Evaluation of Continuous Monitoring as a Tool for Municipal Stormwater Management Programs

The purpose of this study is to evaluate the uncertainty attributable to inadequate temporal sampling of stormwater discharge and water quality, and understand its implications for meeting monitoring objectives relevant to municipal separate storm sewer systems (MS4s). A methodology is presented to evaluate uncertainty attributable to inadequate temporal sampling of continuous stormflow and water quality, and a case study demonstrates the application of the methodology to six small urban watersheds (0.8-6.8 km2) and six large rural watersheds (30-16,192 km2) in Virginia. Results indicate the necessity of high-frequency continuous monitoring for accurately capturing multiple monitoring objectives, including illicit discharges, acute toxicity events, and stormflow pollutant concentrations and loads, as compared to traditional methods of sampling. For example, 1-h sampling in small urban watersheds and daily sampling in large rural watersheds would introduce uncertainty in capturing pollutant loads of 3–46% and 10–28%, respectively. Overall, the outcomes from this study highlight how MS4s can leverage continuous monitoring to meet multiple objectives under current and future regulatory environments

Carbon Sequestration in Managed Temperate Coniferous Forests Under Climate Change

Management of temperate forests has the potential to increase carbon sinks and mitigate climate change. However, those opportunities may be confounded by negative climate change impacts. We therefore need a better understanding of climate change alterations to temperate forest carbon dynamics before developing mitigation strategies. The purpose of this project was to investigate the interactions of species composition, fire, management, and climate change in the Copper–Pine Creek valley, a temperate coniferous forest with a wide range of growing conditions. To do so, we used the LANDIS-II modelling framework including the new Forest Carbon Succession extension to simulate forest ecosystems under four different productivity scenarios, with and without climate change effects, until 2050. Significantly, the new extension allowed us to calculate the net sector productivity, a carbon accounting metric that integrates aboveground and belowground carbon dynamics, disturbances, and the eventual fate of forest products. The model output was validated against literature values. The results implied that the species optimum growing conditions relative to current and future conditions strongly influenced future carbon dynamics. Warmer growing conditions led to increased carbon sinks and storage in the colder and wetter ecoregions but not necessarily in the others. Climate change impacts varied among species and site conditions, and this indicates that both of these components need to be taken into account when considering climate change mitigation activities and adaptive management. The introduction of a new carbon indicator, net sector productivity, promises to be useful in assessing management effectiveness and mitigation activities

Precision neutron interferometric measurement of the nd coherent neutron scattering length and consequences for models of three-nucleon forces

We have performed the first high precision measurement of the coherent neutron scattering length of deuterium in a pure sample using neutron interferometry. We find b_nd = (6.665 +/- 0.004) fm in agreement with the world average of previous measurements using different techniques, b_nd = (6.6730 +/- 0.0045) fm. We compare the new world average for the nd coherent scattering length b_nd = (6.669 +/- 0.003) fm to calculations of the doublet and quartet scattering lengths from several modern nucleon-nucleon potential models with three-nucleon force (3NF) additions and show that almost all theories are in serious disagreement with experiment. This comparison is a more stringent test of the models than past comparisons with the less precisely-determined nuclear doublet scattering length of a_nd = (0.65 +/- 0.04) fm.Comment: 4 pages, 4 figure

Gateway vectors for efficient artificial gene assembly in vitro and expression in yeast Saccharomyces cerevisiae

Peer reviewedPublisher PD

Higher Education and behavior analysis in Europe::Creating a unified approach for the training of autism professionals

Training of behaviour analysts for autism services, has improved notably within a European higher education context. However, regional discrepancies associated with economic, health care, social services, and institutional policies magnify the importance of creating appropriate unified training and consumer protection. Although the European Association for Behaviour Analysis (EABA) has endorsed the Behavior Analyst Certification Board’s (BACB) designations, the absence of European and national regulations, recognition, and accreditation remain significant barriers to quality training and implementation. These challenges are  particularly pertinent in light of BACB decision to limit certification to residents in the USA and Canada after 2022. Advances, challenges, and future directions are discussed within the context of higher education in the United Kingdom, the Czech Republic, Greece, Iceland, Italy, Norway, and Sweden. The post-Bologna European agenda for higher education, globalization and opportunities for the training of behaviour analysts within European higher education are outlined

Patient-rated satisfaction and improvement following hip and knee replacements: Development of prediction models

