Misure di resistività mediante OhmMapper finalizzate allo studio del sito di Torraccia di Chiusi

The paper describes the findings of a geo-electric study conducted at the archaeological site of Torraccia di Chiusi (Siena Province) with the use of soil resistivity modelling. In collaboration with the Département d’Archéologie et Histoire de l’Art (Université catholique de Louvain, Belgium) and the Centro di GeoTecnologie (Università degli Studi di Siena), a new, non-invasive instrument, named the OhmMapper, was used for the first time in an archaeological context to provide geophysical sections of the terrain. The aim of the study was to evaluate the nature and distribution of the buried anthropogenic structures and to properly locate them on the map without the necessity of excavating. The site, located in the valley of the Foci river, has been described as a long lasting settlement (III to VII centuries A.D., although ceramics dating to the II century B.C. have been uncovered). Belgian and Italian archaeologists, who have been digging at the site for the last two years, have also discovered that it had undergone multiple additions and modifications throughout the years (initially a villa, and later perhaps a mansio). The OhmMapper is a capacitively coupled resistivity meter that measures the electrical properties of rocks and soil without ground stakes used in traditional resistivity surveys. A simple coaxial-cable array with transmitter and receiver sections is pulled along the ground either by a single person or attached to an all-terrain vehicle. The dipole-dipole configuration enables the instrument to immediately pick up the horizontal variations in resistivity, thereby enabling the user to identify structures such as walls or cavities. With the OhmMapper, nine sections were made around the perimeter of the area already excavated to collect data on the presence, depth, and dimensions of anthropogenic structures. The results from the sections were refined and placed on a map using an ArcGIS platform. The interpretation of the nine sections resulted in a new hypothesis on the buried anthropogenic structures and a new model of the natural landscape that existed at the site prior to its construction

Parkinson's disease plasma biomarkers: An automated literature analysis followed by experimental validation

Diagnosis of Parkinson's disease (PD) is currently assessed by the clinical evaluation of extrapyramidal signs. The identification of specific biomarkers would be advisable, however most studies stop at the discovery phase, with no biomarkers reaching clinical exploitation. To this purpose, we developed an automated literature analysis procedure to retrieve all the background knowledge available in public databases. The bioinformatic platform allowed us to analyze more than 51,000 scientific papers dealing with PD, containing information on 4121 proteins. Out of these, we could track back 35 PD-related proteins as present in at least two published 2-DE maps of human plasma. Then, 9 different proteins (haptoglobin, transthyretin, apolipoprotein A-1, serum amyloid P component, apolipoprotein E, complement factor H, fibrinogen γ, thrombin, complement C3) split into 32 spots were identified as a potential diagnostic pattern. Eventually, we compared the collected literature data to experimental gels from 90 subjects (45 PD patients, 45 non-neurodegenerative control subjects) to experimentally verify their potential as plasma biomarkers of PD

New discoveries with geophysics in the Accademia of Hadrian's Villa near Tivoli (Rome)

The Accademia Pilot Project concerns one of the lesser known buildings of Hadrian's Villa, the Accademia, which is still in private property and is not open to the public. One of the most significant and unique features of this building – and of the whole Villa – is a network of subterranean service corridors, which was seldom studied. <br><br> For the first time we used Geophysics at Hadrian's Villa, to explore the subterranean tunnels of the Accademia and reconstruct their layout. The survey was done by archaeologist Anna Maria Marras for her Master thesis in Geo-technology (Marras, 2008) and gave very interesting results

The ACTyourCHANGE in Teens Study Protocol: An Acceptance and Commitment Therapy-Based Intervention for Adolescents with Obesity: A Randomized Controlled Trial

