deriving a marginally stable solution have been confined to some perturbative regimes, high connectivity lattices or temperature close to the critical temperature. Using the cavity method, we propose a general non-perturbative approach to the Bethe lattice spin glass problem using approximations that should be hopeful consistent with marginal stability.Comment: 23 pages Revised version, hopefully clearer that the first one: six pages longe

Continuous phase transition in a spin-glass model without time-reversal symmetry

We investigate the phase transition in a strongly disordered short-range three-spin interaction model characterized by the absence of time reversal symmetry in the Hamiltonian. In the mean-field limit the model is well described by the Adam-Gibbs-DiMarzio scenario for the glass transition; however in the short-range case this picture turns out to be modified. The model presents a finite temperature continuous phase transition characterized by a divergent spin-glass susceptibility and a negative specific heat exponent. We expect the nature of the transition in this 3-spin model to be the same as the transition in the Edwards-Anderson model in a magnetic field, with the advantage that the strong crossover effects present in the latter case are absent.Comment: 19 pages, Latex, 16 ps figure

Superscaling predictions for neutrino-induced charged-current charged pion production at MiniBooNE

Superscaling approximation (SuSA) predictions to neutrino-induced charged-current charged pion production in the \Delta-resonance region are explored under MiniBooNE experimental conditions. The results obtained within SuSA for the flux-averaged double-differential cross sections of the \pi+ production for the \nu_\mu+CH_2 reaction as a function of the muon kinetic energy and of the scattering angle, the cross sections averaged over the angle, the total cross section for the \pi+ production, as well as CC1\pi+ to CCQE cross section ratio are compared with the corresponding MiniBooNE experimental data. The SuSA predictions are in good agreement with data on neutrino flux average cross-sections, but a somewhat different dependence on the neutrino energy is predicted than the one resulting from the experimental analysis.Comment: 15 pages, 6 figures, accepted for publication in Physics Letters

Sustainable strategies based on glycine–betaine analogue ionic liquids for the recovery of monoclonal antibodies from cell culture supernatants

Monoclonal antibodies (mAbs) are of crucial interest for therapeutic purposes, particularly in vaccination and immunization, and in the treatment of life-threatening diseases. However, their downstream processing from the complex cell culture media in which they are produced still requires multiple steps, making mAbs extremely high-cost products. Therefore, the development of cost-effective, sustainable and biocompatible purification strategies for mAbs is in high demand to decrease the associated economic, environmental and health burdens. Herein, novel aqueous biphasic systems (ABS) composed of glycine–betaine analogue ionic liquids (AGB-ILs) and K2HPO4/KH2PO4 at pH 7.0, the respective three-phase partitioning (TPP) systems, and hybrid processes combined with ultrafiltration were investigated and compared in terms of performance as alternative strategies for the purification and recovery of anti-human interleukin-8 (anti-IL-8) mAbs, which are specific therapeutics in the treatment of inflammatory diseases, from Chinese Hamster Ovary (CHO) cell culture supernatants. With the studied ABS, mAbs preferentially partition to the IL-rich phase, with recovery yields up to 100% and purification factors up to 1.6. The best systems were optimized in what concerns the IL concentration, allowing to take advantage of IL-based three-phase partitioning approaches where a precipitate enriched in mAbs is obtained at the ABS interface, yielding 41.0% of IgG with a purification factor of 2.7 (purity of 60.9%). Hybrid processes combining the two previous techniques and an ultrafiltration step were finally applied, allowing the recovery of mAbs from the different fractions in an appropriate buffer solution for further biopharmaceutical formulations, while allowing the simultaneous IL removal and reuse. The best results were obtained with the hybrid process combining TPP and ultrafiltration, allowing to obtain mAbs with a purity higher than 60%. The recyclability of the IL was additionally demonstrated, revealing no losses in the purification and recovery performance of these systems for mAbs. The biological activity of anti-IL-8 mAbs is maintained after the several purification and recovery steps, indicating that the novel ABS, three-phase partitioning and hybrid processes comprising AGB-ILs are promising and sustainable strategies in mAbs downstream processing.publishe

GIARPS: commissioning and first scientific results

GIARPS (GIAno \& haRPS) is a project devoted to have on the same focal station of the Telescopio Nazionale Galileo (TNG) both high resolution spectrographs, HARPS-N (VIS) and GIANO-B (NIR), working simultaneously. This could be considered the first and unique worldwide instrument providing cross-dispersed echelle spectroscopy at a resolution of 50,000 in the NIR range and 115,000 in the VIS and over in a wide spectral range ($0.383 - 2.45\ \mu$m) in a single exposure. The science case is very broad, given the versatility of such an instrument and its large wavelength range. A number of outstanding science cases encompassing mainly extra-solar planet science starting from rocky planets search and hot Jupiters to atmosphere characterization can be considered. Furthermore both instruments can measure high precision radial velocities by means the simultaneous thorium technique (HARPS-N) and absorbing cell technique (GIANO-B) in a single exposure. Other science cases are also possible. GIARPS, as a brand new observing mode of the TNG started after the moving of GIANO-A (fiber fed spectrograph) from Nasmyth-A to Nasmyth-B where it was re-born as GIANO-B (no more fiber feed spectrograph). The official Commissioning finished on March 2017 and then it was offered to the community. Despite the work is not finished yet. In this paper we describe the preliminary scientific results obtained with GIANO-B and GIARPS observing mode with data taken during commissioning and first open time observations.Comment: 10 pages, 11 figures, Telescopes and Astronomical instrumentation, SPIE Conf. 201