Rationale: Effective preoperative assessments of determinants of health status and function may improve postoperative outcomes. Aims and Objectives: We developed risk scores of preoperative patient factors and patient-reported outcome measures (PROMs) as predictors of patient-rated satisfaction and improvement following hip and knee replacements. Patients and Methods: Prospectively collected National Health Service and independent sector patient data (n = 30,457), including patients' self-reported demographics, comorbidities, PROMs (Oxford Hip/Knee score (OHS/OKS) and European Quality of Life (EQ5D index and health-scale), were analysed. Outcomes were defined as patient-reported satisfaction and improvement following surgery at 7-month follow-up. Univariable and multivariable-adjusted logistic regressions were undertaken to build prediction models; model discrimination was evaluated with the concordance index (c-index) and nomograms were developed to allow the estimation of probabilities. Results: Of the 14,651 subjects with responses for satisfaction following hip replacements 564 (3.8%) reported dissatisfaction, and 1433 (9.2%) of the 15,560 following knee replacement reported dissatisfaction. A total of 14,662 had responses for perceived improvement following hip replacement (lack of improvement in 391; 2.7%) and 15,588 following knee replacement (lack of improvements in 1092; 7.0%). Patients reporting poor outcomes had worse preoperative PROMs. Several factors, including age, gender, patient comorbidities and EQ5D, were included in the final prediction models: C-indices of these models were 0.613 and 0.618 for dissatisfaction and lack of improvement, respectively, for hip replacement and 0.614 and 0.598, respectively, for knee replacement. Conclusions: Using easily accessible preoperative patient factors, including PROMs, we developed models which may help predict dissatisfaction and lack of improvement following hip and knee replacements and facilitate risk stratification and decision-making processes

Maturity Model for Interoperability Potential Measurement

Interoperability potential concerns the preparation level of an enterprise to establish an efficient collaboration with possible part- ners. In order to improve their interoperability, enterprises need to know witch level of maturity they have achieved. This article pro- poses a complete maturity model composed by a methodology and a reference set of parameters to measure interoperability potential. In order to clarify the proposal, an example of application in a real case is described.Campos, C.; Chalmeta, R.; Grangel, R.; Poler Escoto, R. (2013). Maturity Model for Interoperability Potential Measurement. Information Systems Management. 30(3):218-234. doi:10.1080/10580530.2013.794630S218234303Alfaro, J. J., Rodriguez-Rodriguez, R., Verdecho, M. J., & Ortiz, A. (2009). Business process interoperability and collaborative performance measurement. International Journal of Computer Integrated Manufacturing, 22(9), 877-889. doi:10.1080/09511920902866112Sabucedo, L. Á., & Rifón, L. A. (2010). Managing Citizen Profiles in the Domain of e-Government: The cPortfolio Project. Information Systems Management, 27(4), 309-319. doi:10.1080/10580530.2010.514181Berre, A.-J., Elvesæter, B., Figay, N., Guglielmina, C., Johnsen, S. G., Karlsen, D., … Lippe, S. (s. f.). The ATHENA Interoperability Framework. Enterprise Interoperability II, 569-580. doi:10.1007/978-1-84628-858-6_62Blanc, S., Ducq, Y., & Vallespir, B. (2007). Evolution management towards interoperable supply chains using performance measurement. Computers in Industry, 58(7), 720-732. doi:10.1016/j.compind.2007.05.011Campos, C., Martí, I., Grangel, R., Mascherpa, A. and Chalmeta, R. A methodological proposal for the development of an interoperability framework.Model Driven Interoperability for Sustainable Information Systems (MDISIS′08) (CAiSE′08). Vol. 340, pp.47–57. CEUR-WS. http://ceur-ws.org/Vol-340/paper04.pdfChalmeta, R., & Grangel, R. (2005). Performance measurement systems for virtual enterprise integration. International Journal of Computer Integrated Manufacturing, 18(1), 73-84. doi:10.1080/0951192042000213164Doumeingts, G. and Chen, D. Basic concepts and approaches to develop interoperability of enterprise applications.PRO-VE,IFIP Conference Proceedings. Edited by: Camarinha-Matos, L. M. and Afsarmanesh, H. Vol. 262, pp.323–330. Norwell, MA: Kluwer.Duque, A., Campos, C., Jimenez-Ruiz, E. and Chalmeta, R. An ontological solution to supprot interoperability in the textile industry.Second IFIP WG 5.8 International Workshop, IWEI 2009. Edited by: Poler, M. V. S. R. Vol. 38, pp.38–51. New York: Springer.Guédria, W., Naudet, Y., & Chen, D. (2008). Interoperability Maturity Models – Survey and Comparison –. Lecture Notes in Computer Science, 273-282. doi:10.1007/978-3-540-88875-8_48Hoving, R. (2007). Information Technology Leadership Challenges — Past, Present, and Future. Information Systems Management, 24(2), 147-153. doi:10.1080/10580530701221049Palomares, N., Campos, C., & Palomero, S. (2010). How to Develop a Questionnaire in Order to Measure Interoperability Levels in Enterprises. Enterprise Interoperability IV, 387-396. doi:10.1007/978-1-84996-257-5_36Walsham, G. (1995). Interpretive case studies in IS research: nature and method. European Journal of Information Systems, 4(2), 74-81. doi:10.1057/ejis.1995.