This Randomized Controlled Trial [(RCT) aims to evaluate the effectiveness of a brief Acceptance and Commitment Therapy (ACT)-based intervention combined with treatment as usual (TAU) compared to TAU only in improving psychological conditions in a sample of adolescents with obesity (body mass index, BMI &gt; 97th percentile for age and sex) within the context of a wider multidisciplinary rehabilitation program for weight loss. Fifty consecutive adolescents (12-17 years) of both genders with obesity will be recruited among the patients hospitalized in a clinical center for obesity rehabilitation and randomly allocated into two experimental conditions: ACT + TAU vs. TAU only. Both groups will attend a three-week in-hospital multidisciplinary rehabilitation program for weight loss. The ACT + TAU condition comprises a psychological intervention based on ACT combined with a standard psychological assessment and support to the hospitalization. The TAU comprises the standard psychological assessment and support to the hospitalization. At pre- to post-psychological intervention, participants will complete the Avoidance and Fusion Questionnaire for Youth, the Psychological Well-Being Scale, the Depression Anxiety Stress Scale, the Difficulties in Emotion Regulation Scale, and the Emotional Eating subscale of the Dutch Eating Behavior Questionnaire to assess psychological well-being as the primary outcome and experiential avoidance, psychological distress, emotional dysregulation, and emotional eating as secondary outcomes. Repeated-measures ANOVAs (2 x 2) will be conducted. The study will assess the effectiveness of a brief ACT-based intervention for adolescents with obesity in improving their psychological conditions by targeting specific core processes of the ACT framework (openness, awareness, and engagement). Future directions of the study will assess whether these psychological processes will contribute to addressing long-term weight loss

Gain-tunable complementary common-source amplifier based on a flexible hybrid thin-film transistor technology

In this letter, we report a flexible complementary common-source (CS) amplifier comprising one p-type spray-coated single walled carbon nanotube and one n-type sputtered InGaZnO4 thin-film transistor (TFT). Bottom-gate TFTs were realized on a free-standing flexible polyimide foil using a maximum process temperature of 150 °C. The resulting CS amplifier operates at 10 V supply voltage and exhibits a gain bandwidth product of 60 kHz. Thanks to the use of a p-type TFT acting as a tunable current source load, the amplifier gain can be programmed from 3.5 V/V up to 27.2 V/V (28.7 dB). To the best of our knowledge, this is the highest gain ever obtained for a flexible single-stage CS amplifiers

Air Stable Indium-Gallium-Zinc-Oxide Diodes with a 6.4 GHz Extrinsic Cutoff Frequency Fabricated Using Adhesion Lithography

High speed rectifiers that can be fabricated at low cost whilst still maintaining a high performance are of interest for wireless communication applications. In this letter amorphous indium gallium zinc oxide (a-IGZO) has been used with adhesion lithography (a technique to create asymmetric planar electrodes separated by a nanogap) to fabricate high performance Schottky diode rectifiers. The diode area and junction capacitance can be significantly reduced using this technique, improving device cut-off frequencies. Devices of different widths have been fabricated showing rectification ratios between 103-104. Capacitances measured for devices of various sizes were all on the order of 0.1 pF. By applying ac signals to the diode and measuring the output voltage across a load resistor a cut-off frequency was found. a IGZO diodes with an extrinsic cut-off frequency of 6.4 GHz at a 15 dBM input power have been realized. The devices also show good air stability with little change in current-voltage characteristics after 12 months

Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's

Background: Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The present study aimed to i) further assess the prevalence of NMS and associated distress, ii) establish current rates of NMS reporting across a range of sources, and iii) explore overall and any symptom specific barriers to help-seeking for NMS. Methods: 358 PD patients completed a cross-sectional survey of NMS severity, reporting and barriers to help-seeking. A series of Generalised Estimating Equations were used to determine whether barriers were symptom specific. Results: A mean of 10.5 NMS were reported by each patient. Rates of non-reporting of NMS ranged from 15 to 72% of those experiencing distressing symptoms. The most commonly reported barriers to help-seeking were acceptance of symptoms; lack of awareness that a symptom was associated with PD, and belief that no effective treatments were available. Symptom specific barriers were found for sexual dysfunction (embarrassment), unexplained pain and urinary problems (belief about lack of treatment availability). Conclusion: A diverse range of barriers prevent PD patients reporting NMS to HCPs and these barriers differ between NMS. The study provides the foundations for developing interventions to increase reporting by targeting individual NMS. Increasing rates of help-seeking for NMS by patients to their Parkinson's healthcare providers will increase appropriate clinical care which may improve quality of life and well-being