What is going on around here? Intolerance of uncertainty predicts threat generalization

Attending to stimuli that share perceptual similarity to learned threats is an adaptive strategy. However, prolonged threat generalization to cues signalling safety is considered a core feature of pathological anxiety. One potential factor that may sustain over-generalization is sensitivity to future threat uncertainty. To assess the extent to which Intolerance of Uncertainty (IU) predicts threat generalization, we recorded skin conductance in 54 healthy participants during an associative learning paradigm, where threat and safety cues varied in perceptual similarity. Lower IU was associated with stronger discrimination between threat and safety cues during acquisition and extinction. Higher IU, however, was associated with generalized responding to threat and safety cues during acquisition, and delayed discrimination between threat and safety cues during extinction. These results were specific to IU, over and above other measures of anxious disposition. These findings highlight: (1) a critical role of uncertainty-based mechanisms in threat generalization, and (2) IU as a potential risk factor for anxiety disorder development

How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis

OBJECTIVES: To analyse enrolment to interventional trials during the first wave of the COVID-19 pandemic in England and describe the barriers to successful recruitment in the circumstance of a further wave or future pandemics. DESIGN: We analysed registered interventional COVID-19 trial data and concurrently did a prospective observational study of hospitalised patients with COVID-19 who were being assessed for eligibility to one of the RECOVERY, C19-ACS or SIMPLE trials. SETTING: Interventional COVID-19 trial data were analysed from the clinicaltrials.gov and International Standard Randomized Controlled Trial Number databases on 12 July 2020. The patient cohort was taken from five centres in a respiratory National Institute for Health Research network. Population and modelling data were taken from published reports from the UK government and Medical Research Council Biostatistics Unit. PARTICIPANTS: 2082 consecutive admitted patients with laboratory-confirmed SARS-CoV-2 infection from 27 March 2020 were included. MAIN OUTCOME MEASURES: Proportions enrolled, and reasons for exclusion from the aforementioned trials. Comparisons of trial recruitment targets with estimated feasible recruitment numbers. RESULTS: Analysis of trial registration data for COVID-19 treatment studies enrolling in England showed that by 12 July 2020, 29 142 participants were needed. In the observational study, 430 (20.7%) proceeded to randomisation. 82 (3.9%) declined participation, 699 (33.6%) were excluded on clinical grounds, 363 (17.4%) were medically fit for discharge and 153 (7.3%) were receiving palliative care. With 111 037 people hospitalised with COVID-19 in England by 12 July 2020, we determine that 22 985 people were potentially suitable for trial enrolment. We estimate a UK hospitalisation rate of 2.38%, and that another 1.25 million infections would be required to meet recruitment targets of ongoing trials. CONCLUSIONS: Feasible recruitment rates, study design and proliferation of trials can limit the number, and size, that will successfully complete recruitment. We consider that fewer, more appropriately designed trials, prioritising cooperation between centres would maximise productivity in a further wave

MAVEN IUVS observations of the aftermath of the Comet Siding Spring meteor shower on Mars

We report the detection of intense emission from magnesium and iron in Mars' atmosphere caused by a meteor shower following Comet Siding Spring's close encounter with Mars. The observations were made with the Imaging Ultraviolet Spectrograph, a remote sensing instrument on the Mars Atmosphere and Volatile EvolutioN spacecraft orbiting Mars. Ionized magnesium caused the brightest emission from the planet's atmosphere for many hours, resulting from resonant scattering of solar ultraviolet light. Modeling suggests a substantial fluence of low-density dust particles 1-100μm in size, with the large amount and small size contrary to predictions. The event created a temporary planet-wide ionospheric layer below Mars' main dayside ionosphere. The dramatic meteor shower response at Mars is starkly different from the case at Earth, where a steady state metal layer is always observable but perturbations caused by even the strongest meteor showers are challenging to